As one of classic methods of frequency domain based saliency detection, Spectral residual (SR) method has shown several advantages. However, it usually produces higher saliency values at object edges instead of generating maps that uniformly cover the whole object, which results from failing to exploit all the spatial frequency content of the original image. The Two-Dimensional Fractional Fourier transform (2D-FRFT) is a generalized form of the traditional Fourier Transform (FT) which can abstract more meaningful information of the image under certain conditions. Based on this property, we propose a new method which detects the salient region based on 2D-FRFT domain. Moreover, we also use Hough transform detection and a band-pass filter to refine the saliency map. We conduct experiments on a common used dataset: MSRA. The proposed method is compared with several other saliency detection methods and shown to achieve superior result.