Prof. Pengcheng Li Profile

Prof. Pengcheng Li

at Britton Chance Ctr for Biomedical Photonics

SPIE Involvement:

Conference Program Committee | Conference Chair | Author

Publications (44)

PROCEEDINGS ARTICLE | February 8, 2017

Stress plays provoking role in hypertension-related stroke: injuries of blood-brain barrier function

Proc. SPIE. 10051, Neural Imaging and Sensing

KEYWORDS: Optical imaging, Confocal microscopy, Injuries, Speckle, Magnetic resonance imaging, Resistance, Laser speckle contrast imaging, Laser speckle imaging, Neuroimaging, Blood pressure, Gadolinium, Laser optics, Blood brain barrier, Brain

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SPIE Journal Paper | September 10, 2015

Functional response of cerebral blood flow induced by somatosensory stimulation in rats with subarachnoid hemorrhage

Li, Zhiguo , Huang, Qin , Liu, Peng , Li, Pengcheng , Ma, Lianting , Lu, Jinling

JBO Vol. 20 Issue 09

KEYWORDS: Somatosensory cortex, Blood, Cerebral blood flow, Sensors, Brain, Arteries, Animal model studies, Speckle, Functional imaging, Laser speckle imaging

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Subarachnoid hemorrhage (SAH) is often accompanied by cerebral vasospasm (CVS), which is the phenomenon of narrowing of large cerebral arteries, and then can produce delayed ischemic neurological deficit (DIND) such as lateralized sensory dysfunction. CVS was regarded as a major contributor to DIND in patients with SAH. However, therapy for preventing vasospasm after SAH to improve the outcomes may not work all the time. It is important to find answers to the relationship between CVS and DIND after SAH. How local cerebral blood flow (CBF) is regulated during functional activation after SAH still remains poorly understood, whereas, the regulation of CBF may play an important role in weakening the impact of CVS on cortex function. Therefore, it is worthwhile to evaluate the functional response of CBF in the activated cortex in an SAH animal model. Most evaluation of the effect of SAH is presently carried out by neurological behavioral scales. The functional imaging of cortical activation during sensory stimulation may help to reflect the function of the somatosensory cortex more locally than the behavioral scales do. We investigated the functional response of CBF in the somatosensory cortex induced by an electrical stimulation to contralateral forepaw via laser speckle imaging in a rat SAH model. Nineteen Sprague-Dawley rats from two groups (control group, n=10 and SAH group, n=9) were studied. SAH was induced in rats by double injection of autologous blood into the cisterna magna after CSF aspiration. The same surgical procedure was applied in the control group without CSF aspiration or blood injection. Significant CVS was found in the SAH group. Meanwhile, we observed a delayed peak of CBF response in rats with SAH compared with those in the control group, whereas no significant difference was found in magnitude, duration, and areas under curve of relative CBF changes between the two groups. The results suggest that the regulation function of local CBF during functional activation induced by somatosensory stimulation might not be seriously impaired in the somatosensory cortex of rats with SAH. Therefore, our findings might help to understand the clinical phenomenon that DIND might not occur even when CVS was found in SAH patients.

PROCEEDINGS ARTICLE | March 19, 2015

Detrended fluctuation analysis of cerebral venous dynamics in newborn mice with intracranial hemorrhage

Proc. SPIE. 9448, Saratov Fall Meeting 2014: Optical Technologies in Biophysics and Medicine XVI; Laser Physics and Photonics XVI; and Computational Biophysics

KEYWORDS: Medicine, Biomedical optics, Statistical analysis, Scattering, Light scattering, Diagnostics, Laser speckle contrast imaging, Data processing, Photonics, Blood circulation

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SPIE Journal Paper | December 3, 2012

Dynamic change of collateral flow varying with distribution of regional blood flow in acute ischemic rat cortex

Wang, Zhen , Luo, Weihua , Zhou, Fangyuan , Li, Pengcheng , Luo, Qingming

JBO Vol. 17 Issue 12

KEYWORDS: Blood circulation, Ischemia, Blood, Brain, Laser speckle contrast imaging, Ischemic stroke, Arteries, Tissues, Speckle, Cerebral blood flow

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SPIE Conference Volume | January 24, 2012

Photonics and Optoelectronics Meetings (POEM) 2011: Optoelectronic Sensing and Imaging

SPIE Journal Paper | November 1, 2011

Dedicated hardware processor and corresponding system-on-chip design for real-time laser speckle imaging

Jiang, Chao , Zhang, Hongyan , Wang, Jia , Wang, Yaru , He, Heng , Liu, Rui , Zhou, Fangyuan , Deng, Jialiang , Li, Pengcheng , Luo, Qingming

JBO Vol. 16 Issue 11

KEYWORDS: Field programmable gate arrays, Image processing, LCDs, Video, Blood circulation, CCD cameras, Control systems, Cameras, Clocks, System on a chip

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SPIE Journal Paper | January 1, 2010

Spatiotemporal laser speckle contrast analysis for blood flow imaging with maximized speckle contrast

Qiu, Jianjun , Li, Pengcheng , Luo, Weihua , Wang, Jia , Zhang, Hongyan , Luo, Qingming

JBO Vol. 15 Issue 01

KEYWORDS: Speckle, Blood circulation, Laser speckle contrast imaging, Error analysis, Statistical analysis, Speckle imaging, Computer simulations, Biological research, Numerical simulations, In vivo imaging

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PROCEEDINGS ARTICLE | November 25, 2009

High speed parallel processing of biomedical optics data with PC graphic hardware

Proc. SPIE. 7634, Optical Sensors and Biophotonics

KEYWORDS: Independent component analysis, Biomedical optics, Visualization, Speckle, Graphics processing units, Image processing, Monte Carlo methods, Data processing, Parallel computing, Photon transport

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SPIE Conference Volume | October 28, 2009

Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009)

PROCEEDINGS ARTICLE | March 6, 2009

The multiple parameter hemodynamic imaging system based on ARM

Proc. SPIE. 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine

KEYWORDS: Optical imaging, Human-machine interfaces, Light emitting diodes, Imaging systems, Control systems, Laser speckle contrast imaging, LCDs, Hemodynamics, Embedded systems, Cerebral blood flow

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PROCEEDINGS ARTICLE | March 6, 2009

Impact of magnification of imaging system on laser speckle contrast imaging

Proc. SPIE. 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine

KEYWORDS: Biomedical optics, Imaging systems, Speckle, Scattering, Laser scattering, Laser speckle contrast imaging, Speckle pattern, Blood circulation, Cerebral blood flow, In vivo imaging

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SPIE Journal Paper | November 1, 2008

Acute hyperglycemia compromises cerebral blood flow following cortical spreading depression in rats monitored by laser speckle imaging

Wang, Zhen , Luo, Weihua , Li, Pengcheng , Qiu, Jianjun , Luo, Qingming

JBO Vol. 13 Issue 06

KEYWORDS: Laser speckle imaging, Glucose, Cerebral blood flow, Blood circulation, Ischemic stroke, Speckle, Brain, Printed circuit board testing, Capillaries, Oxygen

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PROCEEDINGS ARTICLE | March 14, 2008

Hemodynamic and electrophysiological responses to functional activation accessed by multi-wavelength optical imaging and electrophysiological recording system

Proc. SPIE. 6863, Optical Diagnostics and Sensing VIII

KEYWORDS: Optical imaging, Light emitting diodes, Imaging systems, Speckle, Spectroscopy, Imaging spectroscopy, Laser speckle imaging, Blood circulation, Hemodynamics, Brain

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PROCEEDINGS ARTICLE | March 14, 2008

Effects of sciatic nerve stimulation on the propagation of cortical spreading depression

Proc. SPIE. 6863, Optical Diagnostics and Sensing VIII

KEYWORDS: Optical imaging, Ischemia, Modulation, Nerve, Electrodes, Brain stimulation, Electrophysiology, Positron emission tomography, Epilepsy, Brain

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SPIE Journal Paper | March 1, 2008

Short-term and long-term effects of optical clearing agents on blood vessels in chick chorioallantoic membrane

Zhu, Dan , Zhang, Jing , Cui, Han , Mao, Zongzhen , Li, Pengcheng , Luo, Qingming

JBO Vol. 13 Issue 02

KEYWORDS: Blood vessels, Glucose, Optical clearing, Blood circulation, Content addressable memory, Tissue optics, Speckle, Laser speckle contrast imaging, Photography, Blood

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PROCEEDINGS ARTICLE | February 28, 2008

Enlarging the linear response range of velocity with optimum imaging parameters and modified data processing in laser speckle imaging

Proc. SPIE. 6863, Optical Diagnostics and Sensing VIII

KEYWORDS: Imaging systems, Speckle, Microscopy, CCD cameras, Speckle pattern, Laser speckle imaging, Data processing, Blood circulation, Cerebral blood flow, Velocity measurements

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PROCEEDINGS ARTICLE | May 1, 2007

Dynamic imaging of cerebral blood flow in rat reperfused mini-stroke model using laser speckle temporal contrast analysis

Proc. SPIE. 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine

KEYWORDS: Ischemia, Speckle, Laser scattering, Laser speckle imaging, Blood circulation, Cerebral blood flow, Spatial resolution, Laser tissue interaction, Somatosensory cortex, Brain

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PROCEEDINGS ARTICLE | April 26, 2007

Application of LASCA for study of blood microcirculation in brain: testing of new prophylactic preparations

Proc. SPIE. 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII

KEYWORDS: Microscopes, Visualization, Speckle, Blood, Head, Spatial resolution, Neuroimaging, Prototyping, Bacteria, Brain

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PROCEEDINGS ARTICLE | February 15, 2007

Elicitation interval dependent spatiotemporal evolution of cortical spreading depression waves revealed by optical intrinsic signal imaging

Proc. SPIE. 6445, Optical Diagnostics and Sensing VII

KEYWORDS: Optical imaging, Potassium, Biomedical optics, Tissues, Blood, Electrodes, Reflectivity, Image acquisition, Wave propagation, Light wave propagation

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PROCEEDINGS ARTICLE | February 15, 2007

A preliminary study on determining the time window of hypothermia cerebral protection in rat cortex by laser speckle flowmetry

Proc. SPIE. 6445, Optical Diagnostics and Sensing VII

KEYWORDS: Veins, Speckle, Blood, Laser scattering, Arteries, Laser speckle imaging, Blood circulation, Hemodynamics, Therapeutics, Cerebral blood flow

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PROCEEDINGS ARTICLE | February 7, 2007

Evaluation the development of focal cerebral ischemia in rats by optical imaging based on the spreading depression signals

Proc. SPIE. 6436, Complex Dynamics and Fluctuations in Biomedical Photonics IV

KEYWORDS: Optical imaging, Biomedical optics, Ischemia, Reflectivity, Arteries, Wave propagation, Optical resolution, Spatial resolution, Neuroimaging, Brain

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PROCEEDINGS ARTICLE | July 21, 2006

Digital speckle-photography, LASCA and cross-correlation techniques for study of blood microflow in isolated vessel

Proc. SPIE. 6163, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII

KEYWORDS: Microscopes, Gaussian beams, Speckle, Scattering, Blood, Photography, Diagnostics, CCD cameras, Speckle pattern, Correlation function

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SPIE Journal Paper | May 1, 2006

In vivo optical reflectance imaging of spreading depression waves in rat brain with and without focal cerebral ischemia

Chen, Shangbin , Feng, Zhe , Li, Pengcheng , Jacques, Steven , Zeng, Shaoqun , Luo, Qingming

JBO Vol. 11 Issue 03

KEYWORDS: Reflectivity, Brain, Neuroimaging, Blood, Optical imaging, Ischemia, Arteries, Skull, In vivo imaging, Biomedical optics

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PROCEEDINGS ARTICLE | March 3, 2006

Frame self-division applied in analysis of intrinsic signal optical imaging data

Proc. SPIE. 6085, Complex Dynamics and Fluctuations in Biomedical Photonics III

KEYWORDS: Signal to noise ratio, Optical imaging, Biomedical optics, Image processing, Interference (communication), Data processing, Photonics, Signal analyzers, Light, Data analysis

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PROCEEDINGS ARTICLE | March 3, 2006

Combine temporal clustering analysis with least square estimation to determine the dynamic pattern of cortical spreading depression

Proc. SPIE. 6085, Complex Dynamics and Fluctuations in Biomedical Photonics III

KEYWORDS: Optical imaging, Biomedical optics, Statistical analysis, Blood, Reflectivity, Image analysis, Wave propagation, Binary data, Functional magnetic resonance imaging, Lead

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PROCEEDINGS ARTICLE | February 2, 2006

Hemodynamic responses to functional activation accessed by optical imaging

Proc. SPIE. 6026, ICO20: Biomedical Optics

KEYWORDS: Optical imaging, Light emitting diodes, Imaging systems, Speckle, Spectroscopy, Imaging spectroscopy, Laser speckle contrast imaging, Laser speckle imaging, Blood circulation, Hemodynamics

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PROCEEDINGS ARTICLE | March 29, 2005

Using threshold segmentation methods to measure dynamic vasodilatation in a series of optical images

Proc. SPIE. 5696, Complex Dynamics and Fluctuations in Biomedical Photonics II

KEYWORDS: Optical imaging, Biomedical optics, Stars, Blood, Image segmentation, Image processing, Arteries, Intrinsic optical signal imaging, Hemodynamics, Algorithm development

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PROCEEDINGS ARTICLE | January 18, 2005

Changes in hemodynamics and light scattering during cortical spreading depression

Proc. SPIE. 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II

KEYWORDS: Optical imaging, Scattering, Spectroscopy, Light scattering, Reflectivity, Hemodynamics, Intrinsic optical signal, Signal detection, Information operations, Brain

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