Ms. Sakshi Sakshi Profile

Sakshi Sakshi

at Indian Institute of Technology (ISM) Dhanbad

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 16 October 2019 Paper

Nonlinear property of neurotransmitter dopamine probed by Z-scan technique

Sakshi Sakshi, Umakanta Tripathy

Proceedings Volume 11205, 112052L (2019) https://doi.org/10.1117/12.2542163

KEYWORDS: Absorption, Neurotransmitters, Thermal effects, Transmittance, Refractive index, Continuous wave operation, Brain, Phase shifts, Parkinson's disease, Molecules

Read Abstract +

The monoamine neurotransmitter dopamine-containing cells originate at the brain’s mesencephalic-diencephalic junction and project to several forebrain targets. Within the central nervous system, dopamine plays a crucial role in reward, motivation and motor control. In the periphery, it is involved in renal vasodilation, natriuresis, and diuresis. Dysfunction in dopaminergic neurotransmission has been implicated in several neurological and psychiatric conditions including mood disorders, schizophrenia, Parkinson's disease, and obsessive-compulsive disorder. It is imperative to understand the property of such a key brain molecule. Therefore, here, we use a continuous-wave (CW) laser closed-aperture (CA) Zscan technique to unravel the nonlinear property of dopamine at physiological condition (pH~7.4). Interestingly, we observe that dopamine shows nonlinearity when exposed to various input laser intensity. We attribute the origin of observed nonlinearity majorly governed by saturated atomic absorption mechanism along with insignificant contribution from thermal lensing effect. Our approach is simple and robust, and our observations have opened up new avenues for investigating dopaminergic processes by utilizing its nonlinear property. This study is of immense importance to researchers in the fields of nonlinear optics, biophysics, and neuroscience.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years