Dr. Romeo Bernini Profile

Dr. Romeo Bernini

Senior Researcher at IREA-CNR

SPIE Involvement:

Conference Program Committee | Author

Publications (41)

PROCEEDINGS ARTICLE | May 17, 2018

Glass based microresonators

Proc. SPIE. 10683, Fiber Lasers and Glass Photonics: Materials through Applications

KEYWORDS: Microresonators, Optical spheres, Resonators, Silica, Waveguides, Scattering, Glasses, Light scattering, Coating, Erbium

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PROCEEDINGS ARTICLE | June 9, 2017

A POCT platform for sepsis biomarkers (Conference Presentation)

Proc. SPIE. 10231, Optical Sensors 2017

KEYWORDS: Optical filters, Microfluidics, Proteins, Diffractive optical elements, Pathology, Luminescence, Fluorescence spectroscopy, Detector arrays, Receptors, Channel projecting optics

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Infectious diseases and sepsis, as a severe and potential medical condition in which the immune system overreacts and finally turns against itself, are a worldwide problem. As a matter of fact, it is considered the main cause of mortality in intensive care. For such a pathology, a timely diagnosis is essential, since it has been shown that each hour of delay in the administration of an effective pharmacological treatment increases the mortality rate of 7%. Therefore, the advent of a POCT platform for sepsis is highly requested by physicians. Biomarkers have gained importance for the diagnosis and treatment monitoring of septic patients, since biomarkers can indicate the severity of sepsis and can differentiate bacterial from viral and fungal infection, and systemic sepsis from local infection. The present paper deals with the development of fluorescence-based bioassays for the sepsis biomarkers and their integration on a multianalyte chip. Among the different biomarker candidates, the attention was focused on procalcitonin (PCT), C-reactive protein (CRP) and interleukine-6 (IL-6) as well as on soluble urokinase plasminogen activator receptor (suPAR) recently proposed as a very effective inflammatory marker, potentially capable of acting also as a prognostic biomarker. Starting point of this new setup was an already developed fluorescence-based optical platform, which makes use of multichannel polymethylmetacrylate chips for the detection of different bioanalytes, and the serial interrogation of the microfluidic channels of the chip. The novel proposed optical setup makes use of a suitable fluorescence excitation and detection scheme, capable of performing the simultaneous interrogation of all the channels. For the excitation part of the optical setup, a diffractive optical element is used which generates a pattern of parallel lines, for the simultaneous excitation of all the channels and for the optimization of the optical power distribution. For the detection part, an array of optical absorbing waveguides (long-pass coloured glass filters) is used, which collects the scattered light and the emitted fluorescence, filters out the excitation component, and is faced to a large area rectangular detector, for the simultaneous fluorescence detection. The implemented sandwich immunoassays comprise a capture antibody immobilized onto the surface of the chip channel and a detection antibody properly labelled with a fluorophore. Limits of detection of 2.7 ng/mL, 0.022 µg/mL, 12 ng/mL and 0,3 ng/mL were achieved for PCT CRP, IL-6 and suPAR, respectively.

PROCEEDINGS ARTICLE | May 2, 2017

Ring resonator for biosensing via flow-through approach (Conference Presentation)

Proc. SPIE. 10081, Frontiers in Biological Detection: From Nanosensors to Systems IX

KEYWORDS: Microfluidics, Microresonators, Biosensing, Resonators, Sensors, Biosensors, Integrated optics, Active remote sensing, Microrings, Plasma

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PROCEEDINGS ARTICLE | April 24, 2017

Novel fluorescence-based POCT platform for therapeutic drug monitoring in transplanted patients (Conference Presentation)

Proc. SPIE. 10072, Optical Diagnostics and Sensing XVII: Toward Point-of-Care Diagnostics

KEYWORDS: Optical components, Photovoltaics, Microfluidics, Optical sensing, Point-of-care devices, Luminescence, Interfaces, Diagnostics, Optical testing, Optical diagnostics

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PROCEEDINGS ARTICLE | April 23, 2017

Simultaneous strain and temperature measurements using dual-wavelength BOTDA

Proc. SPIE. 10323, 25th International Conference on Optical Fiber Sensors

KEYWORDS: Signal to noise ratio, Optical fibers, Modulation, Scattering, Single mode fibers, Fiber optics sensors, Wave propagation, Spatial resolution, Fiber characterization, Temperature metrology

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PROCEEDINGS ARTICLE | April 23, 2017

Experimental demonstration of a Brillouin optical frequency-domain reflectometry (BOFDR) sensor

Proc. SPIE. 10323, 25th International Conference on Optical Fiber Sensors

KEYWORDS: Modulation, Scattering, Sensors, Light scattering, Data acquisition, Reflectometry, Spatial resolution, Acoustics, Signal detection, Temperature metrology

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PROCEEDINGS ARTICLE | April 19, 2017

All-polymeric sensing platform based on packaged self-assembled bottle microresonator (Conference Presentation)

Proc. SPIE. 10106, Integrated Optics: Devices, Materials, and Technologies XXI

KEYWORDS: Microresonators, Optical sensing, Resonators, Silica, Reflection, Polymers, Ultraviolet radiation, Lamps, Nonlinear optics, Planar waveguides

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PROCEEDINGS ARTICLE | March 15, 2016

Whispering gallery modes in self-assembled bottle microresonators coupled to planar waveguide

Proc. SPIE. 9750, Integrated Optics: Devices, Materials, and Technologies XX

KEYWORDS: Microresonators, Optical lithography, Polymethylmethacrylate, Resonators, Waveguides, Polymers, Glasses, Ultraviolet radiation, Photons, Physics, Optical resonators, Planar waveguides, System integration, Microrings, Absorption

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PROCEEDINGS ARTICLE | March 13, 2015

A fuel level sensor for aeronautical applications

Proc. SPIE. 9369, Photonic Instrumentation Engineering II

KEYWORDS: Prisms, Fiber optics, Reflection, Sensors, Water, Multiplexing, Collimators, Reflectometry, Fiber couplers, Singular optics

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PROCEEDINGS ARTICLE | March 4, 2015

Optical heterogeneous bioassay for the detection of the inflammatory biomarker suPAR

Proc. SPIE. 9313, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII

KEYWORDS: Optical filters, Microfluidics, Proteins, Polymethylmethacrylate, Diffractive optical elements, Waveguides, Blood, Luminescence, Receptors, Channel projecting optics

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PROCEEDINGS ARTICLE | February 27, 2015

Silicon-PDMS optofluidic integration

Proc. SPIE. 9367, Silicon Photonics X

KEYWORDS: Refractive index, Microfluidics, Resonators, Waveguides, Cladding, Polymers, Silicon, Solids, Brain-machine interfaces, Liquids

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PROCEEDINGS ARTICLE | June 2, 2014

Distributed optical fiber sensors for integrated monitoring of railway infrastructures

Proc. SPIE. 9157, 23rd International Conference on Optical Fibre Sensors

KEYWORDS: Optical fibers, Safety, Scattering, Sensors, Diagnostics, Fiber optics sensors, Structural health monitoring, Bridges, Spatial resolution, System integration

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PROCEEDINGS ARTICLE | June 2, 2014

Brillouin optical frequency domain analysis in polymer optical fiber

Proc. SPIE. 9157, 23rd International Conference on Optical Fibre Sensors

KEYWORDS: Optical fibers, Modulation, Fiber Bragg gratings, Scattering, Polymer optical fibers, Spatial resolution, Bragg cells, Laser beam diagnostics, Phase only filters, Temperature metrology

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PROCEEDINGS ARTICLE | March 8, 2014

Optofluidic hybrid platform with integrated solid core waveguides

Proc. SPIE. 8988, Integrated Optics: Devices, Materials, and Technologies XVIII

KEYWORDS: Optical fibers, Microfluidics, Polymethylmethacrylate, Waveguides, Polymers, Luminescence, Silicon, Solids, Integrated optics, Liquids

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PROCEEDINGS ARTICLE | March 6, 2014

Liquid jet waveguide for Raman spectroscopy

Proc. SPIE. 8976, Microfluidics, BioMEMS, and Medical Microsystems XII

KEYWORDS: Waveguides, Sensors, Water, Capillaries, Spectroscopy, Chemical compounds, Raman spectroscopy, Chemical analysis, Signal detection, Liquids

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PROCEEDINGS ARTICLE | March 6, 2014

A newly designed optical biochip for a TDM-POCT device

Proc. SPIE. 8976, Microfluidics, BioMEMS, and Medical Microsystems XII

KEYWORDS: Refractive index, Optical design, Prisms, Microfluidics, Polymethylmethacrylate, Polymers, Luminescence, Ocean optics, Time division multiplexing, Adhesives

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PROCEEDINGS ARTICLE | May 20, 2013

Optofluidics: a new tool for sensing

Proc. SPIE. 8794, Fifth European Workshop on Optical Fibre Sensors

KEYWORDS: Refractive index, Microfluidics, Mach-Zehnder interferometers, Resonators, Waveguides, Cladding, Sensors, Silicon, Integrated optics, Liquids

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PROCEEDINGS ARTICLE | May 20, 2013

Modal analysis of a cantilever beam by use of the slope-assisted BOTDA method for damage identification

Proc. SPIE. 8794, Fifth European Workshop on Optical Fibre Sensors

KEYWORDS: Modulation, Sensors, Fiber optics sensors, Solids, Structural health monitoring, Modal analysis, Finite element methods, Shape analysis, Beam shaping, Spatial resolution

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PROCEEDINGS ARTICLE | May 20, 2013

Railway traffic monitoring using Brillouin distributed sensors

Proc. SPIE. 8794, Fifth European Workshop on Optical Fibre Sensors

KEYWORDS: Optical fibers, Safety, Scattering, Sensors, Single mode fibers, Fiber optics sensors, Optical testing, Data acquisition, Distance measurement, Spatial resolution

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PROCEEDINGS ARTICLE | March 9, 2013

Integrated liquid jet waveguide for fluorescence spectroscopy on chip

Proc. SPIE. 8615, Microfluidics, BioMEMS, and Medical Microsystems XI

KEYWORDS: Optical fibers, Microfluidics, Waveguides, Sensors, Calibration, Water, Luminescence, Fluorescence spectroscopy, Signal detection, Liquids

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PROCEEDINGS ARTICLE | March 6, 2013

Optofluidic fiber optic

Proc. SPIE. 8627, Integrated Optics: Devices, Materials, and Technologies XVII

KEYWORDS: Optical fibers, Refractive index, Microfluidics, Waveguides, Fiber optics, Optical properties, Cladding, Optical testing, Liquids, Near field optics

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PROCEEDINGS ARTICLE | February 2, 2012

Optofluidics: waveguides and devices

Proc. SPIE. 8264, Integrated Optics: Devices, Materials, and Technologies XVI

KEYWORDS: Refractive index, Microfluidics, Mach-Zehnder interferometers, Resonators, Waveguides, Cladding, Silicon, Integrated optics, Semiconducting wafers, Liquids

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PROCEEDINGS ARTICLE | February 1, 2012

Micro flow cytometer with 3D hydrodynamic focusing

Proc. SPIE. 8212, Frontiers in Biological Detection: From Nanosensors to Systems IV

KEYWORDS: Optical fibers, Microfluidics, Polymethylmethacrylate, Rhodamine B, Particles, Luminescence, Numerical simulations, 3D metrology, Micro cutting, 3D image processing

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PROCEEDINGS ARTICLE | May 17, 2011

Centimeter-range spatial resolution distributed sensing by BOFDA

Proc. SPIE. 7753, 21st International Conference on Optical Fiber Sensors

KEYWORDS: Optical fibers, Modulation, Scattering, Sensors, Error analysis, Distortion, Fiber optics sensors, Numerical analysis, Spatial resolution, Acoustics

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PROCEEDINGS ARTICLE | January 17, 2011

Liquid core integrated ring resonator

Proc. SPIE. 7943, Silicon Photonics VI

KEYWORDS: Optical fibers, Refractive index, Microfluidics, Finite-difference time-domain method, Resonators, Waveguides, Brain-machine interfaces, Semiconducting wafers, Light wave propagation, Liquids

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PROCEEDINGS ARTICLE | September 9, 2010

Bridge monitoring by Brillouin-based distributed strain measurements

Proc. SPIE. 7653, Fourth European Workshop on Optical Fibre Sensors

KEYWORDS: Optical fibers, Safety, Scattering, Sensors, Fiber optics sensors, Optical testing, Solids, Bridges, Spatial resolution, Prototyping

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PROCEEDINGS ARTICLE | September 9, 2010

Extension of the maximum measuring range in distributed Brillouin fiber sensors by tuning the Stokes/anti-Stokes power ratio

Proc. SPIE. 7653, Fourth European Workshop on Optical Fibre Sensors

KEYWORDS: Optical fibers, Scattering, Sensors, Distortion, Fiber optics sensors, Optical simulations, Picosecond phenomena, Laser beam diagnostics, Beam propagation method, Protactinium

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PROCEEDINGS ARTICLE | February 17, 2010

Waveguide based optofluidics

Proc. SPIE. 7606, Silicon Photonics V

KEYWORDS: Refractive index, Mach-Zehnder interferometers, Waveguides, Cladding, Silicon, Atomic layer deposition, Brain-machine interfaces, Semiconducting wafers, Multimode interference devices, Liquids

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PROCEEDINGS ARTICLE | October 14, 2009

Dynamic strain measurement at randomly addressed optical fiber positions using a time-domain Brillouin sensing system

Proc. SPIE. 7503, 20th International Conference on Optical Fibre Sensors

KEYWORDS: Optical fibers, Modulation, Scattering, Sensors, Modulators, Fiber optics sensors, Optical testing, Sensing systems, Spatial resolution, Laser beam diagnostics

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PROCEEDINGS ARTICLE | May 18, 2009

Pump depletion reduction technique for extended-range distributed Brillouin fiber sensors

Proc. SPIE. 7356, Optical Sensors 2009

KEYWORDS: Sensors, Signal attenuation, Distortion, Fiber optics sensors, Numerical analysis, Solids, Picosecond phenomena, Laser beam diagnostics, Electrooptic modulators

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PROCEEDINGS ARTICLE | May 18, 2009

Perfluorinated polymer optical fiber tapers for fluorescence collection

Proc. SPIE. 7356, Optical Sensors 2009

KEYWORDS: Refractive index, Polymethylmethacrylate, Scattering, Cladding, Glasses, Luminescence, Light scattering, Semiconductor lasers, Mie scattering, Polymer optical fibers

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PROCEEDINGS ARTICLE | February 21, 2009

Polymer optical fiber tapers for biosensing applications

Proc. SPIE. 7173, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications IX

KEYWORDS: Multimode fibers, Optical fibers, Refractive index, Biosensing, Cladding, Polymers, Glasses, Semiconductor lasers, Absorbance, Polymer optical fibers

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PROCEEDINGS ARTICLE | February 9, 2007

Integrated silicon optical sensors based on hollow core waveguide

Proc. SPIE. 6477, Silicon Photonics II

KEYWORDS: Refractive index, Proteins, Waveguides, Cladding, Luminescence, Silicon, Absorbance, Semiconducting wafers, Hollow waveguides, Liquids

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PROCEEDINGS ARTICLE | May 23, 2005

High-resolution distributed fiber-optic frequency-domain Brillouin sensing

Proc. SPIE. 5855, 17th International Conference on Optical Fibre Sensors

KEYWORDS: Data modeling, Modulation, Fiber optics, Scattering, Sensors, Fiber optics sensors, Reconstruction algorithms, Acoustics, Electro optical modeling, Temperature metrology

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PROCEEDINGS ARTICLE | March 31, 2005

Polymer-on-glass waveguide structure for efficient fluorescence-based optical biosensors

Proc. SPIE. 5728, Integrated Optics: Devices, Materials, and Technologies IX

KEYWORDS: Optical filters, Refractive index, Waveguides, Sensors, Polymers, Luminescence, Integrated optics, Planar waveguides, Optical biosensors, Polymer multimode waveguides

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PROCEEDINGS ARTICLE | June 9, 2004

Fiber Bragg grating as ultrasonic wave sensors

Proc. SPIE. 5502, Second European Workshop on Optical Fibre Sensors

KEYWORDS: Refractive index, Modulation, Fiber Bragg gratings, Sensors, Ultrasonography, Reflectivity, Distortion, Ultrasonics, Wave sensors, Acoustics

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PROCEEDINGS ARTICLE | June 9, 2004

Distributed fiber optic Brillouin sensing in the frequency domain

Proc. SPIE. 5502, Second European Workshop on Optical Fibre Sensors

KEYWORDS: Optical fibers, Data modeling, Modulation, Fiber optics, Scattering, Fiber optics sensors, Signal processing, Reconstruction algorithms, Acoustics, Fiber optics tests

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SPIE Journal Paper | September 1, 2002

Reconstruction technique for stimulated Brillouin scattering distributed fiber-optic sensors

Bernini, Romeo , Minardo, Aldo , Zeni, Luigi

OE Vol. 41 Issue 09

KEYWORDS: Reconstruction algorithms, Temperature metrology, Error analysis, Solids, Scattering, Optical engineering, Fiber optics sensors, Sensors, Spectroscopy

PROCEEDINGS ARTICLE | February 22, 2002

Novel data analysis approach for temperature and strain profile reconstruction in distributed fiber optics sensors based on stimulated Brillouin scattering

Proc. SPIE. 4576, Advanced Environmental Sensing Technology II

KEYWORDS: Optical fibers, Scattering, Sensors, Signal attenuation, Fiber optics sensors, Reconstruction algorithms, Spatial resolution, Temperature metrology, Data analysis

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PROCEEDINGS ARTICLE | February 14, 2002

ARROW waveguides-based refractometer for chemical and biochemical sensing application

Proc. SPIE. 4578, Fiber Optic Sensor Technology and Applications 2001

KEYWORDS: Refractive index, Biosensing, Waveguides, Cladding, Sensors, Signal attenuation, Silicon, Integrated optics, Biological and chemical sensing, Standards development

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PROCEEDINGS ARTICLE | November 2, 2000

Optical characterization of doping profiles in silicon

Proc. SPIE. 4099, Optical Metrology Roadmap for the Semiconductor, Optical, and Data Storage Industries

KEYWORDS: Semiconductors, Scattering, Dielectrics, Silicon, Doping, Infrared spectroscopy, Infrared radiation, Reconstruction algorithms, Algorithm development, Inverse optics

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Showing 5 of 41 publications

Conference Committee Involvement (5)

Integrated Optics: Devices, Materials, and Technologies XXIII

2 February 2019 | San Francisco, California, United States

Integrated Optics: Devices, Materials, and Technologies XXII

29 January 2018 | San Francisco, California, United States

Integrated Optics: Devices, Materials, and Technologies XXI

30 January 2017 | San Francisco, California, United States

Integrated Optics: Devices, Materials, and Technologies XX

15 February 2016 | San Francisco, California, United States

Integrated Optics: Devices, Materials, and Technologies XIX

9 February 2015 | San Francisco, California, United States

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