A boundary element method with dual reciprocity method (BEM-DRM) was used to model fluorescence in tissue using
coupled diffusion equations in 3D. This method eliminates the need for node connectivity in a volume mesh of arbitrary
shapes, requiring instead, a surface mesh with interior points to model the fluorescence source in 3D. Results using
BEM-DRM show agreement with data from open source finite-element based software package <i>NIRFAST</i><sup>7</sup> with mean
error difference of 0.08 for optimally chosen support parameter for radial basis functions used.