Dr. Rohith K. Reddy Profile

Dr. Rohith K. Reddy

Assistant Professor at Univ of Houston

SPIE Involvement:

Conference Program Committee | Author

Proceedings Article | 4 March 2019

Natural history of Barrett’s esophagus using tethered capsule OCT endomicroscopy and portable OCT imaging system: initial experience (Conference Presentation)

Jing Dong, Barry Vuong, Timothy Ford, Matthew Beatty, Seyed Hamid Hosseiny, Emilie Beaulieu-Ouellet, Rohith Reddy, Kanwarpal Singh, Hany Osman, Catriona Grant, Anna Huizi Gao, Samantha Leeds, Norman Nishioka, John Poneros, Julian Abrams, Charles Lightdale, Prateek Sharma, Michael Wallace, Herbert Wolfsen, Kenneth Wang, Cadman Leggett, Mireille Rosenberg, Guillermo Tearney

Proc. SPIE. 10867, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIII

KEYWORDS: Endoscopy, Tissues, Imaging systems, Optical coherence tomography, Image resolution, Biopsy, Endomicroscopy, Esophagus, 3D image processing, Clinical trials

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While the most common method used to evaluate and survey patients with Barrett’s Esophagus (BE) is endoscopic biopsy, this procedure is invasive, time-consuming, and suffers from sampling errors. Moreover, it requires patient sedation that increases cost and mandates its operation in specialized settings. Our lab has developed a new imaging tool termed tethered capsule endomicroscopy (TCE) that involves swallowing a tethered capsule which utilizes optical coherence tomography (OCT) to obtain three-dimensional microscopic (10µm) images of the entire esophageal wall as it traverses the luminal organ via peristalsis or is retrieved by pulling up tether. As opposed to endoscopy, TCE procedure is non-invasive, doesn’t require patient sedation and mitigates sampling error by evaluating the microscopic structure of the entire esophagus. The merits of TCE make it a suitable device to investigate the microscopic natural history of BE in a longitudinal manner. Here, we present our initial experience of a multicenter (5-site) clinical trial to study the microscopic natural history of BE. The TCE device used for the study is the new generation capsule with the ball lens optical configuration and a distal scan stepper motor, which provides 30µm (lateral) resolution and 40Hz imaging rate. The portable OCT imaging system is a custom in-house built swept source system and provides 7µm (axial) at a 100 kHz A-line rate with a center wavelength of ~1310 nm. To date, we have successfully enrolled 69 subjects at all sites (MGH: 33, Columbia University: 11, Kansas City VA: 10, Mayo Jacksonville: 8, Mayo Rochester: 7) and 59 have swallowed the capsule (85.5%). There have been no reported adverse events associated with TCE procedure. High-quality OCT images were reliably obtained from patients who swallowed the device, and BE tissues were identified by expert readers. Our initial experience with TCE in a multicenter study demonstrates that this technology is easy to use and efficient in multiple clinical settings. Completion of this longitudinal study is likely to provide new insights on the temporal progression of BE that may impact management strategies.

Proceedings Article | 14 March 2018

Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy (Conference Presentation)

Chia-Pin Liang, Jing Dong, Timothy Ford, Rohith Reddy, Seyed Hamid Hosseiny Darbrazi, Hamid Farrokhi, Matthew Beatty, Kanwarpal Singh, Barry Vuong, Emilie Beaulieu-Ouellet, Catriona Grant, Sarah Giddings, Mireille Rosenberg, Norman Nishioka, Guillermo Tearney

Proc. SPIE. 10470, Endoscopic Microscopy XIII

KEYWORDS: Endoscopy, Cancer, Coherence (optics), Optical coherence tomography, Laser marking, Diagnostics, Surveillance, Endomicroscopy, Esophagus, Laser optics

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Proceedings Article | 27 April 2016

Tethered capsule OCT endomicroscopy for upper gastrointestinal tract imaging by using ball lens probe (Conference Presentation)

Jing Dong, Michalina Gora, Rohith Reddy, Wolfgang Trasischker, Oriane Poupart, Weina Lu, Robert Carruth, Catriona Grant, Amna Soomro, Aubrey Tiernan, Mireille Rosenberg, Norman Nishioka, Guillermo Tearney

Proc. SPIE. 9691, Endoscopic Microscopy XI; and Optical Techniques in Pulmonary Medicine III

KEYWORDS: Endoscopy, Optical fibers, GRIN lenses, Visualization, Surgery, Optical coherence tomography, Glasses, Endomicroscopy, Optics manufacturing, Photomedicine

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Proceedings Article | 10 February 2012

Denoising and deblurring of Fourier transform infrared spectroscopic imaging data

Tan Nguyen, Rohith Reddy, Michael Walsh, Matthew Schulmerich, Gabriel Popescu, Minh Do, Rohit Bhargava

Proc. SPIE. 8296, Computational Imaging X

KEYWORDS: Point spread functions, FT-IR spectroscopy, Data modeling, Imaging systems, Sensors, Image processing, Spectroscopy, Denoising, Imaging spectroscopy, Absorbance

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Proceedings Article | 20 February 2009

Validating the cancer diagnosis potential of mid-infrared spectroscopic imaging

F. Nell Pounder, Rohith Reddy, Michael Walsh, Rohit Bhargava

Proc. SPIE. 7186, Optical Diagnostics and Sensing IX

KEYWORDS: Breast, FT-IR spectroscopy, Cancer, Tumors, Tissues, Sensors, Image segmentation, Spectroscopy, Imaging spectroscopy, Spectral resolution

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Proceedings Article | 8 February 2008

Practical protocols for fast histopathology by Fourier transform infrared spectroscopic imaging

Frances Keith, Rohith Reddy, Rohit Bhargava

Proc. SPIE. 6853, Biomedical Optical Spectroscopy

KEYWORDS: Signal to noise ratio, Breast, FT-IR spectroscopy, Tissues, Image segmentation, Imaging spectroscopy, Data acquisition, Spectral resolution, Image classification, Tissue optics

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Showing 5 of 6 publications

Conference Committee Involvement (2)

Advanced Chemical Microscopy for Life Science and Translational Medicine 2021

23 January 2021 | San Francisco, California, United States

Advanced Chemical Microscopy for Life Science and Translational Medicine

1 February 2020 | San Francisco, California, United States

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