Mr. Sridhar Dubakka Profile

Sridhar Dubakka

at Univ of Arkansas

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Publications (3)

Proceedings Article | 11 April 2007 Paper

Synthesis and photonic property study of ZnO nanowires for a real time photodynamic therapy monitoring probe

D. Sridhar, Jining Xie, Jose Abraham, Vijay Varadan

Proceedings Volume 6528, 65281L (2007) https://doi.org/10.1117/12.717667

KEYWORDS: Zinc oxide, Photodynamic therapy, Tumors, Oxygen, Ultraviolet radiation, Gold, Luminescence, Scanning electron microscopy, Zinc, Nanowires

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In this paper, we present how the photonic properties of zinc oxide (ZnO) nanowires can be used to potentially advance the effectiveness of Photodynamic therapy (PDT), one of the most recent and promising approaches among cancer therapies. Presently, PDT employs laser light to activate intravenously or topically administered photosensitizers to give rise to highly reactive singlet oxygen which has a very short lifetime and is capable of biochemical damage to cell membranes of the tumor. A probe that can monitor in real time the penetration depth of the laser in the tumor and also the evolution of the singlet oxygen, which is critical for tumor eradication, is capable of improving the efficacy of PDT quite significantly. Such a probe, by providing real time feedback, can help us determine whether to increase or decrease the light exposure dose and also if further local administration of photosensitizers is required or not. ZnO nanowires are known to be photoconductive and recent research also demonstrated the temperature dependence of the photocurrent in the nanowires. They are also sensitive to blue and other near UV spectra which is same range of activation wavelengths of most photosensitizers, and hence making them a good candidate for a potential PDT monitoring probe. ZnO nanowires were fabricated on silicon substrates by vapor phase deposition using e-beam evaporated gold as a catalyst. Control of the dimensions of the nanowires could be achieved by varying the dimensions of the catalyst by means of e-beam evaporation process. Photoluminescence properties of ZnO nanowires were investigated at UV and near UV wavelengths. Further, ZnO is also known for its antimicrobial properties, thereby ruling out any possibility of bacterial infection because of the implanted probe. This study was done to compliment the existing expertise of our research group in the design and fabrication of several nanowire based probes and microsensors specifically for neuroelectronic and nanomedicine applications.

Proceedings Article | 11 April 2007 Paper

Piezoelectric 3D nanostructures for developing point-of-care biosensors

Jose Abraham, Sridhar Dubaka, Vijay Varadan, Huajun Zhou, Tierui Zhang, Z. Ryan Tian

Proceedings Volume 6528, 65280V (2007) https://doi.org/10.1117/12.717663

KEYWORDS: Nanostructures, Zinc oxide, Biosensors, Sensors, Point-of-care devices, Heart, Arteries, Nanotechnology, Electronics, Nanowires

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Proceedings Article | 31 March 2006 Paper

Synthesis of oriented ZnO nanostructure arrays for solar cell applications

D. Sridhar, Jining Xie, Jose Abraham, Vijay Varadan, Sang Choi

Proceedings Volume 6172, 617208 (2006) https://doi.org/10.1117/12.668743

KEYWORDS: Zinc oxide, Solar cells, Glasses, Crystals, Nanostructures, Scanning electron microscopy, Transparent conductors, Electron microscopes, Coating, Nanorods

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