A novel compact LED array based light induced fluorescence (LIF) sensor has been developed for real-time in-line
monitoring of intrinsic fluorophores in the solid and liquid state. The sensor is essential for on-the-spot, routine, and cost
effective real-time analysis. The sensor is designed to provide real-time emission response along with various smart
sensing parameters to ensure real-time measurement quality that is required for regulated GMP process monitoring
applications. This work describes a LIF sensor tailored for solid-phase fluorometry. Fundamental figures of merit,
excitation overexposure and smart sensing features required for modern process monitoring and control are discussed
within the context of pharmaceutical solid-phase manufacturing and similar applications.
The introduction of fiber optic accessories for the Hewlett-Packard 8452A diode array spectrophotometer has greatly expanded its utility and, in particular, has enhanced its use as a process application development tool. There is a clear trend toward fiber optic based process photometric analyzers. With the advent of spectroscopy using fiber optics, the stage is set for a logical transition of laboratory developed applications to process implementation. This is particularly true when both the laboratory spectrophotometric and the process photometric analyzers are capable of using the same sensors. This paper presents an example of an application development and its transition to process implementation.
Fiber-optic-based, on-line photometric/spectrophotometric analytic methods are becoming increasingly more important in the process control industries because of unique benefits such as: safety, real-time data capture, immunity to EMI/RFI, and simplicity of installation. End- users employing fiber-optic methods are experiencing increased production yields, less waster, and greater product consistency all because the process can be controlled more efficiently. Extractive and in-situ flow cells have proven to be valuable means of 'looking' at the process stream. These techniques are currently being offered by several manufacturers of on-line fiber-optic photometric/spectrophotometric instruments. Custom Sensors & Technology has developed practical techniques for optical energy transmission in the 250 - 2000 nm wavelength range. In addition to discussing extractive and in-situ methods of sampling, various design considerations are addressed which relate to the efficiency of coupling light energy into and out of extractive flow cells and in-situ probes. In-situ probes can be of the transmission, turbidity, attenuated total reflection, or diffuse reflection types; and can be installed in a sanitary or threaded pipe fitting.