Dr. Ralf B. Schulz Profile

Dr. Ralf B. Schulz

Senior Scientist at Helmholtz Zentrum München GmbH

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Publications (11)

SPIE Journal Paper | 1 April 2011 Open Access

Reconstruction of fluorescence distribution hidden in biological tissue using mesoscopic epifluorescence tomography

Saskia Bjorn, Karl-Hans Englmeier, Vasilis Ntziachristos, Ralf Schulz

JBO, Vol. 16, Issue 04, 046005, (April 2011) https://doi.org/10.1117/12.10.1117/1.3560631

KEYWORDS: Luminescence, Tomography, Tissue optics, Tissues, Skin, Imaging systems, Solids, Data acquisition, Scattering, Monte Carlo methods

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SPIE Journal Paper | 1 May 2010 Open Access

Fast automatic segmentation of anatomical structures in x-ray computed tomography images to improve fluorescence molecular tomography reconstruction

Marcus Freyer, Angelique Ale, Ralf Schulz, Marta Zientkowska, Vasilis Ntziachristos, Karl-Hans Englmeier

JBO, Vol. 15, Issue 03, 036006, (May 2010) https://doi.org/10.1117/12.10.1117/1.3431101

KEYWORDS: Image segmentation, Lung, X-ray computed tomography, Heart, Bone, Data modeling, Tissues, Luminescence, Fluorescence tomography, Tomography

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Proceedings Article | 24 February 2010 Paper

Multiparametric optimization of multispectral optoacoustic tomography for deep tissue imaging

Jürgen Glatz, Nikolaos Deliolanis, Lu Ding, Adrian Taruttis, Amir Rosenthal, Ralf Schulz, Daniel Razansky, Vasilis Ntziachristos

Proceedings Volume 7564, 75642Z (2010) https://doi.org/10.1117/12.842101

KEYWORDS: Proteins, Fluorescent proteins, Tissue optics, Tissues, Tomography, Photoacoustic spectroscopy, Absorption, Light wave propagation, Green fluorescent protein, Deep tissue imaging

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SPIE Journal Paper | 1 November 2009 Open Access

Real-time intraoperative fluorescence imaging system using light-absorption correction

George Themelis, Jung Sun Yoo, Kwangsup Soh, Ralf Schulz, Vasilis Ntziachristos

JBO, Vol. 14, Issue 06, 064012, (November 2009) https://doi.org/10.1117/12.10.1117/1.3259362

KEYWORDS: Luminescence, Imaging systems, Tissues, Signal attenuation, Absorption, Optical properties, Contrast transfer function, Lymphatic system, Cameras, Video

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Proceedings Article | 1 July 2009 Paper

Hybrid fluorescence tomography/x-ray tomography improves reconstruction quality

R. Schulz, A. Ale, A. Sarantopoulos, M. Freyer, R. Söhngen, M. Zientkowska, V. Ntziachristos

Proceedings Volume 7370, 73700H (2009) https://doi.org/10.1117/12.831714

KEYWORDS: Luminescence, Image segmentation, Fluorescence tomography, Imaging systems, Lung, Tomography, Data acquisition, Tissues, X-rays, Neuroimaging

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Proceedings Article | 14 March 2009 Paper

Iterative finite-element-based inversion for quantified detection of molecular targets using optoacoustic tomography

Thomas Jetzfellner, Daniel Razansky, Amir Rosenthal, Ralf Schulz, K.-H. Englmeier, Vasilis Ntziachristos

Proceedings Volume 7258, 725812 (2009) https://doi.org/10.1117/12.811014

KEYWORDS: Absorption, Image quality, Tissue optics, Scattering, Tomography, Reconstruction algorithms, Target detection, Tissues, Quality measurement, Light scattering

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Proceedings Article | 18 July 2007 Paper

High-resolution image acquisition using a compact microlens-coupled detector

Daniel Unholtz, Ralf Schulz, Wolfhard Semmler, Jörg Peter

Proceedings Volume 6631, 66311F (2007) https://doi.org/10.1117/12.728465

KEYWORDS: Sensors, Image sensors, Spatial resolution, Microlens, CMOS sensors, Associative arrays, Image acquisition, Microlens array, Image resolution, Data acquisition

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Proceedings Article | 18 July 2007 Paper

A novel optical detector concept for dedicated and multi-modality in vivo small animal imaging

Jörg Peter, Ralf Schulz, Daniel Unholtz, Wolfhard Semmler

Proceedings Volume 6631, 663110 (2007) https://doi.org/10.1117/12.728500

KEYWORDS: Sensors, Positron emission tomography, CMOS sensors, Magnetic resonance imaging, Tomography, In vivo imaging, Imaging systems, Biomedical optics, Spatial resolution, Data acquisition

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An optical detector suitable for inclusion in tomographic arrangements for non-contact in vivo bioluminescence and fluorescence imaging applications is proposed. It consists of a microlens array (MLA) intended for field-of-view definition, a large-field complementary metal-oxide-semiconductor (CMOS) chip for light detection, a septum mask for cross-talk suppression, and an exchangeable filter to block excitation light. Prototype detector units with sensitive areas of 2.5 cm x 5 cm each were assembled. The CMOS sensor constitutes a 512 x 1024 photodiode matrix at 48 μm pixel pitch. Refractive MLAs with plano-convex lenses of 480 μm in diameter and pitch were selected resulting in a 55 x 105 lens matrix. The CMOS sensor is aligned on the focal plane of the MLA at 2.15mm distance. To separate individual microlens images an opaque multi-bore septum mask of 2.1mm in thickness and bore diameters of 400 μm at 480 μm pitch, aligned with the lens pattern, is placed between MLA and CMOS. Intrinsic spatial detector resolution and sensitivity was evaluated experimentally as a function of detector-object distance. Due to its small overall dimensions such detectors can be favorably packed for tomographic imaging (optical diffusion tomography, ODT) yielding complete 2 π field-of-view coverage. We also present a design study of a device intended to simultaneously image positron labeled substrates (positron emission tomography, PET) and optical molecular probes in small animals such as mice and rats. It consists of a cylindrical allocation of optical detector units which form an inner detector ring while PET detector blocks are mounted in radial extension, those gaining complementary information in a single, intrinsically coregistered experimental data acquisition study. Finally, in a second design study we propose a method for integrated optical and magnetic resonance imaging (MRI) which yields in vivo functional/molecular information that is intrinsically registered with the anatomy of the image object.

Proceedings Article | 11 July 2007 Paper

Applying time-dependent data for fluorescence tomography

Ralf Schulz, Martin Schweiger, Cosimo D'Andrea, Gianluca Valentini, Jörg Peter, Rinaldo Cubeddu, Simon Arridge, Wolfhard Semmler

Proceedings Volume 6626, 66260N (2007) https://doi.org/10.1117/12.728357

KEYWORDS: Luminescence, Data acquisition, Data modeling, Reconstruction algorithms, Diffusion, Photons, Picosecond phenomena, Fluorescence tomography, CCD cameras

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Proceedings Article | 27 October 2005 Paper

Quantifiability and image quality in noncontact fluorescence tomography

Ralf Schulz, Joerg Peter, Wolfhard Semmler, Cosimo D'Andrea, Gianluca Valentini, Rinaldo Cubeddu

Proceedings Volume 5859, 58590Z (2005) https://doi.org/10.1117/12.632855

KEYWORDS: Fluorescence tomography, Image quality, Fourier transforms, Biomedical optics, Charge-coupled devices, Fiber optics

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Proceedings Article | 20 August 2004 Paper

Noncontact diffuse optical tomography

Jorge Ripoll, Ralf Schulz, Vasilis Ntziachristos

Proceedings Volume 5474, (2004) https://doi.org/10.1117/12.578917

KEYWORDS: Sensors, Optical tomography, Scattering, Tomography, Solids, Diffuse optical tomography, Optical properties, 3D modeling, Absorption, CCD image sensors

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Showing 5 of 11 publications

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