Dr. Samuel Mabbott Profile

Dr. Samuel Mabbott

at Texas A&M Univ

SPIE Involvement:

Author

Publications (8)

Proceedings Article | 16 March 2023 Presentation + Paper

Paper fluidic platform with dual-optical readouts to detect microRNA-20a (miR-20a) for preeclampsia

Nandita Chaturvedi, Alyssa Kunkel, Monika Schechinger, Samuel Mabbott, Mahua Choudhury, Gerard Coté

Proceedings Volume 12387, 123870G (2023) https://doi.org/10.1117/12.2648423

KEYWORDS: Gold nanoparticles, Surface enhanced Raman spectroscopy, Absorbance, Visualization, Microfluidics, RGB color model, Visual analytics, Target detection, Raman spectroscopy, Raman scattering, Colorimetry, Cardiovascular disorders, Nucleic acids, Diagnostics

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SPIE Journal Paper | 26 September 2022 Open Access

Portable, multi-modal Raman and fluorescence spectroscopic platform for point-of-care applications

Cyril Soliman, Dandan Tu, Samuel Mabbott, Gerard Coté, Kristen Maitland

JBO, Vol. 27, Issue 09, 095006, (September 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.9.095006

KEYWORDS: Raman spectroscopy, Luminescence, Spectrometers, Surface enhanced Raman spectroscopy, Spectroscopy, Fluorescence spectroscopy, Spectroscopes, Spectral resolution, Light emitting diodes, Diagnostics

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Proceedings Article | 2 March 2022 Presentation + Paper

A low-cost, paper fluidic platform to detect B-type Natriuretic Peptide (BNP) for Congestive Heart Failure (CHF)

Nandita Chaturvedi, Rebekah Arias, Dandan Tu, Samuel Mabbott, Gerard Coté

Proceedings Volume 11968, 1196805 (2022) https://doi.org/10.1117/12.2607695

KEYWORDS: Heart, Nanoparticles, Measurement devices, Visualization, Signal detection, Raman spectroscopy, Raman scattering, RGB color model, Monoclonal antibodies, Gold

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Proceedings Article | 5 March 2021 Presentation + Paper

Towards point-of-care detection of microRNAs using paper-based microfluidics

Siddhant Jaitpal, Suhash Chavva, Samuel Mabbott

Proceedings Volume 11651, 116510C (2021) https://doi.org/10.1117/12.2589180

KEYWORDS: Microfluidics, Point-of-care devices, Surface enhanced Raman spectroscopy, Raman spectroscopy, Nanoparticles, Spectroscopy, Spectroscopes, Signal detection, Signal analyzers, Raman scattering

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SPIE Journal Paper | 20 December 2016 Open Access

Ferric plasmonic nanoparticles, aptamers, and magnetofluidic chips: toward the development of diagnostic surface-enhanced Raman spectroscopy assays

Haley Marks, Po-Jung Huang, Samuel Mabbott, Duncan Graham, Jun Kameoka, Gerard Coté

JBO, Vol. 21, Issue 12, 127005, (December 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.12.127005

KEYWORDS: Nanoparticles, Surface enhanced Raman spectroscopy, Particles, Magnetism, Nickel, Plasmonics, Raman spectroscopy, Iron, Silver, Nanolithography

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Proceedings Article | 22 April 2016 Presentation + Paper

Engineering molecularly-active nanoplasmonic surfaces for DNA detection via colorimetry and Raman scattering

Esmaeil Heydari, Samuel Mabbott, David Thompson, Duncan Graham, Jonathan Cooper, Alasdair Clark

Proceedings Volume 9721, 972105 (2016) https://doi.org/10.1117/12.2209108

KEYWORDS: Plasmonics, Nanoparticles, Scanning probe lithography, Gold, Silver, Biosensors, Target detection, Optical lithography, Colorimetry, Raman scattering

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Proceedings Article | 22 April 2016 Presentation + Paper

Comparison of Fe2O3 and Fe2CoO4 core-shell plasmonic nanoparticles for aptamer mediated SERS assays

Haley Marks, Samuel Mabbott, Po-Jung Huang, George Jackson, Jun Kameoka, Duncan Graham, Gerard Coté

Proceedings Volume 9722, 97220N (2016) https://doi.org/10.1117/12.2213735

KEYWORDS: Nanoparticles, Surface enhanced Raman spectroscopy, Particles, Magnetism, Raman spectroscopy, Silver, Plasmonics, Nanolithography, Microfluidics, Iron

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Proceedings Article | 12 March 2015 Paper

SERS active colloidal nanoparticles for the detection of small blood biomarkers using aptamers

Haley Marks, Samuel Mabbott, George Jackson, Duncan Graham, Gerard Cote

Proceedings Volume 9338, 93381C (2015) https://doi.org/10.1117/12.2078869

KEYWORDS: Nanoparticles, Surface enhanced Raman spectroscopy, Silver, Particles, Raman spectroscopy, Magnetism, Molecules, Blood, Nanolithography, Nanoprobes

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Functionalized colloidal nanoparticles for SERS serve as a promising multifunctional assay component for blood biomarker detection. Proper design of these nanoprobes through conjugation to spectral tags, protective polymers, and sensing ligands can provide experimental control over the sensitivity, range, reproducibility, particle stability, and integration with biorecognition assays. Additionally, the optical properties and degree of electromagnetic SERS signal enhancement can be altered and monitored through tuning the nanoparticle shape, size, material and the colloid’s local surface plasmon resonance (LSPR). Aptamers, synthetic affinity ligands derived from nucleic acids, provide a number of advantages for biorecognition of small molecules and toxins with low immunogenicity. DNA aptamers are simpler and more economical to produce at large scale, are capable of greater specificity and affinity than antibodies, are easily tailored to specific functional groups, can be used to tune inter-particle distance and shift the LSPR, and their intrinsic negative charge can be utilized for additional particle stability.1,2 Herein, a “turn-off” competitive binding assay platform involving two different plasmonic nanoparticles for the detection of the toxin bisphenol A (BPA) using SERS is presented. A derivative of the toxin is immobilized onto a silver coated magnetic nanoparticle (Ag@MNP), and a second solid silver nanoparticle (AgNP) is functionalized with the BPA aptamer and a Raman reporter molecule (RRM). The capture (Ag@MNP) and probe (AgNP) particles are mixed and the aptamer binding interaction draws the nanoparticles closer together, forming an assembly that results in an increased SERS signal intensity. This aptamer mediated assembly of the two nanoparticles results in a 100x enhancement of the SERS signal intensity from the RRM. These pre-bound aptamer/nanoparticle conjugates were then exposed to BPA in free solution and the competitive binding event was monitored by the decrease in SERS intensity.

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