Using a commercial available 200K swept source laser, we demonstrated high resolution wide field angiographic imaging of human retinal. 8mm by 8mm and 10mm by 6mm retina areas were imaged in a single scan within 4 seconds. By montaging four 10 x 6mm scan, 10 x 20mm wide field OCT angiography images were demonstrated.
We propose a three-dimensional (3-D) registration method to correct motion artifacts and construct the volume structure for angiographic and structural optical coherence tomography (OCT). This algorithm is particularly suitable for the nonorthogonal wide-field OCT scan acquired by a ultrahigh-speed swept-source system (>200 kHz A-scan rate). First, the transverse motion artifacts are corrected by the between-frame registration based on en face OCT angiography (OCTA). After A-scan transverse translation between B-frames, the axial motions are corrected based on the rebuilt boundary of inner limiting membrane. Finally, a within-frame registration is performed for local optimization based on cross-sectional OCTA. We evaluated this algorithm on retinal volumes of six normal subjects. The results showed significantly improved retinal smoothness in 3-D-registered structural OCT and image contrast on en face OCTA.