Prof. Samuel Achilefu
Professor/Radiology & Lab Chief at Washington Univ in St Louis
SPIE Involvement:
Fellow status | Conference Program Committee | Conference Chair | Journal Editorial Board Member | Author | Editor | Instructor | Student Chapter Advisor
Area of Expertise:
Molecular Imaging , Molecular Probes , Fluorescence Lifetime , Spectroscopy , Small animal , Microscopy
Profile Summary

Dr. Achilefu is Professor of Radiology, Biomedical Engineering, Biochemistry, and Molecular Biophysics, as well as the Director of Optical Radiology Lab (ORL) at Washington University in St. Louis. The ORL uses a multidisciplinary approach to address important biomedical problems and provide interdisciplinary training to students and postdoctoral fellows. ORL is particularly interested in developing molecular systems and methods to detect diseases at early stages, prevent disease complications, and implement tailored therapeutic regimen. Areas of interest include molecular optical imaging of tumors and angiogenesis as well as the design and development of new molecular probes and nanomaterials for imaging the expression of aberrant genes, proteins, and other pathophysiologic processes. Specific delivery of imaging agents and drugs to target cell organelles or tissue is another area of interest. In addition, the research program involves the biological evaluation of the new materials to assess ligand trafficking in cells, cytotoxicity, cell proliferation, subcellular distribution, enzyme kinetics, and activation of specific molecular pathways in cells. Small animal molecular imaging of pathologic tissues with state-of-the-art optical imaging systems provides preclinical data before human studies. ORL is also interested in developing tissue-specific multi-modal imaging molecules that harness the strengths of optical with other imaging methods such as MRI and PET. Instrument development is a significant part of our research. The lab has a multidisciplinary team of investigators with expertise in a wide range of fields, including chemistry, molecular and cell biology, biochemistry, physics, engineering, veterinary medicine, pathology, and immunology. Collaboration with other labs and institutions is highly encouraged. Dr. Achilefu has published more than 150 scientific papers and received more than 50 US patents as an inventor. He is a Fellow of the SPIE.
Publications (100)

SPIE Journal Paper | October 5, 2018
JBO Vol. 23 Issue 10
KEYWORDS: Surgery, Tumors, Cancer, Imaging systems, In vivo imaging, Luminescence, Tissues, Colorectal cancer, Pancreatic cancer, Pathology

PROCEEDINGS ARTICLE | February 20, 2018
Proc. SPIE. 10508, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications X
KEYWORDS: Gold, Nanoparticles, Metals, Lung, In vivo imaging, Nanocrystals, Signal detection, Single photon emission computed tomography

PROCEEDINGS ARTICLE | February 20, 2018
Proc. SPIE. 10508, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications X
KEYWORDS: Near infrared, Cancer, Tumors, Nanoparticles, Luminescence, Silver, Quantum dots, Toxicity, In vivo imaging, Nanomaterial synthesis

PROCEEDINGS ARTICLE | February 20, 2018
Proc. SPIE. 10508, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications X
KEYWORDS: Confocal microscopy, Near infrared, Cancer, Breast cancer, Tumors, Imaging systems, Luminescence, Chemistry, Near infrared spectroscopy, In vivo imaging

SPIE Journal Paper | June 14, 2017
JBO Vol. 22 Issue 06
KEYWORDS: Skin cancer, In vivo imaging, Luminescence, Molecular imaging, Skin, Tumors, Pathology, Tissue optics, Melanoma, Image processing

Showing 5 of 100 publications
Conference Committee Involvement (34)
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XI
4 February 2019 | San Francisco, California, United States
Optical Tomography and Spectroscopy of Tissue XIII
4 February 2019 | San Francisco, California, United States
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications X
29 January 2018 | San Francisco, California, United States
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IX
30 January 2017 | San Francisco, California, United States
Optical Tomography and Spectroscopy of Tissue XII
30 January 2017 | San Francisco, California, United States
Showing 5 of 34 published special sections
Course Instructor
SC313: Introduction to Chemistry and Biochemistry of Photodiagnostic and Phototherapeutic Agents
Diverse optical diagnostic and therapeutic agents are currently in development for biomedical applications. Some applications are effective with endogenous photoactive residues, others require the use of exogenous products that absorb or emit light in the region of interest. This course introduces the audience to the design and use of exogenous optical agents for various medical interventions, and highlights cases where exogenous photoactive agents are needed. The course also gives an overview of the status of diverse photoactive agents in clinical and pre-clinical settings. The concept of "photomedicine", where optical agents are used for therapy and diagnosis, is introduced. A comparison of optical modality with established imaging modalities (nuclear medicine, MRI, X-ray, and ultrasound) is presented, with emphasis in areas of complementarity.
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