We report our continued study of phase-contrast diffuse optical tomography (PCCDOT) for evaluating its
fidelity in distinguishing malignant breast lesions form benign ones. 144 breast masses were examined
from 134 patients, aging from 22~82 with the mean age of 56. Tissue optical parameters including
refractive index, and absorption and scattering coefficients, were obtained and compared with their
corresponding biopsy/pathology reports. In consistent with our previous study, malignant masses tended to
have a decreased refractive index relative to their surrounding normal tissue, which acts as the key
character to differentiate them from benign masses. The results show that the specificity is improved
significantly over the previous smaller scale study (85% vs. 70%) due to the addition of significantly more
benign cases, while the sensitivity stays about the same (81% vs. 82%) due to the similar number of
malignant cases used compared to the smaller scale study.
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