Dr. Nicole J. Crane Profile

Dr. Nicole J. Crane

SPIE Involvement:

Author

Publications (16)

Proceedings Article | 7 March 2016 Paper

Monitoring combat wound healing by IR hyperspectral imaging

Chris Howle, Abigail Spear, Ehsan Gazi, Nicole Crane

Proceedings Volume 9703, 97031E (2016) https://doi.org/10.1117/12.2213330

KEYWORDS: Infrared imaging, Wound healing, Optical parametric oscillators, Hyperspectral imaging, Injuries, Imaging spectroscopy, Imaging systems, Spectroscopy, Tissues, Mirrors, Absorption, FT-IR spectroscopy, Mid-IR, Biopsy

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Proceedings Article | 4 March 2016 Presentation + Paper

Surface enhanced Raman spectroscopy as a point-of-care diagnostic for infection in wound effluent

Meron Ghebremedhin, Shubha Yesupriya, Nicole Crane

Proceedings Volume 9715, 97150B (2016) https://doi.org/10.1117/12.2212667

KEYWORDS: Surface enhanced Raman spectroscopy, Raman spectroscopy, Signal detection, Point-of-care devices, Diagnostics, Bacteria, Injuries, Microorganisms, Spectroscopy, Metals, Data modeling, Wound healing, Nanoparticles, Statistical modeling, Silver

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Proceedings Article | 4 March 2016 Paper

Raman spectroscopy and the spectral correlation index for predicting wound healing outcome: towards in vivo application

Adam Berger, Nicole Crane, Eric Elster

Proceedings Volume 9715, 97150C (2016) https://doi.org/10.1117/12.2212833

KEYWORDS: Wound healing, Raman spectroscopy, Tissues, Biopsy, Blood, In vivo imaging, Molecular spectroscopy, Collagen, Surgery, Injuries

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Proceedings Article | 29 February 2016 Presentation + Paper

Determining early markers of disease using Raman spectroscopy in a rat combat-trauma model of heterotopic ossification

Katherine Cilwa, Ammar Qureshi, Jonathan Forsberg, Thomas Davis, Nicole Crane

Proceedings Volume 9689, 96894G (2016) https://doi.org/10.1117/12.2213334

KEYWORDS: Injuries, Raman spectroscopy, Tissues, Collagen, Bone, Tissue optics, Diagnostics, Radiography, Cartilage, Proteins, Animal model studies, Spectroscopy, Factor analysis

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Proceedings Article | 5 March 2015 Paper

Validation of hierarchical cluster analysis for identification of bacterial species using 42 bacterial isolates

Meron Ghebremedhin, Shubha Yesupriya, Janos Luka, Nicole Crane

Proceedings Volume 9318, 93180W (2015) https://doi.org/10.1117/12.2076997

KEYWORDS: Raman spectroscopy, Statistical analysis, Bacteria, Data modeling, Statistical modeling, Resistance, Spectroscopy, Biological research, Data acquisition, Microorganisms

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Proceedings Article | 2 March 2015 Paper

Raman spectroscopy of non-penetrating peripheral nerve damage in swine: a tool for spectral pathology of nerves

Katherine Cilwa, Tiffani Slaughter, Eric Elster, Jonathan Forsberg, Nicole Crane

Proceedings Volume 9328, 93280T (2015) https://doi.org/10.1117/12.2079764

KEYWORDS: Nerve, Raman spectroscopy, Injuries, Proteins, Tissues, Tissue optics, Principal component analysis, Fiber optics, Spectroscopy, Surgery

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Proceedings Article | 11 March 2014 Paper

Analysis of temporal dynamics in imagery during acute limb ischemia and reperfusion

John Irvine, John Regan, Tammy Spain, Joseph Caruso, Maricela Rodriquez, Rajiv Luthra, Jonathon Forsberg, Nicole Crane, Eric Elster

Proceedings Volume 9037, 90371F (2014) https://doi.org/10.1117/12.2043958

KEYWORDS: Ischemia, Pathology, Blood, Motion models, Tissues, Animal model studies, Image sensors, Injuries, Data modeling, Composites

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Proceedings Article | 13 March 2013 Paper

Using multimodal imaging techniques to monitor limb ischemia: a rapid noninvasive method for assessing extremity wounds

Rajiv Luthra, Joseph Caruso, Jason Radowsky, Maricela Rodriguez, Jonathan Forsberg, Eric Elster, Nicole Crane

Proceedings Volume 8574, 85740C (2013) https://doi.org/10.1117/12.2000467

KEYWORDS: Tissues, Ischemia, Image sensors, Infrared imaging, Injuries, Surgery, Infrared cameras, Multimodal imaging, Cameras, Infrared radiation

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Over 70% of military casualties resulting from the current conflicts sustain major extremity injuries. Of these the majority are caused by blasts from improvised explosive devices. The resulting injuries include traumatic amputations, open fractures, crush injuries, and acute vascular disruption. Critical tissue ischemia—the point at which ischemic tissues lose the capacity to recover—is therefore a major concern, as lack of blood flow to tissues rapidly leads to tissue deoxygenation and necrosis. If left undetected or unaddressed, a potentially salvageable limb may require more extensive debridement or, more commonly, amputation. Predicting wound outcome during the initial management of blast wounds remains a significant challenge, as wounds continue to “evolve” during the debridement process and our ability to assess wound viability remains subjectively based. Better means of identifying critical ischemia are needed. We developed a swine limb ischemia model in which two imaging modalities were combined to produce an objective and quantitative assessment of wound perfusion and tissue viability. By using 3 Charge-Coupled Device (3CCD) and Infrared (IR) cameras, both surface tissue oxygenation as well as overall limb perfusion could be depicted. We observed a change in mean 3CCD and IR values at peak ischemia and during reperfusion correlate well with clinically observed indicators for limb function and vitality. After correcting for baseline mean R-B values, the 3CCD values correlate with surface tissue oxygenation and the IR values with changes in perfusion. This study aims to not only increase fundamental understanding of the processes involved with limb ischemia and reperfusion, but also to develop tools to monitor overall limb perfusion and tissue oxygenation in a clinical setting. A rapid and objective diagnostic for extent of ischemic damage and overall limb viability could provide surgeons with a more accurate indication of tissue viability. This may help reducing the number of surgical interventions required, by aiding surgeons in identifying and demarcating areas of critical tissue ischemia, so that a more adequate debridement may be performed. This would have obvious benefits of reducing patient distress and decreasing both the overall recovery time and cost of rehabilitation.

SPIE Journal Paper | 1 March 2013 Open Access

Evidence of a heterogeneous tissue oxygenation: renal ischemia/reperfusion injury in a large animal model

Nicole Crane, Scott Huffman, Mehrdad Alemozaffar, Frederick Gage, Ira Levin, Eric Elster

JBO, Vol. 18, Issue 03, 035001, (March 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.3.035001

KEYWORDS: Kidney, Ischemia, Tissues, Reflectivity, Injuries, Tissue optics, Visible radiation, Calibration, Animal model studies, Surgery

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Proceedings Article | 1 February 2012 Paper

Profiling wound healing with wound effluent: Raman spectroscopic indicators of infection

Nicole Crane, Eric Elster

Proceedings Volume 8220, 82200S (2012) https://doi.org/10.1117/12.909405

KEYWORDS: Raman spectroscopy, Wound healing, Bacteria, Spectroscopy, Blood, Surgery, Plasma, Profiling, Microorganisms, Organisms

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SPIE Journal Paper | 25 January 2012 Open Access

Vibrational spectroscopy: a tool being developed for the noninvasive monitoring of wound healing

Nicole Crane, Eric Elster

JBO, Vol. 17, Issue 1, 010902, (January 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.1.010902

KEYWORDS: Wound healing, Raman spectroscopy, Spectroscopy, FT-IR spectroscopy, Tissue optics, Tissues, Molecular spectroscopy, Injuries, Molecules, Imaging spectroscopy

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