Dr. Natasha S. Shah Profile

Dr. Natasha S. Shah

Research Specialist at Univ of California Irvine

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Publications (9)

SPIE Journal Paper | 1 September 2007 Open Access

Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy

Chao Zhou, Regine Choe, Natasha Shah, Turgut Durduran, Guoqiang Yu, Amanda Durkin, David Hsiang, Rita Mehta, John Butler, Albert Cerussi, Bruce Tromberg, Arjun Yodh

JBO, Vol. 12, Issue 05, 051903, (September 2007) https://doi.org/10.1117/12.10.1117/1.2798595

KEYWORDS: Tumors, Blood circulation, Oxygen, Tissues, Tissue optics, Breast, Hemodynamics, Breast cancer, Mode conditioning cables, Biomedical optics

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Proceedings Article | 12 July 2007 Paper

Assessment of collagen absorption and related potential diagnostic applications

Natasha Shah, Paola Taroni, Arianna Giusto, Daniela Comelli, Antonio Pifferi, Lorenzo Spinelli, Alessandro Torricelli, Rinaldo Cubeddu

Proceedings Volume 6629, 66290D (2007) https://doi.org/10.1117/12.727817

KEYWORDS: Collagen, Breast, Absorption, Tissue optics, Tissues, Diagnostics, Scattering, Mammography, Breast cancer, Blood

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SPIE Journal Paper | 1 July 2006 Open Access

In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy

Albert Cerussi, Natasha Shah, David Hsiang, Amanda Durkin, John Butler, Bruce Tromberg

JBO, Vol. 11, Issue 04, 044005, (July 2006) https://doi.org/10.1117/12.10.1117/1.2337546

KEYWORDS: Tumors, Tissues, Tissue optics, Breast, Line scan image sensors, Absorption, Scattering, In vivo imaging, Surface plasmons, Mammography

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SPIE Journal Paper | 1 September 2005 Open Access

Combined diffuse optical spectroscopy and contrast-enhanced magnetic resonance imaging for monitoring breast cancer neoadjuvant chemotherapy: a case study

Natasha Shah, Jessica Gibbs, Dulcy Wolverton, Albert Cerussi, Nola Hylton, Bruce Tromberg

JBO, Vol. 10, Issue 05, 051503, (September 2005) https://doi.org/10.1117/12.10.1117/1.2070147

KEYWORDS: Tumors, Magnetic resonance imaging, Breast, Tissues, Tissue optics, Diffuse optical spectroscopy, Scattering, In vivo imaging, Breast cancer, Skin

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SPIE Journal Paper | 1 May 2004 Open Access

Spatial variations in optical and physiological properties of healthy breast tissue

Natasha Shah, Albert Cerussi, Dorota Jakubowski, David Hsiang, John Butler, Bruce Tromberg

JBO, Vol. 9, Issue 03, (May 2004) https://doi.org/10.1117/12.10.1117/1.1695560

KEYWORDS: Breast, Tissue optics, Tissues, Scattering, Optical properties, Near infrared, Absorption, Breast cancer, Biomedical optics, Chromophores

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Near-infrared (NIR) diffuse optical spectroscopy (DOS) and diffuse optical imaging (DOI) show promise as noninvasive clinical techniques for breast cancer screening and diagnosis. Since NIR methods are based on optical contrast between healthy and diseased tissue, it is essential to characterize the sources of endogenous contrast in normal subjects. We report intra- and inter-subject variation and bilateral asymmetry of the optical and physiological parameters of 31 women using a seven-wavelength NIR frequency-domain photon migration (FDPM) instrument. Wavelength-dependent absorption and reduced scattering parameters (µa and µs, respectively) were measured in four major quadrants and the areolar regions of left and right breasts. These values were used to determine tissue concentrations of oxy-(HbO2) and deoxy-(Hb-R) hemoglobin, lipid content, water concentration, and tissue "scatter power." Mean total hemoglobin for premenopausal (PRE) women (20 to 30 µM) is approximately two-fold higher than for postmenopausal (POST) subjects at all positions. POST women have approximately 50% higher lipid content (50 to 60%) than PRE at all positions. Water concentration on average is 1.8-fold higher for PRE subjects (30 to 40%) than POST. These differences are most pronounced when comparing the areolar complex to the other regions of the breast. In premenopausal women, the areolar regions have 40 to 45% increased total hemoglobin concentration (THC), 20 to 25% lower lipid content, and 30 to 60% higher scatter power versus the quadrants. Small-scale (3 cm) changes in optical properties are negligible compared to large-scale variations over all quadrants, where the intrinsic spatial heterogeneity of healthy breast tissue is 20 to 40% for µa and 5 to 12% for µs. Although no consistent right-left differences are observed in the study population, relative differences between symmetric positions ranged from 18 to 30% for THC, 10 to 40% for adipose, 10 to 25% for water, and 4 to 9% for scattering (674 nm) within an individual.

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