The human body constantly undergoes heat exchange with the environment, and that can be imaged well by thermal imaging. Some application of thermal imaging is in neurology, vascular disorders, rheumatic diseases, oncology, dentistry, and ophthalmology. Every activity described above has unique characteristics. The temperature range for inflammatory condition of the human skin varies significantly from that of an ocular surface. Specific to ophthalmology, the thermal imaging should be able to capture the subtle changes of ocular surface temperature. The existing thermal sensors used in most ophthalmic studies have a dynamic range from -20°C to 350°C and accuracy of 2°C. This paper talks about the development and calibration of a new sensor with optimization in the desired dynamic range and its demonstration for capturing the ocular surface temperature.