Mr. Navid Soltani Profile

Navid Soltani

at Univ Siegen

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Publications (3)

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Proceedings Article | 16 April 2021 Presentation

SEPSIS biomarker detection through lensless fiber-based planar antennas

Pietro Ernesto Lombardi, Ambra Giannetti, Paolo Cecchi, Francesco Chiavaioli, Steffen Howitz, Navid Soltani, Frank Sonntag, Costanza Toninelli, Mario Agio

Proceedings Volume 11772, 117720N (2021) https://doi.org/10.1117/12.2592502

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Sepsis, defined as the systemic inflammatory response to a confirmed or suspected source of infection, is the most severe infection-related condition and its identification can be particularly difficult in the initial stages. The importance of having a Point-of-care testing platform capable of measuring sepsis biomarkers for a secure early-stage diagnosis is evident to reduce delay in treatment and hence recovery period for the patient. We will report on a simple and cost-effective device which also shows high portability. It is based on the optical detection of labeled essays through a fully-automated fiber probe. Efficient signal collection is obtained by replacing the standard glass substrate with a planar metallo-dielectric multilayer which funnels the emission into a narrow cone around the polar axis [1]. Optical interrogation is implemented with a minimized epi-fluorescence monolithic system directly connected to the fiber. On one hand, optical probes provide the ability to detect low quantities of target molecules without direct contact to the sample; on the other hand, nano-photonics promises to overcome the limitations related to bulk optics with precise and fragile alignment procedures. We will report on preliminary results obtained for a reference dry essays (IgG/anti-IgG) marked with ATTO647N, which demonstrates sensitivity overcoming the requirements for CRP-based sepsis detection. We will also discuss optimization steps which are expected to bring sensitivity beyond the level required for PRC-based sepsis detection. The proposed device is also prone to implementation in microfluidic-based protocols. [1] Checcucci S, Lombardi P., Rizvi S., Sgrignuoli F., Gruhler N., Dieleman F.B.C., Cataliotti F.S., Pernice W.H.P., Agio M., and Toninelli C., Beaming light from a quantum emitter with a planar optical antenna, Light: Science and Applications, Vol. 6, e16245 (2017).

Proceedings Article | 5 March 2021 Presentation

Fiber-based planar antennas for spectroscopy and sensing

Navid Soltani, Nemanja Markesevic, Elham Rabbany Esfahany, Gregor Schulte, Sergey Druzhinin, Julian Müller, Florian Sledz, Holger Schönherr, Benjamin Butz, Mario Agio

Proceedings Volume 11658, 1165809 (2021) https://doi.org/10.1117/12.2578494

KEYWORDS: Antennas, Signal detection, Spectroscopy, Gold, Signal processing, Reflectors, Optical fibers, Luminescence, Silica, Sensors

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Fluorescence detection is a well-established method for spectroscopy and sensing. However, since dye molecules are dipolar light sources, a large fraction of the emitted photons can be lost. An effective approach to overcome this problem relies on a planar antenna configuration, which beams the radiation pattern of the dye into a narrow cone. A planar antenna works like a Yagi-Uda antenna, but reflector and director elements are made of thin metal films. Here, by introducing a scanning optical fiber, which incorporates the reflector or the director, we demonstrate a tunable planar antenna for spectroscopic and sensing applications. Our results show that the radiation pattern narrows down to 26 degrees (FWHM), which implies a high collection efficiency by low-NA optics.

Proceedings Article | 1 April 2020 Presentation

SEPSIS biomarker detection through fiber-based planar antennas (Conference Presentation)

Ambra Giannetti, Paolo Cecchi, Francesco Chiavaioli, Steffen Howitz, Pietro Lombardi, Navid Soltani, Frank Sonntag, Costanza Toninelli, Mario Agio

Proceedings Volume 11361, 113610Q (2020) https://doi.org/10.1117/12.2553234

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Sepsis, defined as the systemic inflammatory response to a confirmed or suspected source of infection, is the most severe infection-related condition and its identification can be particularly difficult in the initial stages. The importance of having a POCT platform capable of measuring sepsis biomarkers for a secure early-stage diagnosis is evident since traditional methods of pathogen determination delay treatment and also increase the recovery period for the patient. The biggest advantage of optical probes is the ability to detect low quantities of target molecules without direct contact to the sample. Nanophotonics-based sensing promises to build on the advantages of optical sensing, while overcoming its limitations by providing a high sensitivity, specificity, dynamic range, as well as the possibility for easy integration into simple and affordable devices. The project FASPEC (Fiber-based planar antennas for biosensing and diagnostics) aims at developing and prototyping a high-performance fluorescence-based molecular assay for in-vitro diagnostics that integrates lab-on-a-chip and optical readout functionalities within a single, fully automated platform. The key biophotonics innovation of the project is the replacement of the bulk optics used for collecting the fluorescence signal with a suitably designed optofluidic chip. The latter shall function as an optical antenna to direct fluorescence towards the sensor head, hence enhancing the sensitivity of the fluorescence-based assay by orders of magnitude. Application-specific lab-on-a-chip systems equipped with our high-throughput and ultrasensitive detection scheme have been envisioned.

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