PAL-XFEL has operated general user program successfully from 2017 in both hard (2.5 – 14 keV) and soft (250 – 1300 eV) X-ray beamlines. Particularly in Soft X-ray Scattering and Spectroscopy (SSS) beamline, X-ray absorption and emission spectroscopy (XAS / XES) endstation has conducted general user programs.
In SSS beamline, second experimental instrument, Resonant Soft X-ray Scattering (RSXS) endstation, was built and open from 2020. This endstation mainly supports optical laser pump (800-nm-wavelength and harmonics) soft X-ray probe (400-1300 eV, covers 3d transition metal L2,3-edge, O K-edge, and part of 5f rare-earth element M4,5-edge) time-resolved RSXS experiments, with a time resolution better than 100 fs. Within less than a year, there have been several successful experiments, mainly in 3d transition metal compounds which are important magnetic and strongly correlated materials. The details of the endstation and selected experimental results will be introduced in the presentation.
Surgical resection is the primary treatment for malignant brain tumors. This procedure has a dilemma—aggressive surgical resection tends to extend patient survival; however, it also increases the risk of neurological deficiencies. Current medical imaging methods are not sensitive and their interpretation largely depend on surgeon’s impression. High-speed cellular imaging method by using clinically applicable moxifloxacin was demonstrated for fast and sensitive tumor-detection. The detailed cytoarchitecture of brain tumor mouse model and malignant human brain tumors was revealed. This study showed the potential and feasibility of moxifloxacin-based confocal microscopy as a surgery-guiding method for tumor removal.
Dermal filler injections are common skin cosmetic procedure, but intravascular injection of fillers can lead to various complications. Therefore, real-time imaging of vessels and fillers will be helpful to lower the complications. In this study, angiographic optical coherence tomography (A-OCT) was used for real-time visualization of vessels and fillers. This method was demonstrated in an in vivo mouse model by monitoring filler injection in the tail. The locations of main artery and fillers were identified by A-OCT imaging before and after injection. Our study suggests that the real-time angiographic OCT can serve as a useful tool for filler injection guide.