Prof. Shaoqun Zeng Profile

Prof. Shaoqun Zeng

Professor at Britton Chance Ctr for Biomedical Photonics

SPIE Involvement:

Conference Program Committee | Author

Publications (111)

SPIE Journal Paper | 28 November 2018

Penetration model for chemical reactivation for resin-embedded green fluorescent protein imaging

Longhui Li, Ruixi Chen, Xiuli Liu, Ning Li, Xiaoxiang Liu, Xiaojun Wang, Tingwei Quan, Xiaohua Lv, Shaoqun Zeng

JBO Vol. 24 Issue 05

KEYWORDS: Luminescence, Green fluorescent protein, Chromium, Data modeling, Brain, Diffusion, Lithium, Statistical modeling, Nerve, Optical fibers

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Proceedings Article | 14 March 2018 Presentation

Advanced NeuroGPS-Tree achieves brain-wide reconstruction of neuronal population equal to manual reconstruction level (Conference Presentation)

Tingwei Quan, Hang Zhou, Shiwei Li, Qingming Luo, Hui Gong, Anan Li, Shaoqun Zeng

Proc. SPIE. 10481, Neural Imaging and Sensing 2018

KEYWORDS: Image resolution, 3D modeling, Neuroscience, Reconstruction algorithms, Neuroimaging, 3D visualizations, Neurons, Brain imaging, Brain

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SPIE Journal Paper | 9 February 2018

Chemical reactivation of fluorescein isothiocyanate immunofluorescence-labeled resin-embedded samples

Longhui Li, Gong Rao, Xiaohua Lv, Ruixi Chen, Xiaofeng Cheng, Xiaojun Wang, Shaoqun Zeng, Xiuli Liu

JBO Vol. 23 Issue 02

KEYWORDS: Luminescence, Chromium, Polymers, Tissues, Absorption, Brain, Chemical analysis, Fluorescent proteins, Neuroimaging, Lithium

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SPIE Journal Paper | 16 November 2017

High-refractive index of acrylate embedding resin clarifies mouse brain tissue

Hongfu Zhou, Yumiao Xiong, Yu Wang, Xiaojun Wang, Pei Li, Yadong Gang, Xiuli Liu, Shaoqun Zeng

JBO Vol. 22 Issue 11

KEYWORDS: Tissues, Luminescence, Brain, Refractive index, Microscopy, Tissue optics, Green fluorescent protein, Liquids, Proteins, Lithium

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SPIE Journal Paper | 27 October 2017

Development of a neutral embedding resin for optical imaging of fluorescently labeled biological tissue

Hongfu Zhou, Yadong Gang, Shenghua Chen, Yu Wang, Yumiao Xiong, Longhui Li, Fangfang Yin, Yue Liu, Xiuli Liu, Shaoqun Zeng

JBO Vol. 22 Issue 10

KEYWORDS: Luminescence, Green fluorescent protein, Tissues, Brain, Optical imaging, Polymerization, Confocal microscopy, Nerve, Tissue optics, Microscopy

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Proceedings Article | 8 February 2017 Presentation + Paper

A novel reactive resin for embedding biological tissue

Hongfu Zhou, Xiuli Liu, Yadong Gang, Xiaohua Lv, Shaoqun Zeng

Proc. SPIE. 10051, Neural Imaging and Sensing

KEYWORDS: Biomedical optics, Nerve, Tissues, Microscopy, Luminescence, Electron microscopy, Image quality, Photonics, Epoxies, Fluorescent proteins, Sodium, 3D image processing, Brain mapping, Brain

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Proceedings Article | 8 February 2017 Paper

A pH-sensitive red fluorescent protein compatible with hydrophobic resin embedding

Wenyan Guo, Yadong Gang, Xiuli Liu, Hongfu Zhou, Shaoqun Zeng

Proc. SPIE. 10051, Neural Imaging and Sensing

KEYWORDS: Roads, Biomedical optics, Luminescence, Imaging spectroscopy, Tomography, Photonics, In vivo imaging, Fluorescent proteins, Brain

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SPIE Journal Paper | 30 November 2015

Special Section Guest Editorial:Special Section on Light Microscopy of Connectivity

Shaoqun Zeng, Timothy Murphy

NPh Vol. 2 Issue 04

KEYWORDS: Microscopy, Brain, Brain mapping, Neurons, Neuroimaging, Tissues, Spatial resolution, Confocal microscopy, Biomedical optics, Photonics

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SPIE Journal Paper | 15 October 2015

Fluorescence micro-optical sectioning tomography using acousto-optical deflector-based confocal scheme

Xiaoli Qi, Tao Yang, Longhui Li, Jiancun Wang, Shaoqun Zeng, Xiaohua Lv

NPh Vol. 2 Issue 04

KEYWORDS: Confocal microscopy, Luminescence, Brain, Signal to noise ratio, Imaging systems, Objectives, Tomography, Neuroimaging, Fluorescence tomography, Signal detection

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SPIE Journal Paper | 13 January 2015

Fluorescence imaging of dendritic spines of Golgi-Cox-stained neurons using brightening background

Min Ai, Hanqing Xiong, Tao Yang, Zhenhua Shang, Muqing Chen, Xiuli Liu, Shaoqun Zeng

JBO Vol. 20 Issue 01

KEYWORDS: Luminescence, Neurons, Spine, Brain, Confocal microscopy, Polymers, Neuroimaging, Dendrites, Microscopy, Biomedical optics

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Proceedings Article | 20 March 2014 Paper

Technical considerations on confocal based fluorescence micro-optical sectioning tomography for visualizing brain circuits

Xiaoli Qi, Xiaohua Lv, Hanqing Xiong, Cheng Yan, Jianling Chen, Hui Gong, Qingming Luo, Shaoqun Zeng

Proc. SPIE. 8928, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics

KEYWORDS: Confocal microscopy, Biomedical optics, Visualization, Imaging systems, Luminescence, Image resolution, Tomography, Neuroimaging, Fluorescence tomography, Brain

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SPIE Journal Paper | 11 June 2013

Fast optical sectioning obtained by structured illumination microscopy using a digital mirror device

Dongli Xu, Tao Jiang, Anan Li, Bihe Hu, Zhao Feng, Hui Gong, Shaoqun Zeng, Qingming Luo

JBO Vol. 18 Issue 06

KEYWORDS: Brain, Digital micromirror devices, Mirrors, Microscopy, Neuroimaging, Imaging systems, 3D image processing, Biomedical optics, Luminescence, Neuroscience

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SPIE Journal Paper | 28 May 2013

Improved detectability of neuronal connectivity on mechanical sectioning setup by using confocal detection

Xiaoli Qi, Hanqing Xiong, Xiaohua Lv, Jianling Chen, Hui Gong, Qingming Luo, Shaoqun Zeng

JBO Vol. 18 Issue 05

KEYWORDS: Confocal microscopy, Signal detection, Luminescence, Optical tomography, Tomography, Imaging systems, Neuroimaging, Brain, Image resolution, Mechanics

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Proceedings Article | 26 November 2012 Paper

Optical path difference characteristics of the fluorescence holographic system

Xiaomin Lai, Shaoqun Zeng

Proc. SPIE. 8556, Holography, Diffractive Optics, and Applications V

KEYWORDS: Signal to noise ratio, Holograms, Holography, Cameras, Luminescence, Wavefronts, CCD cameras, Spatial light modulators, Objectives, Spherical lenses

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SPIE Journal Paper | 6 April 2012

Errata: Localization capability and limitation of electron-multiplying charge-coupled, scientific complementary metal-oxide semiconductor, and charge-coupled devices for superresolution imaging

Tingwei Quan, Shaoqun Zeng, Zhen-Li Huang

JBO Vol. 17 Issue 04

KEYWORDS: Semiconductors, Charge-coupled devices, Super resolution, Imaging devices, Biomedical optics, Optoelectronics, Photonics, Mathematics

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SPIE Journal Paper | 1 August 2011

Identification of the direction of the neural network activation with a cellular resolution by fast two-photon imaging

Xiuli Liu, Tingwei Quan, Shaoqun Zeng, Xiaohua Lv

JBO Vol. 16 Issue 08

KEYWORDS: Calcium, Neurons, Signal to noise ratio, Neural networks, Brain, Two photon imaging, Image resolution, Error analysis, Spatial resolution, Two photon excitation microscopy

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SPIE Journal Paper | 1 May 2011

Confocal imaging reveals three-dimensional fine structure difference between ventral and dorsal nerve roots

Yuxiang Wu, Xiaohua Lv, Shaoqun Zeng, Tao Sui, Xiaojian Cao, Peng Sun

JBO Vol. 16 Issue 05

KEYWORDS: Nerve, Optical fibers, Confocal microscopy, 3D image processing, Laser scanners, Injuries, 3D image reconstruction, Biomedical optics, Photonics, Tissues

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SPIE Journal Paper | 1 November 2010

Localization capability and limitation of electron-multiplying charge-coupled, scientific complementary metal-oxide semiconductor, and charge-coupled devices for superresolution imaging

Tingwei Quan, Shaoqun Zeng, Zhenli Huang

JBO Vol. 15 Issue 06

KEYWORDS: Sensors, Cameras, Electron multiplying charge coupled devices, Molecules, Super resolution, CCD cameras, Signal detection, Photodetectors, CCD image sensors, Point spread functions

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SPIE Journal Paper | 1 November 2010

Method to reconstruct neuronal action potential train from two-photon calcium imaging

Tingwei Quan, Xiuli Liu, Xiaohua Lv, Wei Chen, Shaoqun Zeng

JBO Vol. 15 Issue 06

KEYWORDS: Calcium, Luminescence, Reconstruction algorithms, Action potentials, Neurons, Deconvolution, Signal to noise ratio, In vivo imaging, Convolution, Linear filtering

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SPIE Journal Paper | 1 May 2010

Characteristics of calcium signaling in astrocytes induced by photostimulation with femtosecond laser

Yuan Zhao, Yuan Zhang, Wei Zhou, Xiuli Liu, Shaoqun Zeng, Qingming Luo

JBO Vol. 15 Issue 03

KEYWORDS: Calcium, Femtosecond phenomena, Photostimulation, Acquisition tracking and pointing, Wave propagation, Luminescence, Brain, Receptors, Neurons, Ions

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Proceedings Article | 25 February 2009 Paper

Real-time optical imaging of the interaction of epidermal growth factor and its receptor in living cells

Qiaoya Lin, Liang Wang, Shaoqun Zeng, Zhihong Zhang, Gang Zheng

Proc. SPIE. 7178, Biophotonics and Immune Responses IV

KEYWORDS: Optical imaging, Proteins, Green fluorescent protein, Cancer, Visualization, Molecules, Receptors, Fluorescence resonance energy transfer, Signal detection, Bandpass filters

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Proceedings Article | 17 February 2009 Paper

A new red bimolecular fluorescence complementation based on TagRFP

Lingsong Qin, Jun Chu, Ying Zheng, Qingming Luo, Shaoqun Zeng, Zhihong Zhang

Proc. SPIE. 7191, Fluorescence In Vivo Imaging Based on Genetically Engineered Probes: From Living Cells to Whole Body Imaging IV

KEYWORDS: Ferroelectric materials, Proteins, Visual analytics, Visualization, Luminescence, Chromophores, Signal processing, Molecular mechanisms, In vivo imaging, Fluorescent proteins

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Proceedings Article | 12 February 2009 Paper

The generation of the synchronized burst in the cultured neuronal networks

Xiangning Li, Jing Sun, Wenjuan Chen, Shaoqun Zeng, Qingming Luo

Proc. SPIE. 7176, Dynamics and Fluctuations in Biomedical Photonics VI

KEYWORDS: Lithium, Sun, Electrodes, Data processing, Neural networks, Raster graphics, Receptors, In vitro testing, Neurons, Brain

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SPIE Journal Paper | 1 May 2008

Activation of caspase-3 noninvolved in the bystander effect of the herpes simplex virus thymidine kinase gene/ganciclovir (HSV-tk/GCV) system

Zhihong Zhang, Juqiang Lin, Jun Chu, Yan Ma, Shaoqun Zeng, Qingming Luo

JBO Vol. 13 Issue 03

KEYWORDS: Fluorescence resonance energy transfer, Luminescence, Cell death, Multichannel imaging systems, Imaging systems, Green fluorescent protein, Proteins, Fluorescent proteins, Image fusion, Optoelectronics

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Proceedings Article | 18 March 2008 Paper

The effects of respiration motion in PET/CT studies

Lu Wan, Zhijian Wu, Fengyin Zhou, Sheng Ye, Shaoqun Zeng, Chien-Min Kao, Chin-Tu Chen, Yongxue Zhang, Qingguo Xie

Proc. SPIE. 6913, Medical Imaging 2008: Physics of Medical Imaging

KEYWORDS: Tissues, Signal attenuation, Computer simulations, Monte Carlo methods, Computed tomography, Lung cancer, Positron emission tomography, Chest imaging, Fuzzy logic, Expectation maximization algorithms

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Proceedings Article | 14 March 2008 Paper

Effects of sciatic nerve stimulation on the propagation of cortical spreading depression

Xiaoli Sun, Zhidong Yu, Shaoqun Zeng, Qingming Luo, Pengcheng Li

Proc. SPIE. 6863, Optical Diagnostics and Sensing VIII

KEYWORDS: Optical imaging, Ischemia, Modulation, Nerve, Electrodes, Brain stimulation, Electrophysiology, Positron emission tomography, Epilepsy, Brain

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Proceedings Article | 28 February 2008 Paper

Enlarging the linear response range of velocity with optimum imaging parameters and modified data processing in laser speckle imaging

Jianjun Qiu, Pengcheng Li, Sergey Ul'yanov, Shaoqun Zeng, Qingming Luo

Proc. SPIE. 6863, Optical Diagnostics and Sensing VIII

KEYWORDS: Imaging systems, Speckle, Microscopy, CCD cameras, Speckle pattern, Laser speckle imaging, Data processing, Blood circulation, Cerebral blood flow, Velocity measurements

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Proceedings Article | 6 February 2008 Paper

Conversion coefficients for external monoenergic photon beams in the visible Chinese human model

Qian Liu, Guozhi Zhang, Shaoqun Zeng

Proc. SPIE. 6855, Complex Dynamics and Fluctuations in Biomedical Photonics V

KEYWORDS: Mathematical modeling, Data modeling, Tissues, Skin, Particles, Bone, Radiation dosimetry, Bladder, Intestine, Radiation effects

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Proceedings Article | 6 February 2008 Paper

Bifurcation and chaos in the spontaneously firing spike train of cultured neuronal network

Wenjuan Chen, Xiangning Li, Geng Zhu, Wei Zhou, Shaoqun Zeng, Qingming Luo

Proc. SPIE. 6855, Complex Dynamics and Fluctuations in Biomedical Photonics V

KEYWORDS: Lithium, Biomedical optics, Neuroscience, Photonics, Neural networks, Stochastic processes, Time series analysis, Brain mapping, Neurons, Chaos

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Proceedings Article | 8 January 2008 Paper

Measurement of caspase-2 activation during different anti-tumor drugs induced apoptosis by FRET technique

Juqiang Lin, Shaoqun Zeng, Qingming Luo, Chen Rong, Zhihong Zhang

Proc. SPIE. 6826, Optics in Health Care and Biomedical Optics III

KEYWORDS: Proteins, Medicine, Biomedical optics, Cancer, Imaging systems, Optoelectronics, Photonics, Cell death, Fluorescent proteins, Fluorescence resonance energy transfer

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SPIE Journal Paper | 1 January 2008

Fluorescence imaging to assess the matrix metalloproteinase activity and its inhibitor in vivo

Zhihong Zhang, Jie Yang, Jinling Lu, Juqiang Lin, Shaoqun Zeng, Qingming Luo

JBO Vol. 13 Issue 01

KEYWORDS: Luminescence, Tumors, In vivo imaging, Sensors, Proteins, Fluorescence resonance energy transfer, Content addressable memory, Signal detection, Confocal microscopy, Imaging systems

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SPIE Journal Paper | 1 November 2007

Effect of light losses of sample between two integrating spheres on optical properties estimation

Dan Zhu, Wei Lu, Shaoqun Zeng, Qingming Luo

JBO Vol. 12 Issue 06

KEYWORDS: Error analysis, Absorption, Optical properties, Scattering, Statistical analysis, Integrating spheres, Light scattering, Distributed interactive simulations, Anisotropy, Tissue optics

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Proceedings Article | 1 May 2007 Paper

Restoration of fluorescence images from two-photon microscopy using modified nonlinear anisotropic diffusion filter

Hongmin Zhang, Qingming Luo, Shaoqun Zeng

Proc. SPIE. 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine

KEYWORDS: Anisotropic filtering, Luminescence, Diffusion, Image restoration, Laser scanners, Image filtering, Nonlinear filtering, Two photon excitation microscopy, Anisotropic diffusion, Neurons

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Proceedings Article | 1 May 2007 Paper

Dynamic imaging of cerebral blood flow in rat reperfused mini-stroke model using laser speckle temporal contrast analysis

Zhen Wang, Weihua Luo, Pengcheng Li, Shaoqun Zeng, Qingming Luo

Proc. SPIE. 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine

KEYWORDS: Ischemia, Speckle, Laser scattering, Laser speckle imaging, Blood circulation, Cerebral blood flow, Spatial resolution, Laser tissue interaction, Somatosensory cortex, Brain

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Proceedings Article | 1 May 2007 Paper

Synchronies in cultured neuronal network

Yunsheng Lin, Lin Chen, Shaoqun Zeng, Qingming Luo

Proc. SPIE. 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine

KEYWORDS: Electrodes, Data processing, Signal processing, Photonics, Action potentials, Signal detection, Binary data, In vitro testing, Neurons, Brain

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Proceedings Article | 1 May 2007 Paper

Enhancement of spontaneous burst activity of hippocampal neuronal networks with low frequency close-loop stimulation

Yanling Li, Wei Zhou, Shaoqun Zeng, Xiangning Li, Man Liu, Qingming Luo

Proc. SPIE. 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine

KEYWORDS: Lithium, Modulation, Electrodes, Action potentials, Plating, Glia, In vitro testing, Neurons, Synaptic transmission, Brain

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SPIE Journal Paper | 1 March 2007

Analysis of the dispersion compensation of acousto-optic deflectors used for multiphoton imaging

Shaoqun Zeng, Xiaohua Lv, Kun Bi, Chen Zhan, Derong Li, Wei Chen, Wenhui Xiong, Steven Jacques, Qingming Luo

JBO Vol. 12 Issue 02

KEYWORDS: Prisms, Bragg cells, Acousto-optics, Adaptive optics, Scanners, Multiphoton microscopy, Biological research, Luminescence, Optical components, Pulsed laser operation

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Proceedings Article | 15 February 2007 Paper

A preliminary study on determining the time window of hypothermia cerebral protection in rat cortex by laser speckle flowmetry

Wenjia Wang, Qiang Li, Shaoqun Zeng, Qingming Luo, Pengcheng Li

Proc. SPIE. 6445, Optical Diagnostics and Sensing VII

KEYWORDS: Veins, Speckle, Blood, Laser scattering, Arteries, Laser speckle imaging, Blood circulation, Hemodynamics, Therapeutics, Cerebral blood flow

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Proceedings Article | 15 February 2007 Paper

Elicitation interval dependent spatiotemporal evolution of cortical spreading depression waves revealed by optical intrinsic signal imaging

Shangbin Chen, Hui Gong, Shaoqun Zeng, Qingming Luo, Pengcheng Li

Proc. SPIE. 6445, Optical Diagnostics and Sensing VII

KEYWORDS: Optical imaging, Potassium, Biomedical optics, Tissues, Blood, Electrodes, Reflectivity, Image acquisition, Wave propagation, Light wave propagation

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Proceedings Article | 7 February 2007 Paper

Evaluation the development of focal cerebral ischemia in rats by optical imaging based on the spreading depression signals

Shangbin Chen, Zhe Feng, Shaoqun Zeng, Qingming Luo, Pengcheng Li

Proc. SPIE. 6436, Complex Dynamics and Fluctuations in Biomedical Photonics IV

KEYWORDS: Optical imaging, Biomedical optics, Ischemia, Reflectivity, Arteries, Wave propagation, Optical resolution, Spatial resolution, Neuroimaging, Brain

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Proceedings Article | 7 February 2007 Paper

Richardson-Lucy deconvolution for two-photon fluorescence images via non-linear diffusion equation pre-filtering

Hongmin Zhang, Zhitao Zhang, Qingming Luo, Shaoqun Zeng

Proc. SPIE. 6436, Complex Dynamics and Fluctuations in Biomedical Photonics IV

KEYWORDS: Point spread functions, Image processing, Microscopy, Luminescence, Diffusion, Laser scanners, Deconvolution, In vivo imaging, Two photon excitation microscopy, Anisotropic diffusion

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Proceedings Article | 27 October 2006 Paper

Monitoring apoptosis of TK-GFP-expressing ACC-M cells induced by ACV using FRET technique

Tao Xiong, Zhihong Zhang, Juqiang Lin, Jie Yang, Shaoqun Zeng, Qingming Luo

Proc. SPIE. 6047, Fourth International Conference on Photonics and Imaging in Biology and Medicine

KEYWORDS: Proteins, Green fluorescent protein, Tumors, Tissues, Microscopy, Luminescence, Photonics, Cell death, Fluorescent proteins, Fluorescence resonance energy transfer

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SPIE Journal Paper | 1 July 2006

Real-time detection of caspase-2 activation in a single living HeLa cell during cisplatin-induced apoptosis

Juqiang Lin, Zhihong Zhang, Jie Yang, Shaoqun Zeng, Bifeng Liu, Qingming Luo

JBO Vol. 11 Issue 02

KEYWORDS: Fluorescence resonance energy transfer, Cell death, Proteins, Fluorescent proteins, In vitro testing, Luminescence, Spectroscopy, Imaging systems, Bacteria, Biomedical optics

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SPIE Journal Paper | 1 July 2006

Errata: Real-time detection of caspase-2 activation in a single living HeLa cell during cisplatin-induced apoptosis

Juqiang Lin, Zhihong Zhang, Shaoqun Zeng, Bifeng Liu, Qingming Luo, Jie Yang

JBO Vol. 11 Issue 04

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Proceedings Article | 19 May 2006 Paper

Monitoring apoptosis of TK-GFP-expressing ACC-M cells induced by ACV using FRET technique

Tao Xiong, Zhihong Zhang, Juqiang Lin, Jie Yang, Shaoqun Zeng, Qingming Luo

Proc. SPIE. 6218, Chemical and Biological Sensing VII

KEYWORDS: Proteins, Green fluorescent protein, Tumors, Tissues, Microscopy, Luminescence, Cell death, Fluorescent proteins, Fluorescence resonance energy transfer, Cell mechanics

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SPIE Journal Paper | 1 May 2006

In vivo optical reflectance imaging of spreading depression waves in rat brain with and without focal cerebral ischemia

Shangbin Chen, Zhe Feng, Pengcheng Li, Steven Jacques, Shaoqun Zeng, Qingming Luo

JBO Vol. 11 Issue 03

KEYWORDS: Reflectivity, Brain, Neuroimaging, Blood, Optical imaging, Ischemia, Arteries, Skull, In vivo imaging, Biomedical optics

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Proceedings Article | 3 March 2006 Paper

Analysis of synchrony in cultured neuronal network

Yunsheng Lin, Lin Chen, Wei Zhou, Shaoqun Zeng, Qingming Luo

Proc. SPIE. 6085, Complex Dynamics and Fluctuations in Biomedical Photonics III

KEYWORDS: Biomedical optics, Electrodes, Signal processing, Photonics, Action potentials, In vivo imaging, Signal detection, In vitro testing, Neurons, Brain

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Proceedings Article | 3 March 2006 Paper

Responses of cultured neuronal network to different electrical stimuli patterns

Lin Chen, Chuanping Chen, Yunsheng Lin, Shaoqun Zeng, Qingming Luo

Proc. SPIE. 6085, Complex Dynamics and Fluctuations in Biomedical Photonics III

KEYWORDS: Biomedical optics, Modulation, Electrodes, Data acquisition, Photonics, Microelectronics, Electrophysiology, In vitro testing, Network security, Neurons

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Proceedings Article | 3 March 2006 Paper

Frame self-division applied in analysis of intrinsic signal optical imaging data

Weihua Luo, Pengcheng Li, Li Zhang, Xiaohua Lv, Shaoqun Zeng, Qingming Luo

Proc. SPIE. 6085, Complex Dynamics and Fluctuations in Biomedical Photonics III

KEYWORDS: Signal to noise ratio, Optical imaging, Biomedical optics, Image processing, Interference (communication), Data processing, Photonics, Signal analyzers, Light, Data analysis

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Proceedings Article | 3 March 2006 Paper

Combine temporal clustering analysis with least square estimation to determine the dynamic pattern of cortical spreading depression

Shangbin Chen, Pengcheng Li, Hui Gong, Shaoqun Zeng, Qingming Luo

Proc. SPIE. 6085, Complex Dynamics and Fluctuations in Biomedical Photonics III

KEYWORDS: Optical imaging, Biomedical optics, Statistical analysis, Blood, Reflectivity, Image analysis, Wave propagation, Binary data, Functional magnetic resonance imaging, Lead

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Proceedings Article | 3 March 2006 Paper

Analyzing the origin of spontaneous synchronized burst in cultured neuronal networks on MEA

Chuanping Chen, Lin Chen, Yunsheng Lin, Shaoqun Zeng

Proc. SPIE. 6085, Complex Dynamics and Fluctuations in Biomedical Photonics III

KEYWORDS: Biomedical optics, Electrodes, Photonics, Action potentials, Nervous system, Electrophysiology, Signal detection, Dendrites, In vitro testing, Neurons

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Proceedings Article | 22 February 2006 Paper

Application of a FRET probe for Caspase-3 activation in living HeLa cells by sequentially treated cisplatin and TRAIL

Juqiang Lin, Zhihong Zhang, Qiushi Yi, Shaoqun Zeng, Qingming Luo

Proc. SPIE. 6088, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IV

KEYWORDS: Proteins, Cancer, Tumors, Tissues, Imaging systems, Luminescence, Cell death, Fluorescent proteins, Fluorescence resonance energy transfer, Resonance enhancement

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Proceedings Article | 29 March 2005 Paper

Using threshold segmentation methods to measure dynamic vasodilatation in a series of optical images

Shangbin Chen, Pengcheng Li, Shaoqun Zeng, Qingming Luo

Proc. SPIE. 5696, Complex Dynamics and Fluctuations in Biomedical Photonics II

KEYWORDS: Optical imaging, Biomedical optics, Stars, Blood, Image segmentation, Image processing, Arteries, Intrinsic optical signal imaging, Hemodynamics, Algorithm development

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Proceedings Article | 29 March 2005 Paper

Verbal working memory load affects prefrontal cortices activation: evidence from a functional NIRS study in humans

Chengjun Li, Hui Gong, Shaoqun Zeng, Qingming Luo

Proc. SPIE. 5696, Complex Dynamics and Fluctuations in Biomedical Photonics II

KEYWORDS: Light emitting diodes, Imaging systems, Sensors, Hemodynamics, Near infrared spectroscopy, Prefrontal cortex, Neuroimaging, Positron emission tomography, Functional magnetic resonance imaging, Brain

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Proceedings Article | 29 March 2005 Paper

Enhancement of synaptic transmission induced by BDNF in cultured cortical neurons

Jun He, Hui Gong, Shaoqun Zeng, Yanling Li, Qingming Luo

Proc. SPIE. 5696, Complex Dynamics and Fluctuations in Biomedical Photonics II

KEYWORDS: Cadmium, Luminescence, Calcium, Photonics, Receptors, Action potentials, Sodium, Neurons, Synaptic plasticity, Synaptic transmission

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Proceedings Article | 18 January 2005 Paper

Compact whole-body fluorescent imaging of nude mice bearing EGFP expressing tumor

Yanping Chen, Tao Xiong, Jun Chu, Li Yu, Shaoqun Zeng, Qingming Luo

Proc. SPIE. 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II

KEYWORDS: Optical imaging, Green fluorescent protein, Tumors, Visualization, Luminescence, Mercury, Lamps, Lung, In vivo imaging, Fluorescent proteins

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Proceedings Article | 18 January 2005 Paper

Fluorescence correlation spectroscopy considering the effect of photobleaching

Yafeng Liu, Tongsheng Chen, Qingming Luo, Shaoqun Zeng

Proc. SPIE. 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II

KEYWORDS: Signal to noise ratio, Biomedical optics, Sensors, Luminescence, Molecules, Diffusion, Time metrology, Molecular spectroscopy, Fluorescence correlation spectroscopy, Tissue optics

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Proceedings Article | 8 December 2003 Paper

Capillary electrophoresis based on continuous-wave multiphoton excitation fluorescence

Sheng Chen, Qingming Luo, Shaoqun Zeng, Tongsheng Chen, Hui Gong, Ling Fu

Proc. SPIE. 5254, Third International Conference on Photonics and Imaging in Biology and Medicine

KEYWORDS: Continuous wave operation, Femtosecond phenomena, Rhodamine B, Capillaries, Mode locking, Luminescence, Molecules, Semiconductor lasers, Biological research

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Proceedings Article | 8 December 2003 Paper

Calcium imaging of cultured neuronal network on multi-electrode array (MEA)

Wei Zhou, Xiangning Li, Shaoqun Zeng, Qingming Luo

Proc. SPIE. 5254, Third International Conference on Photonics and Imaging in Biology and Medicine

KEYWORDS: Confocal microscopy, Optical filters, Imaging systems, Electrodes, Glasses, Luminescence, Calcium, Plating, Neurons, Cell mechanics

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Proceedings Article | 8 December 2003 Paper

On short-term memory of prefrontal cortex using near-infrared spectroscopy

Chengjun Li, Zhuo Gan, Hui Gong, Qingming Luo, Shaoqun Zeng

Proc. SPIE. 5254, Third International Conference on Photonics and Imaging in Biology and Medicine

KEYWORDS: Near infrared, Light sources, Imaging systems, Sensors, Blood, Near infrared spectroscopy, Prefrontal cortex, Positron emission tomography, Functional magnetic resonance imaging, Brain

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Proceedings Article | 8 December 2003 Paper

Optical imaging of neural activity: from neuron to brain

Qingming Luo, Shaoqun Zeng, Hui Gong

Proc. SPIE. 5254, Third International Conference on Photonics and Imaging in Biology and Medicine

KEYWORDS: Optical imaging, Imaging systems, Light scattering, Near infrared spectroscopy, Neuroimaging, Tissue optics, Signal detection, Functional magnetic resonance imaging, Neurons, Brain

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Proceedings Article | 8 December 2003 Paper

Photobleaching of fluorophores at lower concentration under two-photon excitation microscopy

Tongsheng Chen, Yafeng Liu, Shaoqun Zeng, Qingming Luo

Proc. SPIE. 5254, Third International Conference on Photonics and Imaging in Biology and Medicine

KEYWORDS: Rhodamine B, Luminescence, Photons, Molecules, Bioalcohols, Oxygen, Photonics, Molecular interactions, Two photon excitation microscopy, Absorption

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Proceedings Article | 4 December 2003 Paper

Tissue elaborate structure data collection by a high-resolution optical method and image reconstruction

Rongbing Sheng, Qingming Luo, Dan Zhu, Shaoqun Zeng

Proc. SPIE. 5255, Biomolecular Photonics and Multidimensional Microscopy

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Proceedings Article | 4 December 2003 Paper

Probe dendritic functions through poking and peeking

Wenhui Xiong, Zhishang Zhou, Shaoqun Zeng, Wei Chen

Proc. SPIE. 5255, Biomolecular Photonics and Multidimensional Microscopy

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Proceedings Article | 13 October 2003 Paper

Spatio-temporal characteristics of cerebral blood volume changes in different microvascular compartments evoked by sciatic nerve stimulation in rat somatosensory cortex

Pengcheng Li, Qingming Luo, Weihua Luo, Shangbin Chen, Haiying Chen, Shaoqun Zeng

Proc. SPIE. 5068, Saratov Fall Meeting 2002: Optical Technologies in Biophysics and Medicine IV

KEYWORDS: Optical imaging, Veins, Nerve, Sensors, Blood, Capillaries, Reflectivity, Arteries, Skull, Somatosensory cortex

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SPIE Journal Paper | 1 October 2003

Spatiotemporal characteristics of cerebral blood volume changes in rat somatosensory cortex evoked by sciatic nerve stimulation and obtained by optical imaging

Pengcheng Li, Qingming Luo, Weihua Luo, Shangbin Chen, Haiying Cheng, Shaoqun Zeng

JBO Vol. 8 Issue 04

KEYWORDS: Blood, Nerve, Reflectivity, Optical imaging, Veins, Capillaries, Arteries, Somatosensory cortex, Skull, Sensors

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Proceedings Article | 12 September 2003 Paper

Interaction method of photobleaching produced by the interaction between excitation photons and fluorophore molecules in excited states

Tongsheng Chen, Shaoqun Zeng, Qingming Luo

Proc. SPIE. 4967, Genetically Engineered and Optical Probes for Biomedical Applications

KEYWORDS: Biomedical optics, Green fluorescent protein, Luminescence, Photons, Molecules, Diffusion, Biological research, Molecular interactions, Molecular photonics, Absorption

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Proceedings Article | 12 September 2003 Paper

High-order photobleaching in two-photon excitation fluorescence microscopy inside live cell

Tongsheng Chen, Shaoqun Zeng, Qingming Luo, Wei Zhou, Zhihong Zhang

Proc. SPIE. 4967, Genetically Engineered and Optical Probes for Biomedical Applications

KEYWORDS: Microscopes, Proteins, Multiphoton microscopy, Biomedical optics, Green fluorescent protein, Microscopy, Luminescence, Molecules, In vivo imaging, Multiphoton fluorescence microscopy

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Proceedings Article | 27 August 2003 Paper

Dehydration effect on optical properties of porcine liver

Dan Zhu, Qingming Luo, Jian Cen, Shaoqun Zeng, Xiaohua Lu, Yang Weng

Proc. SPIE. 4961, Laser-Tissue Interaction XIV

KEYWORDS: Liver, Optical properties, Tissues, Scattering, Laser scattering, Integrating spheres, Tissue optics, Laser tissue interaction, Temperature metrology, Absorption

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Proceedings Article | 27 August 2003 Paper

Dynamic measurement of blood flow with optical methods

Ting Zhang, Dan Zhu, Qingming Luo, Shaoqun Zeng, Yang Weng

Proc. SPIE. 4961, Laser-Tissue Interaction XIV

KEYWORDS: Tumors, Tissues, Speckle, Blood, Blood circulation, Charge-coupled devices, Intestine, Velocity measurements, Body temperature, Temperature metrology

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Proceedings Article | 29 July 2003 Paper

Spatiotemporal characteristics of cerebral blood volume changes in different microvascular compartments evoked by sciatic nerve stimulation in rat somatosensory cortex

Pengcheng Li, Qingming Luo, Weihua Luo, Shanbin Chen, Haiying Cheng, Shaoqun Zeng

Proc. SPIE. 4955, Optical Tomography and Spectroscopy of Tissue V

KEYWORDS: Optical imaging, Veins, Nerve, Sensors, Blood, Capillaries, Reflectivity, Arteries, Skull, Somatosensory cortex

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Proceedings Article | 29 July 2003 Paper

Detection of time window of cerebral blood flow response induced by sciatic nerve stimulation using temporal clustering analysis

Zheng Wang, Qingming Luo, Haiying Cheng, Shaoqun Zeng

Proc. SPIE. 4955, Optical Tomography and Spectroscopy of Tissue V

KEYWORDS: Signal to noise ratio, Optical imaging, Nerve, Speckle, Blood, Cerebral blood flow, In vivo imaging, Neuroimaging, Functional magnetic resonance imaging, Brain

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Proceedings Article | 8 July 2003 Paper

Monitoring the regional blood flow in the rat mesentery under the drug's effect by using laser speckle imaging

Haiying Cheng, Qingming Luo, Zheng Wang, Shaoqun Zeng, Jian Cen, Pengcheng Li

Proc. SPIE. 4956, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII

KEYWORDS: Transparency, Doppler effect, Speckle, Blood, Speckle pattern, Laser speckle imaging, Blood circulation, Charge-coupled devices, Spatial resolution, Velocity measurements

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SPIE Journal Paper | 1 July 2003

Modified laser speckle imaging method with improved spatial resolution

Haiying Cheng, Qingming Luo, Shaoqun Zeng, Shangbin Chen, Jian Cen, Hui Gong

JBO Vol. 8 Issue 03

KEYWORDS: Blood circulation, Speckle, Spatial resolution, Blood, Speckle pattern, Laser speckle imaging, Temporal resolution, Doppler effect, Statistical analysis, Cerebral blood flow

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Proceedings Article | 12 April 2002 Paper

Optical imaging in cognitive neuroscience

Qingming Luo, Shaoqun Zeng, Hui Gong