Dr. Thomas S. Mang Profile

Dr. Thomas S. Mang

Dir. Scientific Operations at Pinnacle Biologics Inc

SPIE Involvement:

Author

Proceedings Article | 23 March 2016 Paper

Effects of low-level laser exposure on calcium channels and intracellular release in cultured astrocytes

Thomas Mang, Mohammed Maneshi, David Shucard, Susan Hua, Frederick Sachs

Proceedings Volume 9695, 969509 (2016) https://doi.org/10.1117/12.2222222

KEYWORDS: Calcium, Traumatic brain injury, Microfluidics, Acquisition tracking and pointing, Laser therapeutics, Performance modeling, Absorption, NOx, Oxygen, Luminescence

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Proceedings Article | 29 March 2000 Paper

Low-dose Photofrin-induced PDT offers excellent clinical response with minimal morbidity in chest wall recurrence of breast cancer

Ron Allison, Thomas Mang

Proceedings Volume 3909, (2000) https://doi.org/10.1117/12.379895

KEYWORDS: Photodynamic therapy, Chest, Breast cancer, Radiotherapy, Biopsy, Surgery, Ferroelectric materials, YAG lasers, Tissues

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Proceedings Article | 9 July 1999 Paper

Noncontact point spectroscopy guided by two-channel fluorescence imaging in a hamster cheek pouch model

Victor Yang, Jenny Yeow, Lothar Lilge, James Kost, Thomas Mang, Brian Wilson

Proceedings Volume 3595, (1999) https://doi.org/10.1117/12.351517

KEYWORDS: Luminescence, Imaging spectroscopy, Fluorescence spectroscopy, Spectroscopy, Tissues, Cancer, Tumors, Microscopes, Charge-coupled devices, In vivo imaging

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Proceedings Article | 1 March 1995 Paper

Fluorescence detection of premalignant, malignant, and micrometastatic disease using hexylpyropheophorbide

Kinya Furukawa, David Crean, Thomas Mang, Harubumi Kato, Thomas Dougherty

Proceedings Volume 2371, (1995) https://doi.org/10.1117/12.203403

KEYWORDS: Lymphatic system, Luminescence, Fluorescence spectroscopy, Tumors, In vivo imaging, Laser induced fluorescence, Photometry, Tumor growth modeling, Detector development

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Proceedings Article | 19 July 1994 Paper

Point fluorescence measurements of transformed tissues using 2-[1-hexyloxyethel]-2-devinyl pyropheophorbide-a

Kinya Furukawa, David Crean, Alexander Kuebler, Thomas Mang, Harubumi Kato, Thomas Dougherty

Proceedings Volume 2133, (1994) https://doi.org/10.1117/12.179980

KEYWORDS: Luminescence, Tissues, Tumors, Cancer, Photodetectors, Animal model studies, Tumor growth modeling, Photodynamic therapy, Diagnostics, In vivo imaging

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Proceedings Article | 1 June 1992 Paper

Dosimetry of cylindrical fibers in photodynamic therapy

Thomas Mang, Leroy Wood

Proceedings Volume 1645, (1992) https://doi.org/10.1117/12.60951

KEYWORDS: Optical fibers, Diffusers, Tumors, Photodynamic therapy, Light, Tumor growth modeling, Endoscopy, Phototherapy, Optical spheres, Quartz

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The use of the photosensitizer Photofrin' (dihematoporphyrin ether, DHE)' in the photodynarnic treatment of human disease is becoming well known and widely used. While a number of photosensitizers may be used for photodynamic therapy (PDT), the porphyrins, in particular Photofrin', have received the most attention. This is specifically true for human trials.25 Clinical studies in photodynamic therapy (PDT) have utilized lasers to take advantage of coupling efficiencies to optical fibers allowing light to be delivered to many areas of the body. This is particularly true in endoscopic PDT. Both interstitial and superficial delivery techniques can be applied using one of a variety of delivery fibers available. A fiber with an optically flat end with a lens to produce a spot with a homogeneous intensity is used for superficial applications. Diffusers of various lengths, at the tip of a fiber, produce a cylindrical isotropic pattern and are suited for either intraluminal or interstitial illuminations, Previous studies have measured space irradiance produced by cylindrical fibers to determine the extent to which conditions of use would affect light distribution.6 Further, those studies attempted to assess the impact of variations in light distribution on the therapeutic effect. The therapeutic effect, however, was based upon the use of the cylindrical fiber as an interstitial implant and conclusions, therefore, were made in that context. The manner in which energy is distributed in air by fiberoptics can be described in terms of those surfaces through which the energy flux (energy per unit area per unit time) is everywhere constant. Since the therapeutic light dose has units of energy per unit area, these surfaces are properly called 'isodose-rate' surfaces. A field of treatment that conforms to an isodose-rate surface receives an incidental uniform light dose in a time interval (sec) given by the numerical ratio of the light dose (Joules/cni2) to the dose rate (watts/cm2). The isodose-rate surfaces in the air of the microlens and the sphere diffuser are simple surfaces, namely planes perpendicular to the light beam and spheres centered on the light source, respectively. The isodose-rate surfaces of the cylinder diffuser do not have a simple cycometry. In the following, these surfaces are presented for a line source which is a good approximation of the cylinder diffuser.

Proceedings Article | 1 June 1992 Paper

Individual in-vitro sensitivities of human pancreatic carcinoma cell lines to photodynamic therapy

K. Moesta, Andrew Dmytrijuk, Peter Schlag, Thomas Mang

Proceedings Volume 1645, (1992) https://doi.org/10.1117/12.60926

KEYWORDS: Tumors, Photodynamic therapy, Tissues, In vitro testing, Pancreatic cancer, Pancreas, Tumor growth modeling, Resistance, Data modeling, Control systems

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Proceedings Article | 6 May 1992 Paper

Fluorescence photometric analysis of Photofrin uptake and the detection of precancerous and true epidermoid lesions

Thomas Mang, David Crean, Frank Sindoni, Charles Liebow

Proceedings Volume 1641, (1992) https://doi.org/10.1117/12.59352

KEYWORDS: Luminescence, Tissue optics, Tissues, Tumors, Cancer, Tumor growth modeling, Photometry, In vivo imaging, Diagnostics, Data modeling

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Proceedings Article | 1 June 1991 Paper

Fluorescence detection of tumors: studies on the early diagnosis of microscopic lesions in preclinical and clinical studies

Thomas Mang, Carolyn McGinnis, David Crean, S. Khan, Charles Liebow

Proceedings Volume 1426, (1991) https://doi.org/10.1117/12.44050

KEYWORDS: Luminescence, Tumors, Lymphatic system, Tissue optics, Fluorescence spectroscopy, Tumor growth modeling, In vivo imaging, Animal model studies, Photometry, Cancer

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Proceedings Article | 1 June 1991 Paper

Studies on the absence of photodynamic mechanism in the normal pancreas

Thomas Mang, Thomas Wieman, David Crean

Proceedings Volume 1426, (1991) https://doi.org/10.1117/12.44058

KEYWORDS: Pancreas, Tumors, Tissues, Photodynamic therapy, Luminescence, Glucose, Cancer, Lymphatic system, Pancreatic cancer, Tumor growth modeling

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Proceedings Article | 1 July 1990 Paper

Fiber optic fluorescence detection of low-level porphyrin concentrations in preclinical and clinical studies

Thomas Mang, Carolyn McGinnis, S. Khan

Proceedings Volume 1201, (1990) https://doi.org/10.1117/12.17564

KEYWORDS: Luminescence, Tumors, Lymphatic system, Tissues, Fluorescence spectroscopy, Fiber optics, Photometry, Optical fibers, In vivo imaging, Medicine

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A significant clinical problem in the local treatment of cutaneous metastases of breast cancer (by any modality--surgery, radiation therapy or photodynainic therapy) is the fact that the disease almost always extends beyond the boundary of visible lesions in the form of microscopic deposits. These deposits may be distant from the site of visible disease but are often in close proximity to it and are manifested sooner or later by the development of recurrent lesions at the border of the treated area, thus the "marginal miss" in radiation therapy, the "rim recurrence" in photodynamic therapy, and the "incisional recurrence" following surgical excision. More intelligent use of these treatment modalities demands the ability to detect microscopic deposits of tumor cells using non-invasive methodology. In vivo fluorescence measurements have been made possible by the development of an extremely sensitive fiber optic in vivo fluorescence photometer. The instrument has been used to verify that fluorescence correlated with injected porphyrin levels in various tissues. The delivery of light to excite and detect background fluorescence as well as photosensitizer fluorescence in tissues has been accomplished using two HeNe lasers emitting at 632.8 nm and 612 nm delivered through a single quartz fiber optic. Chopping at different frequencies, contributions of fluorescence may be separated. Fluorescence is picked up via a 400 micron quartz fiber optic positioned appropriately near the target tissue. Validation of these levels was made by extraction of the drug from the tissues with resultant quantitation. Recently, an extensive study was undertaken to determine if fluorescence could be used for the detection of occult, clinically non-palpable metastases in the lymph node of rats. This unique model allowed for the detection of micrometastases in lymph nodes using very low injected doses of the photosensitizer Photofrin II. Data obtained revealed the ability to detect on the order of 50-100 cells using 0.25 mg/kg of sensitizer, a level 20 times lower than normally used for treatment of animal tumors. These results indicate that Photofrin II could be used for fluorescence detection of small metastatic tumors, while substantially reducing the major side effect of PDT; namely, prolonged photosensitivity. Results to be presented demonstrate the ability of this technique to detect microscopic deposits of malignant tumor cells in patients with metastatic breast cancer. These deposits were found in clinically negative areas of the chest wall.

Showing 5 of 11 publications

SPIE Conference Volume | 6 May 1992

Physiological Monitoring and Early Detection Diagnostic Methods

Conference Committee Involvement (1)

Physiological Monitoring and Early Detection Diagnostic Methods

20 January 1992 | Los Angeles, CA, United States

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