Optical coherence tomography is a new emerging technique for cross-sectional imaging with high spatial
resolution of micrometer scale. It enables in vivo and non-invasive imaging with no need to contact the
sample and is widely used in biological and clinic application. In this paper optical coherence tomography is
demonstrated for both biological and clinic applications.
For biological application, a white-light interference microscope is developed for ultrahigh-resolution
full-field optical coherence tomography (full-field OCT) to implement 3D imaging of biological tissue.
Spatial resolution of 0.9μm×1.1μm (transverse×axial) is achieved A system sensitivity of 85 dB is obtained at
an acquisition time of 5s per image. The development of a mouse embryo is studied layer by layer with our
ultrahigh-resolution full-filed OCT.
For clinic application, a handheld optical coherence tomography system is designed for real-time and in situ
imaging of the port wine stains (PWS) patient and supplying surgery guidance for photodynamic therapy
(PDT) treatment. The light source with center wavelength of 1310nm, -3 dB wavelength range of 90 nm and
optical power of 9mw is utilized. Lateral resolution of 8 μm and axial resolution of 7μm at a rate of 2 frames
per second and with 102dB sensitivity are achieved in biological tissue. It is shown that OCT images
distinguish very well the normal and PWS tissues in clinic and are good to serve as a valuable diagnosis tool
for PDT treatment.
A simple method of optical generation millimeter-wave signal employing optical phase modulator and band-elimination
filter is proposed. This simple approach is capable generate millimeter wave signal of quadrupled or sextuple microwave
source frequency with extremely high spectral purity. Millimeter-wave signal 26GHz (quadrupled fundamental
frequency) or 39 GHz (sextuple fundamental frequency) is obtained respectively using different system chromatic
dispersion when the microwave driver signal is at 6.5GHz.
Optical trains with repetition rates as high as 10GHz~40GHz are obtained by using a novel high speed mode-locked fibre laser. It combines both active mode-locked effect and passive mode-locked effect so the FWHM of the output optical pulses can be decreased to 2ps. And the performance of the proposed fiber laser is analysed.