Using diffuse optical spectroscopy the level of oxygenation and hemoglobin concentration in experimental tumor in
comparison with normal muscle tissue of mice have been studied. Subcutaneously growing SKBR-3 was used as a
tumor model. Continuous wave fiber probe diffuse optical spectroscopy system was employed. Optical properties
extraction approach was based on diffusion approximation. Decreased blood oxygen saturation level and increased
total hemoglobin content were demonstrated in the neoplasm. The main reason of such differences between tumor and
norm was significant elevation of deoxyhemoglobin concentration in SKBR-3. The method can be useful for diagnosis
of tumors as well as for study of blood flow parameters of tumor models with different angiogenic properties.
An efficient technique of correction of coherence gate curvature in spectral-domain OCT is proposed. A method of
constructing of different shapes of single spectral component envelop is described. The control of the single spectral
component envelop allows to eliminate over-depth artifacts caused by preserved partial coherence in the optical delays
longer then coherence length.