Artificial intelligence (AI) algorithms, especially deep learning methods have proven to be successful in many medical imaging applications. Computerized breast cancer image analysis can improve diagnosis accuracy. Digital Breast Tomosynthesis (DBT) imaging is a new modality and more advantageous compared to classical digital mammography (DM). Therefore, development of new deep learning algorithms compatible with DBT modality are potent to improve DBT imaging reading time efficiency and increase accuracy for breast cancer diagnosis when used as additional tool for radiologists. In this work, we aimed to build a 3D deep learning model to distinguish malignancy and benign breasts using DBT images. We also investigated effects of different loss functions in our deep learning models. We implemented and evaluated our method on a large data set of 546 patients (205 malignancy and 341 benign). Our results showed that different loss functions lead to an influence on the models performance in our classification tasks, and specific loss function may be selected or customized to adjust a specific performance metric for concrete applications.
Digital mammography (DM) was the most common image guided diagnostic tool in breast cancer detection up till recent years. However, digital breast tomosynthesis (DBT) imaging, which presents more accurate results than DM, is going to replace DM in clinical practice. As in many medical image processing applications, Artificial Intelligence (AI) has been shown promising in reducing radiologists reading time with enhanced cancer diagnostic accuracy. In this paper, we implemented a 3D network using deep learning algorithms to detect breast cancer malignancy using DBT craniocaudal (CC) view images. We created a multi-sub-volume approach, in which the most representative slice (MRS) for malignancy scans is manually selected/defined by expert radiologists. We specifically compared the effects on different selections of the MRS by two radiologists and the resulting model performance variations. The results indicate that our scheme is relatively robust for all three experiments.