We developed a prototype dual-modal ocular imaging system integrating optical-resolution photoacoustic microscopy and high-frequency ultrasound imaging modalities. This system can perform high-resolution ocular imaging from the anterior region down to the fundus area. The novel system successfully imaged the murine eyes in vivo, including iris, lens, retina, and retinal pigment epithelium. Our results demonstrated that this system has a great potential in the diagnosis of ophthalmic diseases.
Ocular imaging plays a key role for the diagnosis of various ocular diseases. In this work, we have developed an ocular
imaging system based on the photoacoustic tomography. This system has successfully imaged the entire eye of a mouse,
from its iris to the retina region, and the imaging is label-free and non-invasively. The resolution of this system reaches
several micron meters, allowing the study of microstructures in various ocular tissues. Our system has the potential to be
a powerful non-invasive imaging method for the ophthalmology.