Mr. Raghav Goel Profile

Raghav Goel

at Univ of Minnesota

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Proceedings Article | 25 February 2008 Paper

Tumor necrosis factor-alpha induced enhancement of cryosurgery

Raghav Goel, Guilio Paciotti, John Bischof

Proceedings Volume 6842, 68420R (2008) https://doi.org/10.1117/12.764020

KEYWORDS: Tumors, Tissues, Injuries, Cancer, Skin, Systems modeling, Temperature metrology, Visualization, Natural surfaces, Argon

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Local recurrence of cancer after cryosurgery is related to the inability to monitor and predict destruction of cancer (temperatures > -40°C) within an iceball. We previously reported that a cytokine adjuvant TNF-α could be used to achieve complete cancer destruction at the periphery of an iceball (0 to -40°C). This study is a further development of that work in which cryosurgery was performed using cryoprobes operating at temperatures > -40°C. LNCaP Pro 5 tumor grown in a dorsal skin fold chamber (DSFC) was frozen at -6°C after TNF-α incubation for 4 or 24 hours. Tumors grown in the hind limb were frozen with a probe tip temperature of -40°C, 4 or 24 hours after systemic injection with TNF-α. Both cryosurgery alone or TNF-α treatment alone caused only a minimal damage to the tumor tissue at the conditions used in the study. The combination of TNF-α and cryosurgery produced a significant damage to the tumor tissue in both the DSFC and the hind limb model system. This augmentation in cryoinjury was found to be time-dependent with 4-hour time period between the two treatments being more effective than 24-hour. These results suggests the possibility of cryotreatment at temperatures > -40°C with the administration of TNF-α.

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