Terahertz (THz, THz+10<sup>12</sup>Hz) spectroscopy is a far-infrared analytical technology with spectral bands locating between microware and infrared ranges. Being of excellent transmission, non-destruction and high discrimination, this technology has been applied in various fields such as physics, chemistry, nondestructive detection, communication, biomedicine public security. Terahertz spectrum is corresponding with vibration and rotation of liquid molecules, which is suitable to identify and study the liquid molecular dynamics. It is as a powerful spectral detection technology, terahertz time-domain spectroscopy is widely used in solution detection. can enable us to extract the material parameters or dielectric spectrum that show material micro-structure and dynamics by measuring amplitude and phase from coherent terahertz pulses. Ionic liquid exists in most biological tissues, and it is very important for life. It has recently been suggested that near-fired terahertz ionic contrast microscopy can be employed to image subtle changes in ionic concentrations arising from neuronal activity. In this paper, we detected Ionic liquid with different concentrations at room temperature by THz-TDS technique in the range of 0.2-1.5 THz. The liquid cell with a thickness of 0.2mm is made of quartz. The absorption coefficient, refractive index and dielectric function of solutions can be extracted based on THz-TDS. We use an expanded model for fitting the dielectric function based on a combination of a Debye relation for the anions and cations. We find A linear increase of the real and imaginary part of the dielectric function compared with pure water with increasing ion concentrations. A good agreement between the model and the experimental results is obtained. By means of dielectric relaxation process, it was found that the characteristic time of molecular movement and the information related to the liquid molecular structure and movement was obtained.
Melamine is an organic base and a trimer of cyanamide, with a 1, 3, 5-triazine skeleton. It is usually used for the production of plastics, glue and flame retardants. Melamine combines with acid and related compounds to form melamine cyanurate and related crystal structures, which have been implicated as contaminants or biomarkers in protein adulterations by lawbreakers, especially in milk powder. This paper is focused on developing an available method for quantitative detection of melamine in the fields of security inspection and nondestructive testing based on THz-TDS. Terahertz (THz) technology has promising applications for the detection and identification of materials because it exhibits the properties of spectroscopy, good penetration and safety. Terahertz time-domain spectroscopy (THz-TDS) is a key technique that is applied to spectroscopic measurement of materials based on ultrafast femtosecond laser. In this study, the melamine and its mixture with polyethylene powder in different consistence are measured using the transmission THz-TDS. And we obtained the refractive index spectra and the absorption spectrum of different concentrations of melamine on 0.2-2.8THz. In the refractive index spectra, it is obvious to see that decline trend with the decrease of concentration; and in the absorption spectrum, two peaks of melamine at 1.98THz and 2.28THz can be obtained. Based on the experimental result, the absorption coefficient and the consistence of the melamine in the mixture are determined. Finally, methods for quantitative detection of materials in the fields of nondestructive testing and quality control based on THz-TDS have been studied.
Terahertz spectrum is corresponding with vibration and rotation of liquid molecules. It is suitable to identify and research the liquid molecular dynamics. As a powerful spectral detection technology, terahertz time-domain spectroscopy (THz- TDS) is widely used in solution detection. The absorption coefficient, refractive index and dielectric function of solutions can be extracted based on terahertz time-domain spectroscopy. NaCl exists in most biological tissues, and it is very important for life. In this paper, we detected NaCl solutions with different concentrations at room temperature by THz-TDS technique in the range of 0.2-1.5 THz. The liquid cell with a thickness of 0.2mm is made of quartz. A linear increase of the real and imaginary part of the dielectric function was observed when compared with pure water with increasing concentrations of NaCl solutions. We fitted the terahertz dielectric function of the NaCl solutions by Debye model, Where the dielectric relaxation time can be obtained. By means of dielectric relaxation process, it was found that the characteristic time of molecular movement and the information related to the liquid molecular structure and movement was obtained.
Terahertz (THz) technology has promising applications for the detection and identification of materials because it has a great advantage in measuring material fingerprint spectrum. Terahertz time-domain spectroscopy (THz-TDS) is a key technique that is applied to spectroscopic measurement of materials. However, it is difficult to press a pellet with small mass of sample and a bulking medium such as polyethylene (PE) powder usually need to be added. Characteristic absorption peaks of the solution in liquid cell is hard to be observed due to the interaction between materials and water molecules. Therefore, one method using the hydrophilic nitrocellulose (NC) membrane as a sample holder was applied to detect samples in an aqueous medium by THz-TDS. In this study, the α-lactose samples were mixed with 20 μl of deionized water and then applied directly onto the double-layered NC membrane sample holder. This mixture is located on the gap of two piece of NC membranes. Firstly the NC membranes with different pore sizes were tested in the experiment. And then the α-lactose solutions with different concentrations were measured on the NC with different pore sizes. Consequently, the small mass of samples can be detected and the characteristic absorption peaks become stronger with the increase of NC pore size. Moreover, compared to the traditional pellet-making and liquid cell detection, this membrane method is more convenient and easy to operate.
There is no corresponding fingerprint characteristic spectrum detecting complex ensemble biological samples in liquid, in the paper, such urine of kidney disease patients as samples of the research, using terahertz time-domain spectroscopy emphatically explores response characteristics of the urine albumin in the terahertz spectrum characteristics, and combined with stoichiometric method, we find a certain kind of relationship between terahertz spectrum data and the content of urine albumin, which offsets the defects of other spectroscopy in measuring liquid protein, and in accordance with hospital clinical data. This study established a semi-qualitative method of using terahertz spectroscopy in detecting non-purification of biological liquid sample, which provides a simple, nondestructive, cheap and fast reference method in identifying the early nephropathy for medical test.