Dr. Sergio Fantini Profile

Dr. Sergio Fantini

Professor at Tufts Univ

SPIE Involvement:

Fellow status | Senior status | Conference Program Committee | Conference Chair | Author

Websites:

Company Website

Profile Summary

Sergio Fantini is Professor of Biomedical Engineering and principal investigator of the “Diffuse Optical Imaging of Tissue Laboratory” (DOIT Lab) at Tufts University. The research in the DOIT Lab aims to develop non-invasive techniques based on diffuse optics to assess cerebral perfusion, detect breast cancer, and quantify skeletal muscle oxygenation. One technique developed in the DOIT Lab, coherent hemodynamics spectroscopy (CHS), exploits transients and oscillatory hemodynamic changes to extract physiological information on the investigated tissue. His research resulted in eleven patents and about two hundred scientific publications. He co-authored with Prof. Irving Bigio (Boston University) a textbook on “Quantitative Biomedical Optics.”

Publications (93)

PROCEEDINGS ARTICLE | February 13, 2018

Measurements of coherent hemodynamics to enrich the physiological information provided by near-infrared spectroscopy (NIRS) and functional MRI

Proc. SPIE. 10487, Multimodal Biomedical Imaging XIII

KEYWORDS: Magnetic resonance imaging, Spectroscopy, Wavelets, Fourier transforms, Data acquisition, Hemodynamics, Near infrared spectroscopy, Cerebral blood flow, Tissue optics, Functional magnetic resonance imaging

SPIE Journal Paper | April 21, 2017

Low-resolution mapping of the effective attenuation coefficient of the human head: a multidistance approach applied to high-density optical recordings

Chiarelli, Antonio , Maclin, Edward , Low, Kathy , Fantini, Sergio , Fabiani, Monica , Gratton, Gabriele

NPh Vol. 4 Issue 02

KEYWORDS: Sensors, Signal to noise ratio, Head, Absorption, Optical properties, Scattering, Light, Signal attenuation, In vivo imaging, Error analysis

PROCEEDINGS ARTICLE | March 24, 2017

Simultaneous and co-localized acousto-optic measurements of spectral and temporal properties of diffusive media

Proc. SPIE. 10059, Optical Tomography and Spectroscopy of Tissue XII

KEYWORDS: Modulation, Scattering, Ultrasonography, Light scattering, Oxygen, Ultrasonics, Blood circulation, Acousto-optics, Signal detection, Absorption

PROCEEDINGS ARTICLE | February 18, 2017

Individual response to neoadjuvant chemotherapy assessed with optical mammography in patients with breast cancer

Proc. SPIE. 10059, Optical Tomography and Spectroscopy of Tissue XII

KEYWORDS: Optical imaging, Breast, Cancer, Breast cancer, Tumors, Tissues, Imaging spectroscopy, Oxygen, Optical testing, Optical spectroscopy, Mammography, Geometrical optics, Tissue optics, Optical spectroscopy imaging, Diffuse optical imaging

PROCEEDINGS ARTICLE | February 18, 2017

Coherent hemodynamics spectroscopy: initial applications in the neurocritical care unit

Proc. SPIE. 10059, Optical Tomography and Spectroscopy of Tissue XII

KEYWORDS: Mathematical modeling, Data modeling, Tissues, Blood, Spectroscopy, Imaging spectroscopy, Optical spectroscopy, Hemodynamics, Near infrared spectroscopy, Cerebral blood flow, Tissue optics, Blood pressure, Autoregressive models, Optical spectroscopy imaging

PROCEEDINGS ARTICLE | February 17, 2017

Induced and spontaneous hemodynamic oscillations in cerebral and extracerebral tissue for coherent hemodynamics spectroscopy

Proc. SPIE. 10059, Optical Tomography and Spectroscopy of Tissue XII

KEYWORDS: Tissues, Blood, Capillaries, Spectroscopy, Hemodynamics, Near infrared spectroscopy, Skull, Brain stimulation, Phase measurement, Tissue optics, Blood pressure, Channel projecting optics, Brain

We report preliminary results of a study for investigating the spatial homogeneity of induced and spontaneous oscillations in the concentration of oxyhemoglobin on the scalp/skull layer of two human subjects. Hemodynamic oscillations were induced by modulation of arterial blood pressure, which triggers the cerebral autoregulation mechanism. Induced hemodynamic oscillations are used in coherent hemodynamics spectroscopy to derive physiological parameters of interest for medical diagnostics. For example, our dedicated mathematical model translates typical near-infrared spectroscopy observables, like the amplitude and phase relationship of the oscillations of oxy- and deoxyhemoglobin concentrations into capillary and venous blood transit times, cutoff frequency of the autoregulation process, and other parameters related to microvascular blood volume. In this study, we focused on the phase relationship between the oscillations of oxyhemoglobin concentrations in three optical channels, two of which feature a short (5 mm) source-detector separation (sampling the scalp/skull only) and the third one features a long (30 mm) source-detector separation (sampling both extracerebral and cerebral tissues). The two main goals of the study were: a) to compare the coherence of induced and spontaneous oscillations; b) to assess if induced and spontaneous oscillations may be assumed to be uniform in the extracerebral layer. This was assessed by studying the phase relationship of oscillations in oxyhemoglobin concentration at the two short source-detector separations. About point a) we verified that induced oscillations have a higher incidence of coherence than spontaneous oscillations: 74% for induced oscillations, and 30% for spontaneous oscillations. About point b) the results show an overall trend for both spontaneous and induced oscillations to be homogeneous or “quasi-homogeneous” in the extracerebral tissue; however, we observed cases where a significant non-zero phase difference was measured, indicating spatial heterogeneity. We propose a method for taking into account the possible inhomogeneous behavior of the oscillations in the scalp/skull in order to increase the accuracy of measurements of cerebral hemodynamic oscillations.

SPIE Journal Paper | June 21, 2016

Cerebral blood flow and autoregulation: current measurement techniques and prospects for noninvasive optical methods

Fantini, Sergio , Sassaroli, Angelo , Tgavalekos, Kristen , Kornbluth, Joshua

NPh Vol. 3 Issue 03

KEYWORDS: Blood, Tissues, Brain, Near infrared spectroscopy, Cerebral blood flow, Arteries, Data modeling, Tissue optics, Ultrasonography, Traumatic brain injury

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SPIE Journal Paper | March 28, 2016

Blood-pressure-induced oscillations of deoxy- and oxyhemoglobin concentrations are in-phase in the healthy breast and out-of-phase in the healthy brain

Tgavalekos, Kristen , Kainerstorfer, Jana , Sassaroli, Angelo , Fantini, Sergio

JBO Vol. 21 Issue 10

KEYWORDS: Breast, Brain, Blood, Hemodynamics, Tissues, Blood circulation, Near infrared spectroscopy, Oxygen, Tissue optics, Capillaries

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PROCEEDINGS ARTICLE | March 9, 2016

Non-invasive assessment of cerebral microcirculation with diffuse optics and coherent hemodynamics spectroscopy

Proc. SPIE. 9690, Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation

KEYWORDS: Modeling, Tissues, Capillaries, Oxygen, Blood circulation, Hemodynamics, Near infrared spectroscopy, Cerebral blood flow, Blood pressure, Diffuse optical imaging, Brain

SPIE Journal Paper | March 1, 2016

Optical oximetry of volume-oscillating vascular compartments: contributions from oscillatory blood flow

Kainerstorfer, Jana , Sassaroli, Angelo , Fantini, Sergio

JBO Vol. 21 Issue 10

KEYWORDS: Blood, Blood circulation, Oxygen, Hemodynamics, Oximetry, Biomedical optics, Tissues, Capillaries, Linear filtering, Near infrared spectroscopy

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SPIE Journal Paper | February 5, 2016

Optical mammography: bilateral breast symmetry in hemoglobin saturation maps

Anderson, Pamela , Sassaroli, Angelo , Kainerstorfer, Jana , Krishnamurthy, Nishanth , Kalli, Sirishma , Makim, Shital , Graham, Roger , Fantini, Sergio

JBO Vol. 21 Issue 10

KEYWORDS: Breast, Tissues, Mammography, Tissue optics, Cancer, Scattering, Data modeling, Biomedical optics, Chromophores, Breast cancer

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PROCEEDINGS ARTICLE | March 12, 2015

Optical mammography instrument for broadband spectral imaging with depth discrimination

Proc. SPIE. 9319, Optical Tomography and Spectroscopy of Tissue XI

KEYWORDS: Breast, Optical fibers, Breast cancer, Sensors, Silicon, Imaging spectroscopy, Optical testing, Mammography, Charge-coupled devices, Tissue optics

PROCEEDINGS ARTICLE | March 12, 2015

Functional near-infrared spectroscopy for adaptive human-computer interfaces

Proc. SPIE. 9319, Optical Tomography and Spectroscopy of Tissue XI

KEYWORDS: Unmanned aerial vehicles, Human-machine interfaces, Cognitive modeling, Data modeling, Calibration, Machine learning, Brain-machine interfaces, Near infrared spectroscopy, Adaptive control, Brain

PROCEEDINGS ARTICLE | March 12, 2015

Dynamic cerebral autoregulation measured with coherent hemodynamics spectroscopy (CHS)

Proc. SPIE. 9319, Optical Tomography and Spectroscopy of Tissue XI

KEYWORDS: Data modeling, Blood, Capillaries, Spectroscopy, Linear filtering, Time metrology, Hemodynamics, Near infrared spectroscopy, Cerebral blood flow, Autoregressive models

PROCEEDINGS ARTICLE | March 5, 2015

Broadband optical mammography: Breast tissue thickness compensation algorithm

Proc. SPIE. 9319, Optical Tomography and Spectroscopy of Tissue XI

KEYWORDS: Breast, Continuous wave operation, Tissues, Sensors, Silicon, Diffusion, Chromophores, Mammography, Tissue optics, Absorption

PROCEEDINGS ARTICLE | March 5, 2015

Comparison of linear and nonlinear models for coherent hemodynamics spectroscopy (CHS)

Proc. SPIE. 9319, Optical Tomography and Spectroscopy of Tissue XI

KEYWORDS: Mathematical modeling, Tissues, Blood, Capillaries, Spectroscopy, Oxygen, Blood circulation, Hemodynamics, Near infrared spectroscopy, Signal detection

PROCEEDINGS ARTICLE | March 5, 2015

3D parameter reconstruction in hyperspectral diffuse optical tomography

Proc. SPIE. 9319, Optical Tomography and Spectroscopy of Tissue XI

KEYWORDS: Mathematical modeling, Data modeling, Sensors, Image restoration, 3D modeling, Chromophores, Inverse problems, Optical tomography, Systems modeling, Absorption

SPIE Journal Paper | February 12, 2014

Reduced speed of microvascular blood flow in hemodialysis patients versus healthy controls: a coherent hemodynamics spectroscopy study

Pierro, Michele , Kainerstorfer, Jana , Civiletto, Amanda , Weiner, Daniel , Sassaroli, Angelo , Hallacoglu, Bertan , Fantini, Sergio

JBO Vol. 19 Issue 02

KEYWORDS: Hemodynamics, Blood, Near infrared spectroscopy, Control systems, Blood circulation, Capillaries, Spectroscopy, Cerebral blood flow, Tissue optics, Blood pressure

PROCEEDINGS ARTICLE | March 25, 2013

Applications of a novel hemodynamic model to functional brain studies with fNIRS and fMRI

Proc. SPIE. 8578, Optical Tomography and Spectroscopy of Tissue X

KEYWORDS: Data modeling, Blood, Capillaries, Oxygen, Signal processing, Blood circulation, Hemodynamics, Neuroimaging, Functional magnetic resonance imaging, Brain

PROCEEDINGS ARTICLE | March 25, 2013

Broadband optical mammography: visualization, oximetry, and depth assessment of blood vasculature

Proc. SPIE. 8578, Optical Tomography and Spectroscopy of Tissue X

KEYWORDS: Breast, X-ray optics, Sensors, Blood, Blood vessels, X-rays, Oxygen, Monte Carlo methods, Mammography, Tissue optics

PROCEEDINGS ARTICLE | March 25, 2013

Frequency-resolved measurements of hemodynamic oscillations and quantitative analysis with a novel hemodynamic model

Proc. SPIE. 8578, Optical Tomography and Spectroscopy of Tissue X

KEYWORDS: Data modeling, Blood, Capillaries, Oxygen, Quantitative analysis, Blood circulation, Hemodynamics, Near infrared spectroscopy, Tissue optics, Functional magnetic resonance imaging

PROCEEDINGS ARTICLE | March 25, 2013

Optical characterization of two-layered tissue-like phantoms using multi-distance, frequency domain near-infrared spectroscopy

Proc. SPIE. 8578, Optical Tomography and Spectroscopy of Tissue X

KEYWORDS: Data modeling, Optical properties, Scattering, Diffusion, Optical testing, Near infrared spectroscopy, Geometrical optics, Tissue optics, Signal detection, Absorption

SPIE Journal Paper | May 14, 2012

Absolute measurement of cerebral optical coefficients, hemoglobin concentration and oxygen saturation in old and young adults with near-infrared spectroscopy

Hallacoglu, Bertan , Sassaroli, Angelo , Fantini, Sergio , Wysocki, Michael , Guerrero-Berroa, Elizabeth , Beeri, Michal , Haroutunian, Vahram , Shaul, Merav , Rosenberg, Irwin , Troen, Aron

JBO Vol. 17 Issue 8

KEYWORDS: Tissues, Near infrared spectroscopy, Optical testing, Oxygen, Brain, Absorption, Optical properties, Biomedical optics, Tissue optics, Calibration

PROCEEDINGS ARTICLE | February 9, 2012

Relative phase of oscillations of cerebral oxy-hemoglobin and deoxy-hemoglobin concentrations during sleep

Proc. SPIE. 8207, Photonic Therapeutics and Diagnostics VIII

KEYWORDS: Human subjects, Electrodes, Heart, Hemodynamics, Near infrared spectroscopy, Phase measurement, Tissue optics, Signal analyzers, Absorption, Brain

PROCEEDINGS ARTICLE | March 3, 2011

Electrical stimulation of peripheral nerves induces optical responses via skeletal muscle kinematics

Proc. SPIE. 7896, Optical Tomography and Spectroscopy of Tissue IX

KEYWORDS: Optical fibers, Human subjects, Nerve, Sensors, Spectroscopy, Skin, Optical testing, Tissue optics, Motion models, Animal model studies

PROCEEDINGS ARTICLE | March 1, 2011

Non-invasive detection and quantification of brain microvascular deficits by near-infrared spectroscopy in a rat model of Vascular Cognitive Impairment

Proc. SPIE. 7896, Optical Tomography and Spectroscopy of Tissue IX

KEYWORDS: Cognitive modeling, Optical properties, Scattering, Blood, Oxygen, Hypoxia, Near infrared spectroscopy, Tissue optics, Absorption, Brain

Structural abnormalities in brain microvasculature are commonly associated with Alzheimer's Disease and other dementias. However, the extent to which structural microvascular abnormalities cause functional impairments in brain circulation and thereby to cognitive impairment is unclear. Non-invasive, near-infrared spectroscopy (NIRS) methods can be used to determine the absolute hemoglobin concentration and saturation in brain tissue, from which additional parameters such as cerebral blood volume (a theoretical correlate of brain microvascular density) can be derived. Validating such NIRS parameters in animal models, and understanding their relationship to cognitive function is an important step in the ultimate application of these methods to humans. To this end we applied a non-invasive multidistance NIRS method to determine the absolute concentration and saturation of cerebral hemoglobin in rat, by separately measuring absorption and reduced scattering coefficients without relying on pre- or post-correction factors. We applied this method to study brain circulation in folate deficient rats, which express brain microvascular pathology1 and which we have shown to develop cognitive impairment.2 We found absolute brain hemoglobin concentration ([HbT]) and oxygen saturation (StO2) to be significantly lower in folate deficient rats (n=6) with respect to control rats (n=5) (for [HbT]: 73±10 μM vs. 95±14 μM; for StO2: 55%±7% vs. 66% ±4%), implicating microvascular pathology and diminished oxygen delivery as a mechanism of cognitive impairment. More generally, our study highlights how noninvasive, absolute NIRS measurements can provide unique insight into the pathophysiology of Vascular Cognitive Impairment. Applying this method to this and other rat models of cognitive impairment will help to validate physiologically meaningful NIRS parameters for the ultimate goal of studying cerebral microvascular disease and cognitive decline in humans.

PROCEEDINGS ARTICLE | March 1, 2011

General perturbative approach to the diffusion equation in the presence of absorbing defects: frequency-domain and time-domain results

Proc. SPIE. 7896, Optical Tomography and Spectroscopy of Tissue IX

KEYWORDS: Lithium, Optical properties, Tissues, Scattering, Sensors, Photons, Diffusion, Fourier transforms, Monte Carlo methods, Absorption

PROCEEDINGS ARTICLE | February 17, 2011

Phase characterization of oscillatory components of the cerebral concentrations of oxy-hemoglobin and deoxy-hemoglobin

Proc. SPIE. 7896, Optical Tomography and Spectroscopy of Tissue IX

KEYWORDS: Human subjects, Hemodynamics, Near infrared spectroscopy, Phase measurement, Tissue optics, Signal analyzers, Functional magnetic resonance imaging, Absorption, Brain, Bandpass filters

PROCEEDINGS ARTICLE | February 17, 2011

Near-infrared optical mammography with broadband spectral imaging for spatially resolved oximetry

Proc. SPIE. 7896, Optical Tomography and Spectroscopy of Tissue IX

KEYWORDS: Breast, Optical fibers, Breast cancer, Tissues, Imaging spectroscopy, Mammography, Near infrared spectroscopy, Tissue optics, Oximetry, Absorption

SPIE Journal Paper | July 1, 2010

Phasor representation of oxy- and deoxyhemoglobin concentrations: what is the meaning of out-of-phase oscillations as measured by near-infrared spectroscopy?

Zheng, Feng , Sassaroli, Angelo , Fantini, Sergio

JBO Vol. 15 Issue 04

KEYWORDS: Tissues, Tissue optics, Near infrared spectroscopy, Phase shifts, Phase measurement, Absorption, Brain mapping, Brain, Human subjects, Brain activation

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SPIE Journal Paper | September 1, 2009

Noninvasive assessment of testicular torsion in rabbits using frequency-domain near-infrared spectroscopy: prospects for pediatric urology

Hallacoglu, Bertan , Matulewicz, Richard , Paltiel, Harriet , Padua, Horacio , Gargollo, Patricio , Cannon, Glenn , Alomari, Ahmad , Sassaroli, Angelo , Fantini, Sergio

JBO Vol. 14 Issue 05

KEYWORDS: Surgery, Testis, Tissues, Near infrared spectroscopy, Tissue optics, Absorption, Optical fibers, Scattering, Oxygen, Diagnostics

PROCEEDINGS ARTICLE | February 24, 2009

Spectral imaging of the human breast for quantitative oximetry

Proc. SPIE. 7174, Optical Tomography and Spectroscopy of Tissue VIII

KEYWORDS: Breast, Scattering, Image processing, Oxygen, Mammography, Absorbance, In vivo imaging, Spatial resolution, Tissue optics, Oximetry

PROCEEDINGS ARTICLE | February 24, 2009

Absolute near-infrared oximetry for urology: a quantitative study of the tissue hemoglobin saturation before and after testicular torsion in a rabbit model

Proc. SPIE. 7174, Optical Tomography and Spectroscopy of Tissue VIII

KEYWORDS: Optical fibers, Tissues, Surgery, Sensors, Oxygen, Near infrared spectroscopy, Tissue optics, Signal detection, Testis, Oximetry

PROCEEDINGS ARTICLE | February 24, 2009

Application of near-infrared spectroscopy for discrimination of mental workloads

Proc. SPIE. 7174, Optical Tomography and Spectroscopy of Tissue VIII

KEYWORDS: Optical fibers, Sensors, Heart, Electroencephalography, Human-computer interaction, Near infrared spectroscopy, Brain activation, Functional magnetic resonance imaging, Absorption, Data analysis

PROCEEDINGS ARTICLE | February 24, 2009

Near-infrared signals associated with electrical stimulation of peripheral nerves

Proc. SPIE. 7174, Optical Tomography and Spectroscopy of Tissue VIII

KEYWORDS: Biomedical optics, Nerve, Sensors, Diagnostics, Optical testing, Action potentials, Tissue optics, Visual optics, Signal detection, Brain

PROCEEDINGS ARTICLE | February 12, 2009

Fourth order perturbation theory for the diffusion equation: continuous wave results for absorbing defects

Proc. SPIE. 7174, Optical Tomography and Spectroscopy of Tissue VIII

KEYWORDS: Lithium, Optical properties, Tissues, Scattering, Sensors, Diffusion, Fourier transforms, Near infrared spectroscopy, Absorption

PROCEEDINGS ARTICLE | February 12, 2008

Data analysis and statistical tests for near-infrared functional studies of the brain

Proc. SPIE. 6850, Multimodal Biomedical Imaging III

KEYWORDS: Optical fibers, Error analysis, Computer simulations, Data processing, Hemodynamics, Near infrared spectroscopy, Brain activation, Functional near infrared spectroscopy, Data analysis, Brain

SPIE Journal Paper | September 1, 2007

Paired-wavelength spectral approach to measuring the relative concentrations of two localized chromophores in turbid media: an experimental study

Liu, Ning , Sassaroli, Angelo , Fantini, Sergio

JBO Vol. 12 Issue 05

KEYWORDS: Chromophores, Absorption, Scattering, Sensors, Tissues, Light scattering, Breast, Oxygen, Optical properties, Tumors

PROCEEDINGS ARTICLE | May 7, 2007

Concurrent NIRS-fMRI activation studies by using a new method for BOLD signal analysis

Proc. SPIE. 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII

KEYWORDS: Tissues, Head, Signal analysis, Hemodynamics, Near infrared spectroscopy, Neuroimaging, Tissue optics, Functional magnetic resonance imaging, Channel projecting optics, Brain

PROCEEDINGS ARTICLE | February 13, 2007

Dual wavelength approach for the estimation of the relative concentration of two absorbers: Monte Carlo simulations

Proc. SPIE. 6434, Optical Tomography and Spectroscopy of Tissue VII

KEYWORDS: Optical properties, Tissues, Scattering, Photons, Diffusion, Light scattering, Monte Carlo methods, Mie scattering, Near infrared spectroscopy, Absorption

PROCEEDINGS ARTICLE | February 8, 2007

Fast optical response to electrical activation in peripheral nerves

Proc. SPIE. 6431, Multimodal Biomedical Imaging II

KEYWORDS: Biomedical optics, Nerve, Electrodes, Optical testing, Hemodynamics, Near infrared spectroscopy, Skull, Nervous system, Tissue optics, Brain

SPIE Journal Paper | July 1, 2006

Fast optical signals in the peripheral nervous system

Tong, Yunjie , Martin, Jeffrey , Sassaroli, Angelo , Clervil, Patricia , Bergethon, Peter , Fantini, Sergio

JBO Vol. 11 Issue 04

KEYWORDS: Tissue optics, Nerve, Nervous system, Scattering, Absorption, Hemodynamics, Optical testing, Near infrared spectroscopy, Signal detection, Biomedical optics

PROCEEDINGS ARTICLE | February 13, 2006

Comparison of optical imaging and functional magnetic resonance imaging of the human brain using a photon-hitting density weight in the calculation of the BOLD signal

Proc. SPIE. 6081, Multimodal Biomedical Imaging

KEYWORDS: Optical imaging, Tissues, Head, Hemodynamics, Near infrared spectroscopy, Neuroimaging, Tissue optics, Brain mapping, Functional magnetic resonance imaging, Brain

SPIE Journal Paper | September 1, 2005

Two-dimensional phased arrays of sources and detectors for depth discrimination in diffuse optical imaging

Liu, Ning , Sassaroli, Angelo , Fantini, Sergio

JBO Vol. 10 Issue 05

KEYWORDS: Sensors, Phased arrays, Phased array optics, Diffuse optical imaging, Optical fibers, Spatial resolution, Detector arrays, Tissue optics, Continuous wave operation, Resolution enhancement technologies

PROCEEDINGS ARTICLE | June 22, 2005

Three-element phased-array approach to improve the spatial resolution in diffuse optical imaging

Proc. SPIE. 5771, Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI

KEYWORDS: Detection and tracking algorithms, Scattering, Scattering media, Sensors, Photons, Phased arrays, Spatial resolution, Phased array optics, Absorption, Diffuse optical imaging

PROCEEDINGS ARTICLE | April 28, 2005

Hemodynamic variations measured with near-infrared spectroscopy in human forearm muscles in response to venous occlusion: an electrical model

Proc. SPIE. 5693, Optical Tomography and Spectroscopy of Tissue VI

KEYWORDS: Human subjects, Capacitors, Tissues, Blood, Spectroscopy, Oxygen, Blood circulation, Hemodynamics, Near infrared spectroscopy, Tissue optics

PROCEEDINGS ARTICLE | April 28, 2005

Studying brain function with concurrent near-infrared spectroscopy (NIRS) and functional magnetic resonance imaging (fMRI)

Proc. SPIE. 5693, Optical Tomography and Spectroscopy of Tissue VI

KEYWORDS: Optical fibers, Laser sources, Human subjects, Sensors, Photomultipliers, Head, Near infrared spectroscopy, Neuroimaging, Functional magnetic resonance imaging, Brain

PROCEEDINGS ARTICLE | April 28, 2005

Studying brain function with near-infrared spectroscopy concurrently with electroencephalography

Proc. SPIE. 5693, Optical Tomography and Spectroscopy of Tissue VI

KEYWORDS: Optical fibers, Sensors, Electrodes, Data acquisition, Hemodynamics, Electroencephalography, Near infrared spectroscopy, Neuroimaging, Tissue optics, Brain

PROCEEDINGS ARTICLE | April 28, 2005

Three-element phased arrays to enhance the spatial resolution and achieve depth discrimination in diffuse optical imaging

Proc. SPIE. 5693, Optical Tomography and Spectroscopy of Tissue VI

KEYWORDS: Sensors, Image resolution, Solids, Image enhancement, Phased arrays, Spatial resolution, Tissue optics, Phased array optics, Resolution enhancement technologies, Diffuse optical imaging

SPIE Journal Paper | November 1, 2004

Near-infrared imaging of the human breast: complementing hemoglobin concentration maps with oxygenation images

Heffer, Erica , Pera, Vivian , Schütz, Oliver , Siebold, Horst , Fantini, Sergio

JBO Vol. 9 Issue 06

KEYWORDS: Breast, Cancer, Tissue optics, Mammography, Absorption, Inverse optics, Blood vessels, Oxygen, Tumors, Optical spheres

SPIE Journal Paper | November 1, 2004

Special Section Guest Editorial: Optics in Breast Cancer

Pogue, Brian , Fantini, Sergio , Moesta, K. Thomas

JBO Vol. 9 Issue 06

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PROCEEDINGS ARTICLE | July 13, 2004

Functional mapping of the human brain with near-infrared spectroscopy in the frequency-domain

Proc. SPIE. 5312, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV

KEYWORDS: Optical spheres, Sensors, Monte Carlo methods, Brain activation, Tissue optics, Spherical lenses, Signal detection, Brain mapping, Absorption, Brain

PROCEEDINGS ARTICLE | May 28, 2004

Study of complex hemodynamic fluctuations in the human brain by simultaneous near-infrared spectro-imaging and functional magnetic resonance imaging

Proc. SPIE. 5330, Complex Dynamics, Fluctuations, Chaos, and Fractals in Biomedical Photonics

KEYWORDS: Statistical analysis, Tissues, Sensors, Hemodynamics, Near infrared spectroscopy, Neuroimaging, Signal detection, Brain mapping, Functional magnetic resonance imaging, Brain

SPIE Journal Paper | March 1, 2004

Spatial distribution of vastus lateralis blood flow and oxyhemoglobin saturation measured at the end of isometric quadriceps contraction by multichannel near-infrared spectroscopy

Quaresima, Valentina , Ferrari, Marco , Franceschini, Maria , Hoimes, Matthew , Fantini, Sergio

JBO Vol. 9 Issue 02

KEYWORDS: Near infrared spectroscopy, Tissue optics, Blood circulation, Oxygen, Optical fibers, Tissues, Sensors, Photometry, Blood, Oximeters

PROCEEDINGS ARTICLE | October 13, 2003

Near-infrared spectroscopy and polysomnography during all-night sleep in human subjects

Proc. SPIE. 5068, Saratov Fall Meeting 2002: Optical Technologies in Biophysics and Medicine IV

KEYWORDS: Human subjects, Blood, Heart, Oxygen, Hemodynamics, Electroencephalography, Near infrared spectroscopy, Cerebral blood flow, Polysomnography, Brain

PROCEEDINGS ARTICLE | July 29, 2003

Optical mammography with single-wavelength contrast enhancement and multiwavelength oxygenation assessment

Proc. SPIE. 4955, Optical Tomography and Spectroscopy of Tissue V

KEYWORDS: Breast, Biomedical optics, Cancer, Breast cancer, Inflammation, Mammography, Absorbance, Tissue optics, Singular optics, Inverse optics

PROCEEDINGS ARTICLE | July 29, 2003

Near-infrared spectroscopy of the human brain during electroconvulsive therapy

Proc. SPIE. 4955, Optical Tomography and Spectroscopy of Tissue V

KEYWORDS: Tissues, Electrodes, Spectroscopy, Oxygen, Electroencephalography, Near infrared spectroscopy, Oximeters, Tissue optics, Oximetry, Brain

PROCEEDINGS ARTICLE | July 29, 2003

Quantitative estimate of spatial/temporal variations in the optical properties of tissue-like media from diffuse reflectance data

Proc. SPIE. 4955, Optical Tomography and Spectroscopy of Tissue V

KEYWORDS: Biomedical optics, Diffuse reflectance spectroscopy, Optical properties, Tissues, Scattering, Reflectivity, CCD cameras, Tissue optics, Liquids, Absorption

SPIE Journal Paper | July 1, 2003

Spatial second-derivative image processing: an application to optical mammography to enhance the detection of breast tumors

Pera, Vivian , Heffer, Erica , Siebold, Horst , Schütz, Oliver , Heywang-Köbrunner, Sylvia , Götz, Linda , Heinig, Anke , Fantini, Sergio

JBO Vol. 8 Issue 03

KEYWORDS: Breast, Tumors, Mammography, Image enhancement, Blood vessels, Image processing, Absorption, Cancer, Biomedical optics, Image analysis

PROCEEDINGS ARTICLE | June 29, 2001

Local measurement of venous saturation in tissue with noninvasive near-infrared respiratory oximetry

Proc. SPIE. 4250, Optical Tomography and Spectroscopy of Tissue IV

KEYWORDS: Statistical analysis, Tissues, Sensors, Blood, Spectroscopy, Fourier transforms, Near infrared spectroscopy, Tissue optics, Oximetry, Absorption

PROCEEDINGS ARTICLE | May 4, 2001

Spatial mapping of blood flow and oxygen consumption in the human calf muscle using near-infrared spectroscopy

Proc. SPIE. 4241, Saratov Fall Meeting 2000: Optical Technologies in Biophysics and Medicine II

KEYWORDS: Tissues, Sensors, Oxygen, Optical testing, Blood circulation, Bismuth, Near infrared spectroscopy, Tissue optics, Neodymium, Astatine

SPIE Journal Paper | July 1, 2000

Blood flow and oxygen consumption with near-infrared spectroscopy and venous occlusion: spatial maps and the effect of time and pressure of inflation

Casavola, Claudia , Paunescu, Lelia , Fantini, Sergio , Gratton, Enrico

JBO Vol. 5 Issue 03

KEYWORDS: Oxygen, Blood circulation, Mercury, Tissues, Near infrared spectroscopy, Absorption, Tissue optics, Scattering, Sensors, Blood

PROCEEDINGS ARTICLE | May 2, 2000

Confocal imaging through scattering media with a volume holographic filter

Proc. SPIE. 3919, Three-Dimensional and Multidimensional Microscopy: Image Acquisition Processing VII

KEYWORDS: Confocal microscopy, Optical filters, Holograms, Holography, Scattering, Polymers, Silicon, Silicon films, Volume holography, Semiconducting wafers

PROCEEDINGS ARTICLE | April 6, 2000

Temporal analysis of fluctuations in cerebral hemodynamics revealed by near-infrared spectroscopy

Proc. SPIE. 4001, Saratov Fall Meeting '99: Optical Technologies in Biophysics and Medicine

KEYWORDS: Human subjects, Coherence (optics), Sensors, Spectroscopy, Electroluminescence, Hemodynamics, Near infrared spectroscopy, Neuroimaging, Tissue optics, Brain

PROCEEDINGS ARTICLE | July 15, 1999

Calf muscle blood flow and oxygen consumption measured with near-infrared spectroscopy during venous occlusion

Proc. SPIE. 3597, Optical Tomography and Spectroscopy of Tissue III

KEYWORDS: Near infrared, Doppler effect, Tissues, Blood, Control systems, Oxygen, Vascular diseases, Blood circulation, Near infrared spectroscopy, Tissue optics

PROCEEDINGS ARTICLE | July 15, 1999

Near-infrared spectroscopy and the tilting table protocol: a novel method to study the blood flow and the oxygen consumption in tissues

Proc. SPIE. 3597, Optical Tomography and Spectroscopy of Tissue III

KEYWORDS: Optical fibers, Near infrared, Tissues, Blood, Spectroscopy, Oxygen, Vascular diseases, Blood circulation, Near infrared spectroscopy, Tissue optics

PROCEEDINGS ARTICLE | July 15, 1999

Photon-density wave fluctuation correlation spectroscopy: study of coherence in the brain and muscles

Proc. SPIE. 3597, Optical Tomography and Spectroscopy of Tissue III

KEYWORDS: Near infrared, Coherence (optics), Data modeling, Tissues, Sensors, Spectroscopy, Head, Tissue optics, Light, Brain

PROCEEDINGS ARTICLE | July 15, 1999

New optical probe designs for absolute (self-calibrating) NIR tissue hemoglobin measurements

Proc. SPIE. 3597, Optical Tomography and Spectroscopy of Tissue III

KEYWORDS: Modulation, Optical properties, Tissues, Sensors, Calibration, Oximeters, Phase measurement, Tissue optics, Stanford Linear Collider, Light

PROCEEDINGS ARTICLE | July 15, 1999

Near-infrared absorption and scattering spectra of tissues in vivo

Proc. SPIE. 3597, Optical Tomography and Spectroscopy of Tissue III

KEYWORDS: Optical fibers, Ischemia, Optical properties, Tissues, Scattering, Spectroscopy, Skin, In vivo imaging, Tissue optics, Absorption

PROCEEDINGS ARTICLE | July 15, 1999

Real-time optical imaging and spectroscopy of brain ischemia and hemorrhage

Proc. SPIE. 3597, Optical Tomography and Spectroscopy of Tissue III

KEYWORDS: Optical imaging, Ischemia, Blood, Spectroscopy, Imaging spectroscopy, Optical spectroscopy, Neuroimaging, Tissue optics, Absorption, Brain

PROCEEDINGS ARTICLE | July 2, 1999

Fluorescence lifetime spectroscopy in multiple-scattering environments: an application to biotechnology

Proc. SPIE. 3600, Biomedical Imaging: Reporters, Dyes, and Instrumentation

KEYWORDS: Optical properties, Tissues, Scattering, Sensors, Spectroscopy, Luminescence, Diffusion, Fluorescence spectroscopy, Quantum efficiency, Absorption

PROCEEDINGS ARTICLE | March 4, 1999

Exploring tissue dynamics by photon-density-wave fluctuation correlation spectroscopy

Proc. SPIE. 3726, Saratov Fall Meeting '98: Light Scattering Technologies for Mechanics, Biomedicine, and Material Science

KEYWORDS: Modulation, Optical properties, Tissues, Spectroscopy, Particles, Light scattering, Phase shift keying, In vivo imaging, Tissue optics, Spectroscopes

PROCEEDINGS ARTICLE | December 30, 1998

Clinical applications of frequency-domain optical mammography

Proc. SPIE. 3566, Photon Propagation in Tissues IV

KEYWORDS: Breast, Breast cancer, Tumors, Scattering, Blood vessels, Mammography, Geometrical optics, Tissue optics, Prototyping, Absorption

SPIE Journal Paper | April 1, 1998

Contrast features of breast cancer in frequency-domain laser scanning mammography

Moesta, K. , Fantini, Sergio , Jess, Helge , Totkas, Susan , Franceschini, Maria-Angela , Kaschke, Michael , Schlag, Peter

JBO Vol. 3 Issue 02

KEYWORDS: Tumors, Breast, Mammography, Breast cancer, Cancer, Absorption, Scattering, Laser scanners, X-rays, Algorithm development

PROCEEDINGS ARTICLE | January 1, 1998

Difference in leg muscle oxygenation during treadmill exercise by a new near-infrared frequency-domain oximeter

Proc. SPIE. 3194, Photon Propagation in Tissues III

KEYWORDS: Near infrared, Oximeters, Thermal modeling

PROCEEDINGS ARTICLE | January 1, 1998

Quantitative near-infrared spectroscopy on patients with peripheral vascular disease

Proc. SPIE. 3194, Photon Propagation in Tissues III

KEYWORDS: Modulation, Control systems, Semiconductor lasers, Vascular diseases, Near infrared spectroscopy, Oximeters, Tissue optics, Laser tissue interaction

PROCEEDINGS ARTICLE | August 18, 1997

Effect of index of refraction mismatch on the recovery of optical properties of cylindrical inhomogeneities in an infinite turbid medium

Proc. SPIE. 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II

KEYWORDS: Data modeling, Optical properties, Tissues, Reflection, Scattering, Sensors, Diffusion, Refraction, Phase measurement, Absorption

PROCEEDINGS ARTICLE | August 18, 1997

Chromophore detection by fluorescence spectroscopy in tissue-like phantoms

Proc. SPIE. 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II

KEYWORDS: Tissues, Scattering, Spectroscopy, Luminescence, Diffusion, Fluorescence spectroscopy, Interference filters, Tissue optics, Rhodamine, Absorption

PROCEEDINGS ARTICLE | August 18, 1997

Effect of spatially distributed light sources on the frequency-domain solution to the diffusion equation

Proc. SPIE. 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II

KEYWORDS: Optical fibers, Light sources, Scattering, Scattering media, Calibration, Photons, Diffusion, Optical testing, Absorption

PROCEEDINGS ARTICLE | August 18, 1997

Optical study of the skeletal muscle during exercise with a second-generation frequency-domain tissue oximeter

Proc. SPIE. 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II

KEYWORDS: Optical fibers, Light sources, Electronics, Light emitting diodes, Tissues, Semiconductor lasers, Oximeters, In vivo imaging, Tissue optics, Prototyping

PROCEEDINGS ARTICLE | August 18, 1997

Experimental recovery of absorption, scattering, and fluorescence parameters in highly scattering media from a single frequency measurement

Proc. SPIE. 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II

KEYWORDS: Tissues, Scattering, Sensors, Spectroscopy, Luminescence, Quantum efficiency, Light scattering, Physics, Signal detection, Absorption

SPIE Journal Paper | April 2, 1997

Quantitative spectroscopic determination of hemoglobin concentration and saturation in a turbid medium: analysis of the effect of water absorption

Franceschini, Maria-Angela , Fantini, Sergio , Cerussi, Albert , Barbieri, Beniamino , Chance, Britton , Gratton, Enrico

JBO Vol. 2 Issue 02

KEYWORDS: Absorption, Tissue optics, Oxygen, Tissues, Spectroscopy, Blood, Oximeters, Nitrogen, Near infrared, Mercury

PROCEEDINGS ARTICLE | December 18, 1995

Frequency-domain optical mammography: the correction of tissue thickness variations within the scanned region

Proc. SPIE. 2626, Photon Propagation in Tissues

KEYWORDS: Breast, Tumors, Modulation, Tissues, Sensors, Phase shift keying, Mammography, Image enhancement, Phase measurement, Tissue optics

PROCEEDINGS ARTICLE | May 30, 1995

Multichannel optical instrument for near-infrared imaging of tissue

Proc. SPIE. 2389, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation

KEYWORDS: Light sources, Optical spheres, Modulation, Optical properties, Scattering, Sensors, Glasses, Light scattering, Tissue optics, Absorption

PROCEEDINGS ARTICLE | May 30, 1995

Cerebral and muscle oxygen saturation measurement by a frequency-domain near-infrared spectroscopic technique

Proc. SPIE. 2389, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation

KEYWORDS: Light emitting diodes, Ischemia, Scattering, Blood, Spectroscopy, Oxygen, Near infrared spectroscopy, Spectroscopes, Absorption, Brain

PROCEEDINGS ARTICLE | May 30, 1995

Photon path distributions in turbid media: applications for imaging

Proc. SPIE. 2389, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation

KEYWORDS: Modulation, Scattering, Sensors, Light scattering, Tomography, Optical tomography, Phase measurement, Tissue optics, Light, Absorption

PROCEEDINGS ARTICLE | May 1, 1995

Tissue optical parameter map generated with frequency-domain spectroscopy

Proc. SPIE. 2396, Biomedical Optoelectronic Instrumentation

KEYWORDS: Optical imaging, Modulation, Scattering, Sensors, Image processing, Spectroscopy, Light scattering, Geometrical optics, Tissue optics, Absorption

PROCEEDINGS ARTICLE | April 12, 1995

In vivo study of human tissues with a portable near-IR tissue spectrometer

Proc. SPIE. 2387, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II

KEYWORDS: Ischemia, Tissues, Scattering, Sensors, Blood, Spectroscopy, Vascular diseases, Head, In vivo imaging, Absorption

PROCEEDINGS ARTICLE | January 31, 1995

Frequency-domain multisource optical spectrometer and oximeter

Proc. SPIE. 2326, Photon Transport in Highly Scattering Tissue

KEYWORDS: Light sources, Light emitting diodes, Tissues, Scattering, Sensors, Spectroscopy, Light scattering, Tissue optics, Signal detection, Absorption

SPIE Journal Paper | January 1, 1995

Frequency-domain multichannel optical detector for noninvasive tissue spectroscopy and oximetry

Fantini, Sergio , Franceschini, Maria-Angela , Maier, John , Walker, Scott , Barbieri, Beniamino , Gratton, Enrico

OE Vol. 34 Issue 01

KEYWORDS: Light emitting diodes, Tissue optics, Absorption, Sensors, Light sources, Tissues, Scattering, Spectroscopy, Modulation, Calibration

PROCEEDINGS ARTICLE | July 28, 1994

Absolute measurement of absorption and scattering coefficients spectra of a multiply scattering medium

Proc. SPIE. 2131, Biomedical Fiber Optic Instrumentation

KEYWORDS: Light sources, Light emitting diodes, Modulation, Tissues, Scattering, Diffusion, Light scattering, Spectrophotometry, Signal detection, Absorption

PROCEEDINGS ARTICLE | June 28, 1994

Absorption spectra of a chromophore in highly scattering media

Proc. SPIE. 2100, Cell and Biotissue Optics: Applications in Laser Diagnostics and Therapy

KEYWORDS: Modulation, Optical properties, Tissues, Scattering, Diffusion, Light scattering, Chromophores, Diodes, Tissue optics, Absorption

PROCEEDINGS ARTICLE | May 19, 1994

LEDs in frequency domain spectroscopy of tissues

Proc. SPIE. 2135, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases

KEYWORDS: Light sources, Light emitting diodes, Modulation, Tissues, Scattering, Spectroscopy, Lamps, In vivo imaging, Signal detection, Absorption

Showing 5 of 93 publications

Conference Committee Involvement (21)

Optical Tomography and Spectroscopy of Tissue XIII

2 February 2019 | San Francisco, California, United States

Optical Tomography and Spectroscopy of Tissue XIII

2 February 2019 | San Francisco, California, United States

Optical Tomography and Spectroscopy of Tissue XII

30 January 2017 | San Francisco, California, United States

Multimodal Biomedical Imaging XII

28 January 2017 | San Francisco, California, United States

Multimodal Biomedical Imaging XI

13 February 2016 | San Francisco, California, United States

Showing 5 of 21 published special sections

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