Prof. Shean-Jen Chen Profile

Prof. Shean-Jen Chen

Professor at National Yang Ming Chiao Tung Univ

SPIE Involvement:

Author

Area of Expertise:

Multiphoton Microscopy , Image Processing , Adaptive Optics , Deep Learning

Websites:

Personal Website

Profile Summary

Shean-Jen Chen, Ph.D. received his B.S. degree from National Taiwan University in 1987 and his M.S. degree in Mechanical Engineering from Columbia University in 1991. In December 1996, he was awarded his Ph.D. degree for research in adaptive noise cancellation and image restoration at University of California, Los Angeles (UCLA). He entered Synchrotron Radiation Research Center of Taiwan in January 1998 where he became involved in the development of soft x-ray active gratings and microfocusing optical systems. He was an Assistant Professor at National Central University of Taiwan from August 2000 to July 2003, and a Distinguished Professor at NCKU from August 2012 to July 2016. From August 2018, he is a Professor and the Dean at College of Photonics, National Chiao Tung University, Taiwan. Currently, he is actively engaged in researching advanced nonlinear optical microscopy and three-dimensional photolithography.

Publications (96)

Proceedings Article | 11 August 2023 Paper

Paper

Volumetric bioimaging via dual-resonant scanning multiphoton microscopy with 3D-generator U-Net

Chai-Wei Hsu, Sumesh Nair, Chun-Yu Lin, Shean-Jen Chen

Proceedings Volume 12622, 126220G (2023) https://doi.org/10.1117/12.2673721

KEYWORDS: 3D modeling, Microscopes, Image quality, Multiphoton microscopy, Image restoration, 3D image processing, Education and training, Voxels, Brain, 3D image restoration

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Proceedings Article | 9 August 2023 Paper

Paper

Clear and deep temporal focusing multiphoton microscopy imaging using deep prediction with PhyCell and ConvLSTM

Hao-Chung Chi, Anupama Nair, Yvonne Yuling Hu, Feng-Chun Hsu, Chia-Wei Hsu, Chun-Yu Lin, Shean-Jen Chen

Proceedings Volume 12630, 1263003 (2023) https://doi.org/10.1117/12.2670700

KEYWORDS: Multiphoton microscopy, 3D modeling, Signal to noise ratio, Image fusion, Stereoscopy, Spatial resolution, Scattering, Photons, Neuroscience, Neurons

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Proceedings Article | 9 August 2023 Paper

Paper

3D micropatterned multiphoton stimulation via deep computer-generated holography with digital propagation matrix

Shang-Yang Lu, Hao-Chung Chi, Liang-Wei Chen, Feng-Chun Hsu, Chun-Yu Lin, Yvonne Yuling Hu, Shean-Jen Chen

Proceedings Volume 12630, 126300A (2023) https://doi.org/10.1117/12.2669895

KEYWORDS: Matrices, Computer generated holography, Digital holography, 3D modeling, Computation time, Spatial light modulators, Holograms, Data modeling, Temporal resolution, Neurons

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Proceedings Article | 9 August 2023 Presentation + Paper

Presentation + Paper

Path following of tracked vehicle via model predictive control with identified long short-term memory dynamic models

Dun-Ren Liu, Chia-Wei Hsu, Chun-Ting Sung, Ting-Chien Chen, Shean-Jen Chen

Proceedings Volume 12621, 126210A (2023) https://doi.org/10.1117/12.2673392

KEYWORDS: Kinematics, System identification, Performance modeling, Data modeling, Model-based design, Complex systems, Autonomous vehicles, Sand, Rain, Error analysis

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Proceedings Article | 9 August 2023 Presentation + Paper

Presentation + Paper

Multiple caterpillar tracking and 3D positioning in orchard via YOLO plus DeepSORT

Sumesh Nair, Chai-Wei Hsu, Yvonne Yuling Hu, Shean-Jen Chen

Proceedings Volume 12621, 126210J (2023) https://doi.org/10.1117/12.2673773

KEYWORDS: Object detection, Detection and tracking algorithms, Education and training, 3D tracking, Cameras, Biomedical applications, Agriculture, Signal filtering, Photonics, Pesticides

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Proceedings Article | 9 August 2023 Presentation + Paper

Presentation + Paper

Path following and obstacle avoidance of tracked vehicle via deep reinforcement learning with model predictive control as reference

Ting-Chien Chen, Yu-Cheng Sung, Chai-Wei Hsu, Dun-Ren Liu, Shean-Jen Chen

Proceedings Volume 12621, 126210C (2023) https://doi.org/10.1117/12.2673641

KEYWORDS: Neural networks, Device simulation, System identification, Control systems, Cameras, Systems modeling, Performance modeling, Mathematical modeling, Data modeling

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Proceedings Article | 30 May 2022 Presentation

Presentation

In vivo 3D imaging in drosophila brain using rapid dual-resonant volumetric multiphoton microscopy with deep restoration

Chia Wei Hsu, Chi-Yu Wang, Chun-Yu Lin, Yvonne Yuling Hu, Chun-Yuan Wu, Hsueh-Cheng Chiang, Shean-Jen Chen

Proceedings Volume PC12144, PC121440W (2022) https://doi.org/10.1117/12.2621632

KEYWORDS: Multiphoton microscopy, Image quality, In vivo imaging, Data modeling, Brain, Neuroimaging, Stereoscopy, Signal to noise ratio, Mathematical modeling, Neural networks

Read Abstract +

Multiphoton microscopy is a very important and powerful technique in the application of in-vivo drosophila brain imaging. However, the photon budget, which is compromising between imaging speed, spatial resolution and accumulating time, remains a huge challenge in biological compatibility. Rapid dual-resonant volumetric multiphoton microscopy combines a tunable acoustic gradient (TAG) lens and a resonant mirror, which can achieve up to 8 kHz frame rate and hundreds of hertz volumes per second temporal resolution. Adaptively sampling each laser pulse by an embedded field programmable gate array (FPGA) with up to 80 MHz pixel rate enables efficient but restricted signal accumulation. This study has developed a generative neural network to restore images from degradation of low signal-to-noise ratio (SNR), missing pixels and pattern residual. A series of training data by adding noise and Lissajous scanning path into the known fluorescent bead images were used to pretrain the model for the rapid dual resonant volumetric multiphoton microscopy system. Experimental results verify that the axial distortion and the image resolution of noisy fluorescent bead images can be effectively restored with the deep-restoration neural network. The mushroom body (MB) of drosophila brain which contains thousands of Kenyon cells in a 200 × 200 × 100 µm3 volume is utilized to demonstrate the strategy. The deep-restoration rapid dual resonant volumetric multiphoton microscopy image not only maintains 256 × 256 × 128 voxels and ~30 volumes per second, but also significantly improves image quality which is compatible to the ground truth. However, in-vivo imaging is time-varying. Base on in-vitro image datasets, in-vivo images via transfer learning is utilized to enables fast and improved image quality efficiently. Despite of one pulse per pixel, in-vivo drosophila brain imaging with deep-restoration not only keeps the advantage of temporal resolution, but also obtains well image quality.

Proceedings Article | 27 May 2022 Presentation + Paper

Presentation + Paper

To improve in-vivo bio images of fast temporal focusing multiphoton microscopy by multi-stage U-Net image restoration

Yu-Hao Tseng, Yvonne Yuling Hu, Chia-Wei Hsu, Chun-Yu Lin, Hsueh Cheng Chiang, Shean-Jen Chen

Proceedings Volume 12144, 121440F (2022) https://doi.org/10.1117/12.2618266

KEYWORDS: Image registration, Network architectures, Multiphoton microscopy, Scattering, Signal to noise ratio, Microscopy, Image segmentation, In vivo imaging, Image restoration, Computer programming

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Proceedings Article | 27 May 2022 Presentation + Paper

Presentation + Paper

3D micropatterned multiphoton stimulation via deep learning-based computer-generated holography with temporal focusing confinement

Liang-Wei Chen, Feng-Chun Hsu, Yvonne Yuling Hu, Chun-Yu Lin, Shean-Jen Chen

Proceedings Volume 12144, 1214403 (2022) https://doi.org/10.1117/12.2618096

KEYWORDS: Computer generated holography, Spatial light modulators, Neurons, Holograms, Modulation, Objectives, Diffraction gratings, Ultrafast phenomena, Temporal resolution, Neural networks

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Proceedings Article | 27 May 2022 Presentation + Paper

Presentation + Paper

Analysis of collagen types I and II at bone fracture healing tissue using polarization SHG

Anupama Nair, Shu-Chun Chuang, Yi-Shan Lin, Chung-Hwan Chen, Chi-Hsiang Lien, Shean-Jen Chen

Proceedings Volume 12144, 121440J (2022) https://doi.org/10.1117/12.2621568

KEYWORDS: Collagen, Bone, Tissues, Polarization, Cartilage, Second-harmonic generation, Liquid crystals, Harmonic generation, Proteins, Medical research

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Proceedings Article | 24 May 2022 Presentation + Paper

Presentation + Paper

Light field multiphoton microscopy with temporal focusing-based volume selective excitation

Feng-Chun Hsu, Yong Da Sie, Chun-Yu Lin, Yvonne Yuling Hu, Shean-Jen Chen

Proceedings Volume 12136, 121360F (2022) https://doi.org/10.1117/12.2621688

KEYWORDS: 3D image processing, Image resolution, Deconvolution, Point spread functions, Luminescence, Microscopy, Microscopes, Brain, Multiphoton microscopy, Electron multiplying charge coupled devices

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Proceedings Article | 24 May 2022 Presentation + Paper

Presentation + Paper

Shack-Hartmann based wavefront and intensity sensing via U-Net

Feng-Chun Hsu, Chun-Yu Lin, Chia-Yuan Chang, Shean-Jen Chen

Proceedings Volume 12136, 121360A (2022) https://doi.org/10.1117/12.2620264

KEYWORDS: Wavefronts, Wavefront sensors, Neural networks, Adaptive optics, Cameras, Sensors, Spatial light modulators, Image sensors, Thermal modeling, Zernike polynomials

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Proceedings Article | 20 May 2022 Presentation + Paper

Presentation + Paper

Simultaneous path following and obstacle avoidance of field-tracked vehicles via model predictive control with deep deterministic policy gradient

Yu-Cheng Sung, Chun-Ting Sung, Wen-Chuan Tseng, Shean-Jen Chen

Proceedings Volume 12137, 121370N (2022) https://doi.org/10.1117/12.2621549

KEYWORDS: Systems modeling, Agriculture, Vehicle control, Unmanned ground vehicles, Control systems design, Control systems, Applied research, Unmanned vehicles, Process control, Photonics

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Proceedings Article | 17 May 2022 Presentation + Paper

Presentation + Paper

Effective laser pest control with modulated UV-A light trapping for mushroom fungus gnats

Sumesh Nair, Chia-Wei Hsu, Yvonne Hu, Ming-Jeh Chien, Shean-Jen Chen

Proceedings Volume 12138, 1213809 (2022) https://doi.org/10.1117/12.2621592

KEYWORDS: Modulation, Light emitting diodes, Laser development, Beam controllers, Mirrors, Control systems, Image processing, Random lasers, Frequency modulation, MATLAB

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Proceedings Article | 17 May 2022 Presentation + Paper

Presentation + Paper

Path following of field-tracked robots based on model predictive control with visual-inertial odometry and identified state-space dynamic model

Chun-Ting Sung, Wen-Chuan Tseng, Meng-Hui Hsu, Shean-Jen Chen

Proceedings Volume 12138, 121380K (2022) https://doi.org/10.1117/12.2619458

KEYWORDS: Robots, Kinematics, Visual process modeling, RGB color model, System identification, Simulink, Visualization, Cameras, Control systems, Actuators

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Proceedings Article | 7 December 2021 Paper

Paper

Reducing labeling time of fluorescent molecules in thick tissue sections

Po-Hang Tseng, Shu-Jen Chiang, Shean-Jen Chen, Chen-Yuan Dong

Proceedings Volume 11922, 1192217 (2021) https://doi.org/10.1117/12.2615790

KEYWORDS: Tissues, Molecules, Diffusion, Liver, Biomedical optics, Tissue optics, Optical clearing, Microscopes, Luminescence, Physics

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Proceedings Article | 22 March 2021 Poster + Presentation + Paper

Poster + Presentation + Paper

Labeling enhancement of hydrophilic and hydrophobic molecules in tissue sections

Paul Tseng, Shu-Jen Chiang, Shean-Jen Chen, Chen-Yuan Dong

Proceedings Volume 11648, 116481E (2021) https://doi.org/10.1117/12.2582702

KEYWORDS: Tissues, Molecules, Diffusion, Liver

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Proceedings Article | 5 March 2021 Presentation

Presentation

Optical diagnosis of precisely cut HNSCC slices for precision medicine

Shu-Jen Chiang, Po-Hang Tseng, Shu-Han Wen, Shih-Chih Chen, Shean-Jen Chen, Mei-Chun Lin, Pei-Jen Lou, Chen-Yuan Dong

Proceedings Volume 11627, 116270C (2021) https://doi.org/10.1117/12.2583814

KEYWORDS: Medicine, Tumors, Precision optics, Spectroscopy, Neck, Imaging spectroscopy, Head

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SPIE Journal Paper | 1 January 2021 Open Access

Open Access

Temporal focusing multiphoton microscopy with optimized parallel multiline scanning for fast biotissue imaging

Chia-Yuan Chang, Chun-Yun Lin, Yvonne Hu, Sheng-Feng Tsai, Feng-Chun Hsu, Shean-Jen Chen

JBO, Vol. 26, Issue 01, 016501, (January 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.1.016501

KEYWORDS: Digital micromirror devices, Multiphoton microscopy, Objectives, Diffraction, Luminescence, Micromirrors, Optical simulations, Beam shaping, Microscopy, Imaging systems

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Proceedings Article | 25 March 2020 Presentation + Paper

Presentation + Paper

Rapid laser pest control system with 3D small object detection

Sumesh Nair, Chia-Ying Chang, Feng-Chun Hsu, Ching-Chieh Su, Shean-Jen Chen

Proceedings Volume 11299, 112990T (2020) https://doi.org/10.1117/12.2546946

KEYWORDS: Head, Control systems, Laser scanners, Cameras, Laser systems engineering, RGB color model, Mirrors, Agriculture, Pulsed laser operation, Laser development

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Proceedings Article | 16 March 2020 Presentation + Paper

Presentation + Paper

Investigation of adsorption and release of photodynamic dyes by Clinoptilolite zeolite

Anupama Nair, V. Hovhannisyan, Shean-Jen Chen

Proceedings Volume 11220, 112200G (2020) https://doi.org/10.1117/12.2546905

KEYWORDS: Skin, Zeolites, Luminescence, Adsorption, Tissues, Photodynamic therapy, Second-harmonic generation, Multiphoton microscopy, Biomedical optics, Particles

Read Abstract +

Proceedings Article | 9 March 2020 Presentation

Presentation

Advanced volumetric light field microscopy with temporal-focusing multiphoton selective excitation (Conference Presentation)

Feng-Chun Hsu, Yong Da Sie, Chia-Yuan Chang, Chun-Yu Lin, Yvonne Hu, Shean-Jen Chen

Proceedings Volume 11245, 112450G (2020) https://doi.org/10.1117/12.2546629

KEYWORDS: Multiphoton microscopy, Microscopy, 3D image processing, Image resolution, Luminescence, Multiphoton fluorescence microscopy, Light sources and illumination, 3D image reconstruction, Modulation, Objectives

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Proceedings Article | 9 March 2020 Presentation

Presentation

Rapid volumetric multiphoton microscopy via dual resonant scanning with deep learning (Conference Presentation)

Chia Wei Hsu, Yu-Shin Hsu, Chun-Yu Lin, Shean-Jen Chen

Proceedings Volume 11244, 112441W (2020) https://doi.org/10.1117/12.2546860

KEYWORDS: Multiphoton microscopy, Mirrors, Field programmable gate arrays, Image enhancement, Temporal resolution, In vivo imaging, Acoustics, Microscopes, Image acquisition, Femtosecond phenomena

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Proceedings Article | 21 February 2020 Paper

Paper

Multiphoton and confocal imaging of precisely cut oral cancer tumor sections for personalized medicine

Shu-Jen Chiang, Po-Hang Tseng, Hsu-Cheng Huang, Shih-Chi Chen, Shean-Jen Chen, Mei-Chun Lin, Pei-Jen Lou, Chen-Yuan Dong

Proceedings Volume 11244, 1124427 (2020) https://doi.org/10.1117/12.2545617

KEYWORDS: Tumors, Cancer, Tissues, Confocal microscopy, Physics, Medicine, Imaging systems, Photonics, Mechanical engineering, Therapeutic agents

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Proceedings Article | 20 February 2020 Paper

Paper

Multiphoton imaging of dye penetration dynamics in tissue sections

Po-Hang Tseng, Shu-Jen Chiang, Shean-Jen Chen, Chen-Yuan Dong

Proceedings Volume 11244, 1124428 (2020) https://doi.org/10.1117/12.2545731

KEYWORDS: Tissues, Diffusion, Molecules, Tissue optics, Photonics, Physics, Imaging systems, 3D modeling, Multiphoton microscopy

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Proceedings Article | 9 September 2019 Paper

Paper

Smart laser weeding system

Chia-Yuan Chang, Chia-Ying Chang, Xin-Ni Huang, Tzu-Cheng Huang, Chi-Yuan Wu, Tsai-Wei Chang, Yeun Chung Lee, Chun-Lin Lu, Ken Y. Hsu, Kan-Shu Chen, Tsui-Hsia Weng, Shean-Jen Chen

Proceedings Volume 11123, 111230X (2019) https://doi.org/10.1117/12.2532014

KEYWORDS: Cameras, Laser systems engineering, Imaging systems, Image segmentation, Agriculture, Calibration, Telecommunications, Image processing, Laser processing, Databases

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Proceedings Article | 31 July 2019 Paper

Paper

Improved and fast biotissue imaging by temporal focusing widefield multiphoton microscopy with spatially modulated illumination

Chia-Yuan Chang, Chun-Yu Lin, Vladimir Hovhannisyan, Shean-Jen Chen

Proceedings Volume 11076, 110760G (2019) https://doi.org/10.1117/12.2526908

KEYWORDS: Modulation, Digital micromirror devices, Multiphoton microscopy, Scattering, Objectives, Microscopy, Diffraction, Spatial frequencies, Microscopes, Luminescence

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Proceedings Article | 22 July 2019 Paper

Paper

Zeolite magnetic nano/micro-particles for adsorption, delivery and release of photodynamic dyes

Vladimir Hovhannisyan, Katarina Siposova, Andrej Musatov, Zuzana Mitroova, Shean-Jen Chen

Proceedings Volume 11075, 110751G (2019) https://doi.org/10.1117/12.2526924

KEYWORDS: Magnetism, Zeolites, Adsorption, Luminescence, Multiphoton microscopy, Nanoparticles

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Proceedings Article | 21 February 2019 Presentation + Paper

Presentation + Paper

Temporal focusing-based multiphoton excitation fluorescence images with background noise cancellation via Hilbert-Huang transform

Yvonne Hu, Yuan-Rong Lo, Chun-Yu Lin, Chia-Yuan Chang, Shean-Jen Chen

Proceedings Volume 10883, 108831C (2019) https://doi.org/10.1117/12.2507695

KEYWORDS: Digital micromirror devices, Diffraction, Luminescence, Spatial frequencies, Microscopy, Objectives, Diffraction gratings, Image filtering, Modulation, Multiphoton microscopy

Read Abstract +

SPIE Journal Paper | 15 November 2018 Open Access

Open Access

Fast and improved bioimaging via temporal focusing multiphoton excitation microscopy with binary digital-micromirror-device holography

Yong Da Sie, Chia-Yuan Chang, Chun-Yu Lin, Nan-Shan Chang, Paul Campagnola, Shean-Jen Chen

JBO, Vol. 23, Issue 11, 116502, (November 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.11.116502

KEYWORDS: Digital micromirror devices, Binary data, Diffraction, Objectives, Holography, Microscopy, Multiphoton microscopy, Digital holography, Fourier transforms, Beam shaping

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SPIE Journal Paper | 1 June 2018 Open Access

Open Access

Natural zeolite for adsorbing and release of functional materials

Vladimir Ararat Hovhannisyan, Chen-Yuan Dong, Feng-Jie Lai, Nan-Shan Chang, Shean-Jen Chen

JBO, Vol. 23, Issue 09, 091411, (June 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.9.091411

KEYWORDS: Particles, Zeolites, Magnetism, Luminescence, Molecules, Adsorption, Second-harmonic generation, Collagen, Minerals, Biomedical optics

Read Abstract +

Proceedings Article | 23 February 2018 Presentation + Paper

Presentation + Paper

Rapid and highly integrated FPGA-based Shack-Hartmann wavefront sensor for adaptive optics system

Yi-Pin Chen, Chia-Yuan Chang, Shean-Jen Chen

Proceedings Volume 10502, 1050203 (2018) https://doi.org/10.1117/12.2289095

KEYWORDS: Field programmable gate arrays, Wavefronts, Cameras, Wavefront sensors, Deformable mirrors, Adaptive optics, Computer aided design, Microlens array, Image transmission, Parallel processing

Read Abstract +

Proceedings Article | 23 February 2018 Paper

Paper

Volumetric bioimaging based on light field microscopy with temporal focusing illumination

Feng-Chun Hsu, Yong Da Sie, Feng-Jie Lai, Shean-Jen Chen

Proceedings Volume 10499, 104991Q (2018) https://doi.org/10.1117/12.2289336

KEYWORDS: 3D image processing, Microscopy, 3D image reconstruction, Image sensors, Microscopes, Electron multiplying charge coupled devices, Multiphoton microscopy, Digital micromirror devices, Luminescence, Objectives

Read Abstract +

Proceedings Article | 23 February 2018 Paper

Paper

Rapid volumetric multiphoton imaging with the combination of an ultrasound lens and a resonant mirror

Chia-Wei Hsu, Tsung-Yen Chiang, Feng-Jie Lai, Shean-Jen Chen

Proceedings Volume 10498, 104982D (2018) https://doi.org/10.1117/12.2289448

KEYWORDS: Objectives, Mirrors, Scanners, Imaging systems, Luminescence, Microscopy, Multiphoton microscopy, Relays, Field programmable gate arrays, Image resolution

Read Abstract +

Proceedings Article | 24 April 2017 Presentation

Presentation

Dynamical measurements of motion behavior of free fluorescent sphere using the wide field temporal focusing microscopy with astigmatism method (Conference Presentation)

Chi-Hsiang Lien, Chun-Yu Lin, Shean-Jen Chen, Fan-Ching Chien

Proceedings Volume 10069, 100691V (2017) https://doi.org/10.1117/12.2252323

KEYWORDS: Biomedical optics, 3D image processing, Multiphoton microscopy, Monochromatic aberrations, 3D metrology, Microscopy, Particles, Motion measurement, Optical spheres, 3D scanning

Read Abstract +

Proceedings Article | 20 February 2017 Presentation + Paper

Presentation + Paper

Improvement of axial excitation confinement in temporal focusing-based multiphoton microscopy via spatially modulated illumination

Chia-Yuan Chang, Shean-Jen Chen

Proceedings Volume 10117, 101170F (2017) https://doi.org/10.1117/12.2251183

KEYWORDS: Multiphoton microscopy, Microscopy, Modulation, Digital micromirror devices, Dispersion, Diffraction, Biomedical optics, Multiphoton processes, Spatial frequencies, Scattering, Beam shaping, Image filtering

Read Abstract +

SPIE Journal Paper | 25 July 2013 Open Access

Open Access

High-throughput fabrication of gray-level biomicrostructures via temporal focusing excitation and laser pulse control

Yi-Cheng Li, Li-Chung Cheng, Chia-Yuan Chang, Chun-Yu Lin, Nan-Shan Chang, Paul Campagnola, Chen-Yuan Dong, Shean-Jen Chen

JBO, Vol. 18, Issue 07, 075004, (July 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.7.075004

KEYWORDS: 3D microstructuring, Pulsed laser operation, Digital micromirror devices, Optical amplifiers, Microfabrication, Beam controllers, Control systems, 3D image processing, Ultrafast phenomena, Imaging systems

Read Abstract +

SPIE Journal Paper | 2 April 2013 Open Access

Open Access

Elucidation of the mechanisms of optical clearing in collagen tissue with multiphoton imaging

Vladimir Hovhannisyan, Po-Sheng Hu, Shean-Jen Chen, Chang-Seok Kim, Chen-Yuan Dong

JBO, Vol. 18, Issue 04, 046004, (April 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.4.046004

KEYWORDS: Collagen, Second-harmonic generation, Tissue optics, Tissues, Optical clearing, Skin, Signal processing, Molecules, Scattering, Transparency

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SPIE Journal Paper | 22 November 2012 Open Access

Open Access

Imaging of biological tissues with pixel-level analysis of second-order susceptibility

Po-Sheng Hu, Ara Ghazaryan, Vladimir Hovhannisyan, Shean-Jen Chen, Yang-Fang Chen, Chang-Seok Kim, Tsung-Hua Tsai, Chen-Yuan Dong

JBO, Vol. 18, Issue 03, 031102, (November 2012) https://doi.org/10.1117/12.10.1117/1.JBO.18.3.031102

KEYWORDS: Second-harmonic generation, Tissues, Collagen, Microscopy, Biological research, Polarization, Skin, Cartilage, Optical fibers, Imaging systems

Read Abstract +

SPIE Journal Paper | 22 November 2012 Open Access

Open Access

Analysis of collagen fiber domain organization by Fourier second harmonic generation microscopy

Ara Ghazaryan, Halley Tsai, Gor Hayrapetyan, Wei-Liang Chen, Yang-Fang Chen, Myung-Yung Jeong, Chang-Seok Kim, Shean-Jen Chen, Chen-Yuan Dong

JBO, Vol. 18, Issue 03, 031105, (November 2012) https://doi.org/10.1117/12.10.1117/1.JBO.18.3.031105

KEYWORDS: Tissues, Second-harmonic generation, Cornea, Collagen, Autoregressive models, Harmonic generation, Microscopy, Biological research, Image analysis, Fourier transforms

Read Abstract +

Proceedings Article | 19 October 2012 Paper

Paper

Fast multiphoton microfabrication of freeform polymer microstructures by spatiotemporal focusing and patterned generation

Y.-C. Li, L.-C. Cheng, C.-H. Lien, C.-Y. Chang, W.-C. Yen, S.-J. Chen

Proceedings Volume 8489, 848905 (2012) https://doi.org/10.1117/12.930307

KEYWORDS: Microfabrication, Polymers, Digital micromirror devices, 3D microstructuring, Optical amplifiers, Objectives, Ultrafast phenomena, Inspection, 3D image processing, Image processing

Read Abstract +

Proceedings Article | 15 October 2012 Paper

Paper

Spatiotemporal focusing-based widefield multiphoton microscopy for fast optical sectioning of thick tissues

Li-Chung Cheng, Chia-Yuan Chang, Wei-Chung Yen, Shean-Jen Chen

Proceedings Volume 8520, 85200N (2012) https://doi.org/10.1117/12.930324

KEYWORDS: Multiphoton microscopy, Microscopes, Ultrafast phenomena, Amplifiers, Spatial resolution, Microscopy, Objectives, Optical amplifiers, Oscillators, Electron multiplying charge coupled devices

Read Abstract +

Proceedings Article | 15 October 2012 Paper

Paper

Widefield multiphoton microscopy with image-based adaptive optics

C.-Y. Chang, L.-C. Cheng, H.-W. Su, W.-C. Yen, S.-J. Chen

Proceedings Volume 8520, 85200O (2012) https://doi.org/10.1117/12.930327

KEYWORDS: Adaptive optics, Microscopes, Multiphoton microscopy, Wavefront distortions, Distortion, Image quality, Image segmentation, Glasses, Thin films, Polishing

Read Abstract +

Proceedings Article | 10 October 2012 Paper

Paper

Two-dimensional freeform optical trapping by surface plasmon enhancement and patterned excitation

H.-W. Su, C.-Y. Lin, S.-J. Chen

Proceedings Volume 8458, 84583B (2012) https://doi.org/10.1117/12.930312

KEYWORDS: Particles, Optical tweezers, Digital micromirror devices, Metals, Surface plasmons, Interfaces, Gold, Dielectrics, Light scattering, Near infrared

Read Abstract +

Proceedings Article | 27 September 2012 Paper

Paper

Mechanism of two-photon fluorescence increment via cross-linked bovine serum albumin

C.-Y. Lin, C.-H. Lien, C.-Y. Chang, S.-J Chen

Proceedings Volume 8459, 84590F (2012) https://doi.org/10.1117/12.930335

KEYWORDS: Quantum efficiency, Luminescence, Femtosecond phenomena, Fluorescence lifetime imaging, Picosecond phenomena, Laser development, Molecules, Rhodamine B, Photons, Field programmable gate arrays

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Proceedings Article | 6 February 2012 Paper

Paper

Three-dimensional gold nanorods-doped multicolor microstructures

C.-H. Lien, K.-C. Cho, W.-S. Kuo, C.-Y. Lin, C.-L. Chui, S.-J. Chen

Proceedings Volume 8234, 82341R (2012) https://doi.org/10.1117/12.914044

KEYWORDS: 3D microstructuring, Plasmons, Proteins, Microfabrication, Femtosecond phenomena, Gold, Plasmonics, 3D image processing, Photochemistry, Absorption

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Proceedings Article | 1 March 2011 Paper

Paper

Study of nanoprisms via apertureless near-field optical microscopy

Chak-Fong Cheang, Yi-Cheng Li, Kuo-Chih Chiu, Chun-Yu Lin, Yun-Chorng Chang, Shean-Jen Chen

Proceedings Volume 7946, 79461M (2011) https://doi.org/10.1117/12.877151

KEYWORDS: Near field, Near field optics, Near field scanning optical microscopy, Silver, Heterodyning, Atomic force microscopy, Surface roughness, Surface plasmons, Interferometry, Optical microscopy

Read Abstract +

Proceedings Article | 17 February 2011 Paper

Paper

Multiphoton imaging and quantification of tissue glycation

Ara Ghazaryan, Jo-Ya Tseng, Wen Lo, Yang-Fang Chen, Vladimir Hovhannisyan, Shean-Jen Chen, Hsin-Yuan Tan, Chen-Yuan Dong

Proceedings Volume 7895, 789509 (2011) https://doi.org/10.1117/12.874536

KEYWORDS: Tissues, Sclera, Multiphoton microscopy, Tissue optics, Cornea, Collagen, Skin, Harmonic generation, Second-harmonic generation, Microscopy

Read Abstract +

Proceedings Article | 12 February 2011 Paper

Paper

Near-infrared Au nanorods in photodynamic therapy, hyperthermia agents, and near-infrared optical imaging

Wen-Shuo Kuo, Chich-Neng Chang, Yi-Ting Chang, Meng-Heng Yang, Yi-Hsin Chien, Shean-Jen Chen, Chen-Sheng Yeh

Proceedings Volume 7910, 791009 (2011) https://doi.org/10.1117/12.876667

KEYWORDS: Gold, Photodynamic therapy, Near infrared, Luminescence, Cancer, Oxygen, Absorption, Laser irradiation, Nanomaterials, Nanorods

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Proceedings Article | 11 February 2011 Paper

Paper

2D nanosphere lithography by using surface plasmon-enhanced optical trapping

Y.-C. Li, C.-Y. Lin, K.-C. Chiu, C.-F. Cheang, Y.-C. Chang, S.-J. Chen

Proceedings Volume 7927, 79270H (2011) https://doi.org/10.1117/12.877129

KEYWORDS: Particles, Optical tweezers, Gold, Dielectrics, Metals, Surface plasmons, Interfaces, Silica, Lithography, Waveguides

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Proceedings Article | 11 February 2011 Paper

Paper

2D freeform plasmonic trapping via spatial light modulator

H.-W. Su, C.-Y. Lin, K.-C. Chiu, H.-L. Tsai, S.-J. Chen

Proceedings Volume 7902, 79020O (2011) https://doi.org/10.1117/12.877134

KEYWORDS: Particles, Optical tweezers, Spatial light modulators, Surface plasmons, Interfaces, Gold, Dielectrics, Light scattering, Metals, Plasmonics

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Proceedings Article | 11 September 2010 Paper

Paper

Three-dimensional polymer microdevices with gold nanorods

W.-S. Kuo, C.-H. Lien, K.-C. Cho, C.-Y. Chang, C.-Y. Lin, P. Campagnola, S.-J. Chen

Proceedings Volume 7757, 77573C (2010) https://doi.org/10.1117/12.864099

KEYWORDS: 3D microstructuring, Femtosecond phenomena, Polymers, Plasmons, Absorption, Gold, Bragg cells, Laser damage threshold, Microfabrication, Field programmable gate arrays

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Proceedings Article | 11 September 2010 Paper

Paper

Surface plasmon-enhanced and quenched two-photon excited fluorescence

C.-Y. Lin, C.-H. Lien, K.-C. Chiu, C.-Y. Chang, S.-H. Chang, T.-F. Guo, S.-J. Chen

Proceedings Volume 7757, 77573A (2010) https://doi.org/10.1117/12.864042

KEYWORDS: Luminescence, Quantum efficiency, Silver, Metals, Silica, Reflection, Surface plasmons, Microscopy, Dielectrics, Objectives

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Proceedings Article | 24 August 2010 Paper

Paper

Widefield multiphoton excited fluorescence microscopy for animal study in vivo

L.-C. Cheng, C.-Y. Chang, C.-H. Lin, Y.-D. Su, T.-Y. Huang, S.-J. Chen

Proceedings Volume 7765, 77650Y (2010) https://doi.org/10.1117/12.864107

KEYWORDS: Luminescence, Multiphoton microscopy, Multiphoton fluorescence microscopy, Microscopy, 3D image processing, Electron multiplying charge coupled devices, Objectives, Signal detection, In vivo imaging, Pulsed laser operation

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SPIE Journal Paper | 1 May 2010 Open Access

Open Access

Label-free structural characterization of mitomycin C-modulated wound healing after photorefractive keratectomy by the use of multiphoton microscopy

Wen Lo, Tsung-Jen Wang, Wei-Liang Chen, Chiu-Mei Hsueh, Shean-Jen Chen, Yang-Fang Chen, Hsiu-Chu Chou, Pi-Jung Lin, Fung-Rong Hu, Chen-Yuan Dong

JBO, Vol. 15, Issue 03, 036005, (May 2010) https://doi.org/10.1117/12.10.1117/1.3432718

KEYWORDS: Second-harmonic generation, Cornea, Collagen, Wound healing, Multiphoton microscopy, Physics, Ophthalmology, Signal detection, Medicine, Image processing

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Proceedings Article | 2 March 2010 Paper

Paper

Monitoring chemically enhanced transdermal delivery of zinc oxide nanoparticles by using multiphoton microscopy

Wen Lo, Chih-Ting Hsu, Tsung-Rong Kuo, Chung-Long Wu, Shu-Jen Chiang, Sung-Jan Lin, Shean-Jen Chen, Chia-Chun Chen, Chen-Yuan Dong

Proceedings Volume 7548, 75480P (2010) https://doi.org/10.1117/12.843187

KEYWORDS: Zinc oxide, Skin, Bioalcohols, Second-harmonic generation, Nanoparticles, Multiphoton microscopy, Absorption, Diffusion, Quantitative analysis, Physics

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SPIE Journal Paper | 1 September 2009 Open Access

Open Access

Multimodal, multiphoton microscopy and image correlation analysis for characterizing corneal thermal damage

Wen Lo, Yu-Lin Chang, Jia-Shiu Liu, Chiu-Mei Hseuh, Vladimir Hovhannisyan, Shean-Jen Chen, Hsian-Yuan Tan, Chen-Yuan Dong

JBO, Vol. 14, Issue 05, 054003, (September 2009) https://doi.org/10.1117/12.10.1117/1.3213602

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Proceedings Article | 17 July 2009 Paper

Paper

Non-ablative processing of biofibers by femtosecond IR laser

Vladimir Hovhannisyan, Wen Lo, Chieh Hu, Shean-Jen Chen, Chen Yuan Dong

Proceedings Volume 7373, 73731X (2009) https://doi.org/10.1117/12.831898

KEYWORDS: Collagen, Optical fibers, Femtosecond phenomena, Second-harmonic generation, Laser applications, Tissues, Infrared lasers, Skin, Laser cutting, Harmonic generation

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Proceedings Article | 17 February 2009 Paper

Paper

Surface plasmon resonance biosensors with plasmonic nanostructures

L.-Y. Yu, C.-Y. Lin, J.-C. Hsu, S.-J. Chen

Proceedings Volume 7192, 71920B (2009) https://doi.org/10.1117/12.809152

KEYWORDS: Biosensors, Metals, Interfaces, Reflection, Glasses, Surface plasmons, Nanostructures, Biological research, Diffraction, Water

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Proceedings Article | 13 February 2009 Paper

Paper

Surface plasmon-enhanced two-photon fluorescence microscopy for live cell membrane imaging

R.-Y. He, K.-C. Cho, N.-S. Chang, Y.-D. Su, S.-J. Chen

Proceedings Volume 7183, 71831L (2009) https://doi.org/10.1117/12.809134

KEYWORDS: Luminescence, Microscopy, Metals, Surface plasmons, Interfaces, Collagen, Signal to noise ratio, Prisms, Microscopes, Thin films

Read Abstract +

Proceedings Article | 28 September 2007 Paper

Paper

Investigating the secondary structures for long oligonucleotides using attenuated-total-reflection nanoplasmon-enhanced Raman scattering

K.-C. Chiu, S.-J. Chen, C.-Y. Lin, L.-Y. Yu

Proceedings Volume 6642, 66420H (2007) https://doi.org/10.1117/12.734044

KEYWORDS: Silver, Raman spectroscopy, Raman scattering, Surface enhanced Raman spectroscopy, Metals, Nanostructures, Spectroscopy, Nanoparticles, Charge-coupled devices, Biological research

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Proceedings Article | 28 September 2007 Paper

Paper

A surface plasmon polariton phase microscope with a subwavelength grating structure

Shean-Jen Chen, Yuan-Deng Su, C. Lin, C.-W. Chang

Proceedings Volume 6642, 66420C (2007) https://doi.org/10.1117/12.734027

KEYWORDS: Spiral phase plates, Imaging systems, Diffraction gratings, Microscopes, Biosensors, Phase imaging, Phase shifts, Prisms, Reflectivity, Phase measurement

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Proceedings Article | 16 May 2007 Paper

Paper

Examination of bacteria drug resistance utilizing surface plasmon resonance

Ya-Ling Chiang, How-Foo Chen, Chi-Hung Lin, Shean-Jen Chen

Proceedings Volume 6585, 65851O (2007) https://doi.org/10.1117/12.722763

KEYWORDS: Surface plasmons, Bacteria, Gold, Scanning electron microscopy, Refractive index, Metals, Water, Resistance, Photodiodes, Prisms

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Proceedings Article | 5 March 2007 Paper

Paper

Compact retinal imaging system with liquid-crystal spatial-light-modulation adaptive optics device

K.-C. Cho, C.-H. Lin, S.-J. Chen

Proceedings Volume 6426, 64261X (2007) https://doi.org/10.1117/12.701737

KEYWORDS: Adaptive optics, Spatial light modulators, LCDs, Wavefronts, Calibration, Phase shifts, Liquid crystals, Imaging systems, Distortion, Retinal scanning

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Proceedings Article | 14 February 2007 Paper

Paper

A surface plasmon phase imaging system with subwavelength grating

Y.-D. Su, L.-Y. Yu, C. Lin, C.-W. Chang, S.-J. Chen

Proceedings Volume 6450, 64500K (2007) https://doi.org/10.1117/12.701755

KEYWORDS: Spiral phase plates, Imaging systems, Diffraction gratings, Phase imaging, Biosensors, Surface plasmons, Phase shifts, Prisms, Reflectivity, Phase measurement

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Proceedings Article | 14 February 2007 Paper

Paper

Investigating the structural changes of β-amyloid peptide aggregation using attenuated-total-reflection surface-enhanced Raman spectroscopy

K.-C. Chiu, L.-Y. Yu, J.-N. Yih, S.-J. Chen

Proceedings Volume 6450, 64500R (2007) https://doi.org/10.1117/12.701757

KEYWORDS: Surface enhanced Raman spectroscopy, Raman spectroscopy, Silver, Nanoparticles, Metals, Raman scattering, Biosensing, Spectroscopy, Signal processing, Charge-coupled devices

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Proceedings Article | 14 February 2007 Paper

Paper

Surface plasmon resonance biosensors with subwavelength grating waveguide

C.-Y. Lin, F.-C. Chien, L.-Y. Yu, C.-W. Chang, K.-C. Chiu, S.-J. Chen

Proceedings Volume 6450, 64500L (2007) https://doi.org/10.1117/12.701758

KEYWORDS: Biosensors, Diffraction gratings, Waveguides, Surface plasmons, Reflectivity, Dielectrics, Diffraction, Metals, Gold, Biological research

Read Abstract +

Proceedings Article | 12 February 2007 Paper

Paper

The investigation of the subwavelength focusing spot resulting from modified surface plasmon wave at planar interface

Jenq-Nan Yih, Shean-Jen Chen, Shuan-Teng Hong, Han-Fai Yau

Proceedings Volume 6447, 64470Q (2007) https://doi.org/10.1117/12.702322

KEYWORDS: Polarization, Transmittance, Surface plasmons, Interfaces, Metals, Near field, Molecules, Surface enhanced Raman spectroscopy, Nanoparticles, Thin films

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Proceedings Article | 10 February 2007 Paper

Paper

A full-field heterodyne surface plasmon resonance dynamic bio-imaging system

C.-H. Lin, Y.-D. Su, C.-H. Huang, K.-C. Cho, S.-J. Chen

Proceedings Volume 6447, 644709 (2007) https://doi.org/10.1117/12.701749

KEYWORDS: Imaging systems, Heterodyning, Sensors, Biosensors, Surface plasmons, Interferometry, Photodiodes, Refractive index, Argon, Dielectrics

Read Abstract +

Proceedings Article | 30 August 2006 Paper

Paper

Direct detection of C-reactive proteins in human serum using nanoparticle-enhanced surface plasmon resonance biosensing

H.-Y. Lin, K. Tsang, W. Hu, H.-Y. Hsu, A. Chiou, G.-L. Chang, S.-J. Chen

Proceedings Volume 6324, 63240C (2006) https://doi.org/10.1117/12.682114

KEYWORDS: Proteins, Biosensors, Surface plasmons, Biosensing, Gold, Sensors, Plasmonics, Chemical vapor deposition, Refractive index, Prisms

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Proceedings Article | 30 August 2006 Paper

Paper

Investigating the secondary structures of long oligonucleotides using attenuated-total-reflection surface-enhanced Raman spectroscopy

K.-C. Chiu, J.-N. Yih, L.-Y. Yu, S.-J. Chen

Proceedings Volume 6323, 63231O (2006) https://doi.org/10.1117/12.682116

KEYWORDS: Surface enhanced Raman spectroscopy, Raman spectroscopy, Silver, Nanoparticles, Metals, Raman scattering, Spectroscopy, Signal processing, Biological research, Signal detection

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Proceedings Article | 30 August 2006 Paper

Paper

Study the enhancement of near electro-magnetic field via plasmonic effects using finite-difference time-domain method and near-field scanning optical microscopy

C.-H. Huang, C.-Y. Lin, S.-J. Chen

Proceedings Volume 6323, 632310 (2006) https://doi.org/10.1117/12.682119

KEYWORDS: Nanoparticles, Gold, Plasmonics, Particles, Dielectrics, Finite-difference time-domain method, Biosensors, Near field scanning optical microscopy, Surface plasmons, Plasmons

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Proceedings Article | 30 August 2006 Paper

Paper

Imaging the cell membrane with surface plasmon resonance phase microscopy

R.-Y. He, Y.-D. Su, G.-L. Chang, S.-J. Chen

Proceedings Volume 6324, 632409 (2006) https://doi.org/10.1117/12.682118

KEYWORDS: Microscopes, Proteins, Surface plasmons, Gold, Phase shifts, Microscopy, Luminescence, Prisms, Thin films, Dielectrics

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Proceedings Article | 30 August 2006 Paper

Paper

Plasmon-enhanced optical waveguide biosensors constructed with sub-wavelength gold grating

F.-C. Chien, C.-Y. Lin, J.-N. Yih, K.-L. Lee, C.-W. Chang, P.-K. Wei, S.-J. Chen

Proceedings Volume 6323, 63230M (2006) https://doi.org/10.1117/12.682124

KEYWORDS: Biosensors, Diffraction gratings, Waveguides, Reflection, Surface plasmons, Reflectivity, Metals, Biological research, Diffraction, Gold

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Proceedings Article | 28 February 2006 Paper

Paper

Coupled waveguide-surface plasmon resonance biosensors constructed with sub-wavelength grating

F.-C. Chien, J.-N. Yih, C.-Y. Lin, K.-L. Lee, Y.-M. Chu, Y.-C. Mao, W.-H. Wang, P.-K. Wei, S.-J. Chen

Proceedings Volume 6095, 60950P (2006) https://doi.org/10.1117/12.647455

KEYWORDS: Biosensors, Waveguides, Diffraction gratings, Reflection, Metals, Biological research, Plasmons, Plasmonics, Surface plasmons, Waveguide modes

Read Abstract +

Proceedings Article | 23 February 2006 Paper

Paper

An investigation into the influence of secondary structures for DNA hybridization using surface plasmon resonance and surface-enhanced Raman scattering

J.-N. Yih, K.-C. Chiu, F.-C. Chien, W.-Y. Chen, S.-J. Chen

Proceedings Volume 6099, 609906 (2006) https://doi.org/10.1117/12.647449

KEYWORDS: Raman spectroscopy, Surface enhanced Raman spectroscopy, Raman scattering, Surface plasmons, Biological research, Nanoparticles, Silver, Microscopes, Signal processing, Charge-coupled devices

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Proceedings Article | 23 February 2006 Paper

Paper

A theoretical and experimental investigation into the enhancement of near electro-magnetic field via plasmon effects

C.-Y. Lin, F.-C. Chien, C.-H. Huang, S.-J. Chen

Proceedings Volume 6099, 60990S (2006) https://doi.org/10.1117/12.647452

KEYWORDS: Nanoparticles, Gold, Particles, Dielectrics, Plasmonics, Biosensors, Finite-difference time-domain method, Plasmons, Surface plasmons, Silver

Read Abstract +

Proceedings Article | 16 February 2006 Paper

Paper

Study of cell adhesion and migration by using a plasmon-enhanced total internal reflection fluorescence microscope

R.-Y. He, K.-C. Chiu, Y.-D. Su, K.-L. Chang, S.-J. Chen

Proceedings Volume 6088, 608802 (2006) https://doi.org/10.1117/12.647444

KEYWORDS: Luminescence, Surface plasmons, Thin films, Prisms, Collagen, Silver, Metals, Signal detection, Proteins, Reflection

Read Abstract +

Proceedings Article | 12 November 2005 Paper

Paper

A label-free optical waveguide biosensor with sub-wavelength gratings

Jenq-Nan Yih, Yen-Chieh Mao, Yi-Ming Chu, Wei-Han Wang, Lai-Sheng Chen, Fan-Ching Chien, Kuang-Li Lee, Pei-Kuan Wei, Shean-Jen Chen

Proceedings Volume 6007, 600712 (2005) https://doi.org/10.1117/12.630610

KEYWORDS: Diffraction gratings, Waveguides, Biosensors, Reflection, Biological research, Diffraction, Proteins, Refractive index, Spectroscopy, Analytical research

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Proceedings Article | 23 May 2005 Paper

Paper

Fiber type of optical coherence tomography with auto-focus design

Yu-Lung Lo, Zhi-Zhong Yan, Shean-Jen Chen

Proceedings Volume 5855, (2005) https://doi.org/10.1117/12.623873

KEYWORDS: Optical coherence tomography, Refractive index, Error analysis, Head, Glasses, Digital video discs, Optical fibers, Modulation, Collimators, Measurement devices

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SPIE Journal Paper | 1 May 2005 Open Access

Open Access

Surface plasmon resonance phase-shift interferometry: Real-time DNA microarray hybridization analysis

Shean-Jen Chen, Yuan-Deng Su, Feng-Ming Hsiu, Chia-Yuan Tsou, Yi-Kuang Chen

JBO, Vol. 10, Issue 03, 034005, (May 2005) https://doi.org/10.1117/12.10.1117/1.1924713

KEYWORDS: Imaging systems, Surface plasmons, Phase measurement, Reconstruction algorithms, Refractive index, Gold, Biological research, Biosensors, Phase interferometry, Image resolution

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Proceedings Article | 31 March 2005 Paper

Paper

Direct detection of the interaction of tiny analytes with receptors using an advanced plasmonic biosensor

Fan-Ching Chien, K.-T. Huang, C.-Y. Lin, Shean-Jen Chen

Proceedings Volume 5703, (2005) https://doi.org/10.1117/12.592530

KEYWORDS: Biosensors, Plasmonics, Gold, Biological research, Proteins, Receptors, Molecular interactions, Argon, Nitrogen, Plasmons

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Proceedings Article | 31 March 2005 Paper

Paper

A common-path phase-shift interferometry surface plasmon imaging system

Y.-T. Su, Shean-Jen Chen, T.-L. Yeh

Proceedings Volume 5703, (2005) https://doi.org/10.1117/12.592532

KEYWORDS: Imaging systems, Phase shifts, Surface plasmons, Gold, Phase interferometry, Interferometry, Spatial resolution, Dielectrics, Liquid crystals, Image resolution

Read Abstract +

SPIE Journal Paper | 1 March 2005

Fabrication and metrology of an electro-optic polymer light modulator based on waveguide-coupled surface plasmon resonance

Jin-Jung Chyou, Chih-Sheng Chu, Z. H. Shih, Chun-Yu Lin, Shean-Jen Chen, Ching-Fong Shu

OE, Vol. 44, Issue 03, 034001, (March 2005) https://doi.org/10.1117/12.10.1117/1.1868775

KEYWORDS: Modulators, Polymers, Waveguides, Modulation, Polymer thin films, Thin films, Interfaces, Metals, Gold, Electrodes

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SPIE Journal Paper | 1 December 2004

New focusing mirror system for synchrotron radiation infrared beamlines

Shean-Jen Chen, Chien-Kuang Kuan, Shen-Yaw Perng, Duan-Jen Wang, H. Ho, T. Tseng, Yi-Chung Lo, Chien-Te Chen

OE, Vol. 43, Issue 12, (December 2004) https://doi.org/10.1117/12.10.1117/1.1813438

KEYWORDS: Mirrors, Infrared radiation, Synchrotron radiation, Metals, Infrared imaging, Polishing, Long wavelength infrared, Prisms, Mechanical engineering, Off axis mirrors

Read Abstract +

Proceedings Article | 16 June 2004 Paper

Paper

Observation of microarray DNA hybridization using surface plasmon resonance phase-shift interferometry

Shean-Jen Chen, C.-Y. Tsou, Y.-K. Chen, Y.-T. Su

Proceedings Volume 5327, (2004) https://doi.org/10.1117/12.530568

KEYWORDS: Imaging systems, Reconstruction algorithms, Surface plasmons, Phase measurement, Image resolution, Gold, Phase interferometry, Sensors, Biosensors, Prisms

Read Abstract +

Proceedings Article | 16 June 2004 Paper

Paper

Nanoparticle-enhanced ultrahigh-resolution surface plasmon resonance biosensors

Fan-Ching Chien, Shean-Jen Chen, Wen-Pin Hu, G.-Y. Lin, Kun-Tsai Huang

Proceedings Volume 5327, (2004) https://doi.org/10.1117/12.530241

KEYWORDS: Gold, Biosensors, Nanoparticles, Dielectrics, Sensors, Surface plasmons, Metals, Silver, Thin films, Particles

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Proceedings Article | 16 June 2004 Paper

Paper

A compact surface plasmon resonance and surface-enhanced Raman scattering sensing device

Jenq-Nan Yih, Shean-Jen Chen, Kun-Tsai Huang, Y.-T. Su, G.-Y. Lin

Proceedings Volume 5327, (2004) https://doi.org/10.1117/12.530246

KEYWORDS: Surface enhanced Raman spectroscopy, Gold, Raman scattering, Nanoparticles, Metals, Surface plasmons, Biosensors, Raman spectroscopy, Dielectrics, Molecules

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Proceedings Article | 16 June 2004 Paper

Paper

Studying protein structural changes based on surface plasmon resonance and surface-enhanced Raman scattering

Wen-Pin Hu, Shean-Jen Chen, Jenq-Nan Yih, G.-Y. Lin, Guan Chang

Proceedings Volume 5327, (2004) https://doi.org/10.1117/12.530593

KEYWORDS: Proteins, Chromium, Surface enhanced Raman spectroscopy, Ions, Raman scattering, Gold, Surface plasmons, Raman spectroscopy, Biological research, Molecules

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Proceedings Article | 16 June 2004 Paper

Paper

Optical biosensors based on four different surface plasmon resonance modes: sensitivity comparison

Fan-Ching Chien, Shean-Jen Chen

Proceedings Volume 5327, (2004) https://doi.org/10.1117/12.530434

KEYWORDS: Biosensors, Metals, Refractive index, Reflectivity, Waveguides, Dielectrics, Surface plasmons, Prisms, Biological research, Signal to noise ratio

Read Abstract +

Proceedings Article | 28 October 2003 Paper

Paper

High-efficiency electro-optic polymer light modulator based on waveguide-coupled surface plasmon resonance

Jin-Jung Chyou, Chih-Sheng Chu, Chih-Hung Shih, Chun-Yu Lin, Kun-Tsai Huang, Shean-Jen Chen, Su-Frang Shu

Proceedings Volume 5221, (2003) https://doi.org/10.1117/12.505525

KEYWORDS: Modulators, Polymers, Waveguides, Modulation, Metals, Surface plasmons, Refractive index, Thin films, Reflection, Gold

Read Abstract +

Proceedings Article | 18 July 2003 Paper

Paper

Surface plasmon resonance phase-shift interferometry: real-time microarray biomolecular interaction analysis

Chia-Yuan Tsou, Shean-Jen Chen, Y.-C. Chen, Feng-Ming Hsiu, Fan-Ching Chien, G.-Y. Lin, Y.-D. Su, Wei-Chih Ku, S.-K. Chiu, C.-M. Tzeng

Proceedings Volume 4966, (2003) https://doi.org/10.1117/12.478354

KEYWORDS: Imaging systems, Surface plasmons, Biological research, Phase measurement, Sensors, Gold, Metals, Phase interferometry, Image resolution, Phase shifts

Read Abstract +

Proceedings Article | 25 September 2002 Paper

Paper

Surface plasmon resonance imaging system with Mach-Zehnder phase-shift interferometry for DNA micro-array hybridization

Feng-Ming Hsiu, Shean-Jen Chen, Chien-Hung Tsai, Chia-Yuan Tsou, Y.-D. Su, G.-Y. Lin, K.-T. Huang, Jin-Jung Chyou, Wei-Chih Ku, S.-K. Chiu, C.-M. Tzeng

Proceedings Volume 4819, (2002) https://doi.org/10.1117/12.450922

KEYWORDS: Imaging systems, Surface plasmons, Sensors, Biosensors, Metals, Gold, Prisms, Phase interferometry, Phase measurement, Dielectrics

Read Abstract +

Proceedings Article | 25 September 2002 Paper

Paper

Multi-experiment linear data analysis for ATR biosensors

Jin-Jung Chyou, Shean-Jen Chen, Chih-Sheng Chu, Chien-Hung Tsai, Fan-Ching Chien, G.-Y. Lin, K.-T. Huang, Wei-Chih Ku, S.-K. Chiu, C.-M. Tzeng

Proceedings Volume 4819, (2002) https://doi.org/10.1117/12.450923

KEYWORDS: Data analysis, Metals, Argon, Dielectrics, Thin films, Biosensors, Surface plasmons, Reflection, Prisms, Statistical analysis

Read Abstract +

Proceedings Article | 16 November 1999 Paper

Paper

Metrology of the mirrors at the Taiwan Light Source

Duan-Jen Wang, T. Tseng, Shean-Jen Chen, Shen-Yaw Perng, Chien-Kuang Kuan, S. Ho

Proceedings Volume 3773, (1999) https://doi.org/10.1117/12.370086

KEYWORDS: Mirrors, Head, Metrology, Temperature metrology, Prisms, Light sources, Sensors, Optical components, Laser induced plasma spectroscopy, Turbulence

Read Abstract +

Proceedings Article | 25 October 1999 Paper

Paper

Two high-order polynomial bendable mirrors in the TLS infrared beamline

Shean-Jen Chen, Chien-Kuang Kuan, Shen-Yaw Perng, Duan-Jen Wang, H. Ho, T. Tseng, Chien-Te Chen, Yi-Chung Lo

Proceedings Volume 3775, (1999) https://doi.org/10.1117/12.366649

KEYWORDS: Mirrors, Infrared radiation, Photons, Synchrotron radiation, Infrared imaging, Polishing, X-rays, Mechanical engineering, Metals, Prisms

Read Abstract +

Showing 5 of 96 publications

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