Prof. Miya Ishihara Profile

Prof. Miya Ishihara

Professor at National Defense Medical College

SPIE Involvement:

Conference Program Committee | Author

Publications (65)

Proceedings Article | 27 February 2019

Validation study of a quantitative photoacoustic image reconstruction using Monte Carlo method and linearization

Shinpei Okawa, Takeshi Hirasawa, Kazuhiro Tsujita, Toshihiro Kushbiki, Masanori Fujita, Miya Ishihara

Proc. SPIE. 10878, Photons Plus Ultrasound: Imaging and Sensing 2019

KEYWORDS: 3D image reconstruction, Tissues, Ultrasonography, Blood vessels, Light scattering, Monte Carlo methods, Transducers, Absorption

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Proceedings Article | 27 February 2019

Performance validation of improved photoacoustic / ultrasound superposed imaging system for evaluation of diabetic neuropathy

Miya Ishihara, Kaku Irisawa, Dai Murakoshi, Takeshi Hirasawa, Shinpei Okawa, Ryuichi Azuma, Takeshi Osonoi, Hitoshi Nukada, Soroku Yagihashi

Proc. SPIE. 10878, Photons Plus Ultrasound: Imaging and Sensing 2019

KEYWORDS: Light sources, Nerve, Imaging systems, Blood, Ultrasonography, Arteries, Hypoxia, Blood oxygen saturation, Photoacoustic spectroscopy, Prototyping

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Proceedings Article | 19 February 2018

Quantitative analysis for peripheral vascularity assessment based on clinical photoacoustic and ultrasound images

Dai Murakoshi, Kazuhiro Hirota, Hiroyasu Ishii, Atsushi Hashimoto, Tetsurou Ebata, Kaku Irisawa, Takatsugu Wada, Toshiro Hayakawa, Kenji Itoh, Miya Ishihara

Proc. SPIE. 10494, Photons Plus Ultrasound: Imaging and Sensing 2018

KEYWORDS: Nerve, Tissues, Imaging systems, Ultrasonography, Skin, Image analysis, Quantitative analysis, Blood circulation, Photoacoustic imaging, Vascular imaging, Prototyping

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Proceedings Article | 19 February 2018

3D quantitative photoacoustic image reconstruction using Monte Carlo method and linearization

Shinpei Okawa, Takeshi Hirasawa, Kazuhiro Tsujita, Toshihiro Kushibiki, Miya Ishihara

Proc. SPIE. 10494, Photons Plus Ultrasound: Imaging and Sensing 2018

KEYWORDS: 3D image reconstruction, Numerical simulations, 3D modeling, Monte Carlo methods, Photoacoustic imaging, Reconstruction algorithms

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Proceedings Article | 19 February 2018

Multispectral photoacoustic tomography for detection of small tumors inside biological tissues

Takeshi Hirasawa, Shinpei Okawa, Kazuhiro Tsujita, Toshihiro Kushibiki, Masanori Fujita, Yasuteru Urano, Miya Ishihara

Proc. SPIE. 10494, Photons Plus Ultrasound: Imaging and Sensing 2018

KEYWORDS: Tumors, Visualization, Tissues, Sensors, Image sensors, Absorbance, Acquisition tracking and pointing, Tissue optics, Acoustics, Signal detection

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Proceedings Article | 18 April 2017

Novel compact photoacoustic imaging system to explore the applications in the medical imaging field

Kaku Irisawa, Takatsugu Wada, Toshiro Hayakawa, Miya Ishihara

Proc. SPIE. 10252, Optical Manipulation Conference

KEYWORDS: Image fusion, Light sources, Doppler effect, Imaging systems, Ultrasonography, Image resolution, Medical imaging, Image quality, Photoacoustic imaging, Tissue optics

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Proceedings Article | 3 March 2017

In vivo photoacoustic imaging of uterine cervical lesion and its image processing based on light propagation in biological medium

Shinpei Okawa, Kiguna Sei, Takeshi Hirasawa, Kaku Irisawa, Kazuhiro Hirota, Takatsugu Wada, Toshihiro Kushibiki, Kenichi Furuya, Miya Ishihara

Proc. SPIE. 10064, Photons Plus Ultrasound: Imaging and Sensing 2017

KEYWORDS: Cancer, Image processing, Image restoration, Diagnostics, Numerical simulations, Cervix, Finite element methods, Photoacoustic imaging, Cervical cancer, In vivo imaging, Absorption

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Proceedings Article | 3 March 2017

Dependence of photoacoustic signal generation characteristics on fluorescence quantum yields of small organic molecule based contrast agents

Takeshi Hirasawa, Ryu Iwatate, Mako Kamiya, Shinpei Okawa, Yasuteru Urano, Miya Ishihara

Proc. SPIE. 10064, Photons Plus Ultrasound: Imaging and Sensing 2017

KEYWORDS: Sensors, Signal attenuation, Quantum efficiency, Multispectral imaging, Photoacoustic imaging, Molecular imaging, Photoacoustic spectroscopy, Tissue optics, Rhodamine

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Proceedings Article | 3 March 2017

Possibility of transrectal photoacoustic imaging-guided biopsy for detection of prostate cancer

Miya Ishihara, Masayuki Shinchi, Akio Horiguchi, Hiroshi Shinmoto, Hitoshi Tsuda, Kaku Irisawa, Takatsugu Wada, Tomohiko Asano

Proc. SPIE. 10064, Photons Plus Ultrasound: Imaging and Sensing 2017

KEYWORDS: Defense and security, Cancer, Tumors, Visualization, Imaging systems, Ultrasonography, Magnetic resonance imaging, Medical research, Diagnostics, Biopsy, Photoacoustic imaging, Prostate, Prostate cancer, Photoacoustic spectroscopy, Target designation

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Proceedings Article | 15 March 2016

Comparison of transrectal photoacoustic, Doppler, and magnetic resonance imaging for prostate cancer detection

Miya Ishihara, Akio Horiguchi, Hiroshi Shinmoto, Hitoshi Tsuda, Kaku Irisawa, Takatsugu Wada, Tomohiko Asano

Proc. SPIE. 9708, Photons Plus Ultrasound: Imaging and Sensing 2016

KEYWORDS: Cancer, Tumors, Doppler effect, Ultrasonography, Magnetic resonance imaging, Medical research, Diagnostics, Biopsy, Transducers, Prostate, Prostate cancer, Photoacoustic spectroscopy, Clinical trials

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Proceedings Article | 15 March 2016

Effect of reference spectra in spectral fitting to discriminate enzyme-activatable photoacoustic probe from intrinsic optical absorbers

Takeshi Hirasawa, Shinpei Okawa, Ryu Iwatate, Mako Kamiya, Yasuteru Urano, Miya Ishihara

Proc. SPIE. 9708, Photons Plus Ultrasound: Imaging and Sensing 2016

KEYWORDS: Biomedical optics, Cancer, Tumors, Tissues, Scattering, Sensors, Multispectral imaging, Photoacoustic imaging, Molecular imaging, Photoacoustic spectroscopy, Tissue optics, Signal detection, Absorption

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Proceedings Article | 15 March 2016

Effects of the optical properties of gold nanoparticles on photoacoustic signals

S. Okawa, T. Hirasawa, R. Sato, T. Kushibiki, M. Ishihara, T. Teranishi

Proc. SPIE. 9708, Photons Plus Ultrasound: Imaging and Sensing 2016

KEYWORDS: Gold, Optical properties, Scattering, Nanoparticles, Photons, Light scattering, Laser scattering, Numerical simulations, Monte Carlo methods, Photoacoustic imaging, Photoacoustic spectroscopy, Absorption

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Proceedings Article | 15 March 2016

Photoacoustic imaging system for peripheral small-vessel imaging based on clinical ultrasound technology

Kaku Irisawa, Kazuhiro Hirota, Atsushi Hashimoto, Dai Murakoshi, Hiroyasu Ishii, Takuji Tada, Takatsugu Wada, Toshiro Hayakawa, Ryuichi Azuma, Naoki Otani, Kenji Itoh, Miya Ishihara

Proc. SPIE. 9708, Photons Plus Ultrasound: Imaging and Sensing 2016

KEYWORDS: Image visualization, 3D acquisition, 3D image reconstruction, Doppler effect, Visualization, Imaging systems, Ultrasonography, Blood vessels, Arteries, Transducers, Photoacoustic imaging, Signal detection

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Proceedings Article | 11 March 2015

Photoacoustic imaging of small organic molecule-based photoacoustic probe in subcutaneous tumor using P(VDF-TrFE) acoustic sensor

Takeshi Hirasawa, Shinpei Okawa, Mako Kamiya, Yasuteru Urano, Miya Ishihara

Proc. SPIE. 9323, Photons Plus Ultrasound: Imaging and Sensing 2015

KEYWORDS: Optical fibers, Ferroelectric materials, Tumors, Sensors, Image sensors, Photoacoustic imaging, In vivo imaging, Acoustics, Signal detection, Absorption

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Proceedings Article | 11 March 2015

Development of photoacoustic imaging technology overlaid on ultrasound imaging and its clinical application

Miya Ishihara, Kazuhiro Tsujita, Akio Horiguchi, Kaku Irisawa, Tomohiro Komatsu, Makoto Ayaori, Takeshi Hirasawa, Tadashi Kasamatsu, Kazuhiro Hirota, Hitoshi Tsuda, Katsunori Ikewaki, Tomohiko Asano

Proc. SPIE. 9323, Photons Plus Ultrasound: Imaging and Sensing 2015

KEYWORDS: Defense and security, Medicine, Veins, Visualization, Ultrasonography, Magnetic resonance imaging, Biopsy, Photoacoustic imaging, Tissue optics, Clinical research

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Purpose: Photoacoustic imaging (PAI) enables one to visualize the distribution of hemoglobin and acquire a map of microvessels without using contrast agents. The purpose of our study is to develop a clinically applicable PAI system integrated with a clinical ultrasound (US) array system with handheld PAI probes providing coregistered PAI and US images. Clinical research trials were performed to evaluate the performance and feasibility of clinical value. Materials and Methods: We developed two types of handheld PAI probes: a linear PAI probe combining a conventional linear-array US probe with optical illumination and a transrectal ultrasonography (TRUS)-type PAI probe. We performed experiments with Japanese white rabbits and conducted clinical research trials of urology and vascular medicine with the approval of the medical human ethics committee of the National Defense Medical College. Results: We successfully acquired high-dynamic-range images of the vascular network ranging from capillaries to landmark arteries and identified the femoral vein, deep femoral vein, and great saphenous vein of rabbits. These major vessels in the rabbits groin are surrounded with microvessels connected to each other. Periprostatic microvessels were monitored during radical prostatectomy for localized prostate cancer and they were colocalized with nerve fibers, and their distribution was consistent with the corresponding PAI. The TRUS-type PAI probe clearly demonstrated the location and extent of the neurovascular bundle (NVB) better than does TRUS alone. Conclusions: The system, which can obtain a PAI, a US image, and a merged image, was innovatively designed so that medical doctors can easily find the location without any prior knowledge or extended skills to analyze the obtained images. Our pilot feasibility study confirms that PAI could be an imaging modality useful in the screening study and diagnostic biopsy.

Proceedings Article | 11 March 2015

Influence of the light propagation models on a linearized photoacoustic image reconstruction of the light absorption coefficient

Shinpei Okawa, Takeshi Hirasawa, Toshihiro Kushibiki, Miya Ishihara

Proc. SPIE. 9323, Photons Plus Ultrasound: Imaging and Sensing 2015

KEYWORDS: Optical fibers, Scattering, Ultrasonography, Image restoration, Numerical simulations, Monte Carlo methods, Reconstruction algorithms, Photoacoustic spectroscopy, 3D image processing, Absorption

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Proceedings Article | 3 March 2014

Reconstruction of the optical absorption coefficient from photoacoustic signals measured by scanning coaxial probe with regularization methods

Shinpei Okawa, Takeshi Hirasawa, Toshihiro Kushibiki, Miya Ishihara

Proc. SPIE. 8943, Photons Plus Ultrasound: Imaging and Sensing 2014

KEYWORDS: Optical fibers, Tissues, Sensors, Image restoration, Numerical simulations, Finite element methods, Photoacoustic spectroscopy, Signal detection, Inverse optics, Absorption

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Proceedings Article | 3 March 2014

The effect of surface charge of plasmonic gold nanoparticles on photoacoustic signal

Miya Ishihara, Takeshi Hirasawa, Shinpei Okawa, Ryota Sato, Yasuteru Urano, Toshiharu Teranishi

Proc. SPIE. 8943, Photons Plus Ultrasound: Imaging and Sensing 2014

KEYWORDS: Gold, Optical fibers, Plasmonics, Cancer, Nanoparticles, Ultrasonography, Transmission electron microscopy, Absorbance, Photoacoustic spectroscopy, Absorption

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Proceedings Article | 3 March 2014

Quantification of optical attenuation coefficient based on continuous wavelet transform of photoacoustic signals measured by a focused broadband acoustic sensor

T. Hirasawa, S. Okawa, M. Fujita, T. Kushibiki, M. Ishihara

Proc. SPIE. 8943, Photons Plus Ultrasound: Imaging and Sensing 2014

KEYWORDS: Sensors, Signal attenuation, Blood vessels, Photoacoustic spectroscopy, Tissue optics, Acoustics, Signal detection, Inverse optics, Continuous wavelet transforms, Near field optics

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Proceedings Article | 4 March 2013

Improvement in quantifying optical absorption coefficients based on continuous wavelet-transform by correcting distortions in temporal photoacoustic waveforms

Takeshi Hirasawa, Masanori Fujita, Shinpei Okawa, Toshihiro Kushibiki, Miya Ishihara

Proc. SPIE. 8581, Photons Plus Ultrasound: Imaging and Sensing 2013

KEYWORDS: Biomedical optics, Sensors, Calibration, Photoacoustic spectroscopy, Tissue optics, Acoustics, Signal detection, Pulsed laser operation, Continuous wavelet transforms, Absorption

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Proceedings Article | 4 March 2013

Reconstruction of the optical properties of inhomogeneous medium from photoacoustic signal with lp sparsity regularization

Shinpei Okawa, Takeshi Hirasawa, Toshihiro Kushibiki, Miya Ishihara

Proc. SPIE. 8581, Photons Plus Ultrasound: Imaging and Sensing 2013

KEYWORDS: Optical properties, Tissues, Image restoration, Numerical simulations, Chromophores, Inverse problems, Finite element methods, Photoacoustic spectroscopy, Signal detection, Absorption

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Proceedings Article | 10 March 2012

Control of anoxic depolarization in rat brain by near-infrared laser irradiation and its monitoring by intrinsic optical signal imaging

Satoko Kawauchi, Shunichi Sato, Yoichi Uozumi, Hiroshi Nawashiro, Miya Ishihara, Hiroshi Ashida

Proc. SPIE. 8211, Mechanisms for Low-Light Therapy VII

KEYWORDS: Near infrared, Phototherapy, Scattering, Light scattering, Laser scattering, Hypoxia, Laser irradiation, Acquisition tracking and pointing, Neuroimaging, Brain

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Proceedings Article | 23 February 2012

Continuous wavelet-transform analysis of photoacoustic signal waveform to determine optical absorption coefficient

T. Hirasawa, M. Ishihara, K. Tsujita, K. Hirota, K. Irisawa, M. Kitagaki, M. Fujita, M. Kikuchi

Proc. SPIE. 8223, Photons Plus Ultrasound: Imaging and Sensing 2012

KEYWORDS: Signal to noise ratio, Scattering, Sensors, Signal attenuation, Ultrasonography, Wavelets, Signal generators, Tissue optics, Continuous wavelet transforms, Absorption

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Proceedings Article | 23 February 2012

Influence of laser pulse width to the photoacoustic temporal waveform and the image resolution with a solid-state excitation laser

K. Irisawa, T. Hirasawa, K. Hirota, K. Tsujita, M. Ishihara

Proc. SPIE. 8223, Photons Plus Ultrasound: Imaging and Sensing 2012

KEYWORDS: Nd:YAG lasers, Solid state lasers, Image resolution, Image quality, Photoacoustic imaging, Photoacoustic spectroscopy, Modulation transfer functions, Signal detection, Pulsed laser operation, Absorption

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Proceedings Article | 17 June 2011

In vivo determination of absorption and scattering properties in rat cerebral cortex using single reflectance fiber probe with two sourcecollector geometries

Izumi Nishidate, Satoko Kawauchi, Shunichi Sato, Miya Ishihara, Makoto Kikuchi, Manabu Sato

Proc. SPIE. 8087, Clinical and Biomedical Spectroscopy and Imaging II

KEYWORDS: Diffuse reflectance spectroscopy, Scattering, Light scattering, Reflectivity, Monte Carlo methods, Cerebral cortex, In vivo imaging, Tissue optics, Absorption, Brain

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Proceedings Article | 23 February 2011

Analysis and verification of dominant factor to obtain the high resolution photo-acoustic imaging

T. Hirasawa, M. Ishihara, M. Kitagaki, I. Bansaku, M. Fujita, M. Kikuchi

Proc. SPIE. 7899, Photons Plus Ultrasound: Imaging and Sensing 2011

KEYWORDS: Imaging systems, Sensors, Ultrasonography, Image resolution, Image sensors, Reconstruction algorithms, Tissue optics, Acoustics, Signal detection, Absorption

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Proceedings Article | 23 February 2011

Multifunctional photoacoustic signals detected by P(VDF/TrFE) film sensor with a wide range of frequency

M. Ishihara, T. Hirasawa, K. Tsujita, M. Kitagaki, I. Bansaku, M. Fujita, M. Kikuchi

Proc. SPIE. 7899, Photons Plus Ultrasound: Imaging and Sensing 2011

KEYWORDS: Optical fibers, Ferroelectric materials, Sensors, Blood vessels, Image sensors, Transducers, Photoacoustic imaging, Photoacoustic spectroscopy, Signal detection, Absorption

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Proceedings Article | 19 February 2011

Effect of the illumination method on photo-acoustic image quality with array transducer based system

Kazuhiro Tsujita, Miya Ishihara, Takeshi Hirasawa, Kaku Irisawa, Kazuhiro Hirota, Yoshiaki Satoh, Makoto Kikuchi

Proc. SPIE. 7899, Photons Plus Ultrasound: Imaging and Sensing 2011

KEYWORDS: Imaging systems, Signal attenuation, Ultrasonography, Image resolution, Fiber lasers, Monte Carlo methods, Image quality, Transducers, Modulation transfer functions, Imaging arrays

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Proceedings Article | 18 February 2011

The usefulness of optical analyses for detecting vulnerable plaques using rabbit models

Kanji Nakai, Miya Ishihara, Satoko Kawauchi, Masashi Shiomi, Makoto Kikuchi, Tatsumi Kaji

Proc. SPIE. 7883, Photonic Therapeutics and Diagnostics VII

KEYWORDS: Spectroscopy, Remote sensing, Luminescence, Fluorescence spectroscopy, Optical analysis, Arteries, Reflectance spectroscopy, Time resolved spectroscopy, Absorption, Animal model studies

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Proceedings Article | 12 February 2011

Near-infrared scattering imaging of depolarization waves in a rat hypoxic brain model and its application to assessment of brain tissue reversibility

Satoko Kawauchi, Shunichi Sato, Yoichi Uozumi, Hiroshi Nawashiro, Miya Ishihara, Makoto Kikuchi

Proc. SPIE. 7907, Biomedical Applications of Light Scattering V

KEYWORDS: Near infrared, Diffuse reflectance spectroscopy, Tissues, Scattering, Light scattering, Reflectivity, Hypoxia, Neuroimaging, Tissue optics, Brain

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SPIE Journal Paper | 1 February 2011

Light-scattering signal may indicate critical time zone to rescue brain tissue after hypoxia

Satoko Kawauchi, Miya Ishihara, Makoto Kikuchi, Shunichi Sato, Yoichi Uozumi, Hiroshi Nawashiro, Susanta Hui, Nikolaos Papanikolopoulos

JBO Vol. 16 Issue 02

KEYWORDS: Brain, Reflectivity, Oxygen, Hypoxia, Tissue optics, Scattering, Near infrared, Light scattering, Diffuse reflectance spectroscopy, Electroencephalography

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Proceedings Article | 26 February 2010

Correlation between light scattering signal and tissue reversibility in rat brain exposed to hypoxia

Satoko Kawauchi, Shunichi Sato, Yoichi Uozumi, Hiroshi Nawashiro, Miya Ishihara, Makoto Kikuchi

Proc. SPIE. 7573, Biomedical Applications of Light Scattering IV

KEYWORDS: Diffuse reflectance spectroscopy, Tissues, Scattering, Light scattering, Nitrogen, Oxygen, Hypoxia, Tissue optics, Signal detection, Brain

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Proceedings Article | 26 February 2010

Development of the hyperspectral cellular imaging system to apply to regenerative medicine

Miya Ishihara, Masato Sato, Kouji Matsumura, Joji Mochida, Makoto Kikuchi

Proc. SPIE. 7566, Optics in Tissue Engineering and Regenerative Medicine IV

KEYWORDS: Hyperspectral imaging, Safety, Tissues, Surgery, Imaging systems, Scattering, Databases, Transplantation, Electron multiplying charge coupled devices, Regenerative medicine

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Proceedings Article | 26 February 2010

Multicolor photoacoustic imaging by a single transducer with piezoelectric copolymer film in a wide frequency range

Tsutomu Ohmori, Miya Ishihara, Kazuhiro Tsujita, Isao Bansaku, Makoto Kikuchi

Proc. SPIE. 7564, Photons Plus Ultrasound: Imaging and Sensing 2010

KEYWORDS: Optical imaging, Tunable lasers, Ferroelectric materials, Tissues, Imaging systems, Molecules, Transducers, Acquisition tracking and pointing, Photoacoustic spectroscopy, Absorption

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Proceedings Article | 24 February 2009

In vivo transcranial measurement of light scattering in rat brains during hypoxia

Satoko Kawauchi, Shunichi Sato, Yoichi Uozumi, Hiroshi Nawashiro, Miya Ishihara, Makoto Kikuchi

Proc. SPIE. 7187, Biomedical Applications of Light Scattering III

KEYWORDS: Diffuse reflectance spectroscopy, Scattering, Blood, Light scattering, Reflectivity, Optical testing, Hypoxia, In vivo imaging, Tissue optics, Brain

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Proceedings Article | 24 February 2009

Cellular functional image using hyperspectral technology for application to regenerative medicine

Miya Ishihara, Mamoru Iwasa, Minoru Doshida, Makoto Kikuchi

Proc. SPIE. 7179, Optics in Tissue Engineering and Regenerative Medicine III

KEYWORDS: Hyperspectral imaging, Safety, Optical properties, Imaging systems, Sensors, Image resolution, 3D modeling, Spectral resolution, Regenerative medicine, Spatial resolution

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Proceedings Article | 24 February 2009

Functional imaging of a single cell: far-field infrared super-resolution microscopy using autofluorescence detection

Tsutomu Ohmori, Keiichi Inoue, Makoto Sakai, Masaaki Fujii, Miya Ishihara, Makoto Kikuchi

Proc. SPIE. 7182, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VII

KEYWORDS: Infrared imaging, Visible radiation, Luminescence, Molecules, Fluorescence spectroscopy, Infrared spectroscopy, Super resolution microscopy, Spatial resolution, Infrared microscopy, Absorption

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Proceedings Article | 22 February 2008

Relationship between light scattering and absorption due to cytochrome c oxidase reduction during loss of tissue viability in brains of rats

Satoko Kawauchi, Shunichi Sato, Hidetoshi Ooigawa, Hiroshi Nawashiro, Miya Ishihara, Makoto Kikuchi

Proc. SPIE. 6864, Biomedical Applications of Light Scattering II

KEYWORDS: Defense and security, Diffuse reflectance spectroscopy, Tissues, Scattering, Blood, Light scattering, Tissue optics, Intrinsic optical signal, Absorption, Brain

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Proceedings Article | 20 February 2008

Cell imaging by transient fluorescence detected infrared microscopy

Tsutomu Ohmori, Makoto Sakai, Miya Ishihara, Makoto Kikuchi, Masaaki Fujii

Proc. SPIE. 6853, Biomedical Optical Spectroscopy

KEYWORDS: Infrared imaging, Diffraction, Visible radiation, Microscopy, Luminescence, Molecules, Fluorescence spectroscopy, Infrared microscopy, Rhodamine, Absorption

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Proceedings Article | 6 February 2008

Modification of measurement methods for evaluation of tissue-engineered cartilage function and biochemical properties using nanosecond pulsed laser

Miya Ishihara, Masato Sato, Toshiharu Kutsuna, Masayuki Ishihara, Joji Mochida, Makoto Kikuchi

Proc. SPIE. 6858, Optics in Tissue Engineering and Regenerative Medicine II

KEYWORDS: Hyperspectral imaging, Cartilage, Tissues, Imaging systems, Sensors, Spectroscopy, Spectral resolution, Regenerative medicine, Spatial resolution, Pulsed laser operation

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Proceedings Article | 12 February 2007

Usefulness and limitation of measurement methods for evaluation of tissue-engineered cartilage function and characterization using nanosecond pulsed laser

Miya Ishihara, Masato Sato, Nagatoshi Kaneshiro, Genya Mitani, Toshihiro Nagai, Toshiharu Kutsuna, Masayuki Ishihara, Joji Mochida, Makoto Kikuchi

Proc. SPIE. 6439, Optics in Tissue Engineering and Regenerative Medicine

KEYWORDS: Cartilage, Tissues, Spectroscopy, 3D modeling, Collagen, Transducers, Time resolved spectroscopy, Regenerative medicine, Pulsed laser operation, Laser tissue interaction

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Proceedings Article | 1 March 2006

Development of a noninvasive multifunctional measurement method using nanosecond pulsed laser for evaluation of regenerative medicine for articular cartilage

Miya Ishihara, Masato Sato, Nagatoshi Kaneshiro, Genya Mitani, Shunichi Sato, Masayuki Ishihara, Joji Mochida, Makoto Kikuchi

Proc. SPIE. 6084, Optical Interactions with Tissue and Cells XVII

KEYWORDS: Cartilage, Tissues, Spectroscopy, Luminescence, Collagen, Time resolved spectroscopy, Photoacoustic spectroscopy, Regenerative medicine, Tissue optics, Pulsed laser operation

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Proceedings Article | 25 April 2005

Photoacoustic detection of neovascularities in skin graft

Mutsuo Yamazaki, Shunichi Sato, Daizo Saitoh, Miya Ishihara, Yoshiaki Okada, Hiroshi Ashida, Minoru Obara

Proc. SPIE. 5686, Photonic Therapeutics and Diagnostics

KEYWORDS: Defense and security, Tissues, Blood, Skin, Transplantation, Chromophores, Transducers, Blood circulation, Photoacoustic spectroscopy, Signal detection

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Proceedings Article | 15 April 2005

Usefulness of the photoacoustic measurement method for monitoring the regenerative process of full-thickness defects in articular cartilage using tissue-engineering technology

Miya Ishihara, Masato Sato, Shunichi Sato, Toshiyuki Kikuchi, Genya Mitani, Nagatoshi Kaneshiro, Masayuki Ishihara, Joji Mochida, Makoto Kikuchi

Proc. SPIE. 5695, Optical Interactions with Tissue and Cells XVI

KEYWORDS: Cartilage, Tissues, Surgery, Transplantation, Transducers, Photoacoustic spectroscopy, Regenerative medicine, In vivo imaging, Tissue optics, In vitro testing

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Proceedings Article | 1 July 2004

Applicability of photoacoustic measurement for biomechanical characterization: from in vitro engineered tissue characterization to in vivo diagnosis

Miya Ishihara, Masato Sato, Shunichi Sato, Toshiyuki Kikuchi, Masayuki Ishihara, Joji Mochida, Kyosuke Fujikawa, Makoto Kikuchi

Proc. SPIE. 5319, Laser Interaction with Tissue and Cells XV

KEYWORDS: Optical fibers, Optical parametric oscillators, Cartilage, Tissues, Reflectivity, Transducers, Photoacoustic spectroscopy, In vivo imaging, Tissue optics, Laser tissue interaction

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SPIE Journal Paper | 1 January 2004

Assessment of expressions of heat shock protein (HSP 72) and apoptosis after ArF excimer laser ablation of the cornea

Miya Ishihara, Masato Sato, Shunichi Sato, Tsunenori Arai, Minoru Obara, Makoto Kikuchi

JBO Vol. 9 Issue 01

KEYWORDS: Laser ablation, Cell death, Excimer lasers, Temperature metrology, Cornea, Proteins, Laser optics, Tissues, Defense and security, Monoclonal antibodies

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Proceedings Article | 27 August 2003

Biomechanical characterization of tissue-engineered cartilages by photoacoustic measurement

Miya Ishihara, Masato Sato, Shunichi Sato, Toshiyuki Kikuchi, Kyosuke Fujikawa, Makoto Kikuchi

Proc. SPIE. 4961, Laser-Tissue Interaction XIV

KEYWORDS: Defense and security, Optical parametric oscillators, Cartilage, Tissues, Transducers, Tissue engineering, Photoacoustic spectroscopy, Tissue optics, Acoustics, Laser tissue interaction

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Proceedings Article | 27 June 2002

Development for medical surgical system with function variability and flexible delivery using dual-wavelength infrared fiber laser

Kyota Naruse, Tsunenori Arai, Satoko Kawauchi, Tetsumi Sumiyoshi, Shoichi Kiyoshima, Miya Ishihara, Shunichi Sato, Makoto Kikuchi, Hitoshi Sekita, Minoru Obara

Proc. SPIE. 4617, Laser Tissue Interaction XIII: Photochemical, Photothermal, and Photomechanical

KEYWORDS: Optical filters, Tissues, Beam delivery, Fiber lasers, Infrared lasers, Sapphire, Infrared radiation, Laser cutting, Laser dentistry, Laser tissue interaction

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Proceedings Article | 17 June 2002

Transdermal delivery of photosensitizer by laser-induced stress wave

Makoto Ogura, Shunichi Sato, Masahiko Kuroki, Hitoshi Wakisaka, Satoko Kawauchi, Miya Ishihara, Makoto Kikuchi, Masahiko Yoshioka, Hiroshi Ashida, Minoru Obara

Proc. SPIE. 4609, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII

KEYWORDS: Defense and security, Electronics, Opacity, Skin, Luminescence, Solids, Liquid crystals, Sodium, HVAC controls, Plasma

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Proceedings Article | 9 July 2001

Nanosecond-time-response temperature measurements using radiation thermometry during 193-nm and 247-nm pulsed light irradiation: comparison of corneal surface temperature histories

Miya Ishihara, Tsunenori Arai, Shunichi Sato, Yuji Morimoto, Minoru Obara, Makoto Kikuchi

Proc. SPIE. 4257, Laser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical

KEYWORDS: Defense and security, Light sources, Cornea, Laser development, Laser ablation, Excimer lasers, Radiometry, Radiation thermometry, Temperature metrology, Absorption

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Proceedings Article | 9 July 2001

Channeling in myocardium tissue through nanosecond pulsed laser photodisruption at visible and near-infrared wavelengths

Makoto Ogura, Shunichi Sato, Tsunenori Arai, Miya Ishihara, Satoko Kawauchi, Takemi Matsui, Akira Kurita, Makoto Kikuchi, Hitoshi Wakisaka, Hiroshi Ashida, Minoru Obara

Proc. SPIE. 4257, Laser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical

KEYWORDS: Tissues, Laser irradiation, Laser ablation, Laser damage threshold, Tissue optics, Q switched lasers, Laser optics, Pulsed laser operation, Laser tissue interaction, Plasma

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Proceedings Article | 9 July 2001

Theoretical study of variable function (cutting/coagulating) laser surgical system using continuous-wave 3 um, 2u m cascade Ho3+:ZBLAN fiber laser

Kyota Naruse, Tsunenori Arai, Satoko Kawauchi, Tetsumi Sumiyoshi, Shoichi Kiyoshima, Miya Ishihara, Shunichi Sato, Makoto Kikuchi, Hitoshi Sekita, Minoru Obara

Proc. SPIE. 4257, Laser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical

KEYWORDS: Microscopes, Continuous wave operation, Tissues, Quantum cascade lasers, Fiber lasers, Laser cutting, Laser dentistry, Laser tissue interaction, Laser systems engineering, Absorption

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Proceedings Article | 16 November 2000

Plasma-mediated tissue ablation with nanosecond laser pulses in the spectral region from ultraviolet to near infrared: in-vitro study with porcine myocardium tissue

Shunichi Sato, Makoto Ogura, Tomoaki Shimada, Miya Ishihara, Tsunenori Arai, Takemi Matsui, Akira Kurita, Minoru Obara, Makoto Kikuchi, Hitoshi Wakisaka, Hiroshi Ashida

Proc. SPIE. 4161, Optical Biopsy and Tissue Optics

KEYWORDS: Optical microscopes, Nd:YAG lasers, Laser irradiation, Laser ablation, Tissue optics, Laser optics, Pulsed laser operation, Laser tissue interaction, In vitro testing, Plasma

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Proceedings Article | 13 June 2000

Ho:YAG laser: intervertebral disk cell interaction using three-dimensional cell culture system

Masato Sato, Miya Ishihara, Tsunenori Arai, Takashi Asazuma, Toshiyuki Kikuchi, Makoto Kikuchi, Kyosuke Fujikawa

Proc. SPIE. 3914, Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical

KEYWORDS: Laser therapeutics, Laser irradiation, Transducers, Thermal effects, Photothermal effect, Photoacoustic spectroscopy, Acoustics, Pulsed laser operation, Ferroelectric polymers, Plasma

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Proceedings Article | 13 June 2000

65MHz bandwidth measurement of thermal emission induced by ArF excimer laser ablation of cornea

Miya Ishihara, Shunichi Sato, Tsunenori Arai, Minoru Obara, Makoto Kikuchi

Proc. SPIE. 3914, Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical

KEYWORDS: Photovoltaics, Mercury cadmium telluride, Cornea, Tissues, Sensors, Laser ablation, Excimer lasers, Signal detection, Photovoltaic detectors, Temperature metrology

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Proceedings Article | 13 June 2000

Myocardium tissue ablation with nanosecond ultraviolet pulses: in-vitro study with porcine myocardium tissues

Tomoaki Shimada, Shunichi Sato, Miya Ishihara, Tsunenori Arai, Takemi Matsui, Akira Kurita, Makoto Kikuchi, Hitoshi Wakisaka, Hiroshi Ashida, Minoru Obara

Proc. SPIE. 3914, Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical

KEYWORDS: Optical parametric oscillators, Tissues, Signal attenuation, Ultraviolet radiation, Nd:YAG lasers, Laser ablation, Tissue optics, Laser tissue interaction, In vitro testing, Absorption

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Proceedings Article | 13 June 2000

Laser-tissue interaction of a continuous-wave 2-um, 3-um cascade oscillation fiber laser: sharp incision with controlled coagulation layer thickness

Tsunenori Arai, Tetsumi Sumiyoshi, Kyota Naruse, Miya Ishihara, Shunichi Sato, Makoto Kikuchi, Tadashi Kasamatsu, Hitoshi Sekita, Minoru Obara

Proc. SPIE. 3914, Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical

KEYWORDS: Continuous wave operation, Laser therapeutics, Liver, Tissues, Photography, Laser development, Fiber lasers, Laser cutting, Laser tissue interaction, Laser systems engineering

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Proceedings Article | 1 February 2000

Characteristics and mechanism of myocardium tissue laser ablation: in-vitro study for transmyocardial laser revascularization

Shunichi Sato, Tomoaki Shimada, Makoto Ogura, Miya Ishihara, Tsunenori Arai, Takemi Matsui, Akira Kurita, Minoru Obara, Makoto Kikuchi, Hitoshi Wakisaka, Hiroshi Ashida

Proc. SPIE. 3885, High-Power Laser Ablation II

KEYWORDS: Optical parametric oscillators, Tissues, Ultraviolet radiation, Nd:YAG lasers, Laser ablation, Q switched lasers, Laser tissue interaction, In vitro testing, Plasma, Absorption

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Proceedings Article | 14 June 1999

Optimum Ho:YAG laser irradiation condition on percutaneous laser disk decompression (PLDD): in-vitro quantitive evaluation of influence on disk cells using three-dimensional cell culture system

Masato Sato, Miya Ishihara, Tsunenori Arai, Takashi Asazuma, Toshiyuki Kikuchi, Makoto Kikuchi, Kyosuke Fujikawa

Proc. SPIE. 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical

KEYWORDS: Laser therapeutics, Laser vision correction, Surgery, Laser irradiation, Laser ablation, Thermal effects, Cell death, Disk lasers, Pulsed laser operation, In vitro testing

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Proceedings Article | 14 June 1999

Temperature monitoring by infrared radiation measurements during ArF excimer laser ablation with cornea

Miya Ishihara, Tsunenori Arai, Shunichi Sato, Hironori Nakano, Minoru Obara, Makoto Kikuchi

Proc. SPIE. 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical

KEYWORDS: Thermography, Cornea, Sensors, Laser ablation, Time metrology, Infrared radiation, Excimer lasers, Pulsed laser operation, Laser tissue interaction, Temperature metrology

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Proceedings Article | 13 May 1998

Comparison of transient measurements of infrared radiation and stress waves for practical ablation monitoring during photorefractive keratectomy

Miya Ishihara, Tsunenori Arai, Makoto Kikuchi, Hironori Nakano, Satoko Kawauchi, Minoru Obara

Proc. SPIE. 3254, Laser-Tissue Interaction IX

KEYWORDS: Cornea, Sensors, Laser irradiation, Laser ablation, Transducers, Infrared radiation, Excimer lasers, Acoustics, Ferroelectric polymers, Temperature metrology

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Proceedings Article | 26 May 1997

Novel monitoring of corneal surface hydration during photorefractive keratectomy using pulsed photothermal radiometry: in-vitro study

Satoko Kawauchi, Hiroko Matsuyama, Minoru Obara, Miya Ishihara, Tsunenori Arai, Makoto Kikuchi, Masayoshi Katoh

Proc. SPIE. 2971, Ophthalmic Technologies VII

KEYWORDS: Infrared sensors, Cornea, Sensors, Laser ablation, Time metrology, Infrared radiation, Excimer lasers, Radiometry, In vitro testing, Absorption

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Proceedings Article | 17 August 1994

Signal analysis of fiber optic probe method from Ho:YAG laser ablation bubble

Miya Ishihara, Makoto Hasegawa, Masato Yano, Akio Nakajima, Tsunenori Arai, Makoto Kikuchi, Minoru Obara

Proc. SPIE. 2134, Laser-Tissue Interaction V; and Ultraviolet Radiation Hazards

KEYWORDS: Fiber optics, Photography, Laser ablation, Signal analysis

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Proceedings Article | 14 July 1993

Measurement for optical properties of mitochondria in vitro

Akio Nakajima, Miya Ishihara, Tsunenori Arai, Yuji Morimoto, Makoto Kikuchi, Fumihiko Kannari, Minoru Obara

Proc. SPIE. 1883, Low-Energy Laser Effects on Biological Systems

KEYWORDS: Liver, Optical properties, Tissues, Particles, Optical testing, Transmittance, Therapeutics, Tissue optics, In vitro testing, Absorption

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Proceedings Article | 7 July 1993

Measurement of cavity collapse time by probe technique on water, agar, and vascular tissue during Ho:YAG laser contact ablation

Miya Ishihara, Akio Nakajima, Tsunenori Arai, Makoto Kikuchi, H. Kannari, Minoru Obara

Proc. SPIE. 1882, Laser-Tissue Interaction IV

KEYWORDS: Fiber optics, Backscatter, Tissues, Laser scattering, Fiber lasers, Optical testing, Laser ablation, Helium neon lasers, Laser beam diagnostics, Laser tissue interaction

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