Dr. Ralf Brinkmann Profile

Dr. Ralf Brinkmann

Managing Director at Medizinisches Laserzentrum Lübeck GmbH

SPIE Involvement:

Conference Program Committee | Author

Publications (129)

Proceedings Article | 11 August 2023 Paper

Air-jet based optical coherence elastography of brain tumor tissue: stiffness evaluation by structural histological analysis

Nicolas Detrez, Sazgar Burhan, Paul Strenge, Jessica Kren, Christian Hagel, Matteo Mario Bonsanto, Dirk Theisen-Kunde, Robert Huber, Ralf Brinkmann

Proceedings Volume 12629, 126290M (2023) https://doi.org/10.1117/12.2670944

KEYWORDS: Tumors, Tissues, Brain tissue, Elastography, Connective tissue, Optical coherence, Brain, Biological samples, Optical coherence tomography, Neurosurgery

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Proceedings Article | 11 August 2023 Paper

Real-time temperature-control for cw retinal laser therapy in a clinical study

Dirk Theisen-Kunde, Claus von der Burchard, Veit Danicke, Jan-Eric Fleger, Christopher Kren, Sebastian Wittmeier, Johann Roider, Ralf Brinkmann

Proceedings Volume 12627, 1262723 (2023) https://doi.org/10.1117/12.2670839

KEYWORDS: Laser therapeutics, Temperature metrology, Laser irradiation, Fiber lasers, Continuous wave operation, Control systems, Thermoelasticity, Temperature control, Retina, Pulsed laser operation

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Proceedings Article | 11 August 2023 Paper

Clinical evaluation of thulium laser/ultrasonic aspirator combination instrument during neurosurgical tumour resection

Dirk Theisen-Kunde, Jessica Kren, Alessa Hutfilz, Matteo Mario Bonsanto, Ralf Brinkmann

Proceedings Volume 12627, 126270Z (2023) https://doi.org/10.1117/12.2670859

KEYWORDS: Laser ultrasonics, YAG lasers, Equipment, Resection, Nervous system, Surgery, Blood vessels, Neurosurgery, Laser therapeutics, Fiber lasers

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Proceedings Article | 11 August 2023 Paper

Fluorescence lifetime imaging microscopy (FLIM) of human middle ear tissue samples

Paula Enzian, Birgit Lange, Zuzana Penxová, Anke Leichtle, Yoko Miura, Karl-Ludwig Bruchhage, Ralf Brinkmann

Proceedings Volume 12627, 126271T (2023) https://doi.org/10.1117/12.2670902

KEYWORDS: Tissues, Fluorescence lifetime imaging, Ear, Fluorescence, Autofluorescence, Fluorophores, Inflammation, FRET and FLIM microscopy

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Proceedings Article | 11 August 2023 Paper

Microscope integrated real time high density 4D MHz-OCT in neurosurgery: a depth and tissue resolving visual contrast channel and the challenge of fused presentation

Wolfgang Draxinger, Dirk Theisen-Kunde, Lion Schuetz, Nicolas Detrez, Paul Strenge, Maximilian Rixius, Veit Danicke, Wolfgang Wieser, Jessica Kren, Patrick Kuppler, Sonja Spar-Hess, Matteo Mario Bonsanto, Ralf Brinkmann, Robert Huber

Proceedings Volume 12627, 126270W (2023) https://doi.org/10.1117/12.2670953

KEYWORDS: Microscopes, Visualization, Neurosurgery, Nervous system, Tumors, Surgery, Imaging systems, Brain, Tissues, Optical coherence tomography

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Proceedings Article | 11 August 2023 Paper

Advanced FFT-based contrast approach for MHz optical coherence elastography

Sazgar Burhan, Nicolas Detrez, Madita Göb, Matteo Mario Bonsanto, Ralf Brinkmann, Robert Huber

Proceedings Volume 12632, 1263215 (2023) https://doi.org/10.1117/12.2670957

KEYWORDS: Optical coherence tomography, Tissues, Biological samples, Elastography, Visualization, Tumors, Brain

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Proceedings Article | 11 August 2023 Paper

Monitoring of fatigue damage in monolithic dental CAD/CAM crowns by optical coherence tomography

Christin Grill, Julie-Jacqueline Kuhl, Maximiliane Amelie Schlenz, Ralf Brinkmann

Proceedings Volume 12632, 126320J (2023) https://doi.org/10.1117/12.2670874

KEYWORDS: Optical coherence tomography, Imaging systems, Teeth, Manufacturing, Zirconium dioxide, Visualization, Composites, Optical properties, Dental materials

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Proceedings Article | 11 August 2023 Paper

Demarcation of brain and tumor tissue with optical coherence tomography using prior neural networks

Paul Strenge, Birgit Lange, Wolfgang Draxinger, Christian Hagel, Christin Grill, Veit Danicke, Dirk Theisen-Kunde, Sonja Spahr-Hess, Matteo Bonsanto, Robert Huber, Heinz Handels, Ralf Brinkmann

Proceedings Volume 12632, 126321P (2023) https://doi.org/10.1117/12.2670907

KEYWORDS: Brain, Tumors, Optical coherence tomography, Brain tissue, White matter, Tissues, Image segmentation, Neural networks

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Proceedings Article | 17 March 2023 Presentation

Optoacoustic temperature measurement with a single microsecond laser pulse

Eric Seifert, Hossameldin Abbas, Ralf Brinkmann

Proceedings Volume PC12360, PC123600T (2023) https://doi.org/10.1117/12.2649833

KEYWORDS: Pulsed laser operation, Temperature metrology, Optoacoustics, Transducers, Semiconductor lasers, Retina, Laser systems engineering, High power lasers, Calibration, Biophotonic applications

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Proceedings Article | 16 March 2023 Presentation + Paper

High speed 4D in-vivo OCT imaging of the human brain: creating high density datasets for machine learning toward identification of malign tissue in real time

Wolfgang Draxinger, Dirk Theisen-Kunde, Lion Schützeck, Nicolas Detrez, Paul Strenge, Veit Danicke, Jessica Kren, Patrick Kuppler, Sonja Spahr-Hess, Matteo Mario Bonsanto, Ralf Brinkmann, Robert Huber

Proceedings Volume 12390, 123900D (2023) https://doi.org/10.1117/12.2648505

KEYWORDS: Optical coherence tomography, Imaging systems, Microscopes, In vivo imaging, Brain, Neuroimaging, Visualization, Tissues, Brain tissue, Tumors

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Proceedings Article | 15 March 2023 Paper

Air-Jet based optical coherence elastography: processing and mechanical interpretation of brain tumor data

Nicolas Detrez, Sazgar Burhan, Katharina Rewerts, Jessica Kren, Christian Hagel, Matteo Mario Bonsanto, Dirk Theisen-Kunde, Robert Huber, Ralf Brinkmann

Proceedings Volume 12381, 1238105 (2023) https://doi.org/10.1117/12.2649835

KEYWORDS: Tumors, Connective tissue, Optical coherence tomography, Viscoelasticity, Brain tissue, Tissues, Optical coherence, Elastography, Deformation, Brain

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Proceedings Article | 8 March 2023 Presentation + Paper

Phase analysis strategies for MHz OCE in the large displacement regime

Sazgar Burhan, Nicolas Detrez, Katharina Rewerts, Madita Göb, Steffen Buschschlüter, Christian Hagel, Matteo Mario Bonsanto, Dirk Theisen-Kunde, Robert Huber, Ralf Brinkmann

Proceedings Volume 12367, 123670Q (2023) https://doi.org/10.1117/12.2652847

KEYWORDS: Tumors, Optical coherence tomography, Biological samples, Brain tissue, Brain, Phase unwrapping, Biomechanics, Elastography, Phase contrast, Surgery

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Proceedings Article | 6 March 2023 Presentation + Paper

Dual wavelength analysis and classification of brain tumor tissue with optical coherence tomography

Paul Strenge, Birgit Lange, Wolfgang Draxinger, Christian Hagel, Christin Grill, Veit Danicke, Dirk Theisen-Kunde, Sonja Spahr-Hess, Matteo Bonsanto, Robert Huber, Heinz Handels, Ralf Brinkmann

Proceedings Volume 12368, 1236805 (2023) https://doi.org/10.1117/12.2649963

KEYWORDS: Tumors, Optical coherence tomography, Brain tissue, White matter, Education and training, Surgery, Brain, Tissues, Neural networks, Signal attenuation

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Proceedings Article | 9 December 2021 Paper

Towards model-based control techniques for retinal laser treatment using only one laser

M. Mordmuller, V. Kleyman, M. Schaller, M. Wilson, K. Worthmann, M. Muller, R. Brinkmann

Proceedings Volume 11923, 1192305 (2021) https://doi.org/10.1117/12.2615851

KEYWORDS: Temperature metrology, Laser therapeutics, Model-based design, Eye, Pulsed laser operation, Retina, Laser energy, Laser tissue interaction, Laser coagulation, Bragg cells

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Proceedings Article | 9 December 2021 Paper

Single pulse optoacoustic temperature measurement

Eric Seifert, Hossameldin Abbas, Ralf Brinkmann

Proceedings Volume 11923, 119230J (2021) https://doi.org/10.1117/12.2615897

KEYWORDS: Temperature metrology, Optoacoustics

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Proceedings Article | 9 December 2021 Paper

Comparison of two optical coherence tomography systems to identify human brain tumor

P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, M. Bonsanto, C. Hagel, R. Huber, R. Brinkmann

Proceedings Volume 11924, 119240L (2021) https://doi.org/10.1117/12.2616044

KEYWORDS: Tumors, Optical coherence tomography, Tissues, Brain, Tissue optics, Signal attenuation, System identification, Optical fibers, Scattering, Optical properties

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Proceedings Article | 7 December 2021 Paper

Fiber-based fluorescence and reflection measurements during laser lithotripsy

L. Krumm, B. Lange, T. Ozimek, J. Wießmeyer, M. Kramer, A. Merseburger, R. Brinkmann

Proceedings Volume 11919, 1191907 (2021) https://doi.org/10.1117/12.2614447

KEYWORDS: Luminescence, Reflection, Laser lithotripsy, Calculi, Mirrors, Statistical modeling, Specular reflections, Ray tracing, Laser therapeutics, Skin

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Proceedings Article | 7 December 2021 Paper

Phase-sensitive optical coherence elastography with a 3.2 MHz FDML-laser using focused air-puff tissue indentation

Katharina Rewerts, Moritz Matthiae, Nicolas Detrez, Steffen Buschschlüter, Matteo Mario Bonsanto, Robert Huber, Ralf Brinkmann

Proceedings Volume 11919, 1191918 (2021) https://doi.org/10.1117/12.2614833

KEYWORDS: Tissues, Tumors, Tissue optics, Optical coherence tomography, Elastography, Brain, Soft tissue optics, Coherence (optics), Surgery, Laser tissue interaction

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Proceedings Article | 7 December 2021 Paper

1.6 MHz FDML OCT for intraoperative imaging in neurosurgery

D. Theisen-Kunde, W. Draxinger, M. Bonsanto, Paul Strenge, Nicolas Detrez, R. Huber, R. Brinkmann

Proceedings Volume 11919, 119191E (2021) https://doi.org/10.1117/12.2614855

KEYWORDS: Optical coherence tomography, Tumors, Tissues, Microscopes, Surgery, Scanners, Video, Tissue optics, Interferometers, Head

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Proceedings Article | 7 December 2021 Paper

Flow controlled air puff generator towards in-situ brain tumor detection based on MHz optical coherence elastography

Nicolas Detrez, Katharina Rewerts, Moritz Matthiae, Steffen Buschschlüter, Matteo Mario Bonsanto, Dirk Theisen-Kunde, Ralf Brinkmann

Proceedings Volume 11919, 1191925 (2021) https://doi.org/10.1117/12.2615022

KEYWORDS: Tissues, Optical coherence tomography, Elastography, Brain, Tumors, Sensors, Coherence (optics), Tissue optics, Soft tissue optics, Natural surfaces

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Proceedings Article | 7 December 2021 Paper

Laser coagulation of brain tissue at 1480 nm and 1940 nm wavelengths

Alessa Hutfilz, Dirk Theisen-Kunde, Matteo Mario Bonsanto, Ralf Brinkmann

Proceedings Volume 11919, 1191904 (2021) https://doi.org/10.1117/12.2614437

KEYWORDS: Laser tissue interaction, Tissue optics, Laser applications, Brain, Optical coherence tomography, Tissues, Natural surfaces, Laser coagulation, Laser ablation, Fiber lasers

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Proceedings Article | 5 March 2021 Poster + Presentation + Paper

Characterization of brain tumor tissue with 1310 nm optical coherence tomography

P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, M. Bonsanto, C. Hagel, R. Huber, R. Brinkmann

Proceedings Volume 11630, 116301T (2021) https://doi.org/10.1117/12.2578409

KEYWORDS: Tumors, Brain, Optical coherence tomography, Tissue optics, Tissues, Signal attenuation, Pathology, Optical properties

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Proceedings Article | 5 March 2021 Poster + Presentation + Paper

Creating a depth-resolved OCT-dataset for supervised classification based on ex vivo human brain samples

P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, C. Hagel, M. Bonsanto, R. Huber, R. Brinkmann

Proceedings Volume 11630, 116301S (2021) https://doi.org/10.1117/12.2578391

KEYWORDS: Optical coherence tomography, Brain, Tissues, Tumors, Surgery, Image registration, Image classification

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Proceedings Article | 21 February 2020 Paper

Segmented OCT data set for depth resolved brain tumor detection validated by histological analysis

P. Strenge, B. Lange, C. Grill, W. Draxinger, M. Bonsanto, C. Hagel, R. Huber, R. Brinkmann

Proceedings Volume 11228, 112282O (2020) https://doi.org/10.1117/12.2545659

KEYWORDS: Optical coherence tomography, Tumors, Brain, Tissues, Cameras, Imaging systems, Neuroimaging, Image resolution, Image segmentation, Statistical analysis

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Proceedings Article | 22 July 2019 Paper

Toward feedback temperature control for retinal laser treatment

H. Abbas, C. Kren, V. Danicke, C. Herzog, R. Brinkmann

Proceedings Volume 11079, 110790B (2019) https://doi.org/10.1117/12.2527169

KEYWORDS: Feedback control, Retina, Laser therapeutics, Mathematical modeling, System identification, Systems modeling, Laser coagulation

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Proceedings Article | 22 July 2019 Paper

Optical coherence tomography controlled selective retina therapy with a novel microsecond laser

Christian Burri, Alessa Hutfilz, Lorenz Grimm, Patrik Arnold, Andreas Ebneter, Ralf Brinkmann, Dirk Theisen-Kunde, Boris Považay, Christoph Meier

Proceedings Volume 11079, 1107903 (2019) https://doi.org/10.1117/12.2526720

KEYWORDS: Optical coherence tomography, Retina, Laser therapeutics, Imaging systems, Diagnostics, Pulsed laser operation, Tissue optics, Laser tissue interaction, Eye, Thermal effects

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Proceedings Article | 22 July 2019 Paper

Heating and optoacoustic temperature determination of cell cultures

Nicolas Detrez, Yoko Miura, Eric Seifert, Dirk Theisen-Kunde, Ralf Brinkmann

Proceedings Volume 11079, 110790W (2019) https://doi.org/10.1117/12.2527024

KEYWORDS: Temperature metrology, Optoacoustics, YAG lasers, Convection, Laser beam diagnostics, Ultrasonics, Q switched lasers, Pulsed laser operation, Thulium, Laser scanners

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Proceedings Article | 22 July 2019 Paper

Dosimetry for microsecond selective laser trabeculoplasty

Katharina Bliedtner, Eric Seifert, Ralf Brinkmann

Proceedings Volume 11079, 1107902 (2019) https://doi.org/10.1117/12.2526987

KEYWORDS: Transducers, Eye, Optoacoustics, Lamps, Ultrasonics, Pulsed laser operation, Laser therapeutics, Feedback loops, Laser irradiation, Fiber coupled lasers

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Proceedings Article | 22 July 2019 Paper

Ex vivo investigation of different μs laser pulse durations for selective retina therapy

Alessa Hutfilz, Christian Burri, Christoph Meier, Ralf Brinkmann

Proceedings Volume 11079, 110791H (2019) https://doi.org/10.1117/12.2526948

KEYWORDS: Pulsed laser operation, Laser therapeutics, Retina, Eye models, Laser energy, Laser damage threshold

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Proceedings Article | 19 July 2019 Paper

Ex vivo and in vivo imaging of human brain tissue with different OCT systems

P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, M. Bonsanto, R. Huber, R. Brinkmann

Proceedings Volume 11078, 110781C (2019) https://doi.org/10.1117/12.2526932

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Proceedings Article | 22 February 2019 Paper

Virtual HE histology by fiber-based picosecond two-photon microscopy

Jan Philip Kolb, Daniel Weng, Hubertus Hakert, Matthias Eibl, Wolfgang Draxinger, Tobias Meyer, Thomas Gottschall, Ralf Brinkmann, Reginald Birngruber, Jürgen Popp, Jens Limpert, Sebastian Nino Karpf, Robert Huber

Proceedings Volume 10882, 108822F (2019) https://doi.org/10.1117/12.2507866

KEYWORDS: Luminescence, Femtosecond phenomena, Picosecond phenomena, Fiber lasers, Optical filters, Tissues, Laser systems engineering, Objectives, Microscopes

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SPIE Journal Paper | 3 November 2018 Open Access

Selective retina therapy: toward an optically controlled automatic dosing

Eric Seifert, Jan Tode, Amelie Pielen, Dirk Theisen-Kunde, Carsten Framme, Johann Roider, Yoko Miura, Reginald Birngruber, Ralf Brinkmann

JBO, Vol. 23, Issue 11, 115002, (November 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.11.115002

KEYWORDS: Retina, Sensors, Visibility, Laser therapeutics, Pulsed laser operation, Eye, Algorithm development, Data acquisition, Optimization (mathematics), Modulation

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Proceedings Article | 8 March 2018 Paper

Toward automated selective retina treatment (SRT): an optical microbubble detection technique

Eric Seifert, Young-Gun Park, Dirk Theisen-Kunde, Young-Jung Roh, Ralf Brinkmann

Proceedings Volume 10474, 104740P (2018) https://doi.org/10.1117/12.2289409

KEYWORDS: Modulation, Pulsed laser operation, Signal processing, Retina, Sensors, Laser therapeutics, Data acquisition, Eye, Luminescence, Angiography

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SPIE Journal Paper | 21 November 2017 Open Access

Power-controlled temperature guided retinal laser therapy

Alexander Baade, Claus von der Burchard, Meike Lawin, Stefan Koinzer, Benedikt Schmarbeck, Kerstin Schlott, Yoko Miura, Johann Roider, Reginald Birngruber, Ralf Brinkmann

JBO, Vol. 22, Issue 11, 118001, (November 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.11.118001

KEYWORDS: Laser therapeutics, Temperature metrology, Visibility, Laser coagulation, Absorption, Calibration, Optoacoustics, Tissues, In vivo imaging, Pulsed laser operation

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SPIE Journal Paper | 13 October 2017 Open Access

Noncontact holographic detection for photoacoustic tomography

Christian Buj, Michael Münter, Benedikt Schmarbeck, Jens Horstmann, Gereon Hüttmann, Ralf Brinkmann

JBO, Vol. 22, Issue 10, 106007, (October 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.10.106007

KEYWORDS: Silicon, Holography, Tissues, Skin, Photoacoustic spectroscopy, Photoacoustic tomography, Natural surfaces, Acquisition tracking and pointing, Acoustics, Signal attenuation

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Proceedings Article | 28 July 2017 Paper

Real time speckle monitoring to control retinal photocoagulation

Katharina Bliedtner, Eric Seifert, Ralf Brinkmann

Proceedings Volume 10413, 1041308 (2017) https://doi.org/10.1117/12.2287815

KEYWORDS: Retina, Speckle, Laser coagulation, Photography

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Proceedings Article | 28 July 2017 Paper

Evaluation of an optoacoustic based gas analysing device

Janine Markmann, Birgit Lange, Dirk Theisen-Kunde, Veit Danicke, Fedor Mayorov, Sebastian Eckert, Pascal Kettmann, Ralf Brinkmann

Proceedings Volume 10411, 104110L (2017) https://doi.org/10.1117/12.2286109

KEYWORDS: Acousto-optics, Optical parametric oscillators, Tunable lasers, Optical gas detection

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SPIE Journal Paper | 20 December 2016 Open Access

Biomedical optics centers: forty years of multidisciplinary clinical translation for improving human health

Bruce Tromberg, R. Rox Anderson, Reginald Birngruber, Ralf Brinkmann, Michael Berns, John Parrish, Gabriela Apiou-Sbirlea

JBO, Vol. 21, Issue 12, 124001, (December 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.12.124001

KEYWORDS: Biomedical optics, Laser therapeutics, Laser applications, Photonics, Tissue optics, Medical research, LASIK, Photomedicine, Medicine, Laser optics

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SPIE Journal Paper | 27 September 2016 Open Access

Lesion strength control by automatic temperature guided retinal photocoagulation

Kerstin Schlott, Stefan Koinzer, Alexander Baade, Reginald Birngruber, Johann Roider, Ralf Brinkmann

JBO, Vol. 21, Issue 09, 098001, (September 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.9.098001

KEYWORDS: Automatic control, Laser coagulation, Temperature metrology, Retina, Laser therapeutics, Tissues, Laser damage threshold, Algorithm development, Optical coherence tomography, In vivo imaging

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Proceedings Article | 5 April 2016 Presentation + Paper

Towards real time speckle controlled retinal photocoagulation

Katharina Bliedtner, Eric Seifert, Leoni Stockmann, Lisa Effe, Ralf Brinkmann

Proceedings Volume 9693, 96931A (2016) https://doi.org/10.1117/12.2212703

KEYWORDS: Speckle, Tissues, Laser coagulation, Laser therapeutics, Speckle pattern, Eye, Field programmable gate arrays, Continuous wave operation, In vivo imaging, Temperature metrology

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Proceedings Article | 15 July 2015 Paper

Differentiation of tissue and kidney stones for laser lithotripsy using different spectroscopic approaches

Birgit Lange, Jens Cordes, Ralf Brinkmann

Proceedings Volume 9542, 95420O (2015) https://doi.org/10.1117/12.2183686

KEYWORDS: Tissues, Luminescence, Reflectivity, Spectroscopy, Ultraviolet radiation, Laser lithotripsy, Signal detection, In vitro testing, Renal calculi, Light sources

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Proceedings Article | 20 March 2015 Paper

Power-controlled temperature guided retinal photocoagulation

Alexander Baade, Wadim Schwarzer, Stefan Koinzer, Kerstin Schlott, Reginald Birngruber, Ralf Brinkmann

Proceedings Volume 9307, 93070B (2015) https://doi.org/10.1117/12.2083042

KEYWORDS: Laser coagulation, Imaging systems, Linear filtering, Sensors, Laser applications, Digital imaging, Detection and tracking algorithms, Channel projecting optics, Convolution, Matrices

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Proceedings Article | 3 March 2014 Paper

Optical full-field holographic detection system for non-contact photoacoustic tomography

Jens Horstmann, Ralf Brinkmann

Proceedings Volume 8943, 89431L (2014) https://doi.org/10.1117/12.2036711

KEYWORDS: Silicon, Photoacoustic spectroscopy, Speckle pattern, Holography, Photoacoustic tomography, Photoacoustic imaging, Interferometry, Data acquisition, Tissue optics, Wave propagation

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Proceedings Article | 26 February 2014 Paper

Consolidated numerical temperature/pressure modelling to assess the accuracy of optoacoustic temperature determination during retinal photocoagulation

Alexander Baade, Kerstin Schlott, Reginald Birngruber, Ralf Brinkmann

Proceedings Volume 8941, 89410H (2014) https://doi.org/10.1117/12.2039189

KEYWORDS: Temperature metrology, Laser coagulation, Tissues, Wave propagation, Absorption, Gaussian beams, Eye, Eye models, Ultrasonics, Diffusion

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Proceedings Article | 26 February 2014 Paper

Laser speckle tracking for monitoring and analysis of retinal photocoagulation

Eric Seifert, Katharina Bliedtner, Ralf Brinkmann

Proceedings Volume 8946, 89460F (2014) https://doi.org/10.1117/12.2038860

KEYWORDS: Speckle, Laser coagulation, Temperature metrology, Eye, Speckle pattern, Laser tissue interaction, Optical flow, Retina, Cameras, Pulsed laser operation

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Proceedings Article | 24 June 2013 Paper

A numerical model for heat and pressure propagation for temperature controlled retinal photocoagulation

Alexander Baade, Kerstin Schlott, Reginald Birngruber, Ralf Brinkmann

Proceedings Volume 8803, 88030O (2013) https://doi.org/10.1117/12.2033590

KEYWORDS: Temperature metrology, Absorption, Wave propagation, Signal attenuation, Tissues, Laser coagulation, Ultrasonics, Retina, Eye, Acoustics

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Proceedings Article | 24 June 2013 Paper

Automatic irradiation control by an optical feedback technique for selective retina treatment (SRT) in a rabbit model

Eric Seifert, Young-Jung Roh, Andreas Fritz, Young Gun Park, Seungbum Kang, Dirk Theisen-Kunde, Ralf Brinkmann

Proceedings Volume 8803, 880303 (2013) https://doi.org/10.1117/12.2033560

KEYWORDS: Retina, Laser irradiation, Automatic control, Visibility, Angiography, Laser therapeutics, Acoustics, Photodiodes, Ultrasonics, Laser damage threshold

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Proceedings Article | 24 June 2013 Paper

Cardiovascular damage after cw and Q-switched 2μm laser irradiation

Ingo Rohde, Jennifer-M. Masch, Dirk Theisen-Kunde, Martin Marczynski-Bühlow, Georg Lutter, Ralf Brinkmann

Proceedings Volume 8803, 88030I (2013) https://doi.org/10.1117/12.2033550

KEYWORDS: Particles, Laser cutting, Q switched lasers, Continuous wave operation, Laser tissue interaction, Tissues, Laser systems engineering, Laser irradiation, Laser ablation, Statistical analysis

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Proceedings Article | 14 June 2013 Paper

Temperature controlled retinal photocoagulation

Kerstin Schlott, Stefan Koinzer, Alexander Baade, Reginald Birngruber, Johann Roider, Ralf Brinkmann

Proceedings Volume 8800, 880009 (2013) https://doi.org/10.1117/12.2033416

KEYWORDS: Temperature metrology, Laser coagulation, Automatic control, Laser beam diagnostics, Ultrasonics, Photography, Tissues, Retina, Eye, Absorption

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Proceedings Article | 14 June 2013 Paper

Non-contact photoacoustic tomography using holographic full field detection

Jens Horstmann, Ralf Brinkmann

Proceedings Volume 8800, 880007 (2013) https://doi.org/10.1117/12.2033599

KEYWORDS: Photoacoustic imaging, Speckle, Silicon, Photoacoustic tomography, Holography, Speckle pattern, Interferometry, Cameras, In vivo imaging, Image acquisition

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SPIE Journal Paper | 15 May 2012 Open Access

Real-time temperature determination during retinal photocoagulation on patients

Ralf Brinkmann, Stefan Koinzer, Kerstin Schlott, Lars Ptaszynski, Marco Bever, Alexander Baade, Susanne Luft, Yoko Miura, Johann Roider, Reginald Birngruber

JBO, Vol. 17, Issue 06, 061219, (May 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.6.061219

KEYWORDS: Laser coagulation, Temperature metrology, Absorption, Tissues, Eye, Diffusion, Retina, Transducers, Light scattering, Optoacoustics

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SPIE Journal Paper | 7 May 2012 Open Access

Automatic temperature controlled retinal photocoagulation

Kerstin Schlott, Stefan Koinzer, Lars Ptaszynski, Marco Bever, Alexander Baade, Johann Roider, Reginald Birngruber, Ralf Brinkmann

JBO, Vol. 17, Issue 06, 061223, (May 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.6.061223

KEYWORDS: Temperature metrology, Laser coagulation, Automatic control, Tissues, Laser damage threshold, Eye, In vivo imaging, Laser beam diagnostics, Laser therapeutics, Optoacoustics

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Proceedings Article | 8 June 2011 Paper

Accuracy of real-time optoacoustic temperature determination during retinal photocoagulation

A. Baade, K. Schlott, S. Luft, L. Ptaszynski, M. Bever, R. Birngruber, R. Brinkmann

Proceedings Volume 8092, 80921B (2011) https://doi.org/10.1117/12.889608

KEYWORDS: Temperature metrology, Calibration, Laser beam diagnostics, Laser coagulation, Tissues, Retina, Eye models, Eye, Solids, Laser tissue interaction

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Proceedings Article | 8 June 2011 Paper

Photoacoustic blood vessel detection during surgical laser interventions

Jens Horstmann, Alexander Baade, Ralf Brinkmann

Proceedings Volume 8092, 80920Z (2011) https://doi.org/10.1117/12.889635

KEYWORDS: Liver, Photoacoustic spectroscopy, Blood vessels, Absorption, Acoustics, Tissues, Tissue optics, Laser tissue interaction, Signal attenuation, Transducers

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Proceedings Article | 2 June 2011 Paper

In vivo study of partial liver resection on pigs using a 1.9 μm thulium fiber laser

D. Theisen-Kunde, H. Wolken, V. Danicke, R. Brinkmann, H. Bruch, M. Kleemann

Proceedings Volume 8092, 809211 (2011) https://doi.org/10.1117/12.889423

KEYWORDS: Fiber lasers, Liver, YAG lasers, Laser systems engineering, Tissues, Laser tissue interaction, Blood, Laser therapeutics, LASIK, Continuous wave operation

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Proceedings Article | 16 February 2011 Paper

Optoacoustic temperature determination and automatic coagulation control in rabbits

Kerstin Schlott, Stefan Koinzer, Lars Ptaszynski, Susanne Luft, Alex Baade, Marco Bever, Johann Roider, Reginald Birngruber, Ralf Brinkmann

Proceedings Volume 7885, 78850T (2011) https://doi.org/10.1117/12.875104

KEYWORDS: Temperature metrology, Automatic control, Tissues, Laser coagulation, Laser beam diagnostics, Eye, In vivo imaging, Calibration, Laser damage threshold, Laser irradiation

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Proceedings Article | 16 February 2011 Paper

Imaging of temperature distribution and retinal tissue changes during photocoagulation by high speed OCT

Heike Müller, Lars Ptaszynski, Kerstin Schlott, Tim Bonin, Marco Bever, Stefan Koinzer, Reginald Birngruber, Ralf Brinkmann, Gereon Hüttmann

Proceedings Volume 7889, 78890E (2011) https://doi.org/10.1117/12.874788

KEYWORDS: Optical coherence tomography, Laser coagulation, Tissue optics, Tissues, Visualization, Coherence (optics), Biomedical optics, Current controlled current source, Mirrors, Microscopes

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Proceedings Article | 12 February 2011 Paper

Dynamics of laser induced micro bubble clusters on tissue phantoms

Andreas Fritz, Andrea Zegelin, Lars Ptaszynski, Reginald Birngruber, Ralf Brinkmann

Proceedings Volume 7885, 78850S (2011) https://doi.org/10.1117/12.875031

KEYWORDS: Retina, Interferometry, Pulsed laser operation, Photography, Interferometers, Laser tissue interaction, Tissues, In vitro testing, Diffusion, Optical coherence tomography

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Proceedings Article | 12 February 2011 Paper

Realtime temperature determination during retinal photocoagulation on patients

Ralf Brinkmann, Stefan Koinzer, Kerstin Schlott, Lars Ptaszynski, Marco Bever, Alex Baade, Yoko Miura, Reginald Birngruber, Johann Roider

Proceedings Volume 7885, 78850R (2011) https://doi.org/10.1117/12.875276

KEYWORDS: Laser coagulation, Temperature metrology, Absorption, Tissues, Retina, Acoustics, Eye, Optical coherence tomography, Light scattering, Ultrasonics

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Proceedings Article | 17 July 2009 Paper

Dynamics of laser-induced transient micro bubble clusters

Andreas Fritz, Lars Ptaszynski, Hardo Stoehr, Ralf Brinkmann

Proceedings Volume 7373, 73730D (2009) https://doi.org/10.1117/12.831951

KEYWORDS: Interferometry, Interferometers, Retina, Eye, Laser therapeutics, Pulsed laser operation, Laser irradiation, Photography, Eye models, Systems modeling

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Proceedings Article | 17 July 2009 Paper

Partial porcine kidney resection in vivo using a 1.92 µm fiber laser system

Dirk Theisen-Kunde, Sönke Tedsen, Veit Danicke, Ralf Brinkmann

Proceedings Volume 7373, 73731B (2009) https://doi.org/10.1117/12.831886

KEYWORDS: Kidney, Fiber lasers, Laser systems engineering, Tissues, Surgery, Blood, Laser tissue interaction, LASIK, Inflammation, Laser therapeutics

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Proceedings Article | 17 July 2009 Paper

Dependence of optoacoustic transients on exciting laser parameters for real-time monitoring of retinal photocoagulation

J. Langejürgen, K. Schlott, M. Bever, K. Hausmann, S. Koinzer, L. Ptaszynski, J. Roider, R. Birngruber, R. Brinkmann

Proceedings Volume 7373, 73730K (2009) https://doi.org/10.1117/12.831913

KEYWORDS: Pulsed laser operation, Laser coagulation, Eye, Laser beam diagnostics, Acoustics, Transducers, In vivo imaging, Tissues, Ultrasonics, Fiber lasers

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Proceedings Article | 17 July 2009 Paper

Time resolved detection of tissue denaturation during retinal photocoagulation

Kerstin Schlott, Jens Langejürgen, Marco Bever, Stefan Koinzer, Reginald Birngruber, Ralf Brinkmann

Proceedings Volume 7373, 73730E (2009) https://doi.org/10.1117/12.831877

KEYWORDS: Temperature metrology, Eye, Laser beam diagnostics, Laser coagulation, Retina, In vivo imaging, Laser tissue interaction, Laser scattering, Scattering, Tissue optics

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Proceedings Article | 13 July 2007 Paper

Partial kidney resection based on 1.94μm fiber laser system

D. Theisen-Kunde, S. Tedsen, K. Herrmann, V. Danicke, R. Brinkmann

Proceedings Volume 6632, 663205 (2007) https://doi.org/10.1117/12.727861

KEYWORDS: Kidney, Tissues, Fiber lasers, Laser systems engineering, Laser cutting, Continuous wave operation, Quartz, Blood, Laser tissue interaction, Tissue optics

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Proceedings Article | 13 July 2007 Paper

Influence of choroidal perfusion on retinal temperature increase during retinal laser treatments

Katharina Herrmann, Christian Flöhr, Jens Stalljohann, Gabriela Apiou-Sbirlea, Jochen Kandulla, Reginald Birngruber, Ralf Brinkmann

Proceedings Volume 6632, 66321D (2007) https://doi.org/10.1117/12.728222

KEYWORDS: Eye, Laser therapeutics, Blood circulation, Eye models, Heat therapy, Temperature metrology, Ultrasonics, Transducers, Absorption, Biomedical optics

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Proceedings Article | 13 July 2007 Paper

Interferometric optical online dosimetry for selective retina treatment (SRT)

Hardo Stoehr, Lars Ptaszynski, Andreas Fritz, Ralf Brinkmann

Proceedings Volume 6632, 663219 (2007) https://doi.org/10.1117/12.728460

KEYWORDS: Interferometry, Interferometers, Retina, Eye, Lamps, Data analysis, Semiconductor lasers, Diodes, In vitro testing, Laser induced damage

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Proceedings Article | 13 July 2007 Paper

Optoacoustic online temperature determination during retinal laser photocoagulation

Kerstin Schlott, Jens Stalljohann, Benjamin Weber, Jochen Kandulla, Katharina Herrmann, Reginald Birngruber, Ralf Brinkmann

Proceedings Volume 6632, 66321B (2007) https://doi.org/10.1117/12.728291

KEYWORDS: Laser coagulation, Eye, Temperature metrology, Retina, Absorption, Laser beam diagnostics, Transducers, Laser therapeutics, Data modeling, Tissues

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Proceedings Article | 13 July 2007 Paper

Dynamics and detection of laser induced microbubbles in the retinal pigment epithelium (RPE)

Andreas Fritz, Lars Ptaszynski, Hardo Stoehr, Ralf Brinkmann

Proceedings Volume 6632, 66321C (2007) https://doi.org/10.1117/12.728344

KEYWORDS: Interferometers, Retina, Eye, Detection and tracking algorithms, Luminescence, Angiography, Interferometry, Photography, Microscopes, Astatine

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Proceedings Article | 5 March 2007 Paper

Interferometric optical online dosimetry for selective retina treatment (SRT)

Hardo Stoehr, Lars Ptaszynski, Andreas Fritz, Ralf Brinkmann

Proceedings Volume 6426, 642619 (2007) https://doi.org/10.1117/12.708521

KEYWORDS: Interferometers, Interferometry, Retina, Eye, In vitro testing, Diodes, Semiconductor lasers, Tissues, Modulation, Mirrors

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SPIE Journal Paper | 1 July 2006 Open Access

Cell disintegration by laser-induced transient microbubbles and its simultaneous monitoring by interferometry

Jörg Neumann, Ralf Brinkmann

JBO, Vol. 11, Issue 04, 041112, (July 2006) https://doi.org/10.1117/12.10.1117/1.2339815

KEYWORDS: Interferometry, Pulsed laser operation, Cell death, Interferometers, Interfaces, Tissues, Laser damage threshold, Laser beam diagnostics, Retina, Laser interferometry

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SPIE Journal Paper | 1 July 2006 Open Access

Noninvasive optoacoustic online retinal temperature determination during continuous-wave laser irradiation

Jochen Kandulla, Hanno Elsner, Reginald Birngruber, Ralf Brinkmann

JBO, Vol. 11, Issue 04, 041111, (July 2006) https://doi.org/10.1117/12.10.1117/1.2236301

KEYWORDS: Temperature metrology, Absorption, Eye, Tissues, Retina, Laser irradiation, Transducers, In vivo imaging, Ultrasonics, Laser therapeutics

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Proceedings Article | 7 March 2006 Paper

Non-invasive optoacoustic temperature determination during retinal cw-laser treatments

Jochen Kandulla, Hanno Elsner, Julien Sandeau, Reginald Birngruber, Ralf Brinkmann

Proceedings Volume 6138, 61381H (2006) https://doi.org/10.1117/12.674409

KEYWORDS: Temperature metrology, Ultrasonics, Laser therapeutics, Transducers, Tissues, Blood circulation, Absorption, Laser beam diagnostics, In vivo imaging, Dye lasers

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SPIE Journal Paper | 1 November 2005 Open Access

Optoacoustic real-time dosimetry for selective retina treatment

Georg Schuele, Hanno Elsner, Carsten Framme, Johann Roider, Reginald Birngruber, Ralf Brinkmann

JBO, Vol. 10, Issue 06, 064022, (November 2005) https://doi.org/10.1117/12.10.1117/1.2136327

KEYWORDS: Angiography, Acoustics, In vitro testing, Retina, Pulsed laser operation, Eye, Transducers, Laser damage threshold, Sensors, Visualization

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SPIE Journal Paper | 1 November 2005 Open Access

Selective targeting of the retinal pigment epithelium using an acousto-optic laser scanner

Clemens Alt, Carsten Framme, Susanne Schnell, Ho Lee, Ralf Brinkmann, Charles Lin

JBO, Vol. 10, Issue 06, 064014, (November 2005) https://doi.org/10.1117/12.10.1117/1.2136314

KEYWORDS: In vitro testing, Angiography, Luminescence, In vivo imaging, Eye, Continuous wave operation, Retina, Scanners, Laser scanners, Frequency modulation

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Proceedings Article | 27 August 2005 Paper

Hemostatic properties of a new cw 2µm laser scalpel for laparoscopic surgery

D. Theisen-Kunde, V. Ott, R. Brinkmann, R. Keller

Proceedings Volume 5863, 58630G (2005) https://doi.org/10.1117/12.633082

KEYWORDS: Arteries, Veins, YAG lasers, Laparoscopy, Laser therapeutics, Surgery, Laser vision correction, Tissues, In vivo imaging, Proteins

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Proceedings Article | 18 April 2005 Paper

Optoacoustic temperature determination at the fundus of the eye during Transpupillary Thermotherapy

Jochen Kandulla, Hanno Elsner, Markus Hilmes, Carolin Hartert, Ralf Brinkmann

Proceedings Volume 5688, (2005) https://doi.org/10.1117/12.608406

KEYWORDS: Temperature metrology, Eye, Ultrasonics, Heat therapy, Transducers, Laser beam diagnostics, Laser therapeutics, In vivo imaging, Signal detection, Lamps

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Proceedings Article | 15 April 2005 Paper

Interferometric noncontact on-line dosimetry control during selective retina treatment (SRT)

Joerg Neumann, Ralf Brinkmann

Proceedings Volume 5695, (2005) https://doi.org/10.1117/12.602290

KEYWORDS: Interferometry, Interfaces, Retina, Pulsed laser operation, Laser tissue interaction, Tissues, Neodymium lasers, Interferometers, Laser induced damage, Diodes

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SPIE Journal Paper | 1 March 2005 Open Access

Boiling nucleation on melanosomes and microbeads transiently heated by nanosecond and microsecond laser pulses

Jörg Neumann, Ralf Brinkmann

JBO, Vol. 10, Issue 02, 024001, (March 2005) https://doi.org/10.1117/12.10.1117/1.1896969

KEYWORDS: Particles, Absorption, Pulsed laser operation, Gold, Nonuniformity corrections, Temperature metrology, Laser damage threshold, Silica, Photography, Thermal modeling

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Proceedings Article | 13 July 2004 Paper

Optoacoustic online dosimetry during selective RPE treatment

Georg Schuele, Hanno Elsner, Hans Hoerauf, Carsten Framme, Johann Roider, Reginald Birngruber, Ralf Brinkmann

Proceedings Volume 5314, (2004) https://doi.org/10.1117/12.529384

KEYWORDS: Angiography, Acoustics, In vitro testing, Transducers, Laser damage threshold, Eye, Retina, Sensors, Pulsed laser operation, Visualization

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Introduction: The selective RPE treatment (SRT) is a new method, which targets retinal diseases associated with disorders in the retinal pigment epithelium (RPE). By applying a train of μs laser pulses, it is possible to selectively damage RPE cells while sparing the adjacent photoreceptors and the neural retina. Due to the ophthalmoscopic invisibility of the RPE effects we investigated an optoacoustic (OA) on-line dosimetry system to monitor RPE damage non-invasively. Material and Methods: For in vitro experiments porcine RPE was irradiated with a Nd:YLF laser pulse train (527nm, 1.7μs, 5-40μJ, 30 pulses, 100 Hz). Pressure waves (optoacoustic transients) generated at the RPE were measured with a piezoelectric transducer. The RPE cell damage was visualised by fluorescence microscopy by means of the vitality stain CalceinAM. During 27 patient treatments (527nm, 1.7μs, 50-150μJ, 30 pulses, 100 Hz) the optoacoustic signals were measured with an ultrasonic transducer embedded in the contact lens. The RPE leakage was visualized by fluorescein and ICG angiography. Results: In vitro: Below the RPE cell damage threshold, the optoacoustic transients from each single pulse are almost similar. With RPE damage, fluctuations of the individual transients are observed during the pulse train. These fluctuations can be explained by statistical irregular microbubble formation around the strong light absorbing melanosomes inside the RPE cells, which occur after the temperature exceeds the vaporization threshold. The transient microbubbles probably lead to RPE cell disruption. An optoacoustic value (OA-value) calculated from the fluctuations was defined in order to assess RPE damage. Patient treatment: If optoacoustic pulse-to-pulse fluctuations were measured, RPE leakage was observed in fluorescein and ICG angiography. In 96% of the irradiated areas, RPE-leakage in fluorescein angiography and OA-value correlated. The stronger the optoacoustic pulse-to-pulse fluctuations, thus the higher the OA-value, the more intense angiographic leakage was observed in ICG-angiography. Conclusion: A non-invasive optoacoustic on-line dosimetry control to monitor RPE damage during SRT was developed. In order to avoid invasive angiography, it is currently evaluated in a multicenter clinical SRT study.

SPIE Journal Paper | 1 March 2004 Open Access

Pump-probe detection of laser-induced microbubble formation in retinal pigment epithelium cells

Jan Roegener, Ralf Brinkmann, Charles Lin

JBO, Vol. 9, Issue 02, (March 2004) https://doi.org/10.1117/12.10.1117/1.1646413

KEYWORDS: Laser beam diagnostics, Cell death, Cavitation, Laser damage threshold, Pulsed laser operation, Particles, Control systems, Laser tissue interaction, Diffusion, Backscatter

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SPIE Journal Paper | 1 January 2004 Open Access

Noninvasive optoacoustic temperature determination at the fundus of the eye during laser irradiation

Georg Schuele, Gereon Huttmann, Carsten Framme, Johann Roider, Ralf Brinkmann

JBO, Vol. 9, Issue 01, (January 2004) https://doi.org/10.1117/12.10.1117/1.1627338

KEYWORDS: Temperature metrology, Pulsed laser operation, In vitro testing, Eye, Absorption, Continuous wave operation, Laser irradiation, Transducers, Laser therapeutics, Retina

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Proceedings Article | 16 October 2003 Paper

Microbubble dynamics around laser heated microparticles

Joerg Neumann, Ralf Brinkmann

Proceedings Volume 5142, (2003) https://doi.org/10.1117/12.499944

KEYWORDS: Photography, Particles, Pulsed laser operation, Laser beam diagnostics, Laser tissue interaction, Nonuniformity corrections, Interfaces, Data modeling, Microscopes, Explosives

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Proceedings Article | 16 October 2003 Paper

Cw high-power IR laser at 2 µm for minimally invasive surgery

Dirk Theisen, Verena Ott, Heinz-Wolfram Bernd, Veit Danicke, Robert Keller, Ralf Brinkmann

Proceedings Volume 5142, (2003) https://doi.org/10.1117/12.500624

KEYWORDS: YAG lasers, Tissues, Laser cutting, Laser tissue interaction, Surgery, Liver, Laser therapeutics, Continuous wave operation, Natural surfaces, Laser ablation

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Proceedings Article | 27 June 2002 Paper

Microbubble dynamics around melanosomes irradiated with microsecond pulses

Joerg Neumann, Ralf Brinkmann

Proceedings Volume 4617, (2002) https://doi.org/10.1117/12.472539

KEYWORDS: Photography, Laser tissue interaction, Retina, Laser damage threshold, Neodymium lasers, Microscopes, Acoustics, Systems modeling, Pulsed laser operation, Laser applications

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Proceedings Article | 27 June 2002 Paper

Selective damage of pigmented cells by means of a rapidly scanned cw laser beam

Ralf Brinkmann, Norbert Koop, Mustafa Oezdemir, Clemens Alt, Georg Schuele, Charles Lin, Reginald Birngruber

Proceedings Volume 4617, (2002) https://doi.org/10.1117/12.472538

KEYWORDS: Laser damage threshold, Retina, Laser scanners, Pulsed laser operation, Continuous wave operation, Eye, Laser tissue interaction, Luminescence, Angiography, Scanners

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Proceedings Article | 13 June 2002 Paper

In-vivo and in-vitro selective targeting of the retinal pigment epithelium using a laser-scanning device

Clemens Alt, Carsten Framme, Susanne Schnell, Georg Schuele, Ralf Brinkmann, Charles Lin

Proceedings Volume 4611, (2002) https://doi.org/10.1117/12.470607

KEYWORDS: Angiography, In vitro testing, Retina, Eye, Laser coagulation, In vivo imaging, Continuous wave operation, Lamps, Phase modulation, Laser therapeutics

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Proceedings Article | 13 June 2002 Paper

Noninvasive temperature measurements during laser irradiation of the retina with optoacoustic techniques

Georg Schuele, Gereon Huettmann, Ralf Brinkmann

Proceedings Volume 4611, (2002) https://doi.org/10.1117/12.470601

KEYWORDS: Temperature metrology, In vitro testing, Pulsed laser operation, Continuous wave operation, Transducers, Calibration, Absorption, Laser therapeutics, Laser beam diagnostics, Laser irradiation

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Proceedings Article | 26 October 2001 Paper

Optical tracing of Q-switched mid-IR laser-induced bubble formation

Tobias Brendel, Ralf Brinkmann

Proceedings Volume 4433, (2001) https://doi.org/10.1117/12.446506

KEYWORDS: Silica, Q switched lasers, Interfaces, Signal detection, Mid-IR, YAG lasers, Pulsed laser operation, Transmission electron microscopy, Prisms, Photography

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Proceedings Article | 26 October 2001 Paper

Myocardial expression of the vascular endothelial growth factor (VEGF) after endocardial laser revascularization (ELR)

Jan Rommerscheid, Dirk Theisen, G. Schmuecker, Ralf Brinkmann, R. Broll

Proceedings Volume 4433, (2001) https://doi.org/10.1117/12.446529

KEYWORDS: Heart, Tissues, Arteries, Computer aided diagnosis and therapy, Surgery, Blood, Pulsed laser operation, Capillaries, LASIK, Patents

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Proceedings Article | 26 October 2001 Paper

Interferometric detection of laser-induced microbubbles in the retinal pigment epithelium

Joerg Neumann, Ralf Brinkmann

Proceedings Volume 4433, (2001) https://doi.org/10.1117/12.446505

KEYWORDS: Interferometry, Cell death, Pulsed laser operation, Interferometers, Tissues, Interfaces, Neodymium lasers, Michelson interferometers, Modulation, Laser development

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Proceedings Article | 26 October 2001 Paper

Optoacoustic detection of selective RPE cell damage during us-laser irradiation

Georg Schuele, Elke Joachimmeyer, Carsten Framme, Johann Roider, Reginald Birngruber, Ralf Brinkmann

Proceedings Volume 4433, (2001) https://doi.org/10.1117/12.446507

KEYWORDS: Laser damage threshold, Pulsed laser operation, Transducers, Neodymium lasers, Lamps, Acoustics, Ophthalmology, Tissue optics, Astatine, Photodynamic therapy

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Proceedings Article | 9 July 2001 Paper

Highly resolved tracing of Q-switched mid-IR laser-induced vaporization

Tobias Brendel, Ralf Brinkmann

Proceedings Volume 4257, (2001) https://doi.org/10.1117/12.434713

KEYWORDS: Interfaces, Silica, Pulsed laser operation, Sensors, Signal detection, Q switched lasers, Prisms, YAG lasers, Charge-coupled devices, Mid-IR

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Proceedings Article | 15 June 2001 Paper

Optoacoustic control system for selective treatment of the retinal pigment epithelium

Georg Schuele, Elke Joachimmeyer, Carsten Framme, Johann Roider, Reginald Birngruber, Ralf Brinkmann

Proceedings Volume 4256, (2001) https://doi.org/10.1117/12.429323

KEYWORDS: Transducers, Laser damage threshold, In vitro testing, Angiography, Retina, Control systems, Neodymium lasers, Pulsed laser operation, Ultrasonics, Fiber lasers

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Proceedings Article | 13 June 2000 Paper

Optoacoustic measurements during us irradiation of the retinal pigment epithelium

Georg Schuele, Gereon Huettmann, Johann Roider, Christopher Wirbelauer, Reginald Birngruber, Ralf Brinkmann

Proceedings Volume 3914, (2000) https://doi.org/10.1117/12.388090

KEYWORDS: Temperature metrology, Pulsed laser operation, Transducers, Picosecond phenomena, Laser tissue interaction, Glasses, Ophthalmology, Neodymium lasers, Signal generators, Ultrasonics

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Proceedings Article | 22 June 1999 Paper

New application system for the holmium laser resection of the prostate

Rolf Eichenauer, Christian Doehn, Gerit Droege, Ralf Brinkmann, Manfred Salamon, Dieter Jocham

Proceedings Volume 3590, (1999) https://doi.org/10.1117/12.350959

KEYWORDS: Prostate, Holmium, Fiber lasers, Tissues, Laser applications, Laser tissue interaction, Bladder, Blood, Laser therapeutics, Laser cutting

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Proceedings Article | 14 June 1999 Paper

Selective RPE photodestruction: mechanism of cell damage by pulsed-laser irradiance in the ns to um time regime

Ralf Brinkmann, Jan Roegener, Charles Lin, Johann Roider, Reginald Birngruber, Gereon Huettmann

Proceedings Volume 3601, (1999) https://doi.org/10.1117/12.350041

KEYWORDS: Pulsed laser operation, Laser damage threshold, Absorption, Neodymium lasers, Q switched lasers, Diffusion, Nd:YAG lasers, Photography, Luminescence, Laser ablation

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Proceedings Article | 4 February 1999 Paper

Myocardial tissue ablation by single high-energy laser pulses for ELR and TMR

Dirk Theisen, Ralf Brinkmann, Hans-Martin Stubbe, Reginald Birngruber

Proceedings Volume 3564, (1999) https://doi.org/10.1117/12.339139

KEYWORDS: Carbon dioxide lasers, Laser ablation, Pulsed laser operation, Holmium, Heart, Laser systems engineering, Laser tissue interaction, Water, Tissues, Optical fibers

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Proceedings Article | 1 July 1998 Paper

Perspectives of holmium laser resection of the prostate: cutting effects with the holmium:YAG laser

Rolf Eichenauer, Gerit Droege, Ralf Brinkmann, Malte Neuss, Evariste Gafumbegete, Dieter Jocham

Proceedings Volume 3245, (1998) https://doi.org/10.1117/12.312271

KEYWORDS: Prostate, Laser cutting, Holmium, Laser tissue interaction, Tissues, Laser ablation, Pulsed laser operation, Fiber lasers, Photography, Cavitation

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Proceedings Article | 14 January 1998 Paper

Influence of pulse width and speckle formation on the ablation thresholds in water by means of pulsed mid-IR laser radiation

Christoph Hansen, Ralf Brinkmann, Reginald Birngruber

Proceedings Volume 3195, (1998) https://doi.org/10.1117/12.297901

KEYWORDS: Speckle, Cavitation, Pulsed laser operation, Modulation, Water, Fiber lasers, Laser damage threshold, Laser ablation, Q switching, Speckle pattern

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Proceedings Article | 14 January 1998 Paper

Analysis of cavitation bubble dynamics by optical online monitoring

Ralf Brinkmann, Christoph Hansen

Proceedings Volume 3195, (1998) https://doi.org/10.1117/12.297910

KEYWORDS: Cavitation, Pulsed laser operation, Water, Fiber lasers, Laser ablation, Q switched lasers, Laser tissue interaction, Reflection, Refractive index, Q switching

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SPIE Journal Paper | 1 January 1998 Open Access

Fundamental studies of fiber-guided soft tissue cutting by means of pulsed mid-infrared lasers and its application in ureterotomy

Ralf Brinkmann, Ansgar Knipper, Gerit Droege, Frank Schroer, Bernd Gromoll, Reginald Birngruber

JBO, Vol. 3, Issue 01, (January 1998) https://doi.org/10.1117/12.10.1117/1.429865

KEYWORDS: Laser ablation, Laser cutting, Pulsed laser operation, Laser tissue interaction, Holmium, Optical fibers, Cavitation, Tissues, Fiber lasers, Photography

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Proceedings Article | 22 December 1997 Paper

Laser thermokeratoplasty: analysis of in-vitro results and refractive changes achieved in a first clinical study

Ralf Brinkmann, Gerd Geerling, Juergen Kampmeier, Norbert Koop, Benno Radt, Reginald Birngruber

Proceedings Volume 3192, (1997) https://doi.org/10.1117/12.297840

KEYWORDS: Temperature metrology, In vitro testing, Collagen, Laser vision correction, Monochromatic aberrations, Continuous wave operation, Mid-IR, Semiconductor lasers, Clinical trials, Cornea

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Proceedings Article | 5 December 1996 Paper

Comparison of thermal corneal lesions by optical coherence tomography (OCT) and polarization histology

Norbert Koop, Ralf Brinkmann, Bjorn Kaftan, Mary Asiyo-Vogel, Ralf Engelhardt, Reginald Birngruber

Proceedings Volume 2930, (1996) https://doi.org/10.1117/12.260877

KEYWORDS: Optical coherence tomography, Collagen, Birefringence, Polarization, Cornea, Microscopy, Tissue optics, Molecules, Semiconductor lasers, Tissues

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Proceedings Article | 5 December 1996 Paper

Laser thermokeratoplasty by means of a continuously emitting laser diode in the mid IR

Ralf Brinkmann, Norbert Koop, Katharina Kamm, Gerd Geerling, Juergen Kampmeier, Reginald Birngruber

Proceedings Volume 2930, (1996) https://doi.org/10.1117/12.260876

KEYWORDS: Semiconductor lasers, Absorption, Cornea, Diodes, Laser systems engineering, In vitro testing, Pulsed laser operation, Holmium, Temperature metrology, Tunable lasers

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Proceedings Article | 5 December 1996 Paper

Biomechanical basis for laser thermokeratoplasty

Juergen Kampmeier, Ralf Brinkmann, Martin Pfleiderer, Erich Schneider, Reginald Birngruber

Proceedings Volume 2930, (1996) https://doi.org/10.1117/12.260879

KEYWORDS: Cornea, Finite element methods, Eye models, Data modeling, Eye, Animal model studies, Laser energy, 3D modeling, Collagen, Surgery

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Proceedings Article | 7 May 1996 Paper

Corneal collagen denaturation in laser thermokeratoplasty

Ralf Brinkmann, Juergen Kampmeier, Ulf Grotehusmann, Alfred Vogel, Norbert Koop, Mary Asiyo-Vogel, Reginald Birngruber

Proceedings Volume 2681, (1996) https://doi.org/10.1117/12.239611

KEYWORDS: Collagen, Holmium, Laser scattering, Light scattering, Pulsed laser operation, Laser beam diagnostics, Tissues, Scattering, Laser vision correction, Helium neon lasers

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Proceedings Article | 10 January 1996 Paper

Laser thermokeratoplasty: determination of biomechanical properties of the cornea

Juergen Kampmeier, Ralf Brinkmann, Reginald Birngruber

Proceedings Volume 2624, (1996) https://doi.org/10.1117/12.229564

KEYWORDS: Cornea, Pulsed laser operation, Laser vision correction, Eye, Laser tissue interaction, Tissues, Laser systems engineering, Laser applications, Collagen, Eye models

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Proceedings Article | 10 January 1996 Paper

Ablation dynamics in laser sclerotomy ab externo

Ralf Brinkmann, Gerit Droege, Dirk Mohrenstecher, M. Scheu, Reginald Birngruber

Proceedings Volume 2632, (1996) https://doi.org/10.1117/12.229582

KEYWORDS: Cavitation, Optical fibers, Pulsed laser operation, Tissues, Laser ablation, Photography, Er:YAG lasers, Laser systems engineering, Laser tissue interaction, Semiconductor lasers

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Proceedings Article | 18 January 1995 Paper

Microsurgery of ureteral strictures using pulsed mid-IR lasers

Ralf Brinkmann, Ansgar Knipper, Gerit Droege, Ado Miller, Bernd Gromoll, Reginald Birngruber

Proceedings Volume 2323, (1995) https://doi.org/10.1117/12.199245

KEYWORDS: Fiber lasers, Pulsed laser operation, Laser cutting, Laser tissue interaction, Holmium, Photography, YAG lasers, In vitro testing, Laser therapeutics, Laser ablation

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Proceedings Article | 4 January 1995 Paper

Geometrical aspects of switch breakdown

Ralf Brinkmann

Proceedings Volume 2343, (1995) https://doi.org/10.1117/12.198656

KEYWORDS: Switches, 3D modeling, Switching, Semiconductors, Ionization, Instrument modeling, Diffusion, Mathematical modeling, Computer simulations, Physics

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Proceedings Article | 1 June 1994 Paper

Intracavity frequency doubling of mu s alexandrite laser pulses

Ralf Brinkmann, K. Schoof

Proceedings Volume 2115, (1994) https://doi.org/10.1117/12.172749

KEYWORDS: Second-harmonic generation, Crystals, Nonlinear crystals, Alexandrite lasers, Pulsed laser operation, Laser resonators, Ultraviolet radiation, Mirrors, Q switched lasers, Optical fibers

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Proceedings Article | 1 April 1994 Paper

Spatially resolved electron-beam induced current transient spectroscopy for deep-center characterization of diamond

Karl Schoenbach, T. Tessnow, Ravindra Joshi, Randy Roush, Ralf Brinkmann

Proceedings Volume 2151, (1994) https://doi.org/10.1117/12.171763

KEYWORDS: Diamond, Electrons, Semiconductors, Spectroscopy, Absorption, Electronics, Electron beams, Physical research, Dielectrics, Spatial resolution

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Proceedings Article | 15 February 1994 Paper

Cutting laser systems for ureteral strictures

C. Durek, Ansgar Knipper, Ralf Brinkmann, Ado Miller, Bernd Gromoll, Dieter Jocham

Proceedings Volume 2086, (1994) https://doi.org/10.1117/12.169123

KEYWORDS: Laser cutting, Laser systems engineering, Laser applications, Surgery, Endoscopy, Laser therapeutics, Computing systems, Endoscopes, Laser tissue interaction, Tissues

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Proceedings Article | 15 February 1994 Paper

Investigations on laser thermokeratoplasty

Ralf Brinkmann, Norbert Koop, Gerit Droege, Ulf Grotehusmann, Andrea Huber, Reginald Birngruber

Proceedings Volume 2079, (1994) https://doi.org/10.1117/12.168730

KEYWORDS: Cornea, Collagen, Pulsed laser operation, Temperature metrology, Tissues, Holmium, Water, Laser tissue interaction, Absorption, Diffusion

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Proceedings Article | 9 June 1993 Paper

Novel curve-fitting technique for characterization of high-resistivity semiconductor materials

Sridhar Panigrahi, Vishnu Lakdawala, Lucy Thomas-Harrington, Ralf Brinkmann

Proceedings Volume 1873, (1993) https://doi.org/10.1117/12.146563

KEYWORDS: Gallium arsenide, Temperature metrology, Semiconductor materials, Switching, Switches, Data acquisition, Algorithm development, Statistical analysis, Analytical research, Chromium

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Proceedings Article | 9 June 1993 Paper

Sudden breakdown of bulk semiconductor switches

Ralf Brinkmann, Karl Schoenbach, David Stoudt, Randy Roush

Proceedings Volume 1873, (1993) https://doi.org/10.1117/12.146544

KEYWORDS: Switches, Magnetism, Switching, Ionization, Semiconductors, Diffusion, Dielectrics, Information operations, Optical semiconductors, Electrons

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Proceedings Article | 14 August 1992 Paper

Laser sclerostomy ab externo with the Erbium:YAG laser using a new flexible application system

Wolfgang Wetzel, M. Scheu, Ralf Brinkmann, Reginald Birngruber

Proceedings Volume 1644, (1992) https://doi.org/10.1117/12.137437

KEYWORDS: Quartz, Laser energy, Eye, Er:YAG lasers, Sclera, Fiber lasers, Laser applications, Signal attenuation, Laser tissue interaction, Laser ablation

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Proceedings Article | 14 August 1992 Paper

Laser thermokeratoplasty: a comparative in-vitro study with an Er:glass and a Cr:Tm:Ho:YAG laser

Ralf Brinkmann, Detlef Micka, Ch. Strunge, C. Nowack, E. El-Hifnawi

Proceedings Volume 1644, (1992) https://doi.org/10.1117/12.137435

KEYWORDS: Cornea, Telescopes, Absorption, Refraction, Laser energy, In vitro testing, Monochromatic aberrations, Laser systems engineering, Pulsed laser operation, Laser scattering

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Proceedings Article | 12 May 1992 Paper

Electron-beam-activated zinc selenide and diamond switches

Karl Schoenbach, Mark Kennedy, Ravindra Joshi, Ralf Brinkmann, Ping-Tong Ho

Proceedings Volume 1632, (1992) https://doi.org/10.1117/12.59072

KEYWORDS: Switches, Diamond, Crystals, Semiconductors, Zinc, Switching, Gallium arsenide, Electrons, Resistance, Silicon

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Proceedings Article | 12 May 1992 Paper

Deep-level characterization studies for optically controlled semiconductor switch materials using a novel technique

Vishnu Lakdawala, Sridhar Panigrahi, Lucy Thomas-Harrington, Ralf Brinkmann

Proceedings Volume 1632, (1992) https://doi.org/10.1117/12.59064

KEYWORDS: Gallium arsenide, Switches, Information operations, Switching, Semiconductor materials, Silicon, Statistical analysis, Semiconductors, Copper, Temperature metrology

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Proceedings Article | 12 May 1992 Paper

Analysis of time-dependent current transport in an optically controlled Cu-compensated GaAs switch

Ralf Brinkmann, Karl Schoenbach, Michael Mazzola, Randy Roush, David Stoudt

Proceedings Volume 1632, (1992) https://doi.org/10.1117/12.59078

KEYWORDS: Switches, Pulsed laser operation, Switching, Gallium arsenide, Data modeling, Semiconductors, Instrument modeling, Silicon, Copper, Pulsed power

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Proceedings Article | 12 May 1992 Paper

Modeling of electron-beam-controlled diamond switches

Ralf Brinkmann, Karl Schoenbach

Proceedings Volume 1632, (1992) https://doi.org/10.1117/12.59076

KEYWORDS: Switches, Diamond, Switching, Dielectrics, Ionization, Semiconductors, Mathematical modeling, Device simulation, Pulsed power, Resistance

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Proceedings Article | 1 July 1991 Paper

Q-switching and pulse shaping with IR lasers

Ralf Brinkmann, K. Bauer

Proceedings Volume 1421, (1991) https://doi.org/10.1117/12.43920

KEYWORDS: Plasmas, Pulsed laser operation, Mirrors, Fiber lasers, Holmium, Resonators, Infrared lasers, Laser applications, Laser tissue interaction, Laser ablation

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Proceedings Article | 1 July 1991 Paper

Fiber fragmentation during laser lithotripsy

Gabriela Flemming, Ralf Brinkmann, Ch. Strunge, Ralf Engelhardt

Proceedings Volume 1421, (1991) https://doi.org/10.1117/12.43922

KEYWORDS: Alexandrite lasers, Fiber lasers, Dye lasers, Q switched fiber lasers, Laser lithotripsy, Pulsed laser operation, Laser therapeutics, Q switching, Laparoscopy, Optical fibers

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Proceedings Article | 1 March 1991 Paper

Equilibrium and nonequilibrium properties of semiconductors with multiply ionizable deep centers

Ralf Brinkmann, Karl Schoenbach, Hans-Joachim Schulz

Proceedings Volume 1361, (1991) https://doi.org/10.1117/12.24401

KEYWORDS: Semiconductors, Thermodynamics, Crystals, Ionization, Chromium, Gallium arsenide, Optoelectronic devices, Doping, Process modeling, Phonons

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Proceedings Article | 1 March 1991 Paper

Energy-level structure and electron transitions of GaAs:Cr optoelectronic materials

Hans-Joachim Schulz, Karl Schoenbach, B. Kimpel, Ralf Brinkmann

Proceedings Volume 1361, (1991) https://doi.org/10.1117/12.24299

KEYWORDS: Optoelectronics, Ions, Chromium, Gallium arsenide, Image processing, Oxidation

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Proceedings Article | 1 March 1991 Paper

High-power switching with electron-beam-controlled semiconductors

Ralf Brinkmann, Karl Schoenbach, Randy Roush, David Stoudt, Vishnu Lakdawala, Glenn Gerdin

Proceedings Volume 1378, (1991) https://doi.org/10.1117/12.25054

KEYWORDS: Switches, Semiconductors, Switching, Electrons, Gallium arsenide, Resistance, Doping, Picosecond phenomena, Copper, Electron beams

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Proceedings Article | 1 February 1991 Paper

Deep-level configuration of GaAs:Si:Cu: a material for a new type of optoelectronic switch

Karl Schoenbach, Hans-Joachim Schulz, Vishnu Lakdawala, B. Kimpel, Ralf Brinkmann, Rudolf Germer, Gordon Barevadia

Proceedings Volume 1362, (1991) https://doi.org/10.1117/12.24476

KEYWORDS: Switches, Copper, Gallium arsenide, Optoelectronic devices, Silicon, Optoelectronics, Physics, Pulsed laser operation, Ionization, Data modeling

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Proceedings Article | 1 June 1990 Paper

Laser-induced shockwave lithotripsy by use of a 1-us Alexandrite laser

Ralf Brinkmann, Wilhelm Meyer, Ralf Engelhardt, John Walling

Proceedings Volume 1200, (1990) https://doi.org/10.1117/12.17441

KEYWORDS: Pulsed laser operation, Laser therapeutics, Alexandrite lasers, Plasma, Laser vision correction, Laser resonators, Resonators, Laser systems engineering, Laser damage threshold, Dye lasers

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Showing 5 of 129 publications

Conference Committee Involvement (30)

Advanced Photonics in Urology 2025

25 January 2025 | San Francisco, United States

Ophthalmic Technologies XXXV

25 January 2025 | San Francisco, United States

Advanced Photonics in Urology 2024

27 January 2024 | San Francisco, California, United States

Ophthalmic Technologies XXXIV

27 January 2024 | San Francisco, California, United States

Advanced Photonics in Urology 2023

28 January 2023 | San Francisco, California, United States

Ophthalmic Technologies XXXIII

28 January 2023 | San Francisco, California, United States

Ophthalmic Technologies XXXII

22 January 2022 | San Francisco, California, United States

Ophthalmic Technologies XXXI

6 March 2021 | Online Only, California, United States

Advanced Photonics in Urology

6 March 2021 | Online Only, California, United States

Ophthalmic Technologies XXX

1 February 2020 | San Francisco, California, United States

Translation of Lasers and Biophotonics Technologies and Procedures: Toward the Clinic

23 June 2019 | Munich, Germany

Ophthalmic Technologies XXIX

2 February 2019 | San Francisco, California, United States

Ophthalmic Technologies XXVIII

27 January 2018 | San Francisco, California, United States

Medical Laser Applications and Laser-Tissue Interactions VIII

25 June 2017 | Munich, Germany

Ophthalmic Technologies XXVII

28 January 2017 | San Francisco, California, United States

Ophthalmic Technologies XXVI

13 February 2016 | San Francisco, California, United States

Medical Laser Applications and Laser-Tissue Interactions VII

21 June 2015 | Munich, Germany

Ophthalmic Technologies XXV

7 February 2015 | San Francisco, California, United States

Ophthalmic Technologies XXIV

1 February 2014 | San Francisco, California, United States

Medical Laser Applications and Laser-Tissue Interactions VI

12 May 2013 | Munich, Germany

Ophthalmic Technologies XXIII

2 February 2013 | San Francisco, California, United States

Ophthalmic Technologies XXII

21 January 2012 | San Francisco, California, United States

Medical Laser Applications and Laser-Tissue Interactions V

24 May 2011 | Munich, Germany

Ophthalmic Technologies XXI

22 January 2011 | San Francisco, California, United States

Ophthalmic Technologies XX

23 January 2010 | San Francisco, California, United States

Therapeutic Laser Applications and Laser-Tissue Interactions

17 June 2009 | Munich, Germany

Ophthalmic Technologies XIX

24 January 2009 | San Jose, California, United States

Ophthalmic Technologies XVIII

19 January 2008 | San Jose, California, United States

Diagnostic Optical Spectroscopy

19 June 2007 | Munich, Germany

Ophthalmic Technologies XVII

20 January 2007 | San Jose, California, United States

Showing 5 of 30 Conference Committees

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