Mr. Tien Nguyen Profile

Tien Nguyen

at Polytechnique Montréal

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Publications (4)

SPIE Journal Paper | 21 February 2023 Open Access

Open-sourced Raman spectroscopy data processing package implementing a baseline removal algorithm validated from multiple datasets acquired in human tissue and biofluids

Guillaume Sheehy, Fabien Picot, Frédérick Dallaire, Katherine Ember, Tien Nguyen, Kevin Petrecca, Dominique Trudel, Frédéric Leblond

JBO, Vol. 28, Issue 02, 025002, (February 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.2.025002

KEYWORDS: Raman spectroscopy, Data processing, Tissues, Equipment, Bubbles, Biological samples, Raman scattering, Fluorescence, Aluminum, Spectroscopy

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SPIE Journal Paper | 9 February 2022 Open Access

Saliva-based detection of COVID-19 infection in a real-world setting using reagent-free Raman spectroscopy and machine learning

Katherine Ember, François Daoust, Myriam Mahfoud, Frédérick Dallaire, Esmat Zamani, Trang Tran, Arthur Plante, Mame-Kany Diop, Tien Nguyen, Amélie St-Georges-Robillard, Nassim Ksantini, Julie Lanthier, Antoine Filiatrault, Guillaume Sheehy, Gabriel Beaudoin, Caroline Quach, Dominique Trudel, Frédéric Leblond

JBO, Vol. 27, Issue 02, 025002, (February 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.2.025002

KEYWORDS: Raman spectroscopy, Crystals, Proteins, Statistical modeling, Spectroscopy, Data modeling, Molecules, Statistical analysis, Feature selection, Aluminum

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SPIE Journal Paper | 6 November 2021 Open Access

Dimensional reduction based on peak fitting of Raman micro spectroscopy data improves detection of prostate cancer in tissue specimens

Arthur Plante, Frédérick Dallaire, Andrée-Anne Grosset, Tien Nguyen, Mirela Birlea, Jahg Wong, François Daoust, Noémi Roy, André Kougioumoutzakis, Feryel Azzi, Kelly Aubertin, Samuel Kadoury, Mathieu Latour, Roula Albadine, Susan Prendeville, Paul Boutros, Michael Fraser, Rob Bristow, Theodorus Van Der Kwast, Michele Orain, Hervé Brisson, Nazim Benzerdjeb, Hélène Hovington, Alain Bergeron, Yves Fradet, Bernard Têtu, Fred Saad, Dominique Trudel, Frédéric Leblond

JBO, Vol. 26, Issue 11, 116501, (November 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.11.116501

KEYWORDS: Raman spectroscopy, Cancer, Tissues, Proteins, Tumor growth modeling, Spectroscopy, Micro raman spectroscopy, Prostate, Prostate cancer, Machine learning

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Significance: Prostate cancer is the most common cancer among men. An accurate diagnosis of its severity at detection plays a major role in improving their survival. Recently, machine learning models using biomarkers identified from Raman micro-spectroscopy discriminated intraductal carcinoma of the prostate (IDC-P) from cancer tissue with a ≥85 % detection accuracy and differentiated high-grade prostatic intraepithelial neoplasia (HGPIN) from IDC-P with a ≥97.8 % accuracy. Aim: To improve the classification performance of machine learning models identifying different types of prostate cancer tissue using a new dimensional reduction technique. Approach: A radial basis function (RBF) kernel support vector machine (SVM) model was trained on Raman spectra of prostate tissue from a 272-patient cohort (Centre hospitalier de l’Université de Montréal, CHUM) and tested on two independent cohorts of 76 patients [University Health Network (UHN)] and 135 patients (Centre hospitalier universitaire de Québec-Université Laval, CHUQc-UL). Two types of engineered features were used. Individual intensity features, i.e., Raman signal intensity measured at particular wavelengths and novel Raman spectra fitted peak features consisting of peak heights and widths. Results: Combining engineered features improved classification performance for the three aforementioned classification tasks. The improvements for IDC-P/cancer classification for the UHN and CHUQc-UL testing sets in accuracy, sensitivity, specificity, and area under the curve (AUC) are (numbers in parenthesis are associated with the CHUQc-UL testing set): +4 % (+8 % ), +7 % (+9 % ), +2 % (6%), +9 (+9) with respect to the current best models. Discrimination between HGPIN and IDC-P was also improved in both testing cohorts: +2.2 % (+1.7 % ), +4.5 % (+3.6 % ), +0 % (+0 % ), +2.3 (+0). While no global improvements were obtained for the normal versus cancer classification task [+0 % (−2 % ), +0 % (−3 % ), +2 % (−2 % ), +4 (+3)], the AUC was improved in both testing sets. Conclusions: Combining individual intensity features and novel Raman fitted peak features, improved the classification performance on two independent and multicenter testing sets in comparison to using only individual intensity features.

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SPIE Journal Paper | 12 February 2021 Open Access

Handheld macroscopic Raman spectroscopy imaging instrument for machine-learning-based molecular tissue margins characterization

François Daoust, Tien Nguyen, Patrick Orsini, Jacques Bismuth, Marie-Maude de Denus-Baillargeon, Israel Veilleux, Alexandre Wetter, Philippe McKoy, Isabelle Dicaire, Maroun Massabki, Kevin Petrecca, Frédéric Leblond

JBO, Vol. 26, Issue 02, 022911, (February 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.2.022911

KEYWORDS: Tissues, Raman spectroscopy, Imaging systems, Imaging spectroscopy, Spatial resolution, Cancer, Surgery, Tumors, Tissue optics, Fiber lasers

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