Dr. Rahul Pal Profile

Dr. Rahul Pal

Instructor at Massachusetts General Hospital

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Author

Publications (18)

Proceedings Article | 12 April 2024 Open Access

Fluorescence lifetime-based tumor contrast enhancement using targeted near infrared probes (Conference Presentation) (Withdrawal Notice)

Rahul Pal, Anand Kumar

Proceedings Volume 11222, 112220G (2024) https://doi.org/10.1117/12.2545246

KEYWORDS: Tumors, Near infrared, Fluorescence, Surgery, Molecules

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Proceedings Article | 13 March 2024 Presentation

Fluorescence lifetime imaging for enhanced tumor contrast using exogenous dyes

Anand T, Kumar, Rahul Pal, Thinzar Lwin, Murali Krishnamoorthy, Hannah Collins, Corey Chan, Andrey Prilutskiy, MacLean Nasrallah, Tom Dijkhuis, Stefan Carp, Yin Hung, Peter Sadow, William Faquin, Brian Nahed, Allen Feng, Kevin Emerick, J. Sven Mieog, Alexander Vahrmeijer, Karthik Rajasekaran, John Y. Lee, Kenneth Rankin, Santiago Lozano-Calderon, Mark Varvares, Kenneth Tanabe

Proceedings Volume PC12825, PC128250P (2024) https://doi.org/10.1117/12.3002108

KEYWORDS: Tumors, Tissues, Surgery, Near infrared, Fluorescence lifetime imaging, Fluorescence, Fluorescence intensity, Image-guided intervention, Contrast agents, Biological imaging

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Proceedings Article | 28 March 2023 Open Access

First clinical results of fluorescence lifetime enhanced tumor imaging using exogenous agents (Conference Presentation) (Withdrawal Notice)

Rahul Pal, Thinzar Lwin, Murali Krishnamoorthy, Stefan Carp, Corey Chan, Maclean Nasrallah, John Y. Lee, Yin Hung, Allen Feng, Kenneth Tanabe, Eben Rosenthal, Brian Nahed, Kevin Emerick, Kenneth Rankin, Santiago Lozano-Calderon, Mark Varvares, Anand T. Kumar

Proceedings Volume PC12361, PC123610H (2023) https://doi.org/10.1117/12.2649241

KEYWORDS: Tumors, Fluorescence imaging, Fluorescence, Surgery, Molecules, Molecular photonics, Biomedical applications

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Proceedings Article | 17 March 2023 Presentation

In vivo imaging of CRISPRi-attenuated receptor expression by using a miniaturized near-infrared anti-EGFR probe (Conference Presentation)

Alexei Bogdanov, Suresh Gupta, Anand Kumar, Rahul Pal, Eric Schmidt

Proceedings Volume PC12398, PC123980E (2023) https://doi.org/10.1117/12.2648483

KEYWORDS: Tumors, In vivo imaging, Receptors, Cancer, Near infrared, Luminescence, Tumor growth modeling, Tissues, Optical imaging, Image registration

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Proceedings Article | 17 March 2023 Presentation

Fluorescence lifetime-enhanced tumor margin assessment in head and neck cancers using receptor targeted probes

Rahul Pal, Thinzar Lwin, Marisa Hom, Mark Varvares, Eben Rosenthal, Anand Kumar

Proceedings Volume 12354, 123540E (2023) https://doi.org/10.1117/12.2649378

KEYWORDS: Receptors, Tumors, Luminescence, Neck, Head, Cancer, Tissues, Surgery, Near infrared, Continuous wave operation

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Proceedings Article | 7 March 2023 Presentation

In-vivo fluorescence lifetime tomography for detection and quantification of immunotherapy marker, PD-L1

Rahul Pal, Aya Matsui, Murali K., Satoru Morita, Homan Kang, Hak Soo Choi, Dan Duda, Anand Kumar

Proceedings Volume PC12376, PC123760P (2023) https://doi.org/10.1117/12.2650664

KEYWORDS: Tumors, In vivo imaging, Tomography, Luminescence, Fluorescence tomography, Liver, Molecular imaging, Cancer, Biopsy

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Proceedings Article | 7 March 2023 Presentation

Modeling and optimization of system parameters for small animal fluorescence lifetime tomography

Murali K., Rahul Pal, Anand T.N. Kumar

Proceedings Volume PC12376, PC123760O (2023) https://doi.org/10.1117/12.2650768

KEYWORDS: Animal model studies, Tomography, Luminescence, Fluorescence tomography, Tissue optics, Optimization (mathematics), Cameras, 3D modeling, Signal to noise ratio, Microchannel plates

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Proceedings Article | 15 March 2021 Open Access

Tumor contrast enhancement using fluorescence lifetime: a new promise for image guided surgery (Conference Presentation) (Withdrawal Notice)

Anand Kumar, Rahul Pal, Lawrence Zukerberg, Kenneth Tanabe

Proceedings Volume 11625, 116250T (2021) https://doi.org/10.1117/12.2576446

KEYWORDS: Tumors, Luminescence, Surgery, Tissues, Image-guided intervention, Signal attenuation, Receptors, Near infrared, Multiplexing

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Proceedings Article | 5 March 2021 Presentation

Use of preclinical models alongside clinical tissues to develop a noninvasive multimodal fluorescence detection approach for oral neoplasia detection

Paula Villarreal, Rahul Pal, Xiaoying Yu, Orly Coblens, Suimin Qiu, Rongguang Liang, Xingde Li, Gracie Vargas

Proceedings Volume 11633, 116330I (2021) https://doi.org/10.1117/12.2591126

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Proceedings Article | 5 March 2021 Poster + Presentation

Quantitative multiplexing in biological tissue using multispectral and fluorescence lifetime imaging

Rahul Pal, Anand T. Kumar

Proceedings Volume 11639, 116391V (2021) https://doi.org/10.1117/12.2578437

KEYWORDS: Multispectral imaging, Multiplexing, Tissues, Tissue optics, Luminescence, In vitro testing, Imaging systems, Visualization, Near infrared, Receptors

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Proceedings Article | 5 March 2021 Presentation

Designing a multimodal imaging workflow for large area fluorescence with nonlinear optical microscopy for oral neoplasia detection: preclinical model and clinical sample study

Rahul Pal, Paula Villarreal, Xiaoying Yu, Suimin Qiu, Orly Coblens, Gracie Vargas

Proceedings Volume 11622, 116220I (2021) https://doi.org/10.1117/12.2591286

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Proceedings Article | 5 March 2021 Presentation

Whole body fluorescence lifetime multiplexing of tumor receptor expression

Rahul Pal, Homan Kang, Hak Soo Choi, Gabriel Duda, Anand T. Kumar

Proceedings Volume 11624, 1162408 (2021) https://doi.org/10.1117/12.2578412

KEYWORDS: Tumors, Receptors, Luminescence, Multiplexing, In vivo imaging, Continuous wave operation, Tumor growth modeling, Tissues, Surveillance, Signal detection

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Proceedings Article | 5 March 2021 Presentation

Multimodal optical assessment of breast tumor aggressiveness and progression in murine models

Bin Deng, Ailis Muldoon, Rahul Pal, Alana Ross, Pamela Pantazopoulos, Zdravka Medarova, Anand T. Kumar, Stefan Carp

Proceedings Volume 11634, 116340B (2021) https://doi.org/10.1117/12.2577699

KEYWORDS: Tumors, Breast, Near infrared spectroscopy, Breast cancer, Tumor growth modeling, Spectroscopy, Luminescence, Indocyanine green, Imaging spectroscopy, Fluorescence spectroscopy

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SPIE Journal Paper | 16 November 2020 Open Access

Multimodal widefield fluorescence imaging with nonlinear optical microscopy workflow for noninvasive oral epithelial neoplasia detection: a preclinical study

Rahul Pal, Paula Villarreal, Xiaoying Yu, Suimin Qiu, Gracie Vargas

JBO, Vol. 25, Issue 11, 116008, (November 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.11.116008

KEYWORDS: Inflammation, Roentgenium, Luminescence, In vivo imaging, Multimodal imaging, Microscopy, Tissues, Optical microscopy, Optical imaging, Tumors

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Significance: Early detection of epithelial cancers and precancers/neoplasia in the presence of benign lesions is challenging due to the lack of robust in vivo imaging and biopsy guidance techniques. Label-free nonlinear optical microscopy (NLOM) has shown promise for optical biopsy through the detection of cellular and extracellular signatures of neoplasia. Although in vivo microscopy techniques continue to be developed, the surface area imaged in microscopy is limited by the field of view. FDA-approved widefield fluorescence (WF) imaging systems that capture autofluorescence signatures of neoplasia provide molecular information at large fields of view, which may complement the cytologic and architectural information provided by NLOM. Aim: A multimodal imaging approach with high-sensitivity WF and high-resolution NLOM was investigated to identify and distinguish image-based features of neoplasia from normal and benign lesions. Approach:In vivo label-free WF imaging and NLOM was performed in preclinical hamster models of oral neoplasia and inflammation. Analyses of WF imaging, NLOM imaging, and dual modality (WF combined with NLOM) were performed. Results: WF imaging showed increased red-to-green autofluorescence ratio in neoplasia compared to inflammation and normal oral mucosa (p < 0.01). In vivo assessment of the mucosal tissue with NLOM revealed subsurface cytologic (nuclear pleomorphism) and architectural (remodeling of extracellular matrix) atypia in histologically confirmed neoplastic tissue, which were not observed in inflammation or normal mucosa. Univariate and multivariate statistical analysis of macroscopic and microscopic image-based features indicated improved performance (94% sensitivity and 97% specificity) of a multiscale approach over WF alone, even in the presence of benign lesions (inflammation), a common confounding factor in diagnostics. Conclusions: A multimodal imaging approach integrating strengths from WF and NLOM may be beneficial in identifying oral neoplasia. Our study could guide future studies on human oral neoplasia to further evaluate merits and limitations of multimodal workflows and inform the development of multiscale clinical imaging systems.

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Proceedings Article | 4 March 2019 Presentation

Fluorescence optical tomography using short-wave infrared light (Conference Presentation)

Steven Hou, Rahul Pal, Anand Kumar

Proceedings Volume 10874, 1087412 (2019) https://doi.org/10.1117/12.2510199

KEYWORDS: Short wave infrared radiation, Luminescence, Infrared radiation, Tomography, Optical tomography, Near infrared, Spatial resolution, Tissue optics, Tissues, Light scattering

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Proceedings Article | 3 May 2016 Presentation

Combining large area fluorescence with multiphoton microscopy for improved detection of oral epithelial neoplasia (Conference Presentation)

Rahul Pal, Jinping Yang, Suimin Qiu, Susan McCammon, Vicente Resto, Gracie Vargas

Proceedings Volume 9701, 970109 (2016) https://doi.org/10.1117/12.2213927

KEYWORDS: Luminescence, Multiphoton microscopy, Microscopy, 3D modeling, Multiphoton fluorescence microscopy, Harmonic generation, Target detection, Analog electronics, Glucose, Connective tissue

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Proceedings Article | 27 April 2016 Presentation

Volumetric imaging of oral epithelial neoplasia by MPM-SHGM: epithelial connective tissue interface (Conference Presentation)

Rahul Pal, Jinping Yang, Suimin Qiu, Vicente Resto, Susan McCammon, Gracie Vargas

Proceedings Volume 9712, 971216 (2016) https://doi.org/10.1117/12.2213942

KEYWORDS: Interfaces, Connective tissue, 3D modeling, Multiphoton microscopy, Microscopy, Diagnostics, Tumor growth modeling, Second-harmonic generation, Image analysis, Cancer

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Proceedings Article | 22 March 2013 Paper

Combination of widefield fluorescence imaging and nonlinear optical microscopy of oral epithelial neoplasia

Rahul Pal, Kert Edward, Tyra Brown, Liang Ma, Jinping Yang, Susan McCammon, Massoud Motamedi, Gracie Vargas

Proceedings Volume 8572, 85720M (2013) https://doi.org/10.1117/12.2005144

KEYWORDS: Luminescence, Microscopy, Tissues, Multiphoton microscopy, Cancer, Atrial fibrillation, Optical imaging, Harmonic generation, Tumors, Biopsy

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Showing 5 of 18 publications

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