Mr. Soheil Ghafurian Profile

Soheil Ghafurian

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Publications (5)

Proceedings Article | 3 March 2017 Paper

3D/2D image registration method for joint motion analysis using low-quality images from mini C-arm machines

Soheil Ghafurian, Ilker Hacihaliloglu, Dimitris Metaxas, Virak Tan, Kang Li

Proceedings Volume 10135, 101350B (2017) https://doi.org/10.1117/12.2254678

KEYWORDS: Image registration, Motion analysis, Fluoroscopy, Kinematics, 3D metrology, Bone, Image analysis, Surgery, Video, Imaging systems, 3D modeling, Image segmentation, Image quality, 3D image processing, Medical imaging

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Proceedings Article | 18 March 2016 Paper

Image-guided intracranial cannula placement for awake in vivo microdialysis in nonhuman primates

Antong Chen, Ashleigh Bone, Catherine D. Hines, Belma Dogdas, Tamara Montgomery, Maria Michener, Christopher Winkelmann, Soheil Ghafurian, Laura Lubbers, John Renger, Ansuman Bagchi, Jason Uslaner, Colena Johnson, Hatim Zariwala

Proceedings Volume 9786, 978620 (2016) https://doi.org/10.1117/12.2217539

KEYWORDS: Brain, Magnetic resonance imaging, Computed tomography, Skull, Neuroimaging, Custom fabrication, Computer aided design, In vivo imaging, Psychiatry, Neurodegeneration, Surgery, Computer aided diagnosis and therapy

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Intracranial microdialysis is used for sampling neurochemicals and large peptides along with their metabolites from the interstitial fluid (ISF) of the brain. The ability to perform this in nonhuman primates (NHP) e.g., rhesus could improve the prediction of pharmacokinetic (PK) and pharmacodynamics (PD) action of drugs in human. However, microdialysis in rhesus brains is not as routinely performed as in rodents. One challenge is that the precise intracranial probe placement in NHP brains is difficult due to the richness of the anatomical structure and the variability of the size and shape of brains across animals. Also, a repeatable and reproducible ISF sampling from the same animal is highly desirable when combined with cognitive behaviors or other longitudinal study end points. Toward that end, we have developed a semi-automatic flexible neurosurgical method employing MR and CT imaging to (a) derive coordinates for permanent guide cannula placement in mid-brain structures and (b) fabricate a customized recording chamber to implant above the skull for enclosing and safeguarding access to the cannula for repeated experiments. In order to place the intracranial guide cannula in each subject, the entry points in the skull and the depth in the brain were derived using co-registered images acquired from MR and CT scans. The anterior/posterior (A/P) and medial-lateral (M/L) rotation in the pose of the animal was corrected in the 3D image to appropriately represent the pose used in the stereotactic frame. An array of implanted fiducial markers was used to transform stereotactic coordinates to the images. The recording chamber was custom fabricated using computer-aided design (CAD), such that it would fit the contours of the individual skull with minimum error. The chamber also helped in guiding the cannula through the entry points down a trajectory into the depth of the brain. We have validated our method in four animals and our results indicate average placement error of cannula to be 1.20 ± 0.68 mm of the targeted positions. The approach employed here for derivation of the coordinates, surgical implantation and post implant validation is built using traditional access to surgical and imaging methods without the necessity of intra-operative imaging. The validation of our method lends support to its wider application in most nonhuman primate laboratories with onsite MR and CT imaging capabilities.

Proceedings Article | 18 March 2016 Paper

Fast generation of digitally reconstructed radiograph through an efficient preprocessing of ray attenuation values

Soheil Ghafurian, Dimitris Metaxas, Virak Tan, Kang Li

Proceedings Volume 9786, 97860C (2016) https://doi.org/10.1117/12.2217756

KEYWORDS: 3D image reconstruction, Radiography, Signal attenuation, Image registration, Image visualization, 3D image processing, Image processing, Volume visualization, Medical imaging, Visualization, Image resolution, Image quality, Electroluminescent displays

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Proceedings Article | 18 March 2016 Paper

Automatic pose correction for image-guided nonhuman primate brain surgery planning

Soheil Ghafurian, Antong Chen, Catherine Hines, Belma Dogdas, Ashleigh Bone, Kenneth Lodge, Stacey O'Malley, Christopher Winkelmann, Ansuman Bagchi, Laura Lubbers, Jason Uslaner, Colena Johnson, John Renger, Hatim Zariwala

Proceedings Volume 9786, 97860O (2016) https://doi.org/10.1117/12.2217534

KEYWORDS: Surgery, Image registration, Brain, Magnetic resonance imaging, 3D image processing, Neuroimaging, Image-guided intervention, Rigid registration, 3D acquisition, Computed tomography, Head, Ear

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Proceedings Article | 18 March 2015 Paper

3D/2D image registration using weighted histogram of gradient directions

Soheil Ghafurian, Ilker Hacihaliloglu, Dimitris Metaxas, Virak Tan, Kang Li

Proceedings Volume 9415, 94151Z (2015) https://doi.org/10.1117/12.2081316

KEYWORDS: 3D modeling, Image registration, Bone, 3D image processing, Distance measurement, 3D image reconstruction, Computed tomography, Medical imaging, Image restoration, Video

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