Dr. Qianqian Fang Profile

Dr. Qianqian Fang

Assistant Professor at Northeastern Univ

SPIE Involvement:

Conference Program Committee | Conference Chair | Author

Publications (17)

SPIE Journal Paper | January 26, 2018

Scalable and massively parallel Monte Carlo photon transport simulations for heterogeneous computing platforms

Yu, Leiming , Nina-Paravecino, Fanny , Kaeli, David , Fang, Qianqian

JBO Vol. 23 Issue 01

KEYWORDS: Monte Carlo methods, Computer simulations, Photon transport, Algorithm development, Copper, Computer programming, Parallel computing, 3D modeling, Profiling, Wavefronts

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SPIE Journal Paper | April 27, 2017

Multimodal breast cancer imaging using coregistered dynamic diffuse optical tomography and digital breast tomosynthesis

Zimmermann, Bernhard , Deng, Bin , Singh, Bhawana , Martino, Mark , Selb, Juliette , Fang, Qianqian , Sajjadi, Amir , Cormier, Jayne , Moore, Richard , Kopans, Daniel , Boas, David , Saksena, Mansi , Carp, Stefan

JBO Vol. 22 Issue 04

KEYWORDS: Digital breast tomosynthesis, Breast, Sensors, Optical fibers, Absorption, X-rays, Breast cancer, Mammography, Tumors, Imaging systems

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SPIE Journal Paper | January 26, 2016

Frequency domain near-infrared multiwavelength imager design using high-speed, direct analog-to-digital conversion

Zimmermann, Bernhard , Fang, Qianqian , Boas, David , Carp, Stefan

JBO Vol. 21 Issue 01

KEYWORDS: Sensors, Imaging systems, Optical properties, Absorption, Scattering, Tissue optics, Breast, Modulation, Field programmable gate arrays, Signal detection

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SPIE Journal Paper | August 11, 2015

Characterizing breast lesions through robust multimodal data fusion using independent diffuse optical and x-ray breast imaging

Moore, Richard , Kopans, Daniel , Boas, David , Deng, Bin , Fradkin, Maxim , Rouet, Jean-Michel , Lundqvist, Mats , Fang, Qianqian

JBO Vol. 20 Issue 08

KEYWORDS: Breast, Tumors, Mammography, Tissue optics, Tissues, X-ray optics, X-rays, X-ray imaging, Image registration, Digital breast tomosynthesis

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SPIE Journal Paper | March 12, 2015

Multimodal reconstruction of microvascular-flow distributions using combined two-photon microscopy and Doppler optical coherence tomography

Gagnon, Louis , Sakadžić, Sava , Lesage, Fréderic , Mandeville, Emiri , Fang, Qianqian , Yaseen, Mohammad , Boas, David

NPh Vol. 2 Issue 01

KEYWORDS: Capillaries, Optical coherence tomography, Angiography, Two photon excitation microscopy, Blood circulation, Resistance, Doppler tomography, Velocity measurements, Blood, Blood pressure

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PROCEEDINGS ARTICLE | March 2, 2015

An empirical approach to estimate near-infra-red photon propagation and optically induced drug release in brain tissues

Proc. SPIE. 9308, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV

KEYWORDS: Tissues, Scattering, Computer simulations, Monte Carlo methods, Optical simulations, Geometrical optics, Tissue optics, Photon transport, Absorption, Brain

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SPIE Journal Paper | January 9, 2014

Comparison of a layered slab and an atlas head model for Monte Carlo fitting of time-domain near-infrared spectroscopy data of the adult head

Selb, Juliette , Ogden, Tyler , Dubb, Jay , Fang, Qianqian , Boas, David

JBO Vol. 19 Issue 01

KEYWORDS: Monte Carlo methods, Head, Absorption, Brain, Data modeling, Scattering, Near infrared spectroscopy, Optical properties, Tissues, Photons

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PROCEEDINGS ARTICLE | March 25, 2013

Systematic evaluation of a time-domain Monte Carlo fitting routine to estimate the adult brain optical properties

Proc. SPIE. 8578, Optical Tomography and Spectroscopy of Tissue X

KEYWORDS: Data modeling, Optical properties, Tissues, Scattering, Diffusion, Monte Carlo methods, Head, Skull, Absorption, Brain

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Time-domain near-infrared spectroscopy (TD-NIRS) offers the ability to measure the absolute baseline optical properties of a tissue. Specifically, for brain imaging, the robust assessment of cerebral blood volume and oxygenation based on measurement of cerebral hemoglobin concentrations is essential for reliable cross-sectional and longitudinal studies. In adult heads, these baseline measurements are complicated by the presence of thick extra-cerebral tissue (scalp, skull, CSF). A simple semi-infinite homogeneous model of the head has proven to have limited use because of the large errors it introduces in the recovered brain absorption. Analytical solutions for layered media have shown improved performance on Monte-Carlo simulated data and layered phantom experiments, but their validity on real adult head data has never been demonstrated. With the advance of fast Monte Carlo approaches based on GPU computation, numerical methods to solve the radiative transfer equation become viable alternatives to analytical solutions of the diffusion equation. Monte Carlo approaches provide the additional advantage to be adaptable to any geometry, in particular more realistic head models. The goals of the present study were twofold: (1) to implement a fast and flexible Monte Carlo-based fitting routine to retrieve the brain optical properties; (2) to characterize the performances of this fitting method on realistic adult head data. We generated time-resolved data at various locations over the head, and fitted them with different models of light propagation: the homogeneous analytical model, and Monte Carlo simulations for three head models: a two-layer slab, the true subject’s anatomy, and that of a generic atlas head. We found that the homogeneous model introduced a median 20 to 25% error on the recovered brain absorption, with large variations over the range of true optical properties. The two-layer slab model only improved moderately the results over the homogeneous one. On the other hand, using a generic atlas head registered to the subject’s head surface decreased the error by a factor of 2. When the information is available, using the true subject anatomy offers the best performance.

PROCEEDINGS ARTICLE | March 25, 2013

Dynamic optical breast imaging for neoadjuvant therapy monitoring

Proc. SPIE. 8578, Optical Tomography and Spectroscopy of Tissue X

KEYWORDS: Optical imaging, Breast, Breast cancer, Tumors, Tissues, Imaging systems, Optical testing, Hemodynamics, Tissue optics

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PROCEEDINGS ARTICLE | March 13, 2013

Diagnosing breast cancer using independent diffuse optical tomography and x-ray mammography scans

Proc. SPIE. 8574, Multimodal Biomedical Imaging VIII

KEYWORDS: Breast, X-ray optics, Breast cancer, Tissues, X-rays, Image registration, Mammography, Tissue optics, Digital mammography, Digital breast tomosynthesis

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SPIE Journal Paper | October 1, 2012

Mesh-based Monte Carlo method in time-domain widefield fluorescence molecular tomography

Chen, Jin , Fang, Qianqian , Intes, Xavier

JBO Vol. 17 Issue 10

KEYWORDS: Monte Carlo methods, Luminescence, Tomography, Sensors, Computer simulations, Photon transport, Picosecond phenomena, Fluorescence tomography, Data modeling, In vivo imaging

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SPIE Journal Paper | October 1, 2011

Two-photon microscopy of cortical NADH fluorescence intensity changes: correcting contamination from the hemodynamic response

Baraghis, Edward , Devor, Anna , Fang, Qianqian , Srinivasan, Vivek , Wu, Weicheng , Boas, David , Sakadžic, Sava , Lesage, Frédéric , Ayata, Cenk , Kasischke, Karl

JBO Vol. 16 Issue 10

KEYWORDS: Luminescence, Blood, Scattering, Signal detection, In vivo imaging, Tissue optics, Fluorescence spectroscopy, Absorption, Hemodynamics, Hypoxia

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PROCEEDINGS ARTICLE | March 1, 2007

Reconstruction of tissue dynamics in the compressed breast using multiplexed measurements and temporal basis functions

Proc. SPIE. 6434, Optical Tomography and Spectroscopy of Tissue VII

KEYWORDS: Breast, Tissues, Imaging systems, Blood, Image restoration, Multiplexing, Oxygen, Hemodynamics, Tissue optics, Absorption

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PROCEEDINGS ARTICLE | February 20, 2007

Clinical data analysis for the combined optical and tomosynthesis breast imaging

Proc. SPIE. 6431, Multimodal Biomedical Imaging II

KEYWORDS: Breast, Tissues, Imaging systems, Sensors, X-rays, Mammography, Tissue optics, X-ray imaging, Breast imaging

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SPIE Journal Paper | November 1, 2006

Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements

Carp, Stefan , Kauffman, Tina , Fang, Qianqian , Rafferty, Elizabeth , Moore, Richard , Kopans, Daniel , Boas, David

JBO Vol. 11 Issue 06

KEYWORDS: Breast, Tissues, Oxygen, Blood, Tissue optics, Blood circulation, Optical fibers, Scattering, Positron emission tomography, Spectroscopy

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PROCEEDINGS ARTICLE | February 13, 2006

Nonlinear image reconstruction algorithm for diffuse optical tomography using iterative block solver and automatic mesh generation from tomosynthesis images

Proc. SPIE. 6081, Multimodal Biomedical Imaging

KEYWORDS: Breast, Imaging systems, Image segmentation, Image restoration, 3D modeling, Medical imaging, Mammography, Reconstruction algorithms, Binary data, 3D image processing

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PROCEEDINGS ARTICLE | June 10, 2003

Microwave imaging for thermal therapy monitoring: temperature accuracy and image reconstruction time improvements

Proc. SPIE. 4954, Thermal Treatment of Tissue: Energy Delivery and Assessment II

KEYWORDS: Thermography, Ultrasonography, Image restoration, Receivers, Data acquisition, Antennas, Reconstruction algorithms, In vivo imaging, Microwave radiation, Microwave imaging

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