Though laser cosmetic therapy has advantages of confirmable efficiency, much less side effects and good safety, but there are still many problems. We have applied VersaPulse multi-wavelength laser, VascuLight(PhotoDerm) intensive pulse light(IPL), LightSheer semi-conductor laser, Quantum Photo-rejuvenation instruments, Sharplan 1080S ultrapulse CO2 laser, 1030C ultrapulse CO2 laser, Sharplan Erbium laser, Sharplan ruby laser, Laserscope Orion laser, continous and pulsed Nd:YAG laser, continous Nd:YAP laser, Q-switch 1064/532 laser, ClearTouch curative instrument for acnes to treat more than ten thousand of patients. This article discusses these problems and solutions in current laser cosmetic therapy. Firstly, the biggest problem in nevus flammeus treatment is low curative rate. VascuLight IPL and VersaPulse laser can work well together in nevus flammeus treatment. Secondly, three problems in the treatment of nevus pigmentosus are the recurrence from incomplete therapy, scars due to exceeding treatment and serious results because MMs in early stages are mistaken for nevus pigmentosus. So we think that the right way to treat nevi is to remove them by surgery and perform a pathological examination. Thirdly, as to the problems of photo-rejuvenation and rhytidectomy, the sequence of therapy efficiency from better to worse is the ultrapulse CO2 laser, the Erbium laser and IPL. Despite good effect, the CO2 laser does not fit colored people because of serious pigmentation. The Erbium laser, which leads to less pigmentation than people expected, can be chosen to treat thick wrinkles. The photo-rejuvenation cannot reduce wrinkle obviously. Fourthly, the reputation of photo-rejuvenation with IPL has been denigrated by disordered markets and many inferior instruments.