Boltzmann headstone S = kB Log W turns out to be the Rosette stone for Greek physics translation optical display of the microwave sensing hieroglyphics. The LHS is the molecular entropy S measuring the degree of uniformity scattering off the sensing cross sections. The RHS is the inverse relationship (equation) predicting the Planck radiation spectral distribution parameterized by the Kelvin temperature T. Use is made of the conservation energy law of the heat capacity of Reservoir (RV) change T Δ S = -ΔE equals to the internal energy change of black box (bb) subsystem. Moreover, an irreversible thermodynamics Δ S > 0 for collision mixing toward totally larger uniformity of heat death, asserted by Boltzmann, that derived the so-called Maxwell-Boltzmann canonical probability. Given the zero boundary condition black box, Planck solved a discrete standing wave eigenstates (equation). Together with the canonical partition function (equation) an average ensemble average of all possible internal energy yielded the celebrated Planck radiation spectral (equation) where the density of states (equation). In summary, given the multispectral sensing data (equation), we applied Lagrange Constraint Neural Network (LCNN) to solve the Blind Sources Separation (BSS) for a set of equivalent bb target temperatures. From the measurements of specific value, slopes and shapes we can fit a set of Kelvin temperatures T’s for each bb targets. As a result, we could apply the analytical continuation for each entropy sources along the temperature-unique Planck spectral curves always toward the RGB color temperature display for any sensing probing frequency.
We describe an affordable, harmless, and administrative (AHA) metabolic biomarker (MBM) for homecare
cancer screening. It may save hundreds of thousands of women’s and thousands of men’s lives every year
from breast cancer and melanoma. The goal is to increase the specificity of infrared (IR) imagery to reduce
the false alarm rate (FAR). The patient’s hands are immersed in icy cold water, about 11oC, for 30 seconds.
We then compare two IR images, taken before and after the cold stimulus, and the difference reveals an
enhanced signal and noise ratio (SNR) at tumorigenesis sites since the contraction of capillaries under cold
challenge is natural to healthy capillaries, except those newly built capillaries during angiogenesis (Folkman,
Nature 1995). Concomitant with the genome and the phenome (molecular signaling by phosphor-mediate
protein causing inflammation byplatelet activating factor (PAF) that transform cells from benign to
malignant is the amplification of nitric oxide (NO) syntheses, a short-lived reactive oxygen species (ROS)
that dilates regional blood vessels; superseding normal autonomic nervous system regulation. A rapidly
growing tumor site might implicate accumulation of ROS, for which NO can rapidly stretch the capillary bed
system usually having thinning muscular lining known asNeo-Angiogenesis (NA) that could behave like
Leaky In-situ Faucet Effect (LIFE) in response to cold challenge.
To emphasize the state of art knowledge of NA, we mentioned in passing the first generation of an anticapillary
growth drug,Avastin by Genetech; it is an antibody protein that is injected for metastasis, while the
second generation drug; Sorafenib by Bayers (2001) and Sutent by Pfizer (2000) both target molecular
signaling loci to block receptor associated tyrosine kinase induced protein phosphorylation in order to reverse
Differentiating benign from malignant in a straightforward manner is required to achieve the wellness
protocol, yet would become prohibitively expensive and impossible to follow through. For example, given
theprobability of detection (PD) about 0.1% over unspecified number of years (e.g. menopause years for
breast cancer), one might need hundred thousand volunteers. We suggested a Time Reversal Invariant
Paradigm (TRIP) (a private communication with Vatican) for gathering equivalent cancer symptom imagery
from recovery histories of dozens of patients. We further mixed it with few % of recovered/non-sick cases for
negative controls. Creating Virtual images and running videos of these, frame by frame, in two directions
(forward and backward in time) resulted in identical Receiver Operation Characteristics (ROC) for both the
computer Aided Target Recognition (AiTR) algorithm and the human radiological experts; namely PD versus
FAR within the standard deviation; even though the physiology could be entirely different. Such aTRIP
would be true taken by any memory-less instantaneous imagery devices (IR, ultrasound, X-rays, MRI
excluding magnetic hysteresis memory).
In summary, such an affordable, harmless, and administrative, neo-angiogenesis metabolic biomarker can
help monitor the transitioning from benign to malignant states of high-risk home alone seniors and also
monitor the progress of home alone seniors treatment at home. Therefore, Smartphone equipped with a day
camera having IR spectral filtering for a contact self imaging called joystick, when augmented with AHA NA
MBM, may be suited for HAS homecare.
Biomedical Wellness (BMW) surveillance system may become indispensible in public health riding on four confluent
trends: (i) The surge of retirement waves of WWII baby boomers; (ii) The longevity of the seniors, thanks to 3 decades
steady NIH budgets~$23B per year; (iii) The economic melting down is exasperating resources for entitlements; (iv) The
emergent Next Gen Internet having the last mile challenges solved entirely and friendly with IT wired and wireless
delivery system, thanks to DoD/DARPA pioneer and numerous entrepreneurs visionary efforts. To be effective in job recreation
in current economic slag, BMW needs a jump start, WH/HHS should establish a balanced investment policy in
health care, not just to illness but to wellness, and a BMW blue ribbon panel (BMWbrp), which must be, however,
independent of NIHbrp, recommending additional resources, say $5B budget for BMW infrastructure building that will
surely create new jobs to prepare badly needed geriatric caretakers. Being governmental investment, the BMWbrp must
come back with a upward-conversion compatible infrastructure Blue-Print, version#1, an open architecture of standard
interfaces, workable with distributed data bases and programming languages. The infrastructure must be simple,
transparent, scalable, to leverage with a win-win-win(senior) CRADA from the private investments worldwide, e.g. from
the insurance companies and home security companies, etc. that can further attract senior community center BOT. To
start whenever the rubber meets the road, we shall enlist the military infrastructure, their sensors suite located in DoD &
DHS labs supported with their affiliated contractors and universities. However, the down selections should be done
under open bids, oversight by BMWbrp, under HHS $5B budget, to translate their sophisticated military persistent and
precision surveillance know-how technology to watch out, no longer the enemy of USA but also, the enemy of mankind,
the malicious microorganisms and disorders. The degree of friendliness must be demanded and measured by the standoff
methodology such as 4 nones: noninvasive, noncontact, and none-stop-to-measure, in this order.
The purpose of this study was to determine whether three investigators would produce similar results when reading/scoring the same breast infrared images. They used their standard methods of analysis (subjective to semi-objective analysis). Two of the investigators submitted breast infrared images from 71 screened patients. The images were stored in a database and displayed for scoring by three investigators (two who submitted the data and one additional reader). The left and right breasts were analyzed separately. The investigators submitted their scores to the database without knowledge of the scores of the other two investigators. Overall, concordance of results among all three investgators was 76% (all three investigators' readings agreed on 107 of 141 breasts). Comparison of paired results of the three investigators resulted in 79 to 94% agreement for the six comparisons (three investigators and two breasts) with an overall agreement of 88% (371 of 424 paired comparisons). This preliminary comparison of three investigators' blinded results of breast infrared image readings from a screening population, demonstrates that breast infrared images taken at different Centers with different techniques can be interpreted by different investigators with very similar results. As the database grows there will be an increase in the number and percentage of patients with abnormal infrared images (high risk and breast cancer patients). This will allow a better and more thorough analysis of the results to refine and standardize the reading technique, and further to allow the assessment of previously untested algorithms with this unique database.