Dr. Tatiana A. Savelieva Profile

Dr. Tatiana A. Savelieva

Research Fellow at AM Prokhorov General Physics Institute

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Publications (9)

Proceedings Article | 2 April 2020 Presentation + Paper

Combined spectroscopic and video fluorescent instrument for intraoperative navigation when removing a glial tumor

Tatiana Savelieva, Maxim Loshchenov, Alexander Borodkin, Kirill Linkov, Alexandra Kosyrkova, Sergey Goryajnov, Alexander Potapov, Victor Loschenov

Proceedings Volume 11363, 113630X (2020) https://doi.org/10.1117/12.2556064

KEYWORDS: Luminescence, Tumors, Tissues, Video, Spectroscopes, Fluorescence spectroscopy, Spectroscopy, Biological research, Brain, Fiber optics

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Proceedings Article | 7 August 2019 Paper

Possible approaches to fluorescence diagnosis and photodynamic therapy for deep-seated tumors

Victor Loschenov, Tatiana Savelieva, Pavel Grachev, Kirill Linkov, Yuliya Maklygina, Igor Romanishkin, Anastasia Ryabova, Daniil Kustov, Sergey Goryajnov, Alexander Potapov

Proceedings Volume 11070, 110706B (2019) https://doi.org/10.1117/12.2526013

KEYWORDS: Tumors, Luminescence, Tissues, Picosecond phenomena, Brain, Video, Biopsy, Photodynamic therapy, Spectroscopy, Cerenkov radiation imaging

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The limited penetration of laser radiation into biological tissue prevents the widespread distribution of photodiagnostics (PD) and photodynamic therapy (PDT) methods to clinical practice. We have investigated several approaches for PD and PDT of deep-seated tumors: 1. Stereotactic biopsy cannula with a laser spectroscopic control. Special fiber ports for long-term installation in the tumor removal area were developed in order to cause tumor cells to migrate not into the depth of brain but along the fibers with occasional laser irradiation for PD and PDT. The fibers are coated with a special compound containing photosensitizer (PS) and nutrients for cancer cells. 2. Neurosurgical aspirator with the function of video-fluorescence and spectroscopic analysis system. More than 500 patients with various types of brain tumors were operated on using fluorescent navigation based on 5-aminolevulinic acid (5-ALA) induced protoporphyrin IX (Pp IX) fluorescence under laser excitation in red spectral range. 3. Diagnostics and navigation of tumors when fluorescence is excited in the red and near infrared ranges. We used indocyanine green (ICG) as near infrared dye to observe blood and lymph vasculature of laboratory animals. This method could be useful while examining tumor bed and adjacent area. 4. Joint action of radiopharmaceuticals and PS based on Cherenkov radiation. Cell death by PDT mechanism via Pp IX excitation by Cherenkov radiation in mitochondria during 18F-fludeoxyglucose decay. This idea achieved good results on rats with C6 glioma. The results of using this approach with chlorin e6 PS in comparable doses are negative. 5. Action through photodynamic inactivation of tumor-associated macrophages and microglia. Idea of minimally invasive method for determining macrophage (microglia) phenotype and their polarization in tumors and their immediate vicinity in situ. This would allow evaluating the effectiveness of the treatment, including PDT. The most promising results were obtained with Pp IX and aluminum phthalocyanine nanoparticles. Studies have been conducted on experimental animals with grafted tumors and, in part, on cancer patients in the clinic.

Proceedings Article | 24 May 2018 Paper

Multispectral imaging technique for skin grafts’ functional state assessment

V. Makarov, D. Pominova, A. Ryabova, T. Saveleva, I. Ignateva, I. Reshetov, V. Loschenov

Proceedings Volume 10677, 1067734 (2018) https://doi.org/10.1117/12.2309783

KEYWORDS: Skin, Luminescence, Tissues, Tissue optics, Nanoparticles, Blood, Transplantation, Spectroscopy, Blood circulation, Optical fibers

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Proceedings Article | 12 April 2018 Paper

Automatic classification of fluorescence and optical diffusion spectroscopy data in neuro-oncology

T. Savelieva, V. Loshchenov, S. Goryajnov, A. Potapov

Proceedings Volume 10582, 105820E (2018) https://doi.org/10.1117/12.2315633

KEYWORDS: Tumors, Tissues, Spectroscopy, Luminescence, Light scattering, Scattering, Diagnostics, Optical spectroscopy, Fluorescence spectroscopy, Diffuse reflectance spectroscopy

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Proceedings Article | 8 May 2014 Paper

The method of intraoperative analysis of structural and metabolic changes in the area of tumor resection

Tatiana Savelieva, Victor Loshchenov, Vladimir Volkov, Kirill Linkov, Sergey Goryainov, Alexander Potapov

Proceedings Volume 9129, 91290T (2014) https://doi.org/10.1117/12.2052480

KEYWORDS: Scattering, Tumors, Diffuse reflectance spectroscopy, Tissues, Tissue optics, Absorption, Luminescence, Fiber optics, Light scattering, Receivers

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Proceedings Article | 26 February 2013 Paper

System for determining the concentration and visualization of the spatial distribution of photosensitizers based on tetrapyrrole compounds in the tissues of the human ocular fundus

Sergey Model, Tatiana Savelieva, Kirill Linkov

Proceedings Volume 8699, 86990E (2013) https://doi.org/10.1117/12.2016675

KEYWORDS: Picosecond phenomena, Tissues, Calibration, Luminescence, Photodynamic therapy, Absorption, Eye, Spectroscopy, Video, Diagnostics

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Proceedings Article | 2 February 2012 Paper

Numerical modelling and in vivo analysis of fluorescent and laser light backscattered from glial brain tumors

Tatiana Savelieva, Nina Kalyagina, Maria Kholodtsova, Victor Loschenov, Sergey Goryainov, Aleksander Potapov

Proceedings Volume 8230, 82300L (2012) https://doi.org/10.1117/12.907444

KEYWORDS: Tumors, Tissues, Light scattering, Brain, Scattering, Optical fibers, Luminescence, Refractive index, Monte Carlo methods, Laser scattering

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Proceedings Article | 5 June 2008 Paper

Multi-spectral imaging of oxygen saturation

Tatiana Savelieva, Aleksander Stratonnikov, Victor Loschenov

Proceedings Volume 7022, 702205 (2008) https://doi.org/10.1117/12.803905

KEYWORDS: Oxygen, Tissues, Diffuse reflectance spectroscopy, Scattering, Imaging systems, Monte Carlo methods, Absorption, Imaging spectroscopy, Real time imaging, Light scattering

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Proceedings Article | 5 June 2008 Paper

The video fluorescent device for diagnostics of cancer of human reproductive system

Nickolay Brysin, Kirill Linkov, Alexander Stratonnikov, Tatiana Savelieva, Victor Loschenov

Proceedings Volume 7022, 702206 (2008) https://doi.org/10.1117/12.803906

KEYWORDS: Video, Luminescence, Cancer, Tumors, Diagnostics, Light emitting diodes, Tumor growth modeling, Projection systems, Spectroscopy, Lamps

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Showing 5 of 9 publications

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