Dr. Sergei G. Kazarian Profile

Dr. Sergei G. Kazarian

at Imperial College London

SPIE Involvement:

Author

Publications (10)

Proceedings Article | 9 March 2015 Paper

Assessing dysplasia of a bronchial biopsy with FTIR spectroscopic imaging

Liberty Foreman, James Kimber, Katherine Oliver, James Brown, Samuel Janes, Tom Fearn, Sergei Kazarian, Peter Rich

Proceedings Volume 9332, 93320S (2015) https://doi.org/10.1117/12.2078966

KEYWORDS: FT-IR spectroscopy, Biopsy, Imaging spectroscopy, Spectroscopy, Principal component analysis, Lung cancer, Tissues, Biological research, Raman spectroscopy, Signal to noise ratio

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Proceedings Article | 4 March 2014 Paper

Attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopic analysis of regenerated bone

Carolina Benetti, Sergei Kazarain, Marco Alves, Alberto Blay, Luciana Correa, Denise Zezell

Proceedings Volume 8926, 892641 (2014) https://doi.org/10.1117/12.2039915

KEYWORDS: Bone, FT-IR spectroscopy, Tissues, Spectroscopy, Carbonates, Laser cutting, Crystals, Surgery, Diamond, Statistical analysis

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SPIE Journal Paper | 1 July 2009 Open Access

Measurement of drug and macromolecule diffusion across atherosclerotic rabbit aorta ex vivo by attenuated total reflection-Fourier transform infrared imaging

Francesca Palombo, Charlene Danoux, Peter Weinberg, Sergei Kazarian

JBO, Vol. 14, Issue 04, 044008, (July 2009) https://doi.org/10.1117/12.10.1117/1.3174395

KEYWORDS: FT-IR spectroscopy, Tissues, Diffusion, Macromolecules, Absorbance, Spectroscopy, Imaging spectroscopy, Crystals, Molecules, Natural surfaces

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SPIE Journal Paper | 1 May 2009 Open Access

Errata: In situ permeation study of drug through the stratum corneum using attenuated total reflection Fourier transform infrared spectroscopic imaging

Jean-Michel Andanson, Sergei Kazarian, Jonathan Hadgraft

JBO, Vol. 14, Issue 03, 039801, (May 2009) https://doi.org/10.1117/12.10.1117/1.3157197

KEYWORDS: FT-IR spectroscopy, Fourier spectroscopy, Imaging spectroscopy, Spectroscopy, Chemical engineering, Pharmacy, Reflectivity

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SPIE Journal Paper | 1 May 2009 Open Access

In situ permeation study of drug through the stratum corneum using attenuated total reflectance Fourier transform infrared spectroscopic imaging

Jean-Michael Andanson, Jonathan Hadgraft, Sergei Kazarian

JBO, Vol. 14, Issue 03, 034011, (May 2009) https://doi.org/10.1117/12.10.1117/1.3130324

KEYWORDS: Skin, Diffusion, Bioalcohols, FT-IR spectroscopy, Infrared spectroscopy, Imaging spectroscopy, Spectroscopy, Sensors, Crystals, Absorbance

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SPIE Journal Paper | 1 November 2008 Open Access

Application of attenuated total reflection Fourier transform infrared imaging and tape-stripping to investigate the three-dimensional distribution of exogenous chemicals and the molecular organization in Stratum corneum

Mila Boncheva, Feng Tay, Sergei Kazarian

JBO, Vol. 13, Issue 06, 064009, (November 2008) https://doi.org/10.1117/12.10.1117/1.3006072

KEYWORDS: Skin, FT-IR spectroscopy, Absorbance, Imaging spectroscopy, Infrared imaging, Spectroscopy, Reflection, Proteins, Image resolution, Sensors

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SPIE Journal Paper | 1 July 2007 Open Access

Chemical imaging of the stratum corneum under controlled humidity with the attenuated total reflection Fourier transform infrared spectroscopy method

Andrew Chan, Sergei Kazarian

JBO, Vol. 12, Issue 04, 044010, (July 2007) https://doi.org/10.1117/12.10.1117/1.2754686

KEYWORDS: Humidity, Tissues, Skin, Proteins, Bioalcohols, FT-IR spectroscopy, Principal component analysis, Imaging spectroscopy, Liquids, Natural surfaces

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Proceedings Article | 28 September 2006 Paper

Fourier transform infared spectroscopic imaging for the identification of concealed drug residue particles and fingerprints

Camilla Ricci, K. L. Andrew Chan, Sergei Kazarian

Proceedings Volume 6402, 64020M (2006) https://doi.org/10.1117/12.689631

KEYWORDS: FT-IR spectroscopy, Particles, Imaging spectroscopy, Spectroscopy, Forensic science, Crystals, Infrared radiation, Spatial resolution, Staring arrays, Sensors

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Proceedings Article | 28 September 2006 Paper

Enhancing forensic science with spectroscopic imaging

Camilla Ricci, Sergei Kazarian

Proceedings Volume 6402, 64020J (2006) https://doi.org/10.1117/12.689429

KEYWORDS: FT-IR spectroscopy, Imaging spectroscopy, Spectroscopy, Forensic science, Tablets, Spatial resolution, Chemical analysis, Sensors, Particles, Staring arrays

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This presentation outlines the research we are developing in the area of Fourier Transform Infrared (FTIR) spectroscopic imaging with the focus on materials of forensic interest. FTIR spectroscopic imaging has recently emerged as a powerful tool for characterisation of heterogeneous materials. FTIR imaging relies on the ability of the military-developed infrared array detector to simultaneously measure spectra from thousands of different locations in a sample. Recently developed application of FTIR imaging using an ATR (Attenuated Total Reflection) mode has demonstrated the ability of this method to achieve spatial resolution beyond the diffraction limit of infrared light in air. Chemical visualisation with enhanced spatial resolution in micro-ATR mode broadens the range of materials studied with FTIR imaging with applications to pharmaceutical formulations or biological samples. Macro-ATR imaging has also been developed for chemical imaging analysis of large surface area samples and was applied to analyse the surface of human skin (e.g. finger), counterfeit tablets, textile materials (clothing), etc. This approach demonstrated the ability of this imaging method to detect trace materials attached to the surface of the skin. This may also prove as a valuable tool in detection of traces of explosives left or trapped on the surfaces of different materials. This FTIR imaging method is substantially superior to many of the other imaging methods due to inherent chemical specificity of infrared spectroscopy and fast acquisition times of this technique. Our preliminary data demonstrated that this methodology will provide the means to non-destructive detection method that could relate evidence to its source. This will be important in a wider crime prevention programme. In summary, intrinsic chemical specificity and enhanced visualising capability of FTIR spectroscopic imaging open a window of opportunities for counter-terrorism and crime-fighting, with applications ranging from analysis of trace evidence (e.g. in soil), tablets, drugs, fibres, tape explosives, biological samples to detection of gunshot residues and imaging of fingerprints.

Proceedings Article | 28 December 1999 Paper

In-situ spectroscopy of polymers processed with supercritical carbon dioxide

Sergei Kazarian, Christopher Lawrence, Brian Briscoe

Proceedings Volume 4060, (1999) https://doi.org/10.1117/12.375295

KEYWORDS: Polymers, Spectroscopy, Crystals, Carbon dioxide, FT-IR spectroscopy, Diamond, Microfluidics, Molecular interactions, Molecular spectroscopy, Infrared spectroscopy

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