SERS spectroscopy was employed to study the interaction of the antitumoral drug paclitaxel with human serum albumin.
The normal Raman spectrum of the paclitaxel was shown in this study for the first time. There were some differences
existing in the surface-enhanced Raman scattering (SERS) spectrum of paclitaxel and its human serum albumin (HSA),
which demonstrated that there was high bioaffinity of paclitaxel to human serum albumin. And it was also found that
there existed some differences in the SERS of the paclitaxel/HSA complexes at different pH values, which may indicated
some significant information on the binding site, by which paclitaxel binds to human serum albumin. It can provide
significant instruction in the synthesis of the drug and in improving the therapeutic efficacy of this drug.