With the rapid development of portable electrical devices, the demand for batteries to power these portable devices increases dramatically. However, the development of the battery technology is slow in energy storage capability and cannot meet such requirements. This paper proposed an optimal frame design for a kind of portable piezoelectric stack energy harvesters, with large force magnification ratio and high energy transmission ratio. Two kinds of design approaches have been studied and explored, i.e., flexure compliant mechanism math based and finite element analysis (FEA) based. Prototypes are fabricated and assembled. Experiments with both static test and dynamic test have been conducted to approve the effectiveness of the proposed design. The measured force magnification ratio of 6.13 times and 21.8 times for the first-stage harvester and the dual-stage harvester are close to the design objective of 7.17 times and 24.4 times. The designed single stage harvester can generate 20.7mW/g2 at resonance frequency of 160Hz with optimal resistance of 393Ω under 0.8g base excitation with 100gram top mass, and the dual stage harvester has power generation of 487mW/g2 at resonance frequency of 38.9Hz with optimal resistance of 818Ω under 1.94g base excitation with 100gram top mass. The proposed two-stage PZT energy harvester can be used to develop portable power regenerator to compensate the urgent battery needs in remote area for both civic and military application.