Prof. Robert Alexander Huber Profile

Prof. Robert Alexander Huber

Professor of Biomedical Imaging at Univ zu Lubeck

SPIE Involvement:

Conference Program Committee | Author

Publications (46)

PROCEEDINGS ARTICLE | August 1, 2017

Long-range live 3D-OCT at different spectral zoom levels

Proc. SPIE. 10416, Optical Coherence Imaging Techniques and Imaging in Scattering Media II

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PROCEEDINGS ARTICLE | August 1, 2017

1060nm FDML laser with centimeter coherence length and 1.67 MHz sweep rate for full eye length and retinal ultra-widefield OCT

Proc. SPIE. 10416, Optical Coherence Imaging Techniques and Imaging in Scattering Media II

KEYWORDS: Eye, Tunable lasers, Coherence (optics), Optical coherence tomography, Mode locking

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PROCEEDINGS ARTICLE | July 28, 2017

Sparse-sampling with time-encoded (TICO) stimulated Raman scattering for fast image acquisition

Proc. SPIE. 10414, Advances in Microscopic Imaging

KEYWORDS: Fiber optics, Mode locking, Microscopy, Image acquisition, Fiber lasers, Raman spectroscopy, Nonlinear optics, Raman scattering

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Modern biomedical imaging modalities aim to provide researchers a multimodal contrast for a deeper insight into a specimen under investigation. A very promising technique is stimulated Raman scattering (SRS) microscopy, which can unveil the chemical composition of a sample with a very high specificity. Although the signal intensities are enhanced manifold to achieve a faster acquisition of images if compared to standard Raman microscopy, there is a trade-off between specificity and acquisition speed. Commonly used SRS concepts either probe only very few Raman transitions as the tuning of the applied laser sources is complicated or record whole spectra with a spectrometer based setup. While the first approach is fast, it reduces the specificity and the spectrometer approach records whole spectra -with energy differences where no Raman information is present-, which limits the acquisition speed. Therefore, we present a new approach based on the TICO-Raman concept, which we call sparse-sampling. The TICO-sparse-sampling setup is fully electronically controllable and allows probing of only the characteristic peaks of a Raman spectrum instead of always acquiring a whole spectrum. By reducing the spectral points to the relevant peaks, the acquisition time can be greatly reduced compared to a uniformly, equidistantly sampled Raman spectrum while the specificity and the signal to noise ratio (SNR) are maintained. Furthermore, all laser sources are completely fiber based. The synchronized detection enables a full resolution of the Raman signal, whereas the analogue and digital balancing allows shot noise limited detection. First imaging results with polystyrene (PS) and polymethylmethacrylate (PMMA) beads confirm the advantages of TICO sparse-sampling. We achieved a pixel dwell time as low as 35 μs for an image differentiating both species. The mechanical properties of the applied voice coil stage for scanning the sample currently limits even faster acquisition.

PROCEEDINGS ARTICLE | July 28, 2017

Single pulse two-photon fluorescence lifetime imaging (SP-FLIM) with MHz pixel rate and an all fiber based setup

Proc. SPIE. 10414, Advances in Microscopic Imaging

KEYWORDS: Fiber optics, Microscopy, Luminescence, Fiber lasers, Nonlinear optics, Fluorescence lifetime imaging, Fret and flim microscopy, Two photon excitation microscopy, Fiber coupled lasers

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PROCEEDINGS ARTICLE | March 7, 2017

Pulse-to-pulse wavelength switching of diode based fiber laser for multi-color multi-photon imaging

Proc. SPIE. 10083, Fiber Lasers XIV: Technology and Systems

KEYWORDS: Two photon imaging, Fiber amplifiers, Laser sources, Switches, Switching, Modulation, Amplifiers, Fiber lasers, Semiconductor lasers, Raman spectroscopy, Diodes, Raman scattering, Picosecond phenomena, Four wave mixing

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PROCEEDINGS ARTICLE | March 3, 2017

Feature tracking for automated volume of interest stabilization on 4D-OCT images

Proc. SPIE. 10135, Medical Imaging 2017: Image-Guided Procedures, Robotic Interventions, and Modeling

KEYWORDS: Detection and tracking algorithms, Visualization, Tissues, Sensors, Optical coherence tomography, Image processing, Image acquisition, Image analysis, Medical imaging, Optical tracking, 3D image processing, Automatic tracking

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PROCEEDINGS ARTICLE | February 21, 2017

Two-photon-excited fluorescence (TPEF) and fluorescence lifetime imaging (FLIM) with sub-nanosecond pulses and a high analog bandwidth signal detection

Proc. SPIE. 10069, Multiphoton Microscopy in the Biomedical Sciences XVII

KEYWORDS: Two photon imaging, Fiber amplifiers, Laser sources, Microscopes, Microscopy, Luminescence, Photons, Fiber lasers, Semiconductor lasers, Data acquisition, Fluorescence lifetime imaging, Picosecond phenomena, Analog electronics, Two photon excitation microscopy, Signal detection

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PROCEEDINGS ARTICLE | February 21, 2017

Analysis of FDML lasers with meter range coherence

Proc. SPIE. 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI

KEYWORDS: Tunable lasers, Biomedical optics, Video acceleration, Coherence (optics), Imaging systems, Interferometers, Optical coherence tomography, Mode locking, Laser development, Image quality, Range imaging

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PROCEEDINGS ARTICLE | February 15, 2017

Short pulse laser induced thermo-elastic deformation imaging

Proc. SPIE. 10062, Optical Interactions with Tissue and Cells XXVIII

KEYWORDS: Biomedical optics, Coherence (optics), Optical coherence tomography, Tissue optics, Elastography, Laser tissue interaction, Absorption

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PROCEEDINGS ARTICLE | June 28, 2016

4D megahertz optical coherence tomography (OCT): imaging and live display beyond 1 gigavoxel/sec (Conference Presentation)

Proc. SPIE. 9720, High-Speed Biomedical Imaging and Spectroscopy: Toward Big Data Instrumentation and Management

KEYWORDS: Microscopes, Coherence imaging, Ophthalmology, Tissues, Imaging systems, Optical coherence tomography, Diagnostics, Image resolution, In vivo imaging, Cardiology

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PROCEEDINGS ARTICLE | April 27, 2016

Micro motor OCT enables catheter based assessment of vascular elasticity (Conference Presentation)

Proc. SPIE. 9710, Optical Elastography and Tissue Biomechanics III

KEYWORDS: Coherence (optics), Tissues, Optical coherence tomography, Mode locking, Arteries, Optical testing, Tissue optics, Elastography, Phase shifts, Current controlled current source

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PROCEEDINGS ARTICLE | April 27, 2016

Heartbeat OCT: a new tool for interventional imaging (Conference Presentation)

Proc. SPIE. 9689, Photonic Therapeutics and Diagnostics XII

KEYWORDS: 3D acquisition, Imaging systems, Optical coherence tomography, Mode locking, Image restoration, Data acquisition, Electrocardiography, Prototyping, 3D image processing, 3D image restoration

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PROCEEDINGS ARTICLE | April 7, 2016

Flexible A-scan rate MHz OCT: computational downscaling by coherent averaging

Proc. SPIE. 9697, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX

KEYWORDS: Tunable lasers, Imaging systems, Interferometers, Calibration, Optical coherence tomography, Image processing, Mode locking, Computing systems, Phase interferometry, Data acquisition, Image quality, Laser stabilization, In vivo imaging, Optical filtering

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PROCEEDINGS ARTICLE | March 8, 2016

Megahertz FDML laser with up to 143nm sweep range for ultrahigh resolution OCT at 1050nm

Proc. SPIE. 9697, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX

KEYWORDS: Point spread functions, Mirrors, Light sources, Tunable lasers, Modulation, Optical coherence tomography, Image processing, Mode locking, Image resolution, Semiconductor lasers, Imaging devices, Spectral resolution, In vivo imaging, Retinal scanning, Absorption

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PROCEEDINGS ARTICLE | July 22, 2015

High definition in vivo retinal volumetric video rate OCT at 0.6 Giga-voxels per second

Proc. SPIE. 9541, Optical Coherence Imaging Techniques and Imaging in Scattering Media

KEYWORDS: Eye, Visualization, Optical coherence tomography, Mode locking, Retina, Scanners, Video, Computing systems, In vivo imaging, Retinal scanning

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PROCEEDINGS ARTICLE | July 14, 2015

Hyperspectral stimulated Raman microscopy with two fiber laser sources

Proc. SPIE. 9536, Advanced Microscopy Techniques IV; and Neurophotonics II

KEYWORDS: Fiber amplifiers, Oscillators, Modulation, Imaging systems, Microscopy, Fiber lasers, Semiconductor lasers, Raman spectroscopy, Laser beam diagnostics, Pulsed laser operation

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PROCEEDINGS ARTICLE | July 14, 2015

Nanosecond two-photon excitation fluorescence imaging with a multi color fiber MOPA laser

Proc. SPIE. 9536, Advanced Microscopy Techniques IV; and Neurophotonics II

KEYWORDS: Two photon imaging, Fiber amplifiers, Biomedical optics, Modulation, Imaging systems, Microscopy, Luminescence, Fiber lasers, Raman spectroscopy, Picosecond phenomena

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PROCEEDINGS ARTICLE | July 9, 2015

Time-encoded Raman scattering (TICO-Raman) with Fourier domain mode locked (FDML) lasers

Proc. SPIE. 9541, Optical Coherence Imaging Techniques and Imaging in Scattering Media

KEYWORDS: Imaging systems, Optical coherence tomography, Mode locking, Microscopy, Laser scattering, Fiber lasers, Raman spectroscopy, Raman scattering, Laser beam diagnostics, Pulsed laser operation

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PROCEEDINGS ARTICLE | July 9, 2015

Fully automated 1.5 MHz FDML laser with more than 100mW output power at 1310 nm

Proc. SPIE. 9541, Optical Coherence Imaging Techniques and Imaging in Scattering Media

KEYWORDS: Coherence imaging, Optical filters, Electronics, Biomedical optics, Optical coherence tomography, Laser applications, Diagnostics, Nondestructive evaluation, Control systems, Laser stabilization

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PROCEEDINGS ARTICLE | March 16, 2015

Dual parametric compounding approach for speckle reduction in OCT

Proc. SPIE. 9312, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX

KEYWORDS: Telescopes, Speckle, Lenses, Interferometers, Optical coherence tomography, Retina, Nondestructive evaluation, Collimators, Space telescopes, Sodium

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PROCEEDINGS ARTICLE | March 16, 2015

Full volumetric video rate OCT of the posterior eye with up to 195.2 volumes/s

Proc. SPIE. 9312, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX

KEYWORDS: Mirrors, Eye, 3D acquisition, Optical coherence tomography, Mode locking, Retina, Scanners, Video, Computing systems, Retinal scanning

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PROCEEDINGS ARTICLE | June 18, 2013

Ultrahigh-speed intravascular optical coherence tomography imaging at 3200 frames per second

Proc. SPIE. 8802, Optical Coherence Tomography and Coherence Techniques VI

KEYWORDS: Optical imaging, GRIN lenses, Coherence imaging, 3D acquisition, Optical coherence tomography, Mode locking, Arteries, Data acquisition, Cardiology, 3D image processing

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PROCEEDINGS ARTICLE | March 20, 2013

History compounding: a novel speckle reduction technique for OCT guided cochleostomy

Proc. SPIE. 8571, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII

KEYWORDS: Refractive index, Diamond, Injuries, Tissues, Speckle, Calibration, Optical coherence tomography, Bone, Speckle pattern, Tissue optics

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SPIE Journal Paper | February 1, 2013

Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser

Torzicky, Teresa , Marschall, Sebastian , Pircher, Michael , Baumann, Bernhard , Bonesi, Marco , Zotter, Stefan , Götzinger, Erich , Trasischker, Wolfgang , Klein, Thomas , Wieser, Wolfgang , Biedermann, Benjamin , Huber, Robert , Andersen, Peter , Hitzenberger, Christoph

JBO Vol. 18 Issue 02

KEYWORDS: Optical coherence tomography, Polarization, Birefringence, Imaging systems, Data acquisition, Image segmentation, Modulation, Mode locking, Retinal scanning, 3D acquisition

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SPIE Journal Paper | June 29, 2012

Ultrahigh-speed non-invasive widefield angiography

Blatter, Cedric , Grajciar, Branislav , Schmoll, Tilman , Leitgeb, Rainer , Klein, Thomas , Wieser, Wolfgang , André, Raphael , Huber, Robert

JBO Vol. 17 Issue 7

KEYWORDS: Angiography, Optical coherence tomography, Retina, Image segmentation, Visualization, Tissues, Capillaries, Vascular imaging, Diagnostics, Gold

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PROCEEDINGS ARTICLE | May 8, 2012

High-speed polarization-sensitive OCT at 1060 nm using a Fourier domain mode-locked swept source

Proc. SPIE. 8427, Biophotonics: Photonic Solutions for Better Health Care III

KEYWORDS: Light sources, Eye, Polarization, Imaging systems, Optical coherence tomography, Image segmentation, Mode locking, Retina, Sclera, In vivo imaging

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PROCEEDINGS ARTICLE | February 18, 2012

Broadband Fourier domain mode-locked laser for optical coherence tomography at 1060 nm

Proc. SPIE. 8213, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI

KEYWORDS: Point spread functions, Light sources, Eye, Modulation, Resonators, Optical coherence tomography, Mode locking, Tunable filters, Laser optics, Absorption

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PROCEEDINGS ARTICLE | February 18, 2012

Multi-MHz FDML OCT: snapshot retinal imaging at 6.7 million axial-scans per second

Proc. SPIE. 8213, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI

KEYWORDS: Eye, Tunable lasers, 3D acquisition, Optical coherence tomography, Mode locking, Retina, Scanners, Laser resonators, Retinal scanning, Pulsed laser operation

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PROCEEDINGS ARTICLE | February 9, 2012

Deep skin structural and microcirculation imaging with extended-focus OCT

Proc. SPIE. 8207, Photonic Therapeutics and Diagnostics VIII

KEYWORDS: Microcirculation imaging, Optical coherence tomography, Capillaries, Skin, Image resolution, Bessel beams, In vivo imaging, Chemical elements, Network architectures, Temperature metrology

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PROCEEDINGS ARTICLE | February 7, 2012

Coherence length extension of Fourier domain mode locked lasers

Proc. SPIE. 8213, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI

KEYWORDS: Optical fibers, Optical filters, Coherence (optics), Imaging systems, Dispersion, Optical coherence tomography, Mode locking, Image resolution, Range imaging, Tunable filters

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PROCEEDINGS ARTICLE | February 1, 2012

Simultaneous dark-bright field swept source OCT for ultrasound detection

Proc. SPIE. 8213, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI

KEYWORDS: Signal to noise ratio, Sensors, Ultrasonography, Optical coherence tomography, Glasses, Interfaces, Light scattering, Phase measurement, Acoustics, Light

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PROCEEDINGS ARTICLE | June 1, 2011

High-speed functional OCT with self-reconstructive Bessel illumination at 1300 nm

Proc. SPIE. 8091, Optical Coherence Tomography and Coherence Techniques V

KEYWORDS: Mirrors, Tissues, Imaging systems, Speckle, Optical coherence tomography, Capillaries, Skin, Image resolution, Bessel beams, In vivo imaging

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PROCEEDINGS ARTICLE | February 12, 2011

Structural and functional imaging with extended focus dark-field OCT at 1300nm

Proc. SPIE. 7889, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV

KEYWORDS: Mirrors, Axicons, Imaging systems, Optical coherence tomography, Glasses, Skin, Image resolution, Functional imaging, Bessel beams, In vivo imaging

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PROCEEDINGS ARTICLE | May 17, 2010

High-power FDML laser for swept source-OCT at 1060 nm

Proc. SPIE. 7715, Biophotonics: Photonic Solutions for Better Health Care II

KEYWORDS: Fiber amplifiers, Point spread functions, Light sources, Optical amplifiers, Semiconductor optical amplifiers, Resonators, Optical coherence tomography, High power lasers, Fiber couplers, Tunable filters

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PROCEEDINGS ARTICLE | February 20, 2010

FDML swept source at 1060 nm using a tapered amplifier

Proc. SPIE. 7554, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV

KEYWORDS: Fiber amplifiers, Point spread functions, Light sources, Optical amplifiers, Semiconductor optical amplifiers, Resonators, Tissues, Optical coherence tomography, Fiber couplers, Tunable filters

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PROCEEDINGS ARTICLE | July 14, 2009

Wavelength swept ASE source

Proc. SPIE. 7372, Optical Coherence Tomography and Coherence Techniques IV

KEYWORDS: Optical filters, Light sources, Tunable lasers, Mach-Zehnder interferometers, Resonators, Optical coherence tomography, Laser resonators, Geometrical optics, Superluminescent sources, Electronic filtering

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PROCEEDINGS ARTICLE | July 14, 2009

Fourier domain mode locked (FDML) lasers for polarization sensitive OCT

Proc. SPIE. 7372, Optical Coherence Tomography and Coherence Techniques IV

KEYWORDS: Coherence imaging, Biomedical optics, Optical spheres, Phase modulation, Polarization, Optical coherence tomography, Mode locking, Fiber lasers, Tissue optics, Laser optics

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PROCEEDINGS ARTICLE | February 18, 2009

Swept source OCT imaging of human anterior segment at 200 kHz

Proc. SPIE. 7163, Ophthalmic Technologies XIX

KEYWORDS: Eye, 3D acquisition, Cornea, Optical coherence tomography, Image segmentation, Mode locking, Image resolution, Data acquisition, In vivo imaging, 3D image processing

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PROCEEDINGS ARTICLE | March 5, 2008

In vivo endomicroscopy using three-dimensional optical coherence tomography and Fourier domain mode locked lasers

Proc. SPIE. 6847, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII

KEYWORDS: Endoscopy, 3D acquisition, Tissues, Imaging systems, Optical coherence tomography, Data acquisition, Endomicroscopy, Colon, In vivo imaging, 3D image processing

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PROCEEDINGS ARTICLE | March 5, 2007

High-speed high-resolution OCT imaging of the retina with frequency swept lasers at 850 nm

Proc. SPIE. 6426, Ophthalmic Technologies XVII

KEYWORDS: Tissues, Imaging systems, Optical coherence tomography, Image segmentation, Retina, Spectroscopy, Laser applications, Image resolution, Semiconductor lasers, Retinal scanning

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PROCEEDINGS ARTICLE | February 9, 2007

Fourier domain mode-locked (FDML) lasers at 1050 nm and 202,000 sweeps per second for OCT retinal imaging

Proc. SPIE. 6429, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI

KEYWORDS: Laser sources, Point spread functions, 3D acquisition, Imaging systems, Optical coherence tomography, Mode locking, Retina, Data acquisition, Retinal scanning, 3D image processing

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PROCEEDINGS ARTICLE | February 7, 2007

Phase-sensitive optical coherence tomography using buffered Fourier domain mode-locked lasers at up to 370,000 scans per second

Proc. SPIE. 6429, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI

KEYWORDS: Signal to noise ratio, Ferroelectric materials, Output couplers, Calibration, Optical coherence tomography, Mode locking, Spectroscopy, Laser stabilization, Phase measurement, Doppler tomography

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PROCEEDINGS ARTICLE | February 20, 2006

Fourier domain mode-locked lasers for swept source OCT imaging at up to 290 kHz scan rates

Proc. SPIE. 6079, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X

KEYWORDS: Laser sources, Optical filters, Mirrors, Light sources, Optical coherence tomography, Mode locking, Fiber lasers, Signal detection, Optical isolators, Standards development

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PROCEEDINGS ARTICLE | October 7, 2005

Fourier domain mode locked lasers for OCT imaging at up to 290 kHz sweep rates

Proc. SPIE. 5861, Optical Coherence Tomography and Coherence Techniques II

KEYWORDS: Laser sources, Optical filters, Tunable lasers, Electronics, Calibration, Optical coherence tomography, Mode locking, Laser applications, Analog electronics, Laser metrology

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PROCEEDINGS ARTICLE | April 13, 2005

High-speed-frequency swept light source for Fourier domain OCT at 20-kHz A-scan rate

Proc. SPIE. 5690, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX

KEYWORDS: Fiber amplifiers, Laser sources, Optical filters, Light sources, Optical amplifiers, Semiconductor optical amplifiers, Signal attenuation, Optical coherence tomography, Fiber couplers, Optical isolators

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PROCEEDINGS ARTICLE | December 4, 2003

Beyond vibrationally mediated electron transfer: interfacial charge injection on a sub-10-fs time scale

Proc. SPIE. 5223, Physical Chemistry of Interfaces and Nanomaterials II

KEYWORDS: Semiconductors, Ultrafast phenomena, Optical amplifiers, Dispersion, Spectroscopy, Molecules, Interfaces, Absorbance, Picosecond phenomena, Absorption

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