Dr. Tomas Hode Profile

Dr. Tomas Hode

President & Chief Innovation Officer at Immunophotonics Inc

SPIE Involvement:

Conference Program Committee | Author

Profile Summary

Dr. Hode started his career in Sweden in the early 90s, working with medical laser education, manufacturing and sales. He later took a PhD at Stockholm University, Sweden, focusing on microanalytical development for applications in space and planetary science, and then moved to the USA on a post-doc to study the development and structure of microbial biofilms. Dr. Hode subsequently returned to industry and co-founded Immunophotonics Inc, and currently holds the role of President and Chief Innovation Officer, where he is overseeing all the technical aspects of the company, and driving innovation. Additionally, Dr. Hode is the chairman of a medical device company in Sweden, is a program committee member of the “Biophotonics and Immune Responses” conference of SPIE, and was previously a board member of the Missouri Biotechnology Association (MOBIO).

Publications (21)

Proceedings Article | 7 March 2017 Presentation + Paper

Presentation + Paper

Laser immunotherapy for advanced solid tumors

Mark Naylor, Xiaosong Li, Tomas Hode, Lu Alleruzzo, Joseph Raker, Siu Kit Lam, Feifan Zhou, Wei Chen

Proceedings Volume 10065, 1006509 (2017) https://doi.org/10.1117/12.2254746

KEYWORDS: Breast cancer, Solids, Melanoma, Tumors, Laser therapeutics, Skin, Oncology, Cancer, Biomedical optics, Laser energy

Read Abstract +

Proceedings Article | 27 April 2016 Presentation

Presentation

Development of InCVAX as a novel in situ autologous vaccine for metastatic cancers (Conference Presentation)

Tomas Hode, Luciano Alleruzzo, Joseph Raker, Samuel Siu Kit Lam, Robert Nordquist, Wei Chen

Proceedings Volume 9709, 97090I (2016) https://doi.org/10.1117/12.2216110

KEYWORDS: Cancer, Oncology, Clinical trials, Phototherapy, Clinical research, Breast cancer, Biomedical optics, Current controlled current source

Read Abstract +

Proceedings Article | 9 March 2015 Paper

Paper

The immunological response created by interstitial and non-invasive laser immunotherapy

Cody Bahavar, Feifan Zhou, Aamr Hasanjee, Connor West, Robert Nordquist, Tomas Hode, Hong Liu, Wei Chen

Proceedings Volume 9324, 93240D (2015) https://doi.org/10.1117/12.2082658

KEYWORDS: Tumors, Laser irradiation, Single walled carbon nanotubes, Cancer, Skin, Biomedical optics, Clinical trials, Breast cancer, Melanoma, Carbon nanotubes

Read Abstract +

Laser immunotherapy (LIT) is an innovative cancer modality that uses laser irradiation and immunological stimulation to treat late-stage, metastatic cancers. LIT can be performed through either interstitial or non-invasive laser irradiation. Although LIT is still in development, recent clinical trials have shown that it can be used to successfully treat patients with late-stage breast cancer and melanoma. The development of LIT has been focused on creating an optimal immune response created by irradiating the tumor. One important factor that could enhance the immune response is the duration of laser irradiation. Irradiating the tumor for a shorter or longer amount of time could weaken the immune response created by LIT. Another factor that could weaken this immune response is the proliferation of regulatory T cells (TRegs) in response to the laser irradiation. However, low dose cyclophosphamide (CY) can help suppress the proliferation of TRegs and help create a more optimal immune response. An additional factor that could weaken the effectiveness of LIT is the selectivity of the laser. If LIT is performed non-invasively, then deeply embedded tumors and highly pigmented skin could cause an uneven temperature distribution inside the tumor. To solve this problem, an immunologically modified carbon nanotube system was created by using an immunoadjuvant known as glycated chitosan (GC) as a surfactant for single-walled carbon nanotubes (SWNTs) to immunologically modify SWNTs. SWNT-GC retains the optical properties of SWNTs and the immunological functions of GC to help increase the selectivity of the laser and create a more optimal immune response. In this preliminary study, tumor-bearing rats were treated with LIT either interstitially by an 805-nm laser with GC and low-dose CY, or non-invasively by a 980-nm laser with SWNT-GC. The goal was to observe the effects of CY on the immune response induced by LIT and to also determine the effect of irradiation duration for interstitial and noninvasive LIT.

Proceedings Article | 13 March 2014 Paper

Paper

Effects of laser immunotherapy on late-stage, metastatic breast cancer patients in a Phase II clinical trial

Gabriela Ferrel, Feifan Zhou, Xiaosong Li, Tomas Hode, Robert Nordquist, Luciano Alleruzzo, Wei Chen

Proceedings Volume 8944, 89440I (2014) https://doi.org/10.1117/12.2041263

KEYWORDS: Tumors, Breast cancer, Cancer, Oncology, Chromium, Clinical trials, Laser therapeutics, Laser irradiation, Semiconductor lasers, Breast

Read Abstract +

Proceedings Article | 27 February 2014 Paper

Paper

Laser assisted immunotherapy (LIT) for chemotherapy-resistant neoplasms: recent case reports

Robert Nordquist, Cody Bahavar, Feifan Zhou, Tomas Hode, Wei Chen, Xiaosong Li, Mark Naylor

Proceedings Volume 8944, 894406 (2014) https://doi.org/10.1117/12.2041646

KEYWORDS: Tumors, Melanoma, Therapeutics, Laser therapeutics, Solids, Breast cancer, Fiber lasers, Chest, Breast, Computed tomography

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Proceedings Article | 27 February 2014 Paper

Paper

Mechanistic studies of systemic immune responses induced by laser-nanotechnology

Wei Chen, Feifan Zhou, Brock Henderson, Bailey Vasquez, Hong Liu, Tomas Hode, Robert Nordquist

Proceedings Volume 8944, 89440U (2014) https://doi.org/10.1117/12.2041265

KEYWORDS: Single walled carbon nanotubes, Tumors, Absorption, Carbon nanotubes, Near infrared, Molecules, Nanotechnology, Absorbance, Flow cytometry, Tissues

Read Abstract +

Proceedings Article | 27 February 2014 Paper

Paper

Effects of cyclophosphamide on laser immunotherapy for the treatment of metastatic cancer

Cody Bahavar, Joseph Acquaviva, Sheyla Rabei, Allie Sikes, Robert Nordquist, Tomas Hode, Hong Liu, Wei Chen

Proceedings Volume 8944, 894408 (2014) https://doi.org/10.1117/12.2040954

KEYWORDS: Tumors, Cancer, Laser irradiation, Oncology, Biomedical optics, Clinical trials, Breast cancer, Melanoma, Fiber lasers, Optical fibers

Read Abstract +

Proceedings Article | 22 February 2013 Paper

Paper

Effects of interstitial laser immunotherapy for the treatment of metastatic cancer

Cody Bahavar, Jessica Goddard, Allie Sikes, Ellen Boarman, Robert Nordquist, Tomas Hode, Hong Liu, Wei Chen

Proceedings Volume 8582, 858207 (2013) https://doi.org/10.1117/12.2006462

KEYWORDS: Tumors, Laser irradiation, Cancer, Oncology, Laser tissue interaction, Skin, Tissues, Magnetic resonance imaging, Temperature metrology, Diffusers

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Proceedings Article | 21 February 2013 Paper

Paper

Photothermal effects of immunologically modified carbon nanotubes

Ryan Griswold, Brock Henderson, Jessica Goddard, Yongqiang Tan, Tomas Hode, Hong Liu, Robert Nordquist, Wei Chen

Proceedings Volume 8582, 85820C (2013) https://doi.org/10.1117/12.999961

KEYWORDS: Single walled carbon nanotubes, Tumors, Carbon nanotubes, Photothermal effect, Nanotechnology, Cancer, Oncology, Absorption, Temperature metrology, Thermal effects

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Proceedings Article | 9 February 2012 Paper

Paper

Long-term effects of laser-imiquimod combination in the treatment of late-stage melanoma patients

Mark Naylor, Henry Le, Xiaosong Li, Robert Nordquist, Tomas Hode, Hong Liu, Wei Chen

Proceedings Volume 8224, 822406 (2012) https://doi.org/10.1117/12.906568

KEYWORDS: Melanoma, Tumors, Laser therapeutics, Cancer, Oncology, Laser irradiation, Skin, Clinical trials, Modulators, Dye lasers

Read Abstract +

Proceedings Article | 9 February 2012 Paper

Paper

Magnetic resonance thermometry for monitoring photothermal effects of interstitial laser irradiation

Jessica Goddard, Jessnie Jose, Daniel Figueroa, Kelvin Le, Hong Liu, Robert Nordquist, Tomas Hode, Wei Chen

Proceedings Volume 8224, 82240A (2012) https://doi.org/10.1117/12.906555

KEYWORDS: Tumors, Laser irradiation, Temperature metrology, Cancer, Liver, Photothermal interactions, Tissues, Magnetism, Photothermal effect, Oncology

Read Abstract +

Proceedings Article | 9 February 2012 Paper

Paper

Interstitial laser irradiation of metastatic mammary tumors in combination with intratumoral injection of immunoadjuvant

Chet Joshi, Jessnie Jose, Daniel Figueroa, Jessica Goddard, Xiaosong Li, Hong Liu, Robert Nordquist, Tomas Hode, Wei Chen

Proceedings Volume 8224, 822408 (2012) https://doi.org/10.1117/12.906539

KEYWORDS: Tumors, Laser irradiation, Diffusers, Tissues, Skin, Laser therapeutics, Cancer, Laser tissue interaction, Oncology, Photothermal interactions

Read Abstract +

SPIE Journal Paper | 1 December 2011 Open Access

Open Access

Assessment of thermal effects of interstitial laser phototherapy on mammary tumors using proton resonance frequency method

Kelvin Le, Xiaosong Li, Daniel Figueroa, Wei Chen, Rheal Towner, Philippe Garteiser, Debra Saunders, Nataliya Smith, Hong Liu, Tomas Hode, Robert Nordquist

JBO, Vol. 16, Issue 12, 128001, (December 2011) https://doi.org/10.1117/12.10.1117/1.3659200

KEYWORDS: Tumors, Temperature metrology, Tissues, Laser irradiation, Liver, Laser tissue interaction, Phototherapy, Thermal effects, Cancer, Fiber lasers

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Proceedings Article | 24 February 2011 Paper

Paper

Photothermal effects in tissues induced by interstitial irradiation of near infrared laser with a cylindrical diffuser

Kelvin Le, Chet Johsi, Daniel Figueroa, Jessica Goddard, Xiaosong Li, Rheal Towner, Debra Saunders, Nataliya Smith, Hong Liu, Tomas Hode, Robert Nordquist, Wei Chen

Proceedings Volume 7900, 79000B (2011) https://doi.org/10.1117/12.873923

KEYWORDS: Tissues, Tumors, Laser irradiation, Temperature metrology, Diffusers, Liver, Laser therapeutics, Fiber lasers, Magnetic resonance imaging, Calibration

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Proceedings Article | 24 February 2011 Paper

Paper

Mechanism study of tumor-specific immune responses induced by laser immunotherapy

Xiaosong Li, Feifan Zhou, Henry Le, Roman Wolf, Eric Howard, Robert Nordquist, Tomas Hode, Hong Liu, Wei Chen

Proceedings Volume 7900, 790006 (2011) https://doi.org/10.1117/12.873919

KEYWORDS: Tumors, Cancer, Oncology, Melanoma, Breast cancer, Spleen, Tissues, Clinical trials, Resistance, Proteins

Read Abstract +

Proceedings Article | 24 February 2011 Paper

Paper

Laser immunotherapy for the treatment of human breast cancer: one-year follow up results

Tomas Hode, Orn Adalsteinsson, Gabriela Ferrel, John Lunn, Maria Guerra, Xiaosong Li, Robert Nordquist, Wei Chen

Proceedings Volume 7900, 790009 (2011) https://doi.org/10.1117/12.874798

KEYWORDS: Tumors, Breast cancer, Cancer, Toxicity, Lung, Oncology, Breast, Laser irradiation, Blood, Computed tomography

Read Abstract +

Proceedings Article | 24 February 2011 Paper

Paper

Interstitial laser immunotherapy for treatment of metastatic mammary tumors in rats

Daniel Figueroa, Chet Joshi, Roman Wolf, Jonny Walla, Jessica Goddard, Mallory Martin, Stanley Kosanke, Fred Broach, Sean Pontius, Destiny Brown, Xiaosong Li, Eric Howard, Robert Nordquist, Tomas Hode, Wei Chen

Proceedings Volume 7900, 79000A (2011) https://doi.org/10.1117/12.873925

KEYWORDS: Tumors, Tissues, Laser irradiation, Cancer, Oncology, Laser tissue interaction, Diffusers, Skin, Fiber lasers, Laser therapeutics

Read Abstract +

Proceedings Article | 10 February 2011 Paper

Paper

To what extent is coherence lost in tissue?

Tomas Hode, Peter Jenkins, Stefan Jordison, Lars Hode

Proceedings Volume 7887, 788703 (2011) https://doi.org/10.1117/12.878827

KEYWORDS: Speckle pattern, Speckle, Tissues, Laser tissue interaction, Semiconductor lasers, Absorption, Helium neon lasers, Laser scattering, Polarization, Cameras

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Proceedings Article | 26 February 2010 Paper

Paper

Laser immunotherapy: initial results from a human breast cancer pilot trial

Tomas Hode, Maria Guerra, Gabriela Ferrel, John Lunn, Orn Adelsteinsson, Robert Nordquist, Wei Chen

Proceedings Volume 7565, 756507 (2010) https://doi.org/10.1117/12.839766

KEYWORDS: Tumors, Breast cancer, Breast, Toxicity, Cancer, Lung, Radiotherapy, Blood, Solids, Tolerancing

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Proceedings Article | 25 February 2009 Paper

Paper

Possible role of laser phototherapy in laser immunotherapy

Tomas Hode, Lars Hode

Proceedings Volume 7178, 71780B (2009) https://doi.org/10.1117/12.809529

KEYWORDS: Phototherapy, Tumors, Surgery, Laser therapeutics, Cancer, Modulation, Proteins, Oxygen, Laser vision correction, Acquisition tracking and pointing

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Proceedings Article | 18 February 2009 Paper

Paper

The importance of coherence in phototherapy

Tomas Hode, Donald Duncan, Sean Kirkpatrick, Peter Jenkins, Lars Hode

Proceedings Volume 7165, 716507 (2009) https://doi.org/10.1117/12.809563

KEYWORDS: Polarization, Speckle, Phototherapy, Absorption, Laser tissue interaction, Speckle pattern, Tissue optics, Photon polarization, Laser therapeutics, Light emitting diodes

Read Abstract +

Showing 5 of 21 publications

Conference Committee Involvement (27)

Biophotonics and Immune Responses XX

25 January 2025 | San Francisco, California, United States

Biophotonics and Immune Responses XIX

28 January 2024 | San Francisco, California, United States

Biophotonics and Immune Responses XVIII

30 January 2023 | San Francisco, California, United States

Mechanisms of Photobiomodulation Therapy XVII

28 January 2023 | San Francisco, California, United States

Biophotonics and Immune Responses XVII

24 January 2022 | San Francisco, California, United States

Biophotonics and Immune Responses XVI

6 March 2021 | Online Only, California, United States

Mechanisms of Photobiomodulation Therapy XVI

6 March 2021 | Online Only, California, United States

Biophotonics and Immune Responses XV

3 February 2020 | San Francisco, California, United States

Mechanisms of Photobiomodulation Therapy XV

1 February 2020 | San Francisco, California, United States

Mechanisms of Photobiomodulation Therapy XIV

2 February 2019 | San Francisco, California, United States

Biophotonics and Immune Responses XIII

29 January 2018 | San Francisco, California, United States

Mechanisms of Photobiomodulation Therapy XIII

27 January 2018 | San Francisco, California, United States

Biophotonics and Immune Responses XII

30 January 2017 | San Francisco, California, United States

Mechanisms of Photobiomodulation Therapy XII

28 January 2017 | San Francisco, California, United States

Biophotonics and Immune Responses XI

15 February 2016 | San Francisco, California, United States

Mechanisms of Photobiomodulation Therapy XI

13 February 2016 | San Francisco, California, United States

Biophotonics and Immune Responses X

9 February 2015 | San Francisco, California, United States

Mechanisms for Low-Light Therapy X

7 February 2015 | San Francisco, California, United States

Biophotonics and Immune Responses IX

3 February 2014 | San Francisco, California, United States

Mechanisms for Low-Light Therapy IX

1 February 2014 | San Francisco, California, United States

Biophotonics and Immune Responses VIII

4 February 2013 | San Francisco, California, United States

Mechanisms for Low-Light Therapy VIII

2 February 2013 | San Francisco, California, United States

Biophotonics and Immune Responses VII

23 January 2012 | San Francisco, California, United States

Biophotonics and Immune Responses VI

24 January 2011 | San Francisco, California, United States

Biophotonics and Immune Responses V

25 January 2010 | San Francisco, California, United States

Mechanisms for Low-Light Therapy V

23 January 2010 | San Francisco, California, United States

Mechanisms for Low-Light Therapy IV

24 January 2009 | San Jose, California, United States

Showing 5 of 27 Conference Committees

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