This paper proposes a brain image registration algorithm, called RABBIT, which achieves fast and accurate image
registration by using an intermediate template generated by a statistical shape deformation model during the image
registration procedure. The statistical brain shape deformation information is learned by means of principal component
analysis (PCA) from a set of training brain deformations, each of them linking a selected template to an individual brain
sample. Using the statistical deformation information, the template image can be registered to a new individual image by
optimizing a statistical deformation model with a small number of parameters, thus generating an intermediate template
very close to the individual brain image. The remaining shape difference between the intermediate template and the
individual brain is then minimized by a general registration algorithm, such as HAMMER. With the help of the
intermediate template, the registration between the template and individual brain images can be achieved fast and with
similar registration accuracy as HAMMER. The effectiveness of the RABBIT has been evaluated by using both
simulated atrophy data and real brain images. The experimental results show that RABBIT can achieve over five times
speedup, compared to HAMMER, without losing any registration accuracy or statistical power in detecting brain
There has been a rapidly increasing demand for the high numerical aperture (NA) in specialty optical fibers used in
recent high power fiber lasers and remote sensing applications. Various polymer clad resins (PCR) have been reported
aimed for a low refractive index to achieve a high NA, which resulted in a lower modulus. In this study, we report a
novel PCR with a higher modulus whilst maintaining a high NA over 0.44 using newly designed fluorinated oligomer
and monomer having low refractive index and high functionality. Some resins prepared various formulations using
synthesized oligomers and then compared curing speed.
In order to clarify the relationship between the water resistance and compositional additives in the primary coating for optical fibers, we prepared various primary coatings that contained silane coupling agents in combination with amine synergists. We observed the appearance of the interface between glass and primary coating after soaking in water at 65° for 30 days. Water resistance was found to be heavily influenced by the content and type of silane coupling agents and amine synergists and their trends are reported.
We studied optical materials with lower refractive indices than silica, which can be used in fiber optic technology applied to medical devices. The materials were tested for biocompatibility. This paper details the experiment based on USP biocompatibility specifications, its results, and the optical properties of this material.