PROCEEDINGS ARTICLE | December 11, 2012
Proc. SPIE. 8553, Optics in Health Care and Biomedical Optics V
KEYWORDS: Hyperspectral imaging, Wound healing, Multimodal imaging, Tissues, Imaging systems, Speckle, Oxygen, Inflammation, Tissue optics, Laser tissue interaction
The wound healing process involves the reparative phases of inflammation, proliferation, and remodeling. Interrupting
any of these phases may result in chronically unhealed wounds, amputation, or even patient death. Quantitative
assessment of wound tissue ischemia, perfusion, and inflammation provides critical information for appropriate
detection, staging, and treatment of chronic wounds. However, no method is available for noninvasive, simultaneous,
and quantitative imaging of these tissue parameters. We integrated hyperspectral, laser speckle, and thermographic
imaging modalities into a single setup for multimodal assessment of tissue oxygenation, perfusion, and inflammation
characteristics. Advanced algorithms were developed for accurate reconstruction of wound oxygenation and appropriate
co-registration between different imaging modalities. The multimodal wound imaging system was validated by an
ongoing clinical trials approved by OSU IRB. In the clinical trial, a wound of 3mm in diameter was introduced on a
healthy subject’s lower extremity and the healing process was serially monitored by the multimodal imaging setup. Our
experiments demonstrated the clinical usability of multimodal wound imaging.
