Prof. Sehyun Shin Profile

Prof. Sehyun Shin

at Korea Univ

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Author

Publications (6)

PROCEEDINGS ARTICLE | March 9, 2016

Study of erythrocyte membrane fluctuation using light scattering analysis

Proc. SPIE. 9718, Quantitative Phase Imaging II

KEYWORDS: Diffraction, Biomedical optics, Statistical analysis, Spatial frequencies, Scattering, Blood, Light scattering, Diagnostics, Image sensors, Picosecond phenomena

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SPIE Journal Paper | March 1, 2010

Comparison of light-transmission and -backscattering methods in the measurement of red blood cell aggregation

Nam, Jeong-Hun , Yang, Yijie , Chung, Seok , Shin, Sehyun

JBO Vol. 15 Issue 02

KEYWORDS: Backscatter, Blood, Artificial intelligence, Polarizers, Polarization, Laser optics, Light scattering, Multiple scattering, Photodiodes, Semiconductor lasers

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PROCEEDINGS ARTICLE | February 25, 2006

Early diagnosis of diabetic vascular complications: impairment of red blood cell deformability

Proc. SPIE. 6080, Advanced Biomedical and Clinical Diagnostic Systems IV

KEYWORDS: Diffraction, Cameras, Blood, Semiconductor lasers, CCD cameras, Pathogens, Kidney, Chemical elements, Liquids, Protactinium

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Reduced deformability of red blood cells (RBCs) may play an important role on the pathogenesis of chronic vascular complications of diabetes mellitus. However, available techniques for measuring RBC deformability often require washing process after each measurement, which is not optimal for day-to-day clinical use at point of care. The objectives of the present study are to develop a device and to delineate the correlation of impaired RBC deformability with diabetic nephropathy. We developed a disposable ektacytometry to measure RBC deformability, which adopted a laser diffraction technique and slit rheometry. The essential features of this design are its simplicity (ease of operation and no moving parts) and a disposable element which is in contact with the blood sample. We studied adult diabetic patients divided into three groups according to diabetic complications. Group I comprised 57 diabetic patients with normal renal function. Group II comprised 26 diabetic patients with chronic renal failure (CRF). Group III consisted of 30 diabetic subjects with end-stage renal disease (ESRD) on hemodialysis. According to the renal function for the diabetic groups, matched non-diabetic groups were served as control. We found substantially impaired red blood cell deformability in those with normal renal function (group I) compared to non-diabetic control (P = 0.0005). As renal function decreases, an increased impairment in RBC deformability was found. Diabetic patients with chronic renal failure (group II) when compared to non-diabetic controls (CRF) had an apparently greater impairment in RBC deformability (P = 0.07). The non-diabetic cohort (CRF), on the other hand, manifested significant impairment in red blood cell deformability compared to healthy control (P = 0.0001). The newly developed slit ektacytometer can measure the RBC deformability with ease and accuracy. In addition, progressive impairment in cell deformability is associated with renal function loss in all patients regardless of the presence or absence of diabetes. In diabetic patients, early impairment in RBC deformability appears in patients with normal renal function.

PROCEEDINGS ARTICLE | December 6, 2005

Hemodynamic investigation on blood flow in a rugged microchannel

Proc. SPIE. 6050, Optomechatronic Micro/Nano Devices and Components

KEYWORDS: Microfluidics, Visualization, Blood, Particles, Computing systems, CCD cameras, Blood circulation, Hemodynamics, Spatial resolution, Velocity measurements

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PROCEEDINGS ARTICLE | February 16, 2005

Disposable biosensor for measuring red blood cell deformability using laser-diffraction technique

Proc. SPIE. 5651, Biomedical Applications of Micro- and Nanoengineering II

KEYWORDS: Diffraction, Cameras, Blood, Biosensors, Control systems, Semiconductor lasers, CCD cameras, Chemical elements, Frame grabbers, Protactinium

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PROCEEDINGS ARTICLE | January 18, 2005

Disposable laser-diffraction ektacytometry to measure red blood cell deformability

Proc. SPIE. 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II

KEYWORDS: Diffraction, Cameras, Blood, Computing systems, Control systems, Semiconductor lasers, CCD cameras, Data acquisition, Frame grabbers, Protactinium

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