Dr. Ozden Yalcin-Ozuysal Profile

Dr. Ozden Yalcin-Ozuysal

at Izmir Institute of Technology

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 24 August 2023 Paper

Plasmonic functional assay platform for measuring single cell growth through refractive index sensing

Meryem Beyza Avci, Seda Nur Topkaya, Ozden Yalcin-Ozuysal, Ali Khademhosseini, Arif Cetin

Proceedings Volume 12627, 126272N (2023) https://doi.org/10.1117/12.2670999

KEYWORDS: Plasmonics, Refractive index, Profiling, Aluminum, Mode conditioning cables, Adhesion, Windows, Sensors, Resistance, Cancer

Read Abstract +

Measuring cell growth on adhesive substrates is critical for understanding cell biophysical properties and drug response. Traditional optical techniques have low sensitivity and vary in reliability depending on cell type, while microfluidic technologies rely on cell suspension. In this study, a new platform has been developed that is able to measure the weight and growth of individual cells in real−time. The platform can determine the growth rates of cells in just 10 minutes and map the growth of cell populations in short intervals. It can also identify differences in the growth of different subpopulations within a larger group. The platform was used to study the growth of MCF−7 cells and the impact of two intracellular metabolic processes on cell proliferation. The platform demonstrated the negative effect of serum starvation on cell growth and the role of a particular enzyme, ornithine decarboxylase (ODC), in cell proliferation. It was also able to show the ability of an external factor, putrescine, to rescue cells from the inhibitory effects of low osmolarity. In addition to measuring intracellular processes, the platform can determine the response of cancer cells to drug treatment. It showed the susceptibility of MCF−7 cells to a particular drug, difluoromethylornithine (DFMO), and the ability of a resistant subpopulation to survive in the presence of the drug. The platform’s ability to quickly measure cell growth in small samples makes it a potential tool for both research and clinical use.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years