Cervical intraneoplasia (CIN), during its progression, shows an increased cell atypia and affects thicker epithelial structure. Photodynamic therapy (PDT) may constitute an attractive minimally invasive treatment technique. CIN mostly occurs at the squamous-columnar junction (SCJ) of the cervix, resulting in a challenge to achieve the aimed PDT uniform photosensitizer distribution and irradiation. The development of the clinical protocol and of the customized optical treatment probe is essential for an improved PDT response for CIN 1,2 and 3. Results of the developed instrumentation in an ongoing clinical study will be discussed.
Cervical intraepithelial neoplasia (CIN) is the precursor of invasive cervical cancer and associated with human papillomavirus (HPV) infection. Photodynamic therapy (PDT) is a technique that has been used for the treatment of tumors. PDT is based on the accumulation of a photosensitizer in target cells that will generate cytotoxic reactive oxygen species upon illumination, inducing the death of abnormal tissue and PDT with less damaging to normal tissues than surgery, radiation, or chemotherapy and seems to be a promising alternative procedure for CIN treatment. The CIN high grades (II and III) presents potential indications for PDT due the success of PDT for CIN low grade treatment. The patients with CIN high grade that were treated with new clinic protocol shows lesion regression to CIN low grade 60 days after the treatment. The new clinical protocol using for treatment of CIN high grade shows great potential to become a public health technique.