Moscow megapolis is among the world's 20 largest megacities. Intensive air emissions of pollutants affect not only the state of the atmosphere above the megapolis, but also far beyond its limits. To obtain diagnostic and predictive assessments of this impact intensive measurements of air pollutants as well as chemical transport simulations are developed, and an important task continue to be agreement of parameters used in chemical transport models (CTMs) with experimental results. We present preliminary results of the comparison of the measured by DOAS technique and simulated by SILAM NO2 integral contents (IC) at Zvenigorod Scientific Station (ZSS) located in 38 km west from Moscow. The comparison covers January and July of 2014 when background and polluted by Moscow air mass observed at ZSS. The measured NO2 IC in the ABL observed at ZSS does not exceed 0.5×1016 molec×cm-2 in background conditions of the atmosphere when non-east wind direction dominated. It grows up to 5.4×1016 molec×cm-2 when polluted air masses come from Moscow megacity. Simulated NO2 IC has similar behavior. As a whole, a good agreement between measured and simulated datasets is observed. Some underestimation of the NO2 emission presents for sources located to the west and south-west from ZSS and overestimation ones for sources located to the north and north-west from ZSS.