I am Pharmacist with Ph.D. in Medical Pathophysiology (Structural Biology, Cell, Molecular and Development - State University of Campinas, Brazil). Currently I am holding a position as Research Scientist by the University of Sao Paulo. As the leader in two laboratories (microbial control and culture cells) on Biophotonics Group, I am investigating the effects and specificity of different nanostructured photosensitizers on tumor cell death and microbial control, the nanodelivery of these compounds for a better clinical protocols especially for non-melanoma skin cancer and cervical intraepithelial neoplasia treatments, and combined therapies for antifouling strategies in materials and in patients (would healing).
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Evaluating photodynamic therapy with protoporphyrin IX in the context of mitochondrial bioenergetics
High-grade cervical intraepithelial neoplasia treatment comparing two photodynamic therapy protocols
This study aimed to evaluate the use of infrared and fluorescence imaging as new non-invasive diagnostic tools in patients with suspected onychomycosis, and compare them with established techniques.
For fluorescence analysis, a Clinical Evince (MM Optics®) was used, which consists of an optical assembly with UV LED light source wavelength 400 nm ± 10 nm and the maximum light intensity: 40 mW/cm2 ± 20%. For infrared analysis, a Fluke® Camera FKL model Ti400 was used. Patients with onychomycosis and control group were analyzed for comparison. The fluorescence images were processed using MATLAB® routines, and infrared images were analyzed using the SmartView® 3.6 software analysis provided by the company Fluke®.
The results demonstrated that both infrared and fluorescence could be complementary to diagnose different types of onychomycosis lesions. The simplicity of operation, quick response and non-invasive assessment of the nail patients in real time, are important factors to be consider for an implementation.
Comparative in vivo study of precursors of PpIX (ALA and MAL) used topically in photodynamic therapy
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