Mr. Muqing Lin Profile

Muqing Lin

at Univ of California Irvine

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Proceedings Article | 17 February 2012 Paper

An elastic registration framework to estimate prostate deformation in endorectal MR scans

Muqing Lin, Vijay Parthasarathy, Harsh Agarwal, Peter Choyke, Baris Turkbey, Tobias Klinder, Jochen Kruecker

Proceedings Volume 8316, 831610 (2012) https://doi.org/10.1117/12.912353

KEYWORDS: Prostate, Image registration, Magnetic resonance imaging, Image segmentation, Biopsy, Rigid registration, Tissues, Ultrasonography, Image fusion, Natural surfaces

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In an effort to improve the accuracy of transrectal ultrasound (TRUS)-guided needle biopsies of the prostate, it is important to understand the non-rigid deformation of the prostate. To understand the deformation of the prostate when an endorectal coil (ERC) is inserted, we develop an elastic registration framework to register prostate MR images with and without ERC. Our registration framework uses robust point matching (RPM) to get the correspondence between the surface landmarks in the source and target volumes followed by elastic body spline (EBS) registration based on the corresponding landmark pairs. Together with the manual rigid alignment, we compared our registration framework based on pure surface landmarks to the registration based on both surface and internal landmarks in the center of the prostate. In addition, we assessed the impact of constraining the warping in the central zone of the prostate using a Gaussian weighting function. Our results show that elastic surface-driven prostate registration is feasible, and that internal landmarks further improve the registration in the central zone while they have little impact on the registration in the peripheral zone of the prostate. Results varied case by case depending on the accuracy of the prostate segmentation and the amount of warping present in each image pair. The most accurate results were obtained when using a Gaussian weighting in the central zone to limit the EBS warping driven by surface points. This suggests that a Gaussian constrain of the warping can effectively compensate for the limitations of the isotropic EBS deformation model, and for erroneous warping inside the prostate created by inaccurate surface landmarks driving the EBS.

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